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Tag Content
UUCD2 ID IUUC-Bta-012959
UUCD1 version UUC-BoT-00864
Ensembl Protein ID ENSBTAP00000051164.2
UniProt Accession Q1JQB2; A5D9G0; BUB3_BOVIN
Genbank Protein ID ABQ13019.1; AAI16091.1
Protein Name Mitotic checkpoint protein BUB3
Genbank Nucleotide ID BT030579; BC116090
Gene Name BUB3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000017913.5 ENSBTAT00000057027.2 ENSBTAP00000051164.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.20e-29 99.9 95 128
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           H ++++c+++ ++ + +v+Gs+D t+k+WD+rt 
   Q: 95   HDAPIRCVEYcPEvNVMVTGSWDQTVKLWDPRTP 128
           999********999****************9985 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity).
 Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity).
Protein Sequence
(Fasta)
MTGSNEFKLN QPPEDGISSV KFSPNTSQFL LVSSWDTSVR LYDVPANSMR LKYQHTGAVL 60
DCAFYDPTHA WSGGLDHQLK MHDLNTDQEN LVGTHDAPIR CVEYCPEVNV MVTGSWDQTV 120
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Protein Fasta Sequence


>IUUC-Bta-012959|E3,WD_repeat|Bos taurus
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Nucleotide Sequence
(Fasta)
GAGCGGCGGC GGGCGCGGCG GCTGAGTTGC TTCTGAACGG AGCCCGAGGT AGCGGGGCGA 60
GGTGGCCGGG CGGAGGCACG GGCTTTCCGG GGATGCCCCC GGGGTTCCCT AGCCAGCGGA 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012959|E3,WD_repeat|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0013--ADP-ribosylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0995--Kinetochore
KW-0469--Meiosis
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005654--C:nucleoplasm
GO:0008608--P:attachment of spindle microtubules to kinetochore
GO:0051301--P:cell division
GO:0051321--P:meiotic cell cycle
GO:0000070--P:mitotic sister chromatid segregation
GO:0051983--P:regulation of chromosome segregation
GO:0071173--P:spindle assembly checkpoint
KEGG bta:539594
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000710 Aegilops tauschii 50.00 6.00e-65 241.00
IUUC-Aml-002418 Ailuropoda melanoleuca 99.69 0.00e+00 686.00
IUUC-Atr-002511 Amborella trichopoda 53.42 2.00e-103 368.00
IUUC-Apl-003201 Anas platyrhynchos 96.00 0.00e+00 666.00
IUUC-Aca-004657 Anolis carolinensis 98.16 0.00e+00 678.00
IUUC-Aly-005707 Arabidopsis lyrata 55.66 4.00e-105 374.00
IUUC-Ath-007454 Arabidopsis thaliana 55.03 6.00e-104 370.00
IUUC-Acl-008120 Aspergillus clavatus 38.07 1.00e-69 256.00
IUUC-Afu-009061 Aspergillus fumigatus 38.18 9.00e-71 260.00
IUUC-Ani-009457 Aspergillus nidulans 39.15 6.00e-72 264.00
IUUC-Ang-009848 Aspergillus niger 37.64 5.00e-68 251.00
IUUC-Aor-009886 Aspergillus oryzae 36.86 5.00e-64 238.00
IUUC-Ate-010388 Aspergillus terreus 38.35 8.00e-69 253.00
IUUC-Ame-011039 Astyanax mexicanus 88.04 1.00e-178 618.00
IUUC-Bgr-012134 Blumeria graminis 37.04 1.00e-68 253.00
IUUC-Bci-013818 Botrytis cinerea 39.70 3.00e-69 255.00
IUUC-Bdi-014928 Brachypodium distachyon 53.42 6.00e-104 370.00
IUUC-Bol-016443 Brassica oleracea 55.80 2.00e-105 375.00
IUUC-Bra-016981 Brassica rapa 55.66 2.00e-106 378.00
IUUC-Cel-018211 Caenorhabditis elegans 43.64 2.00e-77 282.00
IUUC-Cja-018807 Callithrix jacchus 99.69 0.00e+00 687.00
IUUC-Cfa-020279 Canis familiaris 100.00 4.00e-149 520.00
IUUC-Cpo-022411 Cavia porcellus 100.00 0.00e+00 687.00
IUUC-Cre-022964 Chlamydomonas reinhardtii 46.48 5.00e-79 287.00
IUUC-Csa-024046 Chlorocebus sabaeus 100.00 5.00e-153 533.00
IUUC-Cho-024930 Choloepus hoffmanni 99.38 0.00e+00 684.00
IUUC-Cin-025561 Ciona intestinalis 70.15 2.00e-141 494.00
IUUC-Csv-026129 Ciona savignyi 68.92 7.00e-140 489.00
IUUC-Cgl-026764 Colletotrichum gloeosporioides 37.82 8.00e-67 247.00
IUUC-Cne-026832 Cryptococcus neoformans 39.08 3.00e-54 206.00
IUUC-Dre-028257 Danio rerio 86.20 7.00e-166 576.00
IUUC-Dno-029433 Dasypus novemcinctus 99.69 0.00e+00 688.00
IUUC-Dor-030318 Dipodomys ordii 99.69 0.00e+00 686.00
IUUC-Dme-031609 Drosophila melanogaster 60.56 8.00e-117 413.00
IUUC-Ete-032903 Echinops telfairi 82.46 3.00e-154 537.00
IUUC-Eca-034333 Equus caballus 100.00 0.00e+00 687.00
IUUC-Fca-035848 Felis catus 100.00 0.00e+00 687.00
IUUC-Fal-037239 Ficedula albicollis 96.63 0.00e+00 675.00
IUUC-Fox-037712 Fusarium oxysporum 36.52 3.00e-65 241.00
IUUC-Fso-038165 Fusarium solani 36.89 1.00e-64 239.00
IUUC-Gmo-039586 Gadus morhua 85.76 2.00e-172 597.00
IUUC-Gga-040565 Gallus gallus 96.91 0.00e+00 671.00
IUUC-Gac-041299 Gasterosteus aculeatus 86.46 1.00e-174 605.00
IUUC-Gma-042865 Glycine max 53.77 3.00e-102 365.00
IUUC-Ggo-045135 Gorilla gorilla 100.00 0.00e+00 687.00
IUUC-Hsa-045788 Homo sapiens 100.00 0.00e+00 687.00
IUUC-Itr-048845 Ictidomys tridecemlineatus 100.00 0.00e+00 686.00
IUUC-Lch-050423 Latimeria chalumnae 93.56 0.00e+00 654.00
IUUC-Lpe-051670 Leersia perrieri 55.28 2.00e-107 381.00
IUUC-Loc-052148 Lepisosteus oculatus 90.18 0.00e+00 633.00
IUUC-Lma-053147 Leptosphaeria maculans 39.71 1.00e-68 253.00
IUUC-Laf-054429 Loxodonta africana 99.08 0.00e+00 678.00
IUUC-Mcc-055649 Macaca mulatta 100.00 0.00e+00 687.00
IUUC-Meu-056019 Macropus eugenii 85.76 3.00e-163 566.00
IUUC-Mtr-058803 Medicago truncatula 53.73 1.00e-103 369.00
IUUC-Mla-059131 Melampsora laricipopulina 39.94 4.00e-69 254.00
IUUC-Mga-059227 Meleagris gallopavo 96.32 0.00e+00 665.00
IUUC-Mmr-060811 Microcebus murinus 100.00 0.00e+00 687.00
IUUC-Mdo-062582 Monodelphis domestica 95.52 0.00e+00 673.00
IUUC-Mmu-064048 Mus musculus 100.00 0.00e+00 690.00
IUUC-Mac-064572 Musa acuminata 54.46 3.00e-104 371.00
IUUC-Mpu-066592 Mustela putorius furo 100.00 0.00e+00 687.00
IUUC-Mlu-067466 Myotis lucifugus 98.15 0.00e+00 672.00
IUUC-Nfi-068486 Neosartorya fischeri 38.22 9.00e-70 257.00
IUUC-Ncr-068899 Neurospora crassa 38.29 7.00e-69 254.00
IUUC-Nle-069273 Nomascus leucogenys 100.00 0.00e+00 687.00
IUUC-Opr-070473 Ochotona princeps 94.15 0.00e+00 647.00
IUUC-Ont-072515 Oreochromis niloticus 87.42 9.00e-179 619.00
IUUC-Oan-073344 Ornithorhynchus anatinus 99.64 2.00e-170 590.00
IUUC-Ocu-073931 Oryctolagus cuniculus 99.38 0.00e+00 686.00
IUUC-Oba-075450 Oryza barthii 55.28 2.00e-107 381.00
IUUC-Obr-076202 Oryza brachyantha 55.28 2.00e-107 382.00
IUUC-Ogl-077809 Oryza glaberrima 55.28 2.00e-107 381.00
IUUC-Ogu-078034 Oryza glumaepatula 51.60 8.00e-103 366.00
IUUC-Oin-079586 Oryza indica 55.28 2.00e-107 381.00
IUUC-Olo-080351 Oryza longistaminata 50.96 5.00e-94 337.00
IUUC-Ome-081913 Oryza meridionalis 45.20 4.00e-79 288.00
IUUC-Oni-082048 Oryza nivara 55.28 2.00e-107 381.00
IUUC-Opu-083951 Oryza punctata 55.28 3.00e-107 381.00
IUUC-Oru-084904 Oryza rufipogon 55.28 4.00e-107 380.00
IUUC-Osa-085399 Oryza sativa 55.28 2.00e-107 382.00
IUUC-Ola-086605 Oryzias latipes 87.65 1.00e-177 615.00
IUUC-Oga-088115 Otolemur garnettii 100.00 0.00e+00 687.00
IUUC-Oar-089301 Ovis aries 99.69 0.00e+00 685.00
IUUC-Pan-092156 Papio anubis 100.00 0.00e+00 687.00
IUUC-Psi-094031 Pelodiscus sinensis 97.85 0.00e+00 681.00
IUUC-Pma-094724 Petromyzon marinus 81.60 7.00e-168 582.00
IUUC-Pno-094848 Phaeosphaeria nodorum 40.08 7.00e-52 196.00
IUUC-Ppa-096018 Physcomitrella patens 57.83 2.00e-109 388.00
IUUC-Pfo-096256 Poecilia formosa 87.42 9.00e-178 615.00
IUUC-Pab-097757 Pongo abelii 100.00 0.00e+00 687.00
IUUC-Pop-099511 Populus trichocarpa 55.17 1.00e-105 375.00
IUUC-Pca-100326 Procavia capensis 99.15 1.00e-142 498.00
IUUC-Ppe-101462 Prunus persica 55.35 1.00e-104 372.00
IUUC-Pva-102523 Pteropus vampyrus 100.00 0.00e+00 687.00
IUUC-Pgr-103482 Puccinia graminis 40.29 1.00e-56 213.00
IUUC-Ptt-103911 Puccinia triticina 39.09 9.00e-66 244.00
IUUC-Pte-104350 Pyrenophora teres 38.82 4.00e-68 251.00
IUUC-Pyt-104538 Pyrenophora triticirepentis 38.82 4.00e-68 251.00
IUUC-Rno-105388 Rattus norvegicus 64.72 7.00e-109 387.00
IUUC-Sha-106976 Sarcophilus harrisii 99.69 0.00e+00 685.00
IUUC-Sja-107725 Schizosaccharomyces japonicus 37.20 3.00e-55 208.00
IUUC-Spo-108103 Schizosaccharomyces pombe 37.88 1.00e-54 206.00
IUUC-Ssl-108521 Sclerotinia sclerotiorum 35.47 4.00e-37 147.00
IUUC-Smo-109187 Selaginella moellendorffii 54.06 5.00e-104 370.00
IUUC-Sit-110412 Setaria italica 52.55 1.00e-98 353.00
IUUC-Sly-111541 Solanum lycopersicum 54.49 7.00e-103 367.00
IUUC-Stu-112371 Solanum tuberosum 54.17 2.00e-102 365.00
IUUC-Sar-113159 Sorex araneus 77.97 2.00e-105 374.00
IUUC-Sbi-114880 Sorghum bicolor 54.97 2.00e-106 378.00
IUUC-Sre-115205 Sporisorium reilianum 31.28 4.00e-46 178.00
IUUC-Ssc-116399 Sus scrofa 100.00 0.00e+00 687.00
IUUC-Tgu-117029 Taeniopygia guttata 96.28 0.00e+00 667.00
IUUC-Tru-118385 Takifugu rubripes 87.35 1.00e-176 612.00
IUUC-Tsy-118842 Tarsius syrichta 99.08 0.00e+00 682.00
IUUC-Tni-120539 Tetraodon nigroviridis 86.24 4.00e-175 606.00
IUUC-Tca-121027 Theobroma cacao 55.03 1.00e-103 369.00
IUUC-Tre-122098 Trichoderma reesei 36.89 3.00e-62 232.00
IUUC-Tvi-122569 Trichoderma virens 37.46 4.00e-65 241.00
IUUC-Tae-123002 Triticum aestivum 54.66 3.00e-106 378.00
IUUC-Tur-126282 Triticum urartu 51.36 1.00e-66 245.00
IUUC-Tme-127210 Tuber melanosporum 48.10 4.00e-83 301.00
IUUC-Tbe-128159 Tupaia belangeri 68.92 1.00e-122 432.00
IUUC-Ttr-128743 Tursiops truncatus 100.00 0.00e+00 687.00
IUUC-Uma-129496 Ustilago maydis 32.69 4.00e-40 159.00
IUUC-Vda-129882 Verticillium dahliae 39.94 1.00e-69 256.00
IUUC-Vpa-130790 Vicugna pacos 100.00 5.00e-159 553.00
IUUC-Vvi-131671 Vitis vinifera 54.35 1.00e-103 369.00
IUUC-Xtr-132887 Xenopus tropicalis 82.41 3.00e-158 550.00
IUUC-Xma-134127 Xiphophorus maculatus 87.42 1.00e-177 615.00
IUUC-Yli-134366 Yarrowia lipolytica 40.33 1.00e-53 203.00
Created Date 25-Jun-2017

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