iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004565

UUCD1 version

UUC-AnC-00920

Ensembl Protein ID

ENSACAP00000011102.2

UniProt Accession

G1KL25; G1KL25_ANOCA

Protein Name

Uncharacterized protein

Gene Name

UBE2K

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000011290.3	ENSACAT00000011332.3	ENSACAP00000011102.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.20e-44	151.4	21	146
UBD/Alpha-Helix/UBA	4.50e-11	42.5	161	199

Active Site

Position(s)	Description	Evidence
92	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 11   kdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsv 98
           k+++++i++++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+ilk  ++W +a+++
   Q: 21   KTSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDILK--DQWAAAMTL 106
           566789********.9***************************************************99********9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 107  RTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 146
           *************************************986 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL + ++++e A+e+Ll+
   Q: 161  EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLS 199
           6789*********************************97 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

VISLCLKLQY KQYRQRLSNF KTSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 60
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGATCTCTT TGTGTCTTAA ATTGCAGTAT AAACAATATA GGCAGAGGTT GTCCAAGTTA 60
GTAAAATACT ACACACTTTG ATGCTGTATA ATAATGGTAA CCTACTATCA ATACAGTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0032433--C:filopodium tip
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0035458--P:cellular response to interferon-beta
GO:0010994--P:free ubiquitin chain polymerization
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	66.67	2.00e-25	108.00
IUUC-Aml-001286	Ailuropoda melanoleuca	94.74	3.00e-99	353.00
IUUC-Atr-003063	Amborella trichopoda	51.46	7.00e-38	149.00
IUUC-Apl-004122	Anas platyrhynchos	91.37	1.00e-95	341.00
IUUC-Aly-006390	Arabidopsis lyrata	51.72	5.00e-42	163.00
IUUC-Ath-006637	Arabidopsis thaliana	50.00	3.00e-39	154.00
IUUC-Ago-007714	Ashbya gossypii	47.47	7.00e-36	143.00
IUUC-Acl-008189	Aspergillus clavatus	55.65	4.00e-26	111.00
IUUC-Afl-008489	Aspergillus flavus	44.57	4.00e-27	114.00
IUUC-Afu-008850	Aspergillus fumigatus	42.05	6.00e-27	114.00
IUUC-Ani-009361	Aspergillus nidulans	57.26	1.00e-24	106.00
IUUC-Ang-009548	Aspergillus niger	54.55	5.00e-25	107.00
IUUC-Aor-010105	Aspergillus oryzae	44.57	4.00e-27	114.00
IUUC-Ate-010389	Aspergillus terreus	43.48	5.00e-27	114.00
IUUC-Ame-011454	Astyanax mexicanus	91.58	1.00e-96	345.00
IUUC-Bgr-012255	Blumeria graminis	54.76	1.00e-31	129.00
IUUC-Bta-012992	Bos taurus	94.74	3.00e-99	353.00
IUUC-Bci-013806	Botrytis cinerea	44.15	2.00e-35	142.00
IUUC-Bdi-015024	Brachypodium distachyon	53.61	3.00e-38	151.00
IUUC-Bol-015985	Brassica oleracea	51.72	2.00e-42	165.00
IUUC-Bra-016805	Brassica rapa	51.72	1.00e-42	165.00
IUUC-Cel-018353	Caenorhabditis elegans	49.74	4.00e-51	193.00
IUUC-Cja-019051	Callithrix jacchus	94.21	2.00e-98	350.00
IUUC-Cfa-020016	Canis familiaris	94.74	3.00e-99	353.00
IUUC-Cpo-022026	Cavia porcellus	94.74	3.00e-99	353.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	49.21	3.00e-40	157.00
IUUC-Csa-023059	Chlorocebus sabaeus	94.74	3.00e-99	353.00
IUUC-Cho-024276	Choloepus hoffmanni	96.60	2.00e-73	267.00
IUUC-Cin-025598	Ciona intestinalis	61.93	2.00e-50	191.00
IUUC-Csv-025831	Ciona savignyi	61.08	8.00e-50	189.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	51.52	5.00e-33	134.00
IUUC-Cne-027068	Cryptococcus neoformans	43.72	1.00e-38	152.00
IUUC-Dre-028139	Danio rerio	91.58	1.00e-96	345.00
IUUC-Dno-029169	Dasypus novemcinctus	94.74	6.00e-98	349.00
IUUC-Dor-030382	Dipodomys ordii	80.00	8.00e-78	282.00
IUUC-Dse-031335	Dothistroma septosporum	58.87	9.00e-36	143.00
IUUC-Dme-032003	Drosophila melanogaster	62.96	5.00e-62	229.00
IUUC-Ete-032868	Echinops telfairi	85.26	1.00e-77	281.00
IUUC-Eca-033428	Equus caballus	94.74	3.00e-99	353.00
IUUC-Eeu-035103	Erinaceus europaeus	73.44	4.00e-49	186.00
IUUC-Fca-035366	Felis catus	94.74	3.00e-99	353.00
IUUC-Fal-037016	Ficedula albicollis	94.74	3.00e-99	353.00
IUUC-Fox-037969	Fusarium oxysporum	46.84	1.00e-32	132.00
IUUC-Fso-038296	Fusarium solani	46.11	4.00e-34	137.00
IUUC-Gmo-039135	Gadus morhua	90.53	2.00e-95	341.00
IUUC-Ggr-039768	Gaeumannomyces graminis	52.17	5.00e-24	104.00
IUUC-Gga-041018	Gallus gallus	94.21	5.00e-99	352.00
IUUC-Gac-041503	Gasterosteus aculeatus	91.05	3.00e-96	343.00
IUUC-Gma-042779	Glycine max	52.91	4.00e-41	160.00
IUUC-Ggo-045032	Gorilla gorilla	94.74	3.00e-99	353.00
IUUC-Hsa-046490	Homo sapiens	94.74	3.00e-99	353.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	94.74	3.00e-99	353.00
IUUC-Lch-050588	Latimeria chalumnae	68.72	4.00e-76	276.00
IUUC-Lpe-051070	Leersia perrieri	53.01	2.00e-29	122.00
IUUC-Loc-052549	Lepisosteus oculatus	92.11	4.00e-97	346.00
IUUC-Lma-052949	Leptosphaeria maculans	57.72	6.00e-36	144.00
IUUC-Laf-053688	Loxodonta africana	100.00	1.00e-97	348.00
IUUC-Mcc-055606	Macaca mulatta	94.74	3.00e-99	353.00
IUUC-Mor-056946	Magnaporthe oryzae	38.66	2.00e-22	99.00
IUUC-Mpo-057441	Magnaporthe poae	54.48	6.00e-24	103.00
IUUC-Mtr-058002	Medicago truncatula	52.33	3.00e-41	160.00
IUUC-Mga-059254	Meleagris gallopavo	99.44	7.00e-98	348.00
IUUC-Mvi-060346	Microbotryum violaceum	42.54	4.00e-31	127.00
IUUC-Mmr-061211	Microcebus murinus	94.74	3.00e-99	353.00
IUUC-Mdo-062458	Monodelphis domestica	93.68	1.00e-96	345.00
IUUC-Mmu-063648	Mus musculus	94.74	3.00e-99	353.00
IUUC-Mac-065447	Musa acuminata	50.54	2.00e-39	154.00
IUUC-Mpu-066407	Mustela putorius furo	94.74	1.00e-98	352.00
IUUC-Mlu-067682	Myotis lucifugus	99.45	4.00e-100	356.00
IUUC-Nfi-068517	Neosartorya fischeri	42.05	7.00e-27	113.00
IUUC-Ncr-068749	Neurospora crassa	49.30	5.00e-36	144.00
IUUC-Nle-069712	Nomascus leucogenys	99.45	1.00e-98	352.00
IUUC-Opr-070651	Ochotona princeps	94.74	3.00e-99	353.00
IUUC-Ont-071433	Oreochromis niloticus	91.05	3.00e-96	343.00
IUUC-Oan-073058	Ornithorhynchus anatinus	100.00	1.00e-78	284.00
IUUC-Ocu-074939	Oryctolagus cuniculus	94.74	3.00e-99	353.00
IUUC-Oba-075530	Oryza barthii	53.94	1.00e-29	122.00
IUUC-Obr-076838	Oryza brachyantha	53.99	4.00e-29	120.00
IUUC-Ogl-077606	Oryza glaberrima	53.94	1.00e-29	122.00
IUUC-Ogu-078238	Oryza glumaepatula	53.94	1.00e-29	122.00
IUUC-Oin-079643	Oryza indica	53.94	3.00e-29	121.00
IUUC-Ome-081274	Oryza meridionalis	53.94	1.00e-29	122.00
IUUC-Oni-082651	Oryza nivara	53.94	1.00e-29	122.00
IUUC-Opu-083933	Oryza punctata	53.94	2.00e-29	121.00
IUUC-Oru-085054	Oryza rufipogon	53.94	3.00e-29	121.00
IUUC-Osa-085716	Oryza sativa	53.94	3.00e-29	121.00
IUUC-Ola-087043	Oryzias latipes	91.05	3.00e-96	343.00
IUUC-Olu-087846	Ostreococcus lucimarinus	46.84	6.00e-41	159.00
IUUC-Oga-088897	Otolemur garnettii	99.44	1.00e-97	348.00
IUUC-Oar-089673	Ovis aries	92.46	3.00e-100	357.00
IUUC-Ptr-091295	Pan troglodytes	94.74	3.00e-99	353.00
IUUC-Pan-092034	Papio anubis	98.90	4.00e-98	350.00
IUUC-Psi-093498	Pelodiscus sinensis	94.74	3.00e-99	353.00
IUUC-Pma-094115	Petromyzon marinus	86.67	7.00e-85	305.00
IUUC-Pno-095102	Phaeosphaeria nodorum	43.72	4.00e-37	147.00
IUUC-Ppa-095326	Physcomitrella patens	48.85	2.00e-37	148.00
IUUC-Pfo-096940	Poecilia formosa	91.05	3.00e-96	343.00
IUUC-Pab-098279	Pongo abelii	94.74	3.00e-99	353.00
IUUC-Pop-099543	Populus trichocarpa	52.30	3.00e-42	164.00
IUUC-Pca-100782	Procavia capensis	94.21	3.00e-97	347.00
IUUC-Ppe-101789	Prunus persica	52.00	4.00e-36	144.00
IUUC-Pva-102147	Pteropus vampyrus	100.00	2.00e-52	197.00
IUUC-Pte-104370	Pyrenophora teres	56.91	2.00e-35	142.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	44.26	2.00e-35	142.00
IUUC-Rno-104984	Rattus norvegicus	94.74	3.00e-99	353.00
IUUC-Sce-106394	Saccharomyces cerevisiae	45.09	2.00e-33	135.00
IUUC-Sha-106848	Sarcophilus harrisii	99.46	1.00e-99	355.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	46.28	2.00e-38	152.00
IUUC-Smo-109656	Selaginella moellendorffii	50.87	2.00e-38	151.00
IUUC-Sit-110639	Setaria italica	52.41	3.00e-37	147.00
IUUC-Sly-110978	Solanum lycopersicum	52.30	1.00e-42	165.00
IUUC-Stu-112088	Solanum tuberosum	52.30	5.00e-43	166.00
IUUC-Sar-113285	Sorex araneus	84.36	4.00e-76	276.00
IUUC-Sbi-113986	Sorghum bicolor	52.41	4.00e-37	147.00
IUUC-Ssc-116314	Sus scrofa	94.74	3.00e-99	353.00
IUUC-Tgu-117427	Taeniopygia guttata	100.00	4.00e-98	349.00
IUUC-Tru-118618	Takifugu rubripes	85.79	3.00e-91	327.00
IUUC-Tsy-119208	Tarsius syrichta	91.00	1.00e-99	354.00
IUUC-Tni-119667	Tetraodon nigroviridis	91.58	1.00e-96	345.00
IUUC-Tca-121446	Theobroma cacao	52.87	8.00e-43	166.00
IUUC-Tre-122053	Trichoderma reesei	39.88	5.00e-30	124.00
IUUC-Tae-125119	Triticum aestivum	54.22	6.00e-31	126.00
IUUC-Tme-127024	Tuber melanosporum	51.70	9.00e-38	149.00
IUUC-Tbe-127752	Tupaia belangeri	94.74	9.00e-99	352.00
IUUC-Ttr-128287	Tursiops truncatus	100.00	2.00e-97	347.00
IUUC-Vda-129947	Verticillium dahliae	42.20	7.00e-31	126.00
IUUC-Vpa-130481	Vicugna pacos	94.74	3.00e-99	353.00
IUUC-Vvi-131429	Vitis vinifera	50.29	3.00e-39	154.00
IUUC-Xtr-132710	Xenopus tropicalis	77.60	8.00e-85	305.00
IUUC-Xma-134308	Xiphophorus maculatus	90.53	1.00e-95	342.00
IUUC-Yli-134523	Yarrowia lipolytica	48.30	8.00e-33	133.00
IUUC-Zma-135733	Zea mays	51.12	2.00e-35	142.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence