iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-008005

Ensembl Protein ID

AAS52985

UniProt Accession

Q756G2; TOM1_ASHGO

Genbank Protein ID

AAS52985.2

Protein Name

Probable E3 ubiquitin-protein ligase TOM1; HECT-type E3 ubiquitin transferase TOM1

Genbank Nucleotide ID

AE016818

Gene Name

TOM1; AER304C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AER304C	AAS52985	AAS52985

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-117	391.3	2924	3256

Active Site

Position(s)	Description	Evidence
3225	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlk.krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           +d+k ++le++f+gE+g+d+gG+tre+++ ls++++npd+ lf   ++dk+t++pn++sg+ npehl++F+f+G+++gka+ d+ +ld+++s+ +yk +
   Q: 2924 EDIKiSKLEISFKGEAGVDAGGITREWYQVLSRQMFNPDYALFIPVASDKTTFRPNRTSGI-NPEHLSFFKFIGMIIGKAISDQCFLDCHFSREVYKNI 3021
           5666569*****************************************************9.89*********************************** PP
   S: 101  lgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfne 199
           lgk++ l+d+e++d ++yksl +i+en   di+++ ++ tfsv+++ +ge k+ eL+++G+++ Vt++Nk++Yvk++vey+l++++k q+e+f +Gf+ 
   Q: 3022 LGKPVALKDMESLDLDYYKSLIWILEN---DITDI-IEETFSVETDDYGEHKVIELIENGAHVAVTEQNKHDYVKKIVEYKLQTSVKDQMENFLQGFYA 3116
           *************************99...99999.9************************************************************** PP
   S: 200  viplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirk.da 293
           +ip++l+s+F+e+elell++G ++idv+d+k++t y + yt++ ++i++Fw+++++f++eer+++LqFvTg+s++Pl+Gf+el+     ++f i++ ++
   Q: 3117 IIPKDLISIFDEQELELLVSGLPDIDVDDWKNNTIYVN-YTPTCKQINYFWRAVRSFDKEERAKLLQFVTGTSKVPLNGFKELSgvngISKFSIHRdYG 3214
           ************************************77.***********************************************9977788888688 PP
   S: 294  sddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFe 334
           s drlPss+TCfn+L+LP Y+s+e+l+  Ll+Ai+e+ +gF+
   Q: 3215 SIDRLPSSHTCFNQLDLPAYDSYETLRGSLLLAINEGhEGFG 3256
           88***************************************8 PP

Organism

Ashbya gossypii

Functional Description
(View)

Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins.

Protein Sequence
(Fasta)

MVVTLTKLER LQKAEKSRTF KPLIDELINC EDAVFVGKLE AIREWDRPKD DLFLWIPVLD 60
RMDDMLGKVV AKYKYHTTDC KRHPVKLIEM AKPDEDWVAT LLFFTCRLLN NTSNRSLYSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGTGA CATTGACGAA GTTGGAAAGA CTACAGAAGG CGGAGAAGTC GCGCACATTC 60
AAACCACTCA TCGATGAGCT GATCAACTGC GAGGATGCGG TGTTTGTGGG GAAGTTGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0509--mRNA transport
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005730--C:nucleolus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000448--P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480--P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000447--P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472--P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007067--P:mitotic nuclear division
GO:0051028--P:mRNA transport
GO:0006913--P:nucleocytoplasmic transport
GO:0006997--P:nucleus organization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ago:AGOS_AER304C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	39.17	2.00e-104	373.00
IUUC-Aml-001684	Ailuropoda melanoleuca	46.73	2.00e-130	460.00
IUUC-Atr-003044	Amborella trichopoda	45.49	4.00e-126	445.00
IUUC-Aca-005263	Anolis carolinensis	46.53	3.00e-132	466.00
IUUC-Aly-006157	Arabidopsis lyrata	38.62	1.00e-131	463.00
IUUC-Ath-007160	Arabidopsis thaliana	41.55	6.00e-123	435.00
IUUC-Acl-008254	Aspergillus clavatus	57.68	0.00e+00	751.00
IUUC-Afl-008712	Aspergillus flavus	57.61	0.00e+00	758.00
IUUC-Afu-009022	Aspergillus fumigatus	57.70	0.00e+00	752.00
IUUC-Ani-009412	Aspergillus nidulans	57.48	0.00e+00	739.00
IUUC-Ang-009771	Aspergillus niger	56.90	0.00e+00	746.00
IUUC-Aor-010186	Aspergillus oryzae	57.17	0.00e+00	720.00
IUUC-Ate-010253	Aspergillus terreus	57.19	0.00e+00	746.00
IUUC-Ame-011067	Astyanax mexicanus	54.27	6.00e-132	465.00
IUUC-Bgr-012043	Blumeria graminis	54.93	0.00e+00	700.00
IUUC-Bta-012813	Bos taurus	46.73	2.00e-130	460.00
IUUC-Bci-013995	Botrytis cinerea	55.62	0.00e+00	719.00
IUUC-Bdi-014884	Brachypodium distachyon	42.78	1.00e-126	447.00
IUUC-Bol-016533	Brassica oleracea	53.60	4.00e-86	308.00
IUUC-Bra-016726	Brassica rapa	38.79	3.00e-132	466.00
IUUC-Cel-018179	Caenorhabditis elegans	50.24	3.00e-124	439.00
IUUC-Cja-018741	Callithrix jacchus	46.45	5.00e-128	452.00
IUUC-Cfa-020083	Canis familiaris	46.73	1.00e-130	460.00
IUUC-Cpo-021923	Cavia porcellus	44.08	1.00e-94	341.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	47.75	8.00e-125	437.00
IUUC-Csa-023853	Chlorocebus sabaeus	52.82	2.00e-130	459.00
IUUC-Cho-024718	Choloepus hoffmanni	54.52	2.00e-119	423.00
IUUC-Cin-025627	Ciona intestinalis	51.90	1.00e-127	450.00
IUUC-Csv-025872	Ciona savignyi	51.90	2.00e-125	439.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	56.67	0.00e+00	730.00
IUUC-Cne-027095	Cryptococcus neoformans	34.82	1.00e-159	556.00
IUUC-Cme-027267	Cyanidioschyzon merolae	44.63	2.00e-104	372.00
IUUC-Dre-028525	Danio rerio	45.68	6.00e-116	412.00
IUUC-Dno-029680	Dasypus novemcinctus	52.82	2.00e-130	460.00
IUUC-Dor-030902	Dipodomys ordii	48.83	4.00e-112	399.00
IUUC-Dse-031197	Dothistroma septosporum	53.42	0.00e+00	705.00
IUUC-Dme-032122	Drosophila melanogaster	48.32	9.00e-127	448.00
IUUC-Eca-033915	Equus caballus	51.76	1.00e-128	454.00
IUUC-Eeu-034963	Erinaceus europaeus	52.46	2.00e-128	453.00
IUUC-Fca-035824	Felis catus	46.73	2.00e-130	460.00
IUUC-Fox-037756	Fusarium oxysporum	56.11	0.00e+00	731.00
IUUC-Fso-038464	Fusarium solani	56.13	0.00e+00	719.00
IUUC-Gmo-039073	Gadus morhua	47.69	7.00e-132	464.00
IUUC-Ggr-039946	Gaeumannomyces graminis	56.20	0.00e+00	720.00
IUUC-Gga-040309	Gallus gallus	56.68	2.00e-102	362.00
IUUC-Gac-042430	Gasterosteus aculeatus	47.69	7.00e-132	464.00
IUUC-Gma-044216	Glycine max	38.48	3.00e-130	459.00
IUUC-Hsa-046879	Homo sapiens	52.82	2.00e-130	460.00
IUUC-Hvu-047697	Hordeum vulgare	42.70	7.00e-126	444.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	46.73	6.00e-131	460.00
IUUC-Kpa-049228	Komagataella pastoris	52.12	0.00e+00	983.00
IUUC-Lch-050252	Latimeria chalumnae	46.83	3.00e-130	459.00
IUUC-Lpe-051550	Leersia perrieri	45.55	8.00e-126	444.00
IUUC-Loc-052472	Lepisosteus oculatus	47.69	1.00e-131	464.00
IUUC-Lma-053159	Leptosphaeria maculans	56.60	0.00e+00	735.00
IUUC-Laf-054154	Loxodonta africana	52.82	2.00e-130	459.00
IUUC-Mcc-055085	Macaca mulatta	46.73	2.00e-130	460.00
IUUC-Mor-057201	Magnaporthe oryzae	55.64	0.00e+00	720.00
IUUC-Mpo-057597	Magnaporthe poae	56.04	0.00e+00	722.00
IUUC-Mtr-058273	Medicago truncatula	39.74	7.00e-128	451.00
IUUC-Mla-058888	Melampsora laricipopulina	52.10	3.00e-127	446.00
IUUC-Mvi-060320	Microbotryum violaceum	45.79	3.00e-168	585.00
IUUC-Mmr-060820	Microcebus murinus	52.82	2.00e-130	459.00
IUUC-Mdo-062930	Monodelphis domestica	46.53	3.00e-132	466.00
IUUC-Mmu-063601	Mus musculus	52.82	2.00e-130	460.00
IUUC-Mac-065229	Musa acuminata	38.66	2.00e-129	456.00
IUUC-Mpu-066653	Mustela putorius furo	52.82	2.00e-130	460.00
IUUC-Mlu-067418	Myotis lucifugus	45.69	3.00e-132	466.00
IUUC-Nfi-068278	Neosartorya fischeri	57.70	0.00e+00	753.00
IUUC-Ncr-068813	Neurospora crassa	56.33	0.00e+00	729.00
IUUC-Nle-069418	Nomascus leucogenys	52.82	2.00e-130	459.00
IUUC-Ont-071300	Oreochromis niloticus	47.69	5.00e-132	465.00
IUUC-Oan-073046	Ornithorhynchus anatinus	46.37	3.00e-131	462.00
IUUC-Ocu-074178	Oryctolagus cuniculus	52.82	1.00e-130	460.00
IUUC-Oba-075757	Oryza barthii	43.45	6.00e-128	451.00
IUUC-Obr-076553	Oryza brachyantha	43.63	8.00e-127	447.00
IUUC-Ogl-077520	Oryza glaberrima	43.45	8.00e-128	451.00
IUUC-Ogu-078278	Oryza glumaepatula	43.15	7.00e-128	451.00
IUUC-Oin-079767	Oryza indica	43.45	8.00e-128	451.00
IUUC-Olo-080380	Oryza longistaminata	43.12	4.00e-126	445.00
IUUC-Ome-081925	Oryza meridionalis	43.12	4.00e-126	445.00
IUUC-Oni-082619	Oryza nivara	43.45	7.00e-128	451.00
IUUC-Opu-083684	Oryza punctata	43.12	4.00e-126	445.00
IUUC-Oru-084501	Oryza rufipogon	43.45	9.00e-128	451.00
IUUC-Osa-086251	Oryza sativa	43.15	6.00e-128	449.00
IUUC-Olu-087813	Ostreococcus lucimarinus	45.32	7.00e-111	391.00
IUUC-Oga-088903	Otolemur garnettii	52.82	2.00e-130	460.00
IUUC-Oar-090210	Ovis aries	46.73	2.00e-130	460.00
IUUC-Pan-092368	Papio anubis	44.86	9.00e-115	408.00
IUUC-Pno-094871	Phaeosphaeria nodorum	56.45	0.00e+00	730.00
IUUC-Ppa-095834	Physcomitrella patens	38.60	1.00e-122	434.00
IUUC-Pfo-096232	Poecilia formosa	47.69	4.00e-132	465.00
IUUC-Pab-098583	Pongo abelii	52.82	2.00e-130	460.00
IUUC-Pop-099468	Populus trichocarpa	39.88	4.00e-134	472.00
IUUC-Ppe-101641	Prunus persica	38.84	6.00e-131	461.00
IUUC-Pva-102116	Pteropus vampyrus	49.06	5.00e-116	412.00
IUUC-Pgr-103465	Puccinia graminis	42.24	2.00e-156	546.00
IUUC-Ptt-103813	Puccinia triticina	40.22	1.00e-140	493.00
IUUC-Pte-104018	Pyrenophora teres	56.45	0.00e+00	730.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	55.89	0.00e+00	724.00
IUUC-Sce-106449	Saccharomyces cerevisiae	50.87	0.00e+00	3134.00
IUUC-Sha-106961	Sarcophilus harrisii	46.53	4.00e-132	465.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	40.26	0.00e+00	778.00
IUUC-Spo-108024	Schizosaccharomyces pombe	40.62	0.00e+00	754.00
IUUC-Smo-109640	Selaginella moellendorffii	44.40	5.00e-123	435.00
IUUC-Sit-110598	Setaria italica	44.38	8.00e-130	457.00
IUUC-Sly-111706	Solanum lycopersicum	41.30	9.00e-129	454.00
IUUC-Sar-113291	Sorex araneus	53.38	2.00e-126	447.00
IUUC-Sbi-114042	Sorghum bicolor	41.27	5.00e-128	451.00
IUUC-Sre-114958	Sporisorium reilianum	54.91	7.00e-165	571.00
IUUC-Ssc-115754	Sus scrofa	52.82	2.00e-130	459.00
IUUC-Tru-118570	Takifugu rubripes	47.69	6.00e-132	465.00
IUUC-Tni-120836	Tetraodon nigroviridis	47.50	2.00e-128	452.00
IUUC-Tca-121479	Theobroma cacao	38.29	2.00e-129	456.00
IUUC-Tre-121909	Trichoderma reesei	56.39	0.00e+00	724.00
IUUC-Tvi-122370	Trichoderma virens	55.75	0.00e+00	724.00
IUUC-Tae-125214	Triticum aestivum	49.04	1.00e-122	432.00
IUUC-Tme-127172	Tuber melanosporum	44.48	0.00e+00	872.00
IUUC-Ttr-129253	Tursiops truncatus	46.73	3.00e-130	459.00
IUUC-Uma-129355	Ustilago maydis	54.05	2.00e-164	570.00
IUUC-Vda-129886	Verticillium dahliae	55.73	0.00e+00	713.00
IUUC-Vpa-130708	Vicugna pacos	46.73	4.00e-130	459.00
IUUC-Vvi-131078	Vitis vinifera	43.27	2.00e-130	460.00
IUUC-Xtr-132123	Xenopus tropicalis	50.00	8.00e-120	424.00
IUUC-Xma-133869	Xiphophorus maculatus	47.69	4.00e-132	465.00
IUUC-Yli-134657	Yarrowia lipolytica	45.87	0.00e+00	885.00
IUUC-Zma-135570	Zea mays	40.79	6.00e-129	454.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence