iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000073643.11	ENSMUST00000113512.7	ENSMUSP00000109140.1
ENSMUSG00000073643.11	ENSMUST00000187005.6	ENSMUSP00000139961.1
ENSMUSG00000073643.11	ENSMUST00000113510.7	ENSMUSP00000109138.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt	PHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.20e-18	65.3	240	271
UBD/Beta-Prp	3.00e-40	139.4	20	272

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gH d+v +l++   ++ lvs+s Dg i vW++
   Q: 240  GHHDRVQSLCYlqLTRQLVSCSADGGIAVWNM 271
           899*******9884489*************97 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvtt.gkllrsl.sgheaevtavkfspdgkilvtgseD.rtikvw....dlstgkc 86
           ++gh+++v      +p+++ ++t+s+d+ti+vw  ++ g++  s+     ++ +a+ +++d+  ++ +++D +++  +    d+++   
   Q: 20   IEGHQDAVTA-ALLIPKEDGVITASEDRTIRVWLKRDsGQYWPSIyHTMASPCSAMAYHHDS-RRIFVGQDnGAVMEFhvseDFNKMNF 106
           6677776666.555599999999999999999966551555666635556679999999998.7777777764444444669999**** PP
   S: 87   vhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl..lr 173
           + t+ +h+++v ++ fs   ++++s++hd+ +    +++g  l       +++ +c++++ d++  + G + +++ l +l+++++  ++
   Q: 107  IKTYPAHQNRVSAIIFSLAAEWVISTGHDKCVSWMCTRSGNMLG--RHFFSSWASCLQYDLDTQHAFVGDYSGQITLLKLEQNTCsvIT 193
           ******************9**************99999999997..777899****************************999885578 PP
   S: 174  tltgghtdsvyslsfdsngkelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlr 252
           tl+g h++s+ +l +d+ ++ l sg+ d++v++wd+  ++     l+gh d v+s+  ++ +  lvs+s+Dg i +W+++
   Q: 194  TLKG-HEGSIACLWWDPIQRLLFSGASDNSVIMWDIGgRKGRTLLLQGHHDRVQSLCYLQLTRQLVSCSADGGIAVWNMD 272
           8898.*******************************9855557889*******************************754 PP

Organism

Mus musculus

Functional Description
(View)

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).

Protein Sequence
(Fasta)

MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV WLKRDSGQYW 60
PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED FNKMNFIKTY PAHQNRVSAI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGAAGCCA TGGCAAGAAC AAGGCAATAG GAGGCGGAAG GAAGACAGCC GGAGCGGTGT 60
AGCCCGAACG CGGTTCCCCG GAAACTGGTG CAGCAGCAGA GAGAGGCCTG AACGCTGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0967--Endosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00064--FYVE
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005634--C:nucleus
GO:0005545--F:1-phosphatidylinositol binding
GO:0046872--F:metal ion binding
GO:0034141--P:positive regulation of toll-like receptor 3 signaling pathway
GO:0034145--P:positive regulation of toll-like receptor 4 signaling pathway

KEGG

mmu:69368

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001526	Ailuropoda melanoleuca	95.53	0.00e+00	814.00
IUUC-Apl-003661	Anas platyrhynchos	90.98	0.00e+00	724.00
IUUC-Aca-005225	Anolis carolinensis	91.18	0.00e+00	786.00
IUUC-Ame-011044	Astyanax mexicanus	77.51	0.00e+00	666.00
IUUC-Bta-012602	Bos taurus	98.05	0.00e+00	848.00
IUUC-Cja-019529	Callithrix jacchus	96.59	0.00e+00	843.00
IUUC-Cfa-020512	Canis familiaris	95.90	0.00e+00	747.00
IUUC-Cpo-022239	Cavia porcellus	94.39	0.00e+00	818.00
IUUC-Csa-023535	Chlorocebus sabaeus	95.93	0.00e+00	704.00
IUUC-Cho-024858	Choloepus hoffmanni	78.78	0.00e+00	649.00
IUUC-Dre-028520	Danio rerio	80.39	0.00e+00	689.00
IUUC-Dno-030005	Dasypus novemcinctus	97.56	0.00e+00	845.00
IUUC-Dor-030500	Dipodomys ordii	96.31	2.00e-176	611.00
IUUC-Ete-032870	Echinops telfairi	79.55	5.00e-146	509.00
IUUC-Eca-033284	Equus caballus	94.65	0.00e+00	810.00
IUUC-Fca-036212	Felis catus	97.25	0.00e+00	754.00
IUUC-Fal-037595	Ficedula albicollis	91.67	0.00e+00	811.00
IUUC-Gmo-038664	Gadus morhua	82.31	0.00e+00	735.00
IUUC-Gga-040400	Gallus gallus	91.42	0.00e+00	807.00
IUUC-Gac-041434	Gasterosteus aculeatus	82.84	0.00e+00	739.00
IUUC-Hsa-045884	Homo sapiens	97.80	0.00e+00	848.00
IUUC-Itr-048815	Ictidomys tridecemlineatus	98.11	0.00e+00	662.00
IUUC-Lch-049995	Latimeria chalumnae	87.80	0.00e+00	779.00
IUUC-Loc-052075	Lepisosteus oculatus	86.17	0.00e+00	757.00
IUUC-Laf-054345	Loxodonta africana	96.59	0.00e+00	842.00
IUUC-Mcc-055293	Macaca mulatta	96.34	0.00e+00	837.00
IUUC-Mga-059585	Meleagris gallopavo	90.14	0.00e+00	721.00
IUUC-Mmr-061268	Microcebus murinus	97.80	0.00e+00	850.00
IUUC-Mdo-061857	Monodelphis domestica	93.38	0.00e+00	819.00
IUUC-Mpu-066391	Mustela putorius furo	97.56	0.00e+00	843.00
IUUC-Mlu-067636	Myotis lucifugus	95.62	0.00e+00	746.00
IUUC-Nle-068974	Nomascus leucogenys	97.07	0.00e+00	844.00
IUUC-Opr-070553	Ochotona princeps	83.90	0.00e+00	703.00
IUUC-Oan-073659	Ornithorhynchus anatinus	93.86	0.00e+00	691.00
IUUC-Ocu-074034	Oryctolagus cuniculus	97.32	0.00e+00	844.00
IUUC-Ola-087030	Oryzias latipes	82.60	0.00e+00	740.00
IUUC-Oga-087962	Otolemur garnettii	96.99	0.00e+00	758.00
IUUC-Oar-089377	Ovis aries	98.05	0.00e+00	848.00
IUUC-Ptr-090728	Pan troglodytes	97.32	0.00e+00	845.00
IUUC-Pan-092130	Papio anubis	96.10	0.00e+00	836.00
IUUC-Psi-093886	Pelodiscus sinensis	91.74	0.00e+00	729.00
IUUC-Pfo-097254	Poecilia formosa	83.66	0.00e+00	745.00
IUUC-Pab-097594	Pongo abelii	97.56	0.00e+00	846.00
IUUC-Pca-100741	Procavia capensis	87.09	0.00e+00	655.00
IUUC-Pva-102441	Pteropus vampyrus	94.20	0.00e+00	695.00
IUUC-Rno-105767	Rattus norvegicus	98.78	0.00e+00	854.00
IUUC-Sha-106731	Sarcophilus harrisii	92.84	0.00e+00	731.00
IUUC-Ssc-115316	Sus scrofa	97.63	7.00e-125	439.00
IUUC-Tgu-116691	Taeniopygia guttata	91.67	0.00e+00	810.00
IUUC-Tru-118169	Takifugu rubripes	83.33	0.00e+00	740.00
IUUC-Tsy-119047	Tarsius syrichta	84.62	0.00e+00	630.00
IUUC-Tni-120708	Tetraodon nigroviridis	83.13	0.00e+00	737.00
IUUC-Tbe-127442	Tupaia belangeri	97.25	0.00e+00	756.00
IUUC-Ttr-128779	Tursiops truncatus	85.37	0.00e+00	724.00
IUUC-Vpa-130488	Vicugna pacos	93.27	1.00e-118	418.00
IUUC-Xtr-131994	Xenopus tropicalis	80.93	0.00e+00	726.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence