iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132431

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Neural precursor cell-expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

Genbank Nucleotide ID

AAMC01101742

Gene Name

nedd4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000016554.3	ENSXETT00000036077.2	ENSXETP00000036077.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-133	445.4	629	958

Active Site

Position(s)	Description	Evidence
928	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef +E+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld+++
   Q: 629  FLKARLWIEFDNEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFF 717
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k++ l d+e+vd+e+y+sl++i+en   d +  gldl f+v+ee++g+t+++eLk gG++i Vtn+Nk+eY++lv+++r
   Q: 718  IRPFYKMMLQKPIILYDMESVDSEYYNSLQWILEN---DPS--GLDLCFTVDEELFGQTHQHELKAGGSQILVTNKNKKEYIHLVIQWR 801
           *********************************99...555..567777789************************************* PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + +++++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv++++++tkyk+gy++ +++iqwFw+++ ++++e+r ++LqFvTg
   Q: 802  FMNRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNNWREHTKYKNGYSQGHQVIQWFWKAVLMMDAEKRIRLLQFVTG 890
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p+lf+++k++++++lP+++TCfn+L+LP+Y+s e l +kL +Aie+++gF+
   Q: 891  TSRVPMNGFAELYgsngPQLFTVEKWGTPEKLPRAHTCFNRLDLPPYESFEDLWDKLHIAIENAQGFD 958
           *******************************************************************8 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

IHWNYKNPAY QLKVVKESTR ILRVKVIAGI GLAKKDILGA SDPYVKLTVY DPANGILSSA 60
QTKTVRKTLN PKWNEEILFR VYPQKHRLLL EVFDENRLTR DDFLGQVDVP LHQLPTENPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCATTGGA ACTATAAAAA TCCTGCATAT CAGTTAAAAG TGGTTAAAGT GACATAATAG 60
TGTTGCAGTA AATGGTTTGT AAGTCATTGG TTTATTTTGC TTTGAAAAGT TTTATACTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	70.28	0.00e+00	1199.00
IUUC-Apl-003886	Anas platyrhynchos	70.49	0.00e+00	1295.00
IUUC-Bta-012453	Bos taurus	67.97	0.00e+00	1149.00
IUUC-Cfa-020258	Canis familiaris	69.82	0.00e+00	1166.00
IUUC-Cpo-021648	Cavia porcellus	69.44	0.00e+00	1316.00
IUUC-Csa-023334	Chlorocebus sabaeus	69.76	0.00e+00	1281.00
IUUC-Ete-032409	Echinops telfairi	76.03	0.00e+00	772.00
IUUC-Eca-033441	Equus caballus	70.50	0.00e+00	1271.00
IUUC-Fca-036384	Felis catus	70.11	0.00e+00	1180.00
IUUC-Fal-037547	Ficedula albicollis	71.67	0.00e+00	1299.00
IUUC-Gga-040524	Gallus gallus	71.86	0.00e+00	1298.00
IUUC-Hsa-046479	Homo sapiens	71.00	0.00e+00	1204.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	64.91	0.00e+00	825.00
IUUC-Lch-050445	Latimeria chalumnae	65.64	0.00e+00	1106.00
IUUC-Loc-052645	Lepisosteus oculatus	67.43	0.00e+00	1263.00
IUUC-Laf-053638	Loxodonta africana	69.08	0.00e+00	1124.00
IUUC-Mcc-055585	Macaca mulatta	84.30	0.00e+00	885.00
IUUC-Meu-056897	Macropus eugenii	91.29	4.00e-163	568.00
IUUC-Mga-059362	Meleagris gallopavo	72.78	0.00e+00	1323.00
IUUC-Mmr-061061	Microcebus murinus	70.79	0.00e+00	1204.00
IUUC-Mpu-066567	Mustela putorius furo	71.71	0.00e+00	1339.00
IUUC-Mlu-068148	Myotis lucifugus	70.30	0.00e+00	1179.00
IUUC-Nle-069225	Nomascus leucogenys	70.62	0.00e+00	1226.00
IUUC-Ont-071664	Oreochromis niloticus	66.28	0.00e+00	1194.00
IUUC-Oan-073019	Ornithorhynchus anatinus	72.96	0.00e+00	1276.00
IUUC-Ocu-074409	Oryctolagus cuniculus	71.00	0.00e+00	1219.00
IUUC-Oga-088241	Otolemur garnettii	64.29	0.00e+00	1039.00
IUUC-Oar-089797	Ovis aries	69.69	0.00e+00	1243.00
IUUC-Psi-093618	Pelodiscus sinensis	70.85	0.00e+00	1163.00
IUUC-Pab-098394	Pongo abelii	71.89	0.00e+00	1325.00
IUUC-Pca-100568	Procavia capensis	61.06	0.00e+00	932.00
IUUC-Sha-107370	Sarcophilus harrisii	66.82	0.00e+00	1144.00
IUUC-Tgu-117474	Taeniopygia guttata	71.76	0.00e+00	1301.00
IUUC-Tni-119993	Tetraodon nigroviridis	62.36	0.00e+00	1143.00
IUUC-Tbe-127408	Tupaia belangeri	62.65	0.00e+00	848.00
IUUC-Ttr-128437	Tursiops truncatus	62.78	0.00e+00	908.00
IUUC-Vpa-130503	Vicugna pacos	70.66	0.00e+00	862.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence