iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tur-126330

Ensembl Protein ID

TRIUR3_30795-P1

UniProt Accession

M8A786; M8A786_TRIUA

Genbank Protein ID

EMS68322.1

Protein Name

Ubiquitin-activating enzyme E1 2

Genbank Nucleotide ID

KD008348

Gene Name

TRIUR3_30795

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIUR3_30795	TRIUR3_30795-T1	TRIUR3_30795-P1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.50e-171	571.2	410	898

Active Site

Position(s)	Description	Evidence
591	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YD Qi ++G++ q+kl++ak+++vG g+lGcE+lKnL+l+G+     g++tv+D+d +e+snl+rqFLfr++++g++K+ vaa a+  +np+ +
   Q: 410  YDAQISVFGSTLQNKLEEAKIFMVGSGALGCEFLKNLALMGIscsqnGNLTVTDDDVIEKSNLSRQFLFRDWNIGQPKSTVAATAAMVINPKLH 503
           ********************************************************************************************** PP
   S: 90   veaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketp 180
           vea +++ ++++e+++   F +++d Vv+aldn+ ar++++++c++ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p
   Q: 504  VEALQNRASPETENVFndaFWENLDAVVNALDNVTARMYIDSRCVYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFP 597
           **************99****************************************************************************** PP
   S: 181  naaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfec 262
            +++h+++wa              +n +l++ +   + +     ++ ++ +++v + l   + e+f++ i++a+ +f+ +++n +kql+  f+ 
   Q: 598  HNIDHCLTWArsefegllektpTEVNAFLSNPTTYISAARTAGDAQARDQLERVIECLDRDKCETFQDSITWARLKFEDYFSNRVKQLTFTFPE 691
           ***********999988888885555555544444444444555666666666666777788899***************************** PP
   S: 263  divtkskspfwv...........................................................sfcsnaealqvpekvekdeevvk 297
           d +t+s++pfw+                                                             +++  ++ ++ek+++   ++ 
   Q: 692  DSMTSSGAPFWSapkrfprpvefsssdpsqlsfilaaailraetfgipipewaktpnklaaeavdkvivpdFQPKQGVKIVTDEKATSLSSASV 785
           **************************************************99999998888888886666433344444445555555555444 PP
   S: 298  asap.lylllralerfekk..kgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviK 386
           ++a+ ++ l+++le+++k+  +g  ++ ++fekddd   ++d+++ +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++K
   Q: 786  DDAAvIEELIAKLEEVSKTlpSGFHMNPIQFEKDDDTnfHMDVIAGFANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELYK 878
           44448***********99755899***********************************.********************************** PP
   S: 387  vvsg..kfeplknfflfdae 404
           ++ g  k e ++n+f ++a+
   Q: 879  ALAGghKVEDYRNTFANLAI 898
           ***9999********99876 PP

Organism

Triticum urartu

Protein Sequence
(Fasta)

MAGRGNEIDE DLHSRQLAVY GRETMKRLFG SNVLVSGLQG LGAEIAKNLV LAGVKSVTLH 60
DDGNVELWDL SSNFFLSEND VGQNRAQACV QKLQELNNAV LVSALTGDLT KEHLSKFQAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGGGA GGGGGAACGA GATCGACGAG GACCTGCACA GCCGCCAGCT CGCCGTCTAT 60
GGCCGCGAGA CCATGAAGCG CCTCTTCGGC TCCAACGTCC TCGTCTCTGG ACTCCAGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	99.51	0.00e+00	2037.00
IUUC-Atr-002684	Amborella trichopoda	78.90	0.00e+00	1645.00
IUUC-Apl-004158	Anas platyrhynchos	40.20	0.00e+00	688.00
IUUC-Aca-004620	Anolis carolinensis	45.71	0.00e+00	875.00
IUUC-Aly-005418	Arabidopsis lyrata	78.12	0.00e+00	1686.00
IUUC-Ath-006891	Arabidopsis thaliana	77.28	0.00e+00	1670.00
IUUC-Ame-010933	Astyanax mexicanus	46.79	0.00e+00	844.00
IUUC-Bgr-012281	Blumeria graminis	43.76	0.00e+00	808.00
IUUC-Bdi-014335	Brachypodium distachyon	95.96	0.00e+00	1977.00
IUUC-Bol-015665	Brassica oleracea	78.50	0.00e+00	1660.00
IUUC-Bra-017252	Brassica rapa	78.81	0.00e+00	1689.00
IUUC-Cfa-020622	Canis familiaris	44.56	0.00e+00	841.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	60.29	0.00e+00	1181.00
IUUC-Cin-025790	Ciona intestinalis	43.52	0.00e+00	857.00
IUUC-Csv-026084	Ciona savignyi	42.95	0.00e+00	843.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	47.32	0.00e+00	882.00
IUUC-Cme-027290	Cyanidioschyzon merolae	39.74	0.00e+00	694.00
IUUC-Dse-031524	Dothistroma septosporum	44.36	0.00e+00	806.00
IUUC-Dme-032045	Drosophila melanogaster	44.75	0.00e+00	842.00
IUUC-Ete-033124	Echinops telfairi	39.76	4.00e-133	468.00
IUUC-Eca-033330	Equus caballus	45.89	0.00e+00	887.00
IUUC-Eeu-035323	Erinaceus europaeus	40.88	2.00e-152	532.00
IUUC-Fca-036255	Felis catus	45.99	0.00e+00	881.00
IUUC-Fal-036848	Ficedula albicollis	39.56	0.00e+00	694.00
IUUC-Gmo-039338	Gadus morhua	44.21	0.00e+00	834.00
IUUC-Gga-040747	Gallus gallus	40.00	0.00e+00	685.00
IUUC-Gac-041773	Gasterosteus aculeatus	44.92	0.00e+00	843.00
IUUC-Gma-043165	Glycine max	80.69	0.00e+00	1715.00
IUUC-Lch-050371	Latimeria chalumnae	46.24	0.00e+00	888.00
IUUC-Lma-053315	Leptosphaeria maculans	45.97	0.00e+00	862.00
IUUC-Mtr-058572	Medicago truncatula	80.43	0.00e+00	1660.00
IUUC-Mga-059721	Meleagris gallopavo	40.24	0.00e+00	666.00
IUUC-Mvi-060437	Microbotryum violaceum	42.68	0.00e+00	796.00
IUUC-Mmr-061405	Microcebus murinus	45.23	0.00e+00	850.00
IUUC-Ncr-068698	Neurospora crassa	45.93	0.00e+00	843.00
IUUC-Ont-071671	Oreochromis niloticus	46.43	0.00e+00	875.00
IUUC-Oan-073268	Ornithorhynchus anatinus	41.42	0.00e+00	634.00
IUUC-Oba-075120	Oryza barthii	90.53	0.00e+00	1817.00
IUUC-Obr-076557	Oryza brachyantha	91.03	0.00e+00	1834.00
IUUC-Ola-087002	Oryzias latipes	47.14	0.00e+00	884.00
IUUC-Olu-087687	Ostreococcus lucimarinus	58.80	0.00e+00	1138.00
IUUC-Ptr-090609	Pan troglodytes	41.11	0.00e+00	690.00
IUUC-Psi-093489	Pelodiscus sinensis	39.61	0.00e+00	692.00
IUUC-Pma-094214	Petromyzon marinus	47.02	1.00e-33	134.00
IUUC-Pno-095154	Phaeosphaeria nodorum	44.35	0.00e+00	827.00
IUUC-Ppa-095227	Physcomitrella patens	73.99	0.00e+00	1553.00
IUUC-Pfo-097184	Poecilia formosa	46.13	0.00e+00	869.00
IUUC-Pop-098934	Populus trichocarpa	79.03	0.00e+00	1664.00
IUUC-Ppe-102012	Prunus persica	78.90	0.00e+00	1696.00
IUUC-Pva-102584	Pteropus vampyrus	46.28	0.00e+00	916.00
IUUC-Pte-104200	Pyrenophora teres	45.36	0.00e+00	858.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	44.76	0.00e+00	851.00
IUUC-Sce-106245	Saccharomyces cerevisiae	44.98	0.00e+00	848.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	45.30	0.00e+00	849.00
IUUC-Spo-108034	Schizosaccharomyces pombe	44.15	0.00e+00	822.00
IUUC-Sit-110281	Setaria italica	91.54	0.00e+00	1871.00
IUUC-Stu-112109	Solanum tuberosum	78.44	0.00e+00	1688.00
IUUC-Sar-113737	Sorex araneus	46.29	0.00e+00	882.00
IUUC-Sbi-114089	Sorghum bicolor	91.93	0.00e+00	1872.00
IUUC-Ssc-115777	Sus scrofa	45.97	0.00e+00	882.00
IUUC-Tgu-116565	Taeniopygia guttata	39.56	0.00e+00	688.00
IUUC-Tru-118742	Takifugu rubripes	47.05	0.00e+00	835.00
IUUC-Tsy-119436	Tarsius syrichta	36.26	1.00e-164	573.00
IUUC-Tni-120401	Tetraodon nigroviridis	46.92	0.00e+00	840.00
IUUC-Tca-121436	Theobroma cacao	79.78	0.00e+00	1686.00
IUUC-Tbe-127587	Tupaia belangeri	40.47	8.00e-139	487.00
IUUC-Vpa-130716	Vicugna pacos	39.43	0.00e+00	662.00
IUUC-Vvi-130857	Vitis vinifera	81.74	0.00e+00	1712.00
IUUC-Xtr-132026	Xenopus tropicalis	39.98	0.00e+00	669.00
IUUC-Xma-133805	Xiphophorus maculatus	45.93	0.00e+00	847.00
IUUC-Yli-134547	Yarrowia lipolytica	45.28	0.00e+00	850.00
IUUC-Zma-135758	Zea mays	90.04	0.00e+00	1831.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence