iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-041082

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AADN04000024

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000013057.5	ENSGALT00000021310.5	ENSGALP00000021279.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-63	214.1	60	376

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl N+g tC +NS+LQ+ ++   +++ l +     ++    +++k+++  ++  l+e+++ +k+kavsprel+ +l++    ++ + q
   Q: 60   VGLYNIGQTCCLNSLLQVFLMNIHFTKILRRISVPVCA----TQKKKNVPYQMLLLLEKMQCGKQKAVSPRELVLCLEAHR--VTMFVQ 142
           6******************************5555555....56899***************************9998655..5699** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
            Da  ++  l + l++++                          k+ +  + +sdl+ +++++++ c+ c ++++r++++l+l++p+ +
   Q: 143  YDAAQLFLTLWNLLKKQM--------------------------KNPELVEKLSDLYTISVQEHLACQICSSETKRNSSMLSLPVPLLD 205
           ******************..........................567778899************************************ PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
           ++++ +++l++cL+ f+++eel+g+n+++ce+c kk+  ++++kl +lP++L++hLkRf+f ++    +ki++++ fp+ Ld + ++t+
   Q: 206  SDSSMLKTLEKCLQCFFRPEELTGHNMCFCEHCGKKTPFQQSVKLVHLPQTLTIHLKRFCFGRS-AYIHKISNCLPFPQDLDFNAVLTE 293
           *************************************************************998.5557***************87777 PP
   S: 268  ....peekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkrr 338
                 +++k   kYeL+avv HsG++s GHY+ay+++ ++ kW++f+Ds V++v++++v+++ g       +taY+lfY+++
   Q: 294  qqcqAYDNEKAAWKYELFAVVAHSGTTSYGHYCAYIRSlTECKWYCFNDSFVEQVSWDDVKSTYGhsdlywgQTAYLLFYMKK 376
           3333333444499*************************56666*******************888***************985 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MLLMSHRGGH QESKKKLEIS PSETMKAEEE NYKEEAKEPK SEDWRSPSVF GAADLKNRAV 60
GLYNIGQTCC LNSLLQVFLM NIHFTKILRR ISVPVCATQK KKNVPYQMLL LLEKMQCGKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTTCTGTG ATTGTACATG CAATGCTATT GATGAGCCAT AGAGGTGGGC ATCAAGAAAG 60
CAAGAAGAAA CTAGAGATAT CACCAAGTGA GACCATGAAG GCAGAAGAAG AAAATTATAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	55.24	9.00e-100	356.00
IUUC-Apl-004006	Anas platyrhynchos	79.38	8.00e-156	542.00
IUUC-Aca-005088	Anolis carolinensis	56.36	1.00e-95	342.00
IUUC-Ame-010606	Astyanax mexicanus	35.94	2.00e-45	176.00
IUUC-Bta-013036	Bos taurus	53.14	4.00e-98	350.00
IUUC-Cja-019052	Callithrix jacchus	51.70	7.00e-87	313.00
IUUC-Cfa-020554	Canis familiaris	55.66	1.00e-103	369.00
IUUC-Cpo-022421	Cavia porcellus	50.00	2.00e-98	352.00
IUUC-Csa-023737	Chlorocebus sabaeus	50.25	6.00e-56	209.00
IUUC-Cho-024807	Choloepus hoffmanni	47.42	1.00e-39	156.00
IUUC-Dre-027408	Danio rerio	35.33	2.00e-45	176.00
IUUC-Dno-029813	Dasypus novemcinctus	47.80	7.00e-74	270.00
IUUC-Dor-030532	Dipodomys ordii	51.12	4.00e-100	357.00
IUUC-Ete-032254	Echinops telfairi	48.19	5.00e-96	343.00
IUUC-Eca-033482	Equus caballus	55.38	4.00e-103	367.00
IUUC-Eeu-034451	Erinaceus europaeus	47.64	3.00e-54	204.00
IUUC-Fca-036313	Felis catus	55.25	1.00e-103	369.00
IUUC-Fal-037216	Ficedula albicollis	72.49	1.00e-160	558.00
IUUC-Gmo-038649	Gadus morhua	32.92	9.00e-48	183.00
IUUC-Gac-042439	Gasterosteus aculeatus	37.03	1.00e-54	206.00
IUUC-Ggo-044957	Gorilla gorilla	51.82	6.00e-80	290.00
IUUC-Hsa-046381	Homo sapiens	52.41	8.00e-105	373.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	51.41	4.00e-102	364.00
IUUC-Loc-052688	Lepisosteus oculatus	37.69	9.00e-51	193.00
IUUC-Laf-054109	Loxodonta africana	51.81	3.00e-103	368.00
IUUC-Mcc-054814	Macaca mulatta	52.00	2.00e-103	368.00
IUUC-Meu-056253	Macropus eugenii	54.90	3.00e-81	294.00
IUUC-Mmr-061613	Microcebus murinus	54.44	2.00e-102	365.00
IUUC-Mdo-061890	Monodelphis domestica	53.19	6.00e-95	340.00
IUUC-Mmu-064329	Mus musculus	51.26	6.00e-96	343.00
IUUC-Mpu-066342	Mustela putorius furo	55.49	4.00e-105	374.00
IUUC-Mlu-067010	Myotis lucifugus	51.56	5.00e-101	360.00
IUUC-Nle-069148	Nomascus leucogenys	51.84	2.00e-103	369.00
IUUC-Opr-070988	Ochotona princeps	47.13	2.00e-40	159.00
IUUC-Ont-072039	Oreochromis niloticus	36.68	7.00e-53	200.00
IUUC-Oan-073740	Ornithorhynchus anatinus	47.12	4.00e-55	207.00
IUUC-Ocu-074498	Oryctolagus cuniculus	54.46	5.00e-94	337.00
IUUC-Ola-086753	Oryzias latipes	37.07	7.00e-54	204.00
IUUC-Oga-088497	Otolemur garnettii	50.56	4.00e-100	357.00
IUUC-Oar-089505	Ovis aries	53.14	1.00e-96	346.00
IUUC-Ptr-091656	Pan troglodytes	52.69	4.00e-106	377.00
IUUC-Pan-092498	Papio anubis	52.00	2.00e-103	369.00
IUUC-Psi-093409	Pelodiscus sinensis	58.79	3.00e-125	441.00
IUUC-Pfo-096507	Poecilia formosa	34.29	4.00e-48	184.00
IUUC-Pab-097828	Pongo abelii	54.21	2.00e-99	355.00
IUUC-Pca-100299	Procavia capensis	51.77	5.00e-62	231.00
IUUC-Pva-102972	Pteropus vampyrus	52.15	3.00e-97	348.00
IUUC-Rno-105738	Rattus norvegicus	51.46	3.00e-97	348.00
IUUC-Sha-107309	Sarcophilus harrisii	52.72	7.00e-91	326.00
IUUC-Sar-112983	Sorex araneus	49.48	3.00e-73	268.00
IUUC-Ssc-116049	Sus scrofa	54.75	4.00e-100	357.00
IUUC-Tgu-117115	Taeniopygia guttata	74.14	1.00e-143	501.00
IUUC-Tru-118022	Takifugu rubripes	35.48	5.00e-49	187.00
IUUC-Tsy-118986	Tarsius syrichta	54.03	6.00e-34	137.00
IUUC-Tni-120306	Tetraodon nigroviridis	35.56	1.00e-45	176.00
IUUC-Tbe-127768	Tupaia belangeri	48.69	2.00e-61	229.00
IUUC-Ttr-128686	Tursiops truncatus	53.87	2.00e-98	351.00
IUUC-Xtr-132032	Xenopus tropicalis	42.27	8.00e-71	259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence