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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046434
UUCD1 version UUC-HoS-00531
Ensembl Protein ID ENSP00000261837.7
UniProt Accession O14775; B2RBR5; Q9HAU9; Q9UFT3; GBB5_HUMAN
Genbank Protein ID AAC63826.1; CAB55946.1; AAM15921.1; AAG18444.1; BAG37312.1; AAH13997.1
Protein Name Guanine nucleotide-binding protein subunit beta-5; Gbeta5; Transducin beta chain 5
Genbank Nucleotide ID AF017656; AL117471; AF501885; AF300650; AK314775; BC013997
Gene Name GNB5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000069966.18 ENST00000261837.11 ENSP00000261837.7
ENSG00000069966.18 ENST00000396335.8 ENSP00000379626.4
ENSG00000069966.18 ENST00000561313.5 ENSP00000454185.1
ENSG00000069966.18 ENST00000560116.1 ENSP00000453176.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.10e-42 141.2 235 275
UBD/Beta-Prp 4.90e-54 185.2 189 394
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDlrtgvllk 37
           gH ++v cl++    +++++vsG+ D++ +vWD+r+g +++
   Q: 235  GHGADVLCLDLapseTGNTFVSGGCDKKAMVWDMRSGQCVQ 275
           8***********9644499********************98 PP
   

   UBD/Beta-Prp
   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sgdklvsGshdrtirvwdletgqcleetlsg 135
           +s+  h++  +a++f +++  ++t+s D+t  +wd+++g+ +++++gh ++vl+l++ p  +g+++vsG+ d+ ++vwd+++gqc++  ++ 
   Q: 189  KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTFVSGGCDKKAMVWDMRSGQCVQ-AFET 279
           567889999*********99***************************************9778************************.**** PP
   S: 136  hdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvk 226
           h++ +n+v++ p+g+ ++sGs+D t+rl+dl+ ++ +    ++       s++f+ +g+ l +g +d t+++wd+ +g+ v +l gh++ v+
   Q: 280  HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYsKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 371
           ***************************************95333556778999*************************************** PP
   S: 227  svrfspnderlvsgssDgsiriW 249
            +r+sp+++ + sgs D ++r+W
   Q: 372  TLRVSPDGTAFCSGSWDHTLRVW 394
           *********************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
 Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Protein Sequence
(Fasta)
MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLSYCSTCA EIMATEGLHE NETLASLKSE 60
AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT LKGHGNKVLC MDWCKDKRRI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046434|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCACCTCTC ACCATCTGCT CTGTGGCTCC CAGTGCTGAC TCTGGAAGGT ATGTGCATGC 60
TGACATTCGG TTAAAATACT CCAGCTTTTG AAATGCTCAG AAAAGCATCC AGATGAGTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046434|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0051087--F:chaperone binding
GO:0031682--F:G-protein gamma-subunit binding
GO:0005096--F:GTPase activator activity
GO:0003924--F:GTPase activity
GO:0004871--F:signal transducer activity
GO:1901386--P:negative regulation of voltage-gated calcium channel activity
GO:0043547--P:positive regulation of GTPase activity
GO:0006457--P:protein folding
GO:0007165--P:signal transduction
KEGG hsa:10681
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001811 Ailuropoda melanoleuca 92.66 0.00e+00 766.00
IUUC-Apl-003399 Anas platyrhynchos 98.72 0.00e+00 650.00
IUUC-Aca-004861 Anolis carolinensis 93.42 0.00e+00 780.00
IUUC-Ame-011851 Astyanax mexicanus 92.02 0.00e+00 687.00
IUUC-Bta-012438 Bos taurus 99.15 0.00e+00 731.00
IUUC-Cel-018408 Caenorhabditis elegans 64.93 3.00e-139 488.00
IUUC-Cja-019086 Callithrix jacchus 100.00 0.00e+00 819.00
IUUC-Cfa-021255 Canis familiaris 97.71 0.00e+00 761.00
IUUC-Cpo-021398 Cavia porcellus 96.97 0.00e+00 801.00
IUUC-Csa-023776 Chlorocebus sabaeus 99.72 0.00e+00 733.00
IUUC-Cin-025305 Ciona intestinalis 57.92 1.00e-131 462.00
IUUC-Csv-026058 Ciona savignyi 57.60 4.00e-128 451.00
IUUC-Dre-028432 Danio rerio 84.81 0.00e+00 679.00
IUUC-Dno-029958 Dasypus novemcinctus 86.90 5.00e-147 513.00
IUUC-Dor-031013 Dipodomys ordii 99.22 5.00e-153 533.00
IUUC-Dme-031889 Drosophila melanogaster 68.60 5.00e-149 520.00
IUUC-Eca-033977 Equus caballus 94.18 0.00e+00 771.00
IUUC-Eeu-035079 Erinaceus europaeus 97.96 0.00e+00 799.00
IUUC-Fca-035693 Felis catus 92.44 0.00e+00 762.00
IUUC-Fal-037345 Ficedula albicollis 98.58 0.00e+00 729.00
IUUC-Gmo-039222 Gadus morhua 91.22 0.00e+00 661.00
IUUC-Gga-040320 Gallus gallus 98.58 0.00e+00 730.00
IUUC-Gac-042644 Gasterosteus aculeatus 91.50 0.00e+00 689.00
IUUC-Ggo-044489 Gorilla gorilla 95.96 0.00e+00 780.00
IUUC-Itr-048771 Ictidomys tridecemlineatus 93.67 8.00e-177 612.00
IUUC-Loc-052790 Lepisosteus oculatus 90.56 0.00e+00 724.00
IUUC-Laf-054255 Loxodonta africana 97.96 0.00e+00 804.00
IUUC-Mcc-055610 Macaca mulatta 99.49 0.00e+00 815.00
IUUC-Meu-056819 Macropus eugenii 86.48 0.00e+00 694.00
IUUC-Mga-059740 Meleagris gallopavo 87.28 0.00e+00 717.00
IUUC-Mmr-061221 Microcebus murinus 99.24 0.00e+00 820.00
IUUC-Mdo-062619 Monodelphis domestica 98.30 0.00e+00 726.00
IUUC-Mmu-064266 Mus musculus 99.24 0.00e+00 821.00
IUUC-Mpu-065766 Mustela putorius furo 99.34 0.00e+00 628.00
IUUC-Mlu-067221 Myotis lucifugus 91.69 0.00e+00 753.00
IUUC-Nle-069515 Nomascus leucogenys 99.68 0.00e+00 661.00
IUUC-Opr-070195 Ochotona princeps 90.84 0.00e+00 729.00
IUUC-Ont-071535 Oreochromis niloticus 78.73 5.00e-172 597.00
IUUC-Oan-072899 Ornithorhynchus anatinus 97.84 3.00e-107 380.00
IUUC-Ocu-074666 Oryctolagus cuniculus 99.67 0.00e+00 630.00
IUUC-Ola-086578 Oryzias latipes 92.61 0.00e+00 654.00
IUUC-Oga-089090 Otolemur garnettii 98.49 0.00e+00 812.00
IUUC-Oar-090017 Ovis aries 92.39 0.00e+00 744.00
IUUC-Ptr-091280 Pan troglodytes 90.38 0.00e+00 729.00
IUUC-Pan-092198 Papio anubis 99.06 0.00e+00 660.00
IUUC-Psi-093030 Pelodiscus sinensis 85.57 0.00e+00 721.00
IUUC-Pma-094140 Petromyzon marinus 83.10 5.00e-105 373.00
IUUC-Pfo-097182 Poecilia formosa 92.35 0.00e+00 668.00
IUUC-Pab-098157 Pongo abelii 100.00 0.00e+00 738.00
IUUC-Pca-100988 Procavia capensis 77.72 8.00e-172 596.00
IUUC-Pva-102232 Pteropus vampyrus 86.57 4.00e-177 613.00
IUUC-Rno-105526 Rattus norvegicus 95.77 0.00e+00 696.00
IUUC-Sha-106754 Sarcophilus harrisii 97.22 0.00e+00 760.00
IUUC-Ssc-115390 Sus scrofa 98.99 0.00e+00 815.00
IUUC-Tgu-117377 Taeniopygia guttata 87.79 0.00e+00 704.00
IUUC-Tru-117938 Takifugu rubripes 92.35 0.00e+00 655.00
IUUC-Tsy-119392 Tarsius syrichta 85.06 0.00e+00 668.00
IUUC-Tni-119834 Tetraodon nigroviridis 72.66 1.00e-165 575.00
IUUC-Tbe-127469 Tupaia belangeri 96.01 0.00e+00 733.00
IUUC-Ttr-128252 Tursiops truncatus 95.45 0.00e+00 775.00
IUUC-Vpa-130173 Vicugna pacos 80.95 8.00e-158 549.00
IUUC-Xtr-131803 Xenopus tropicalis 91.90 0.00e+00 731.00
Created Date 25-Jun-2017

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