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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046648
Ensembl Protein ID ENSP00000384371.2
UniProt Accession P41182; A7E241; B8PSA7; D3DNV5; BCL6_HUMAN
Genbank Protein ID CAA79937.1; AAC50054.1; ABX45135.1; EAW78140.1; EAW78141.1; AAI50185.1
Protein Name B-cell lymphoma 6 protein; B-cell lymphoma 5 protein; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51
Genbank Nucleotide ID Z21943; U00115; S67779; AC072022; CH471052; BC150184
Gene Name BCL6; BCL5; LAZ3; ZBTB27; ZNF51
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000113916.17 ENST00000406870.6 ENSP00000384371.2
ENSG00000113916.17 ENST00000419510.6 ENSP00000398014.2
ENSG00000113916.17 ENST00000450123.6 ENSP00000413122.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanmiRecords
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.00e-13 53.1 32 98
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.dvqpevfrallkFlYtgklden 68
           +Dv++vv +e+f+ahk vL+a+S  Fy+ f+ +l+ +   + ++++ ++ pe f  ll+F+Yt++l++ 
   Q: 32   TDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCN--LSVINLDpEINPEGFCILLDFMYTSRLNLR 98
           7**********************************76..699999988*****************9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
 Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
Protein Sequence
(Fasta)
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 60
FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 120
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Protein Fasta Sequence


>IUUC-Hsa-046648|E3,BTB_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATACCATCGT CTTGGGCCCG GGGAGGGAGA GCCACCTTCA GGCCCCTCGA GCCTCGAACC 60
GGAACCTCCA AATCCGAGAC GCTCTGCTTA TGAGGACCTC GAAATATGCC GGCCAGTGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046648|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0031490--F:chromatin DNA binding
GO:0042802--F:identical protein binding
GO:0001161--F:intronic transcription regulatory region sequence-specific DNA binding
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0030036--P:actin cytoskeleton organization
GO:0030183--P:B cell differentiation
GO:0000902--P:cell morphogenesis
GO:0006974--P:cellular response to DNA damage stimulus
GO:0048821--P:erythrocyte development
GO:0002467--P:germinal center formation
GO:0006954--P:inflammatory response
GO:0002903--P:negative regulation of B cell apoptotic process
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0001953--P:negative regulation of cell-matrix adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:0048294--P:negative regulation of isotype switching to IgE isotypes
GO:0032764--P:negative regulation of mast cell cytokine production
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process
GO:0030890--P:positive regulation of B cell proliferation
GO:0051272--P:positive regulation of cellular component movement
GO:0031065--P:positive regulation of histone deacetylation
GO:0045666--P:positive regulation of neuron differentiation
GO:0000060--P:protein import into nucleus, translocation
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0002634--P:regulation of germinal center formation
GO:0043087--P:regulation of GTPase activity
GO:0050776--P:regulation of immune response
GO:0050727--P:regulation of inflammatory response
GO:0043380--P:regulation of memory T cell differentiation
GO:0007266--P:Rho protein signal transduction
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
GO:0042092--P:type 2 immune response
KEGG hsa:604
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001625 Ailuropoda melanoleuca 95.90 0.00e+00 1363.00
IUUC-Atr-002779 Amborella trichopoda 34.44 1.00e-05 45.10
IUUC-Apl-003263 Anas platyrhynchos 78.62 0.00e+00 1134.00
IUUC-Ame-010714 Astyanax mexicanus 59.09 0.00e+00 806.00
IUUC-Bta-012576 Bos taurus 95.18 0.00e+00 1342.00
IUUC-Cja-018906 Callithrix jacchus 97.45 0.00e+00 1400.00
IUUC-Cfa-021058 Canis familiaris 94.45 0.00e+00 1342.00
IUUC-Cpo-022328 Cavia porcellus 95.89 0.00e+00 1384.00
IUUC-Csa-023942 Chlorocebus sabaeus 98.45 0.00e+00 1416.00
IUUC-Cho-024599 Choloepus hoffmanni 90.72 0.00e+00 776.00
IUUC-Cin-025470 Ciona intestinalis 80.99 9.00e-60 225.00
IUUC-Csv-025860 Ciona savignyi 82.11 1.00e-59 224.00
IUUC-Dre-027605 Danio rerio 60.53 0.00e+00 829.00
IUUC-Dno-029476 Dasypus novemcinctus 89.44 0.00e+00 1297.00
IUUC-Dor-030724 Dipodomys ordii 94.76 0.00e+00 1338.00
IUUC-Dme-031902 Drosophila melanogaster 42.39 8.00e-14 72.40
IUUC-Ete-032678 Echinops telfairi 91.08 0.00e+00 1278.00
IUUC-Eca-034377 Equus caballus 96.32 0.00e+00 1370.00
IUUC-Eeu-034532 Erinaceus europaeus 91.17 0.00e+00 844.00
IUUC-Fca-036465 Felis catus 96.46 0.00e+00 1375.00
IUUC-Fal-036977 Ficedula albicollis 78.71 0.00e+00 1150.00
IUUC-Gmo-039515 Gadus morhua 80.50 1.00e-113 402.00
IUUC-Gga-040505 Gallus gallus 78.90 0.00e+00 1140.00
IUUC-Gac-041393 Gasterosteus aculeatus 59.39 0.00e+00 808.00
IUUC-Gma-043945 Glycine max 32.58 8.00e-05 42.70
IUUC-Ggo-044500 Gorilla gorilla 99.44 0.00e+00 1430.00
IUUC-Itr-048732 Ictidomys tridecemlineatus 92.22 0.00e+00 1314.00
IUUC-Lch-050387 Latimeria chalumnae 58.14 0.00e+00 753.00
IUUC-Loc-052103 Lepisosteus oculatus 61.96 0.00e+00 860.00
IUUC-Laf-053636 Loxodonta africana 95.06 0.00e+00 1375.00
IUUC-Mcc-055290 Macaca mulatta 98.44 0.00e+00 1420.00
IUUC-Meu-055910 Macropus eugenii 80.06 0.00e+00 1163.00
IUUC-Mga-059925 Meleagris gallopavo 78.48 0.00e+00 1127.00
IUUC-Mvi-060431 Microbotryum violaceum 30.16 1.50e-02 34.30
IUUC-Mmr-060855 Microcebus murinus 96.46 0.00e+00 1371.00
IUUC-Mmu-063292 Mus musculus 94.63 0.00e+00 1328.00
IUUC-Mpu-066598 Mustela putorius furo 95.47 0.00e+00 1342.00
IUUC-Mlu-067370 Myotis lucifugus 94.35 0.00e+00 1325.00
IUUC-Nle-069870 Nomascus leucogenys 98.58 0.00e+00 1420.00
IUUC-Opr-070986 Ochotona princeps 92.63 0.00e+00 1297.00
IUUC-Ont-072475 Oreochromis niloticus 59.66 0.00e+00 771.00
IUUC-Oan-073596 Ornithorhynchus anatinus 84.83 0.00e+00 1194.00
IUUC-Ocu-073970 Oryctolagus cuniculus 94.92 0.00e+00 1378.00
IUUC-Ola-087102 Oryzias latipes 59.86 0.00e+00 809.00
IUUC-Oga-088873 Otolemur garnettii 95.76 0.00e+00 1380.00
IUUC-Oar-090083 Ovis aries 89.94 0.00e+00 1245.00
IUUC-Ptr-090628 Pan troglodytes 99.72 0.00e+00 1437.00
IUUC-Pan-092324 Papio anubis 98.02 0.00e+00 1407.00
IUUC-Psi-093695 Pelodiscus sinensis 79.75 0.00e+00 1109.00
IUUC-Pfo-096460 Poecilia formosa 58.24 0.00e+00 790.00
IUUC-Pab-098012 Pongo abelii 99.58 0.00e+00 1436.00
IUUC-Pca-100127 Procavia capensis 93.32 0.00e+00 1249.00
IUUC-Pva-102830 Pteropus vampyrus 94.48 0.00e+00 1340.00
IUUC-Rno-105752 Rattus norvegicus 95.05 0.00e+00 1332.00
IUUC-Sha-107259 Sarcophilus harrisii 83.33 0.00e+00 1196.00
IUUC-Sar-113610 Sorex araneus 91.92 0.00e+00 1060.00
IUUC-Ssc-115327 Sus scrofa 95.04 0.00e+00 1357.00
IUUC-Tgu-116457 Taeniopygia guttata 79.75 0.00e+00 1165.00
IUUC-Tru-118520 Takifugu rubripes 58.72 0.00e+00 794.00
IUUC-Tni-119969 Tetraodon nigroviridis 59.14 0.00e+00 794.00
IUUC-Tbe-127327 Tupaia belangeri 90.65 0.00e+00 1280.00
IUUC-Ttr-129204 Tursiops truncatus 93.34 0.00e+00 1306.00
IUUC-Xtr-132937 Xenopus tropicalis 67.28 0.00e+00 909.00
Created Date 25-Jun-2017

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