iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018312

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1

Genbank Nucleotide ID

FO081584

Gene Name

brd-1; K04C2.4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00000265	K04C2.4.1	K04C2.4.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
IID	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16628214

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.016	16.0	31	66

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 13   lvlpCgHvfhadCl...qkwpglknssskefrCPlC 45
           l  +C+H+++ +C+   q+ p  k+ss  + +CP C
   Q: 31   LGSSCKHAYCWECIatfQQKPSGKRSSVARHMCPSC 66
           3356*********96666669*************** PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Involved in ubiquitination. Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity. Involved in DNA repair. Has a reactive role in the response to DNA damage by ionizing radiation. Protects against chromosome non-disjunction and fragmentation to aid chromosome stability.

Protein Sequence
(Fasta)

MFENTKKALE TFRTAIECVK CKKPRGDLQY LGSSCKHAYC WECIATFQQK PSGKRSSVAR 60
HMCPSCAFPL DTSKITEAHM LKTCFDTLSE LNDLLQKVGT TSLTQAEFAC TQNIFNKEKT 120

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Nucleotide Sequence
(Fasta)

GATTTAATTA TTGTTTCAGC GTCAAATAAT GTTTGAAAAC ACTAAAAAAG CATTGGAAAC 60
GTTTCGAACA GCTATCGAGT GTGTTAAATG GTAAGTTGTT GTACAAGATT TTGCCTCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001357--BRCT_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF12796--Ank_2

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK

Gene Ontology

GO:0031436--C:BRCA1-BARD1 complex
GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0016567--P:protein ubiquitination

KEGG

cel:CELE_K04C2.4

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002346	Ailuropoda melanoleuca	24.78	6.00e-14	71.20
IUUC-Apl-004108	Anas platyrhynchos	22.89	7.00e-11	61.20
IUUC-Aca-005387	Anolis carolinensis	23.71	1.00e-12	67.40
IUUC-Bta-013417	Bos taurus	24.23	1.00e-13	70.50
IUUC-Bdi-014760	Brachypodium distachyon	25.69	2.00e-08	53.90
IUUC-Cja-019415	Callithrix jacchus	25.45	6.00e-15	74.70
IUUC-Cfa-020351	Canis familiaris	24.35	7.00e-15	74.70
IUUC-Cpo-021746	Cavia porcellus	25.43	1.00e-12	67.40
IUUC-Csa-023450	Chlorocebus sabaeus	26.15	5.00e-14	72.00
IUUC-Csv-025987	Ciona savignyi	23.62	1.00e-14	73.20
IUUC-Dno-029038	Dasypus novemcinctus	22.62	4.00e-12	65.50
IUUC-Dor-030826	Dipodomys ordii	25.00	5.00e-13	68.60
IUUC-Ete-033061	Echinops telfairi	24.92	5.00e-11	61.60
IUUC-Fca-035414	Felis catus	24.78	1.00e-14	73.90
IUUC-Fal-037357	Ficedula albicollis	24.93	3.00e-15	75.90
IUUC-Gmo-039649	Gadus morhua	33.33	7.00e-09	53.50
IUUC-Ggo-045300	Gorilla gorilla	26.15	9.00e-14	70.90
IUUC-Hsa-045826	Homo sapiens	25.50	4.00e-14	72.00
IUUC-Itr-048456	Ictidomys tridecemlineatus	25.00	5.00e-11	62.00
IUUC-Lpe-050895	Leersia perrieri	24.62	3.00e-08	53.10
IUUC-Laf-054591	Loxodonta africana	24.46	9.00e-15	74.30
IUUC-Mcc-055017	Macaca mulatta	24.84	1.00e-13	70.50
IUUC-Mmr-061544	Microcebus murinus	24.01	4.00e-17	82.00
IUUC-Mdo-062408	Monodelphis domestica	24.15	3.00e-12	65.90
IUUC-Mmu-064203	Mus musculus	26.91	3.00e-15	75.90
IUUC-Mpu-066899	Mustela putorius furo	25.07	1.00e-14	73.90
IUUC-Mlu-067781	Myotis lucifugus	23.90	1.00e-14	73.90
IUUC-Nle-069031	Nomascus leucogenys	26.15	5.00e-14	72.00
IUUC-Ont-072557	Oreochromis niloticus	24.06	6.00e-12	64.70
IUUC-Ocu-074785	Oryctolagus cuniculus	22.75	1.00e-14	73.90
IUUC-Oga-088383	Otolemur garnettii	24.71	9.00e-13	67.80
IUUC-Oar-089357	Ovis aries	25.58	6.00e-16	78.20
IUUC-Ptr-090959	Pan troglodytes	26.15	1.00e-13	70.90
IUUC-Pan-092160	Papio anubis	26.22	6.00e-14	71.60
IUUC-Psi-093036	Pelodiscus sinensis	24.76	7.00e-12	64.70
IUUC-Pma-094720	Petromyzon marinus	34.59	2.00e-10	60.50
IUUC-Pab-098198	Pongo abelii	24.15	4.00e-14	72.40
IUUC-Pva-102243	Pteropus vampyrus	24.71	1.00e-12	67.40
IUUC-Rno-104832	Rattus norvegicus	25.14	4.00e-13	68.90
IUUC-Sar-113203	Sorex araneus	37.35	5.00e-10	57.00
IUUC-Ssc-115611	Sus scrofa	24.50	5.00e-14	71.60
IUUC-Tgu-116812	Taeniopygia guttata	23.59	7.00e-14	71.20
IUUC-Tni-120842	Tetraodon nigroviridis	23.82	1.00e-10	60.50
IUUC-Tca-121417	Theobroma cacao	23.89	1.00e-07	50.80
IUUC-Tae-124838	Triticum aestivum	24.75	7.00e-08	51.60
IUUC-Tur-126725	Triticum urartu	24.75	4.00e-08	52.40
IUUC-Tbe-127550	Tupaia belangeri	24.50	4.00e-11	62.00
IUUC-Ttr-128364	Tursiops truncatus	22.55	1.00e-12	67.00
IUUC-Vpa-130659	Vicugna pacos	23.92	2.00e-15	76.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence