iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ata-000367

Ensembl Protein ID

EMT09352

UniProt Accession

M8AY08; M8AY08_AEGTA

Genbank Protein ID

EMT09352.1

Protein Name

Ubiquitin-activating enzyme E1 2

Genbank Nucleotide ID

KD563654

Gene Name

F775_29880

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
F775_29880	EMT09352	EMT09352

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.40e-173	576.4	409	897

Active Site

Position(s)	Description	Evidence
590	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahees 96
           YD Qi ++G++ q+kl++ak+++vG g+lGcE+lKnL+l+G+     g++tv+D+d +e+snl+rqFLfr++++g++K+ vaa a+  +np+ +vea +++
   Q: 409  YDAQISVFGSKLQNKLEQAKIFMVGSGALGCEFLKNLALMGIscsqnGKLTVTDDDVIEKSNLSRQFLFRDWNIGQPKSTVAATAAMAINPKLHVEALQNR 509
           ***************************************************************************************************** PP
   S: 97   iteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.... 190
            ++++e+++   F +++d Vv+aldn+ ar++++++c++ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++h+++wa    
   Q: 510  ASPETENVFndaFWENLDAVVNALDNVTARMYIDSRCVYFQKPLLESGTLGAKCNAQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWArsef 610
           *******99*****************************************************************************************999 PP
   S: 191  ........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv......... 274
                     +n +l++ +  +  +     ++ ++ +++v + l + + e+f+++i++a+ +f+ +++n +kql+  f+ d +t+s++pfw+         
   Q: 611  egllektpTEVNGFLSNPSVYVAAARTAGDAQARDQLERVIECLHGDKCETFQDCITWARLKFEDYFSNRVKQLTYTFPEDSMTSSGAPFWSapkrfprpl 711
           9999999988888888888888888888888999999999999999******************************************************* PP
   S: 275  ..................................................sfcsnaealqvpekvekdeevvkasap..lylllralerfekk..kgrkpg 321
                                                               +++  ++ ++ek+++   ++ ++ +  ++ l+++le+ +k+  +g  ++
   Q: 712  efsstdpsqlnfilaasilraetfgipipdwaktrnkvaaeavdkvivpeFQPKQGVKIVTDEKATSISSASVDD-AgvIEELITKLEQISKTlpPGFHMN 811
           *******************************99988888888888666632233334444555555555544333.369************976689**** PP
   S: 322  elsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
            ++fekddd   ++d+++ +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++Kv+ g  k e ++n+f ++a+
   Q: 812  PIQFEKDDDTnfHMDVIAGFANMRARNYSIPE-VDKLKAKFIAGRIIPAIATATAMATGLVCLELYKVLAGghKVEDYRNTFANLAI 897
           ********************************.**************************************999********99876 PP

Organism

Aegilops tauschii

Protein Sequence
(Fasta)

MARPTEIDED LHSRQLAVYG RETMKRLFAS NVLVSGLQGL GAEIAKNLVL AGVKSVTLHD 60
DGNVELWDLS SNFFLSEKDV GQNRAQACVL KLQDLNNAVI ISTLTGDLTK EHLSKFQAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAGGC CCACGGAGAT CGACGAGGAC CTCCACAGCC GCCAGCTCGC CGTGTACGGC 60
CGCGAGACCA TGAAGCGCCT CTTCGCCTCC AACGTCCTCG TCTCCGGACT CCAGGGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

KEGG

ats:F775_29880

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001311	Ailuropoda melanoleuca	46.23	0.00e+00	891.00
IUUC-Aca-004620	Anolis carolinensis	45.19	0.00e+00	874.00
IUUC-Ago-007873	Ashbya gossypii	45.44	0.00e+00	812.00
IUUC-Acl-008181	Aspergillus clavatus	45.30	0.00e+00	810.00
IUUC-Afl-008455	Aspergillus flavus	46.21	0.00e+00	805.00
IUUC-Afu-009065	Aspergillus fumigatus	46.08	0.00e+00	845.00
IUUC-Ani-009371	Aspergillus nidulans	46.10	0.00e+00	811.00
IUUC-Ang-009737	Aspergillus niger	46.50	0.00e+00	821.00
IUUC-Aor-010007	Aspergillus oryzae	46.21	0.00e+00	805.00
IUUC-Ate-010466	Aspergillus terreus	46.67	0.00e+00	860.00
IUUC-Bta-012767	Bos taurus	46.45	0.00e+00	899.00
IUUC-Bci-013721	Botrytis cinerea	45.72	0.00e+00	800.00
IUUC-Bdi-014843	Brachypodium distachyon	95.07	0.00e+00	1863.00
IUUC-Cel-018260	Caenorhabditis elegans	39.48	0.00e+00	653.00
IUUC-Cja-019152	Callithrix jacchus	46.35	0.00e+00	894.00
IUUC-Cfa-020622	Canis familiaris	44.48	0.00e+00	842.00
IUUC-Cpo-022526	Cavia porcellus	46.50	0.00e+00	886.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	60.91	0.00e+00	1184.00
IUUC-Csa-023780	Chlorocebus sabaeus	46.54	0.00e+00	898.00
IUUC-Cin-025790	Ciona intestinalis	44.19	0.00e+00	860.00
IUUC-Cne-026960	Cryptococcus neoformans	44.65	0.00e+00	842.00
IUUC-Dno-028884	Dasypus novemcinctus	46.30	0.00e+00	893.00
IUUC-Dor-030229	Dipodomys ordii	44.23	0.00e+00	840.00
IUUC-Eca-033330	Equus caballus	46.11	0.00e+00	891.00
IUUC-Fca-036255	Felis catus	45.86	0.00e+00	882.00
IUUC-Fox-038007	Fusarium oxysporum	47.16	1.00e-136	479.00
IUUC-Fso-038339	Fusarium solani	46.96	0.00e+00	838.00
IUUC-Ggo-045336	Gorilla gorilla	46.45	0.00e+00	879.00
IUUC-Hsa-045982	Homo sapiens	46.35	0.00e+00	876.00
IUUC-Hvu-047418	Hordeum vulgare	98.03	0.00e+00	1947.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	46.15	0.00e+00	891.00
IUUC-Kpa-049112	Komagataella pastoris	46.00	0.00e+00	828.00
IUUC-Loc-052936	Lepisosteus oculatus	47.42	0.00e+00	888.00
IUUC-Laf-053948	Loxodonta africana	47.05	0.00e+00	872.00
IUUC-Mcc-055843	Macaca mulatta	46.45	0.00e+00	895.00
IUUC-Meu-056258	Macropus eugenii	46.40	0.00e+00	886.00
IUUC-Mor-057269	Magnaporthe oryzae	44.80	0.00e+00	839.00
IUUC-Mpo-057435	Magnaporthe poae	45.51	0.00e+00	839.00
IUUC-Mla-059176	Melampsora laricipopulina	46.65	0.00e+00	866.00
IUUC-Mmr-061405	Microcebus murinus	45.15	0.00e+00	850.00
IUUC-Mdo-062032	Monodelphis domestica	45.09	0.00e+00	863.00
IUUC-Mmu-063721	Mus musculus	45.67	0.00e+00	883.00
IUUC-Mac-065505	Musa acuminata	81.58	0.00e+00	1702.00
IUUC-Mpu-066409	Mustela putorius furo	46.35	0.00e+00	897.00
IUUC-Mlu-067217	Myotis lucifugus	46.21	0.00e+00	884.00
IUUC-Nfi-068407	Neosartorya fischeri	46.30	0.00e+00	825.00
IUUC-Ncr-068698	Neurospora crassa	45.91	0.00e+00	845.00
IUUC-Nle-070072	Nomascus leucogenys	43.50	0.00e+00	801.00
IUUC-Opr-070715	Ochotona princeps	36.05	2.00e-157	549.00
IUUC-Ocu-074544	Oryctolagus cuniculus	46.30	0.00e+00	898.00
IUUC-Ogl-077887	Oryza glaberrima	91.72	0.00e+00	1813.00
IUUC-Osa-085949	Oryza sativa	91.72	0.00e+00	1845.00
IUUC-Oga-088594	Otolemur garnettii	46.53	0.00e+00	877.00
IUUC-Oar-090068	Ovis aries	46.30	0.00e+00	892.00
IUUC-Pan-092114	Papio anubis	46.54	0.00e+00	896.00
IUUC-Pab-097861	Pongo abelii	46.30	0.00e+00	867.00
IUUC-Pca-100347	Procavia capensis	43.40	0.00e+00	712.00
IUUC-Pgr-103336	Puccinia graminis	45.77	0.00e+00	832.00
IUUC-Ptt-103939	Puccinia triticina	46.41	0.00e+00	829.00
IUUC-Rno-105462	Rattus norvegicus	45.57	0.00e+00	868.00
IUUC-Sha-107142	Sarcophilus harrisii	46.29	0.00e+00	886.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	44.90	0.00e+00	805.00
IUUC-Sly-111237	Solanum lycopersicum	79.61	0.00e+00	1622.00
IUUC-Stu-112001	Solanum tuberosum	79.80	0.00e+00	1629.00
IUUC-Sar-113737	Sorex araneus	46.36	0.00e+00	885.00
IUUC-Sre-115148	Sporisorium reilianum	45.57	0.00e+00	813.00
IUUC-Ssc-115777	Sus scrofa	46.06	0.00e+00	884.00
IUUC-Tni-120401	Tetraodon nigroviridis	47.00	0.00e+00	842.00
IUUC-Tre-122009	Trichoderma reesei	46.83	0.00e+00	821.00
IUUC-Tvi-122259	Trichoderma virens	47.11	0.00e+00	833.00
IUUC-Tae-125113	Triticum aestivum	100.00	0.00e+00	1952.00
IUUC-Tur-126189	Triticum urartu	99.11	0.00e+00	1944.00
IUUC-Tme-127055	Tuber melanosporum	44.46	0.00e+00	794.00
IUUC-Tbe-127587	Tupaia belangeri	41.28	8.00e-140	490.00
IUUC-Ttr-128331	Tursiops truncatus	46.25	0.00e+00	879.00
IUUC-Uma-129387	Ustilago maydis	45.32	0.00e+00	818.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence