iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050105

Ensembl Protein ID

ENSLACP00000003857.1

UniProt Accession

H3A2I6; H3A2I6_LATCH

Genbank Protein ID

ENSLACP00000003857

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01233316

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000003434.1	ENSLACT00000003892.1	ENSLACP00000003857.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-29	101.5	390	423
E3 activity/RING/U-box	5.80e-14	52.1	3	64
UBD/Beta-Prp	6.90e-49	166.8	232	503

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 390  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 423
           8**********976699**************986 PP

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s+++++r+ Iek++a++g+ +P+++qpl+ee l++ ++ + +  +
   Q: 3    LVCSISNEVPEHPCVSPvSNHVFERRLIEKYIAENGT-DPINGQPLSEELLIDIKVAHPIRPK 64
           68**********************************9.***************9998877665 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
            d+s ++tg++d+ + v+d ++++ l++l+gh+++vt+v f+p++++  ++s D ti++w++ + +cv+++++he  v+ ls++++gd+
   Q: 232  SDTSKVLTGGADKNVVVFDKKSEQILATLKGHNKKVTSVVFHPSQDLVFSASPDTTIRIWSVPSTSCVQVIRAHEGAVTGLSLHATGDY 320
           57889************************************************************************************ PP
   S: 109  lvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelv 196
           l+s s+d+     d++tg  l + t+++   + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l+
   Q: 321  LLSSSEDQFWAFSDVHTGRILTKvTDEVSGCALTCAQFHPDGLIFGTGTIDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYLA 408
           *********************99888999999*************************************9.****************** PP
   S: 197  sgsldgtvklwdlqtgecvrtlng.htdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgs 284
           ++++d++vklwdl++ +  +t +   +  vks+ f++ +++l+ ++ D  ++i  +++ + +  ++ h    + va+   ++ ++++ s
   Q: 409  TAADDSSVKLWDLRKLKNFKTIQLdDNFEVKSLMFDQSGTYLALAGTDMRVFI--CKQWTEILHFTEHSGLTTGVAF--GQHAHFLASS 493
           **************666655555413345677777777777777777777777..5555555556665656666666..4455555555 PP
   S: 285  e.dskvniwk 293
           + d ++++++
   Q: 494  GmDRSLKFYS 503
           5566666665 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MSLVCSISNE VPEHPCVSPV SNHVFERRLI EKYIAENGTD PINGQPLSEE LLIDIKVAHP 60
IRPKPPSSTS IPAILKSLQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAGAGGAG AAAGGGCCTG TACGTTGTGT GGCAGCGTTC TCGCGCTCAG GAGGGGAAAC 60
GCGGTTCCGG GGAAATTGCA GAGAGAAAGA CCAGTGCGCG CGCCTTTAGT CCGGGCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator

KEGG

lcm:102351823

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	39.45	2.00e-95	343.00
IUUC-Aml-001230	Ailuropoda melanoleuca	87.58	0.00e+00	892.00
IUUC-Atr-002594	Amborella trichopoda	43.62	2.00e-117	416.00
IUUC-Apl-003686	Anas platyrhynchos	80.37	0.00e+00	682.00
IUUC-Aca-005272	Anolis carolinensis	89.88	0.00e+00	939.00
IUUC-Aly-005586	Arabidopsis lyrata	44.02	9.00e-118	417.00
IUUC-Ath-007696	Arabidopsis thaliana	43.69	3.00e-114	405.00
IUUC-Acl-008335	Aspergillus clavatus	34.92	5.00e-66	244.00
IUUC-Afl-008527	Aspergillus flavus	35.23	4.00e-71	261.00
IUUC-Afu-008957	Aspergillus fumigatus	37.19	3.00e-76	279.00
IUUC-Ani-009280	Aspergillus nidulans	38.03	5.00e-65	241.00
IUUC-Ang-009746	Aspergillus niger	37.13	2.00e-67	249.00
IUUC-Aor-009905	Aspergillus oryzae	36.50	2.00e-74	273.00
IUUC-Ate-010412	Aspergillus terreus	37.76	2.00e-65	242.00
IUUC-Ame-011561	Astyanax mexicanus	86.67	2.00e-111	395.00
IUUC-Bgr-012283	Blumeria graminis	33.06	9.00e-56	211.00
IUUC-Bta-013242	Bos taurus	89.88	0.00e+00	938.00
IUUC-Bci-013901	Botrytis cinerea	36.03	5.00e-68	251.00
IUUC-Bdi-014277	Brachypodium distachyon	43.71	5.00e-121	427.00
IUUC-Bol-016207	Brassica oleracea	44.89	2.00e-117	415.00
IUUC-Bra-017650	Brassica rapa	44.53	7.00e-118	417.00
IUUC-Cel-018271	Caenorhabditis elegans	51.38	1.00e-149	522.00
IUUC-Cja-019879	Callithrix jacchus	89.90	0.00e+00	934.00
IUUC-Cfa-020175	Canis familiaris	89.88	0.00e+00	939.00
IUUC-Cpo-022379	Cavia porcellus	90.28	0.00e+00	941.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	40.35	3.00e-97	348.00
IUUC-Csa-023500	Chlorocebus sabaeus	90.08	0.00e+00	940.00
IUUC-Cho-025065	Choloepus hoffmanni	79.42	3.00e-137	480.00
IUUC-Cin-025699	Ciona intestinalis	68.81	3.00e-173	601.00
IUUC-Csv-026128	Ciona savignyi	66.15	0.00e+00	675.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.90	6.00e-65	241.00
IUUC-Cne-026860	Cryptococcus neoformans	38.55	2.00e-95	342.00
IUUC-Dre-028187	Danio rerio	83.76	0.00e+00	849.00
IUUC-Dno-029453	Dasypus novemcinctus	90.08	0.00e+00	940.00
IUUC-Dor-030150	Dipodomys ordii	90.34	1.00e-118	419.00
IUUC-Dse-031220	Dothistroma septosporum	32.24	4.00e-59	221.00
IUUC-Dme-031906	Drosophila melanogaster	66.53	0.00e+00	673.00
IUUC-Ete-033035	Echinops telfairi	78.57	0.00e+00	797.00
IUUC-Eca-033478	Equus caballus	89.68	0.00e+00	935.00
IUUC-Eeu-034974	Erinaceus europaeus	89.36	0.00e+00	627.00
IUUC-Fca-036194	Felis catus	89.24	0.00e+00	929.00
IUUC-Fal-037417	Ficedula albicollis	89.29	0.00e+00	934.00
IUUC-Fox-037922	Fusarium oxysporum	34.53	2.00e-62	233.00
IUUC-Fso-038256	Fusarium solani	33.33	3.00e-64	239.00
IUUC-Gmo-038713	Gadus morhua	86.14	0.00e+00	870.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.25	8.00e-52	197.00
IUUC-Gga-041143	Gallus gallus	89.48	0.00e+00	936.00
IUUC-Gac-042129	Gasterosteus aculeatus	84.55	0.00e+00	882.00
IUUC-Gma-044273	Glycine max	44.44	1.00e-119	423.00
IUUC-Ggo-045262	Gorilla gorilla	90.08	0.00e+00	940.00
IUUC-Hsa-046036	Homo sapiens	90.08	0.00e+00	940.00
IUUC-Hvu-047442	Hordeum vulgare	43.67	1.00e-66	246.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	89.88	0.00e+00	908.00
IUUC-Lpe-050976	Leersia perrieri	44.10	1.00e-117	416.00
IUUC-Loc-052042	Lepisosteus oculatus	72.71	0.00e+00	648.00
IUUC-Lma-053143	Leptosphaeria maculans	33.06	2.00e-61	230.00
IUUC-Laf-053451	Loxodonta africana	86.76	0.00e+00	927.00
IUUC-Mcc-055786	Macaca mulatta	90.08	0.00e+00	940.00
IUUC-Meu-056161	Macropus eugenii	90.46	3.00e-131	461.00
IUUC-Mor-057215	Magnaporthe oryzae	32.15	1.00e-53	203.00
IUUC-Mpo-057419	Magnaporthe poae	31.21	2.00e-49	189.00
IUUC-Mtr-057756	Medicago truncatula	43.50	4.00e-115	408.00
IUUC-Mla-059085	Melampsora laricipopulina	37.81	4.00e-85	308.00
IUUC-Mga-060158	Meleagris gallopavo	83.37	0.00e+00	832.00
IUUC-Mvi-060441	Microbotryum violaceum	38.64	1.00e-80	293.00
IUUC-Mmr-061085	Microcebus murinus	90.08	0.00e+00	940.00
IUUC-Mdo-061804	Monodelphis domestica	90.28	0.00e+00	941.00
IUUC-Mmu-063608	Mus musculus	86.62	0.00e+00	927.00
IUUC-Mac-064972	Musa acuminata	45.11	8.00e-116	410.00
IUUC-Mpu-065700	Mustela putorius furo	89.88	0.00e+00	939.00
IUUC-Mlu-068223	Myotis lucifugus	87.09	0.00e+00	928.00
IUUC-Nfi-068504	Neosartorya fischeri	37.19	4.00e-76	278.00
IUUC-Ncr-068729	Neurospora crassa	35.62	7.00e-63	234.00
IUUC-Nle-069754	Nomascus leucogenys	90.08	0.00e+00	940.00
IUUC-Opr-070621	Ochotona princeps	86.72	0.00e+00	883.00
IUUC-Ont-071377	Oreochromis niloticus	84.95	0.00e+00	863.00
IUUC-Oan-073498	Ornithorhynchus anatinus	68.00	1.00e-113	402.00
IUUC-Ocu-074182	Oryctolagus cuniculus	86.48	0.00e+00	927.00
IUUC-Oba-075509	Oryza barthii	42.80	4.00e-118	418.00
IUUC-Obr-076480	Oryza brachyantha	43.19	5.00e-119	421.00
IUUC-Ogl-077052	Oryza glaberrima	42.80	4.00e-118	418.00
IUUC-Ogu-078919	Oryza glumaepatula	42.80	5.00e-118	417.00
IUUC-Oin-079357	Oryza indica	42.08	2.00e-111	395.00
IUUC-Olo-080376	Oryza longistaminata	42.56	5.00e-106	377.00
IUUC-Ome-081973	Oryza meridionalis	42.01	1.00e-105	376.00
IUUC-Oni-082849	Oryza nivara	42.80	2.00e-118	419.00
IUUC-Opu-083243	Oryza punctata	42.61	1.00e-117	416.00
IUUC-Oru-084613	Oryza rufipogon	43.13	4.00e-118	417.00
IUUC-Osa-085407	Oryza sativa	42.97	5.00e-118	417.00
IUUC-Ola-086566	Oryzias latipes	83.92	0.00e+00	853.00
IUUC-Olu-087757	Ostreococcus lucimarinus	38.52	2.00e-91	329.00
IUUC-Oga-089010	Otolemur garnettii	86.39	0.00e+00	892.00
IUUC-Oar-089638	Ovis aries	89.88	0.00e+00	938.00
IUUC-Ptr-091141	Pan troglodytes	90.08	0.00e+00	940.00
IUUC-Pan-092662	Papio anubis	90.08	0.00e+00	940.00
IUUC-Psi-093777	Pelodiscus sinensis	89.02	0.00e+00	766.00
IUUC-Pno-095115	Phaeosphaeria nodorum	33.97	2.00e-63	236.00
IUUC-Ppa-095841	Physcomitrella patens	44.06	2.00e-117	415.00
IUUC-Pfo-096390	Poecilia formosa	83.56	0.00e+00	857.00
IUUC-Pab-098250	Pongo abelii	90.13	0.00e+00	881.00
IUUC-Pop-099854	Populus trichocarpa	44.21	1.00e-117	416.00
IUUC-Pca-100553	Procavia capensis	89.88	0.00e+00	933.00
IUUC-Ppe-101383	Prunus persica	43.65	4.00e-113	401.00
IUUC-Pva-102189	Pteropus vampyrus	89.68	0.00e+00	937.00
IUUC-Pgr-103304	Puccinia graminis	36.23	6.00e-82	298.00
IUUC-Ptt-103984	Puccinia triticina	36.05	3.00e-85	309.00
IUUC-Pte-104385	Pyrenophora teres	32.70	8.00e-67	247.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.12	2.00e-67	249.00
IUUC-Rno-105581	Rattus norvegicus	89.88	0.00e+00	940.00
IUUC-Sha-107071	Sarcophilus harrisii	86.31	0.00e+00	927.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	29.69	6.00e-35	142.00
IUUC-Spo-108315	Schizosaccharomyces pombe	32.37	2.00e-44	173.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	35.68	5.00e-67	248.00
IUUC-Smo-109648	Selaginella moellendorffii	46.12	6.00e-125	440.00
IUUC-Sit-109873	Setaria italica	43.82	4.00e-117	415.00
IUUC-Sly-111673	Solanum lycopersicum	45.02	3.00e-111	395.00
IUUC-Stu-112125	Solanum tuberosum	43.82	1.00e-109	390.00
IUUC-Sbi-114696	Sorghum bicolor	41.73	4.00e-106	378.00
IUUC-Sre-115134	Sporisorium reilianum	32.12	1.00e-72	266.00
IUUC-Ssc-116260	Sus scrofa	89.68	0.00e+00	937.00
IUUC-Tgu-116533	Taeniopygia guttata	89.68	0.00e+00	937.00
IUUC-Tru-117800	Takifugu rubripes	84.55	0.00e+00	889.00
IUUC-Tsy-118980	Tarsius syrichta	85.10	0.00e+00	849.00
IUUC-Tni-120334	Tetraodon nigroviridis	68.32	0.00e+00	701.00
IUUC-Tca-121807	Theobroma cacao	44.51	2.00e-120	426.00
IUUC-Tre-121920	Trichoderma reesei	31.92	3.00e-61	228.00
IUUC-Tvi-122294	Trichoderma virens	32.00	3.00e-53	202.00
IUUC-Tae-125713	Triticum aestivum	44.29	1.00e-121	429.00
IUUC-Tur-126664	Triticum urartu	40.00	2.00e-111	396.00
IUUC-Tme-127026	Tuber melanosporum	35.07	3.00e-68	252.00
IUUC-Tbe-127582	Tupaia belangeri	89.67	0.00e+00	628.00
IUUC-Ttr-128313	Tursiops truncatus	89.48	0.00e+00	927.00
IUUC-Uma-129626	Ustilago maydis	32.59	7.00e-73	268.00
IUUC-Vda-129699	Verticillium dahliae	36.05	7.00e-67	248.00
IUUC-Vpa-130593	Vicugna pacos	89.43	0.00e+00	836.00
IUUC-Vvi-131668	Vitis vinifera	44.08	6.00e-120	424.00
IUUC-Xtr-132186	Xenopus tropicalis	83.14	0.00e+00	754.00
IUUC-Xma-133212	Xiphophorus maculatus	83.37	0.00e+00	852.00
IUUC-Yli-134607	Yarrowia lipolytica	57.58	6.00e-42	162.00
IUUC-Zma-135662	Zea mays	44.68	1.00e-118	420.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence