• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
iUUCD ID IUUC-Mcc-055508
Ensembl Protein ID ENSMMUP00000007251.3
UniProt Accession F7FZ57; F7FZ57_MACMU
Genbank Protein ID ENSMMUP00000007251
Protein Name Histone-lysine N-methyltransferase 2A
Genbank Nucleotide ID JSUE03013508
Gene Name KMT2A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000005482.3 ENSMMUT00000007723.3 ENSMMUP00000007253.3
ENSMMUG00000005482.3 ENSMMUT00000007721.3 ENSMMUP00000007251.3
ENSMMUG00000005482.3 ENSMMUT00000068042.1 ENSMMUP00000043106.1
ENSMMUG00000005482.3 ENSMMUT00000043676.2 ENSMMUP00000036669.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.80e-25 90.0 1477 1530
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1477 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1530
           58********************************.*****99999*******876 PP
   
Organism Macaca mulatta
Functional Description
(View)

Functional Description


     Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin.
 Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin.
Protein Sequence
(Fasta)
MAHSCRWRFP ARPGTTGAAA AGGAGARGRP AQRVPALLLP PAPVGRGGPG APPSPPAVAA 60
AAAAAGSSGA GVPGGAAAAS AASSSSASSS SSSSSSASSG PALLRVGPGF DAALQVSAAI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055508|E3,PHD|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTCACTTCA CGCGGGCAAC ATGGCGCACA GCTGTCGGTG GCGCTTCCCC GCCCGACCCG 60
GGACCACGGG GGCGGCGGCG GCGGGGGGCG CCGGGGCTAG GGGGCGCCCC GCGCAACGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055508|E3,PHD|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2
Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC
SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET
Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0006351--P:transcription, DNA-templated
GO:0008542--P:visual learning
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002274 Ailuropoda melanoleuca 94.71 0.00e+00 6146.00
IUUC-Atr-002455 Amborella trichopoda 48.10 8.00e-39 155.00
IUUC-Apl-003478 Anas platyrhynchos 79.35 0.00e+00 4012.00
IUUC-Aca-005086 Anolis carolinensis 65.18 0.00e+00 2932.00
IUUC-Aly-006448 Arabidopsis lyrata 48.10 4.00e-39 157.00
IUUC-Ath-006690 Arabidopsis thaliana 47.40 5.00e-37 150.00
IUUC-Ame-011195 Astyanax mexicanus 43.77 0.00e+00 787.00
IUUC-Bta-012974 Bos taurus 94.02 0.00e+00 6055.00
IUUC-Bol-016540 Brassica oleracea 48.05 1.00e-37 151.00
IUUC-Cja-019226 Callithrix jacchus 95.71 0.00e+00 6261.00
IUUC-Cfa-021049 Canis familiaris 94.39 0.00e+00 6052.00
IUUC-Cpo-021459 Cavia porcellus 93.25 0.00e+00 4343.00
IUUC-Cre-022891 Chlamydomonas reinhardtii 50.00 1.00e-38 156.00
IUUC-Csa-023434 Chlorocebus sabaeus 99.72 0.00e+00 5853.00
IUUC-Cho-024652 Choloepus hoffmanni 90.41 0.00e+00 3934.00
IUUC-Cin-025724 Ciona intestinalis 54.46 2.00e-96 347.00
IUUC-Csv-026268 Ciona savignyi 36.96 1.00e-133 471.00
IUUC-Cme-027224 Cyanidioschyzon merolae 34.18 3.00e-12 67.40
IUUC-Dre-028180 Danio rerio 68.23 0.00e+00 1161.00
IUUC-Dno-029068 Dasypus novemcinctus 90.69 0.00e+00 5782.00
IUUC-Dor-030550 Dipodomys ordii 86.84 0.00e+00 5098.00
IUUC-Ete-032834 Echinops telfairi 84.86 0.00e+00 2810.00
IUUC-Eca-033615 Equus caballus 95.32 0.00e+00 6008.00
IUUC-Eeu-035136 Erinaceus europaeus 82.78 0.00e+00 1179.00
IUUC-Fca-036453 Felis catus 91.94 0.00e+00 2714.00
IUUC-Fal-037256 Ficedula albicollis 78.16 0.00e+00 4985.00
IUUC-Gmo-038641 Gadus morhua 67.53 0.00e+00 1093.00
IUUC-Gga-040828 Gallus gallus 78.83 0.00e+00 4941.00
IUUC-Gac-041452 Gasterosteus aculeatus 70.49 0.00e+00 1159.00
IUUC-Gma-043554 Glycine max 49.02 4.00e-38 153.00
IUUC-Ggo-045124 Gorilla gorilla 95.01 0.00e+00 5984.00
IUUC-Hsa-046143 Homo sapiens 98.60 0.00e+00 6261.00
IUUC-Itr-049024 Ictidomys tridecemlineatus 92.54 0.00e+00 5308.00
IUUC-Lch-049704 Latimeria chalumnae 63.94 0.00e+00 3868.00
IUUC-Loc-052181 Lepisosteus oculatus 78.87 0.00e+00 1314.00
IUUC-Laf-053946 Loxodonta africana 94.60 0.00e+00 5908.00
IUUC-Meu-056485 Macropus eugenii 81.79 0.00e+00 3070.00
IUUC-Mtr-058327 Medicago truncatula 41.52 1.00e-38 155.00
IUUC-Mga-059943 Meleagris gallopavo 75.99 0.00e+00 4571.00
IUUC-Mmr-061178 Microcebus murinus 94.00 0.00e+00 6109.00
IUUC-Mdo-063031 Monodelphis domestica 86.44 0.00e+00 4047.00
IUUC-Mmu-063650 Mus musculus 89.60 0.00e+00 4159.00
IUUC-Mpu-066495 Mustela putorius furo 94.87 0.00e+00 4133.00
IUUC-Mlu-068045 Myotis lucifugus 85.96 0.00e+00 5438.00
IUUC-Nle-069064 Nomascus leucogenys 98.77 0.00e+00 6322.00
IUUC-Opr-071043 Ochotona princeps 88.14 0.00e+00 4436.00
IUUC-Ont-072556 Oreochromis niloticus 69.95 0.00e+00 1129.00
IUUC-Oan-073324 Ornithorhynchus anatinus 77.37 0.00e+00 2124.00
IUUC-Ocu-074190 Oryctolagus cuniculus 92.59 0.00e+00 5915.00
IUUC-Oba-075647 Oryza barthii 49.36 3.00e-38 154.00
IUUC-Olo-080577 Oryza longistaminata 47.71 9.00e-36 145.00
IUUC-Ome-081214 Oryza meridionalis 49.36 3.00e-38 154.00
IUUC-Oni-083000 Oryza nivara 49.36 3.00e-38 154.00
IUUC-Opu-083842 Oryza punctata 49.36 3.00e-38 154.00
IUUC-Oru-084361 Oryza rufipogon 49.36 3.00e-38 154.00
IUUC-Oga-088208 Otolemur garnettii 94.79 0.00e+00 6012.00
IUUC-Oar-090152 Ovis aries 94.02 0.00e+00 6091.00
IUUC-Ptr-091127 Pan troglodytes 98.68 0.00e+00 6225.00
IUUC-Pan-092679 Papio anubis 99.66 0.00e+00 5080.00
IUUC-Psi-094059 Pelodiscus sinensis 79.67 0.00e+00 5012.00
IUUC-Pma-094258 Petromyzon marinus 60.47 0.00e+00 684.00
IUUC-Pfo-096536 Poecilia formosa 68.60 0.00e+00 1117.00
IUUC-Pab-098262 Pongo abelii 98.71 0.00e+00 6341.00
IUUC-Pca-100358 Procavia capensis 89.74 0.00e+00 5505.00
IUUC-Pva-102522 Pteropus vampyrus 89.82 0.00e+00 4791.00
IUUC-Rno-105200 Rattus norvegicus 89.73 0.00e+00 4090.00
IUUC-Sha-107174 Sarcophilus harrisii 85.67 0.00e+00 5412.00
IUUC-Smo-109164 Selaginella moellendorffii 51.95 1.00e-40 162.00
IUUC-Sly-111176 Solanum lycopersicum 48.37 5.00e-36 146.00
IUUC-Stu-112529 Solanum tuberosum 48.37 2.00e-38 154.00
IUUC-Sar-113503 Sorex araneus 83.37 0.00e+00 3134.00
IUUC-Sbi-114254 Sorghum bicolor 26.92 1.00e-10 62.40
IUUC-Tgu-117047 Taeniopygia guttata 78.71 0.00e+00 4944.00
IUUC-Tsy-118953 Tarsius syrichta 89.65 0.00e+00 3122.00
IUUC-Tni-120837 Tetraodon nigroviridis 66.23 0.00e+00 1135.00
IUUC-Tbe-127950 Tupaia belangeri 88.44 0.00e+00 2894.00
IUUC-Ttr-128643 Tursiops truncatus 92.74 0.00e+00 5846.00
IUUC-Vpa-130660 Vicugna pacos 90.80 0.00e+00 2025.00
IUUC-Vvi-131476 Vitis vinifera 46.75 3.00e-39 157.00
IUUC-Xtr-132869 Xenopus tropicalis 62.19 0.00e+00 2288.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved