iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.40e-91	305.0	212	556

Active Site

Position(s)	Description	Evidence
221	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
518	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgy 87
           +Gl+NlgNtC++N+vLQcLs++++lr+++l+  ++++++     ++ +el++++++++ +lw  ++ +av+p+++ ++++k+ ++fsgy
   Q: 212  VGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRrDFRQEVPG---GGRAQELTEAFADVIGALWhPDSCEAVNPTRFRAVFQKYVPSFSGY 297
           6******************************667777776...5789***************888899********************* PP
   S: 88   eqqDaqEflaflldqleeelkk..................eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           +qqDaqEfl+ l+++l+ e+++                  ++    +ee e ++ ++ +  +++  ++++s i+dlF gqlks +kc++
   Q: 298  SQQDAQEFLKLLMERLHLEINRrgrrappilasgpvpsppRRGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
           ********************9999999999999998877755556666666666667777***************************** PP
   S: 159  cdnvssreepfldlslpvpgkeet.kkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksr 246
           c+ +s+++e f+dlslp+p+k     k sl+dc++ ftkeeele+en+  c++c++k++++kkl+++++P++L+lhL+Rf  s +++s 
   Q: 387  CGYRSTTFEVFCDLSLPIPKKGFAgGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRF--STSRGSI 473
           *******************887541456****************************************************..6667999 PP
   S: 247  ekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           +k +  v+fpl+ L+l  f +++      +  Y+L+a ++HsGs++ GHY+a+++  + +W  ++Ds+V++v+e++v +   s++Yvlf
   Q: 474  KKSSVGVDFPLQrLSLGDFASDKVG----SPVYQLYALCNHSGSVHYGHYTALCRC-QTGWHVYNDSRVSPVSENQVAS---SEGYVLF 554
           9**********99*******99554....68*************************.777*******************...******* PP
   S: 335  Yk 336
           Y+
   Q: 555  YQ 556
           *8 PP

Organism

Rattus norvegicus

Functional Description
(View)

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.

Protein Sequence
(Fasta)

MPQASEHRLG RTREPPVNVQ PRVGAKIPFP PRARSKERRN PVPGPNSMLR PLPPRPGPPD 60
ERLKKLDLGR GRTSGSRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLTR SKSVSSGDLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGTGGCCG GGCGGCACCA ACAAAGATGG CGGCGGCCCT TGCGGCGGGA GCAAGCTGGG 60
CAACAGCTGC GGCTAAAGCT GCAGCCTGGC CTGCGGGGAG GCTGTTCGGG GGTAGGAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0008234--F:cysteine-type peptidase activity
GO:0046872--F:metal ion binding
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0016578--P:histone deubiquitination
GO:0031175--P:neuron projection development
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:688466

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001858	Ailuropoda melanoleuca	95.75	0.00e+00	999.00
IUUC-Aca-004612	Anolis carolinensis	58.79	1.00e-174	606.00
IUUC-Ame-011548	Astyanax mexicanus	52.26	1.00e-103	369.00
IUUC-Bta-012626	Bos taurus	95.58	0.00e+00	974.00
IUUC-Cja-018853	Callithrix jacchus	96.64	0.00e+00	1024.00
IUUC-Cfa-021167	Canis familiaris	96.28	0.00e+00	989.00
IUUC-Cpo-021305	Cavia porcellus	95.58	0.00e+00	954.00
IUUC-Csa-023454	Chlorocebus sabaeus	96.81	0.00e+00	1027.00
IUUC-Cho-024836	Choloepus hoffmanni	95.34	2.00e-107	382.00
IUUC-Dre-028454	Danio rerio	53.67	1.00e-107	383.00
IUUC-Dno-029955	Dasypus novemcinctus	90.36	0.00e+00	635.00
IUUC-Dor-031053	Dipodomys ordii	96.11	0.00e+00	1045.00
IUUC-Ete-032416	Echinops telfairi	94.76	7.00e-143	500.00
IUUC-Eca-033817	Equus caballus	95.22	0.00e+00	1006.00
IUUC-Fca-036400	Felis catus	95.41	0.00e+00	984.00
IUUC-Gmo-038926	Gadus morhua	54.80	2.00e-104	372.00
IUUC-Gac-041331	Gasterosteus aculeatus	53.59	7.00e-108	384.00
IUUC-Ggo-045174	Gorilla gorilla	96.81	0.00e+00	1027.00
IUUC-Hsa-046443	Homo sapiens	96.64	0.00e+00	1020.00
IUUC-Itr-048329	Ictidomys tridecemlineatus	95.95	0.00e+00	1008.00
IUUC-Lch-050539	Latimeria chalumnae	62.00	9.00e-106	377.00
IUUC-Loc-051808	Lepisosteus oculatus	55.28	4.00e-115	408.00
IUUC-Laf-053730	Loxodonta africana	93.49	0.00e+00	1002.00
IUUC-Mcc-055541	Macaca mulatta	96.81	0.00e+00	1027.00
IUUC-Meu-056279	Macropus eugenii	89.75	0.00e+00	961.00
IUUC-Mmr-060913	Microcebus murinus	96.11	0.00e+00	945.00
IUUC-Mdo-061807	Monodelphis domestica	89.93	0.00e+00	887.00
IUUC-Mmu-063599	Mus musculus	97.89	0.00e+00	984.00
IUUC-Mpu-066329	Mustela putorius furo	96.64	0.00e+00	991.00
IUUC-Mlu-067359	Myotis lucifugus	92.37	0.00e+00	879.00
IUUC-Nle-068975	Nomascus leucogenys	94.51	0.00e+00	995.00
IUUC-Opr-071096	Ochotona princeps	94.51	0.00e+00	964.00
IUUC-Ocu-074228	Oryctolagus cuniculus	96.83	0.00e+00	991.00
IUUC-Ola-086684	Oryzias latipes	50.99	2.00e-102	365.00
IUUC-Oga-088007	Otolemur garnettii	78.45	0.00e+00	760.00
IUUC-Oar-090226	Ovis aries	94.98	0.00e+00	758.00
IUUC-Ptr-091522	Pan troglodytes	96.81	0.00e+00	1027.00
IUUC-Pan-091954	Papio anubis	96.46	0.00e+00	1019.00
IUUC-Psi-093216	Pelodiscus sinensis	60.35	0.00e+00	671.00
IUUC-Pfo-096257	Poecilia formosa	50.70	9.00e-103	366.00
IUUC-Pab-098691	Pongo abelii	96.64	0.00e+00	1026.00
IUUC-Pca-101133	Procavia capensis	87.79	0.00e+00	942.00
IUUC-Pva-102681	Pteropus vampyrus	92.92	0.00e+00	934.00
IUUC-Sha-107145	Sarcophilus harrisii	89.76	0.00e+00	878.00
IUUC-Ssc-115586	Sus scrofa	96.81	0.00e+00	972.00
IUUC-Tgu-117491	Taeniopygia guttata	81.82	4.00e-114	403.00
IUUC-Tni-120746	Tetraodon nigroviridis	51.94	8.00e-96	343.00
IUUC-Tbe-127465	Tupaia belangeri	98.14	7.00e-126	444.00
IUUC-Ttr-128274	Tursiops truncatus	93.63	0.00e+00	944.00
IUUC-Xtr-131989	Xenopus tropicalis	49.48	6.00e-128	451.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence