iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108315

UUCD1 version

UUC-ScP-00073

Ensembl Protein ID

SPAC29A4.08c.1:pep

UniProt Accession

O14011; PRP19_SCHPO

Genbank Protein ID

AAF67750.1; CAB10135.1

Protein Name

Pre-mRNA-processing factor 19; Complexed with cdc5 protein 8; RING-type E3 ubiquitin transferase PRP19

Genbank Nucleotide ID

AF254351; CU329670

Gene Name

prp19; cwf8; SPAC29A4.08c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC29A4.08c	SPAC29A4.08c.1	SPAC29A4.08c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-07	29.7	374	412
E3 activity/RING/U-box	8.10e-11	40.0	2	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           H+++v  l+f  ++ +l+v+ +dD  i +WDlr+  l++
   Q: 374  HSSPVKTLQFgeNGyWLVVTTNDDSDIFIWDLRKSELVQ 412
           9**********9999*****************9987765 PP

E3 activity/RING/U-box

   S: 7    lCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnl 59
            C+Is+e +++Pv++  sG +y+++ Ie+ +++  k +Pvt+q+ t edlvP +
   Q: 2    FCSISGETPKEPVISRvSGNVYEKRLIEQVIRETSK-DPVTQQECTLEDLVPVK 54
           6**********************************9.***************76 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Probable ubiquitin-protein ligase involved in pre-mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. May also function in DNA repair.

Protein Sequence
(Fasta)

MFCSISGETP KEPVISRVSG NVYEKRLIEQ VIRETSKDPV TQQECTLEDL VPVKVPDFVR 60
PRPPSATSLP ALLSLFQEEW DSVALEQFEL RRNLTETKQE LSTALYSLDA ALRVISRLTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTCTAGCT ATTACACACA GAAACCAACG TGTGCCGAAT GTTTTGCTCA ATCAGTGGAG 60
AAACGCCAAA AGAACCGGTG ATTTCTCGTG TAAGTGGTAT GTTTGTACAA TAATTTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR013915--Pre-mRNA_splic_Prp19
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF08606--Prp19

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0005634--C:nucleus
GO:0071014--C:post-mRNA release spliceosomal complex
GO:0000974--C:Prp19 complex
GO:0005681--C:spliceosomal complex
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006281--P:DNA repair
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPAC29A4.08c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000890	Aegilops tauschii	39.81	6.00e-37	145.00
IUUC-Aml-001230	Ailuropoda melanoleuca	32.48	3.00e-51	194.00
IUUC-Atr-002594	Amborella trichopoda	30.12	3.00e-48	184.00
IUUC-Apl-003686	Anas platyrhynchos	26.10	7.00e-21	92.80
IUUC-Aca-005272	Anolis carolinensis	33.33	7.00e-52	196.00
IUUC-Aly-006002	Arabidopsis lyrata	29.57	2.00e-46	178.00
IUUC-Ath-007693	Arabidopsis thaliana	29.48	3.00e-46	177.00
IUUC-Ago-007879	Ashbya gossypii	28.60	1.00e-33	135.00
IUUC-Acl-008335	Aspergillus clavatus	32.00	1.00e-61	228.00
IUUC-Afl-008527	Aspergillus flavus	33.33	5.00e-72	263.00
IUUC-Afu-008957	Aspergillus fumigatus	31.12	1.00e-68	251.00
IUUC-Ani-009280	Aspergillus nidulans	31.68	2.00e-61	228.00
IUUC-Ang-009746	Aspergillus niger	34.63	2.00e-70	257.00
IUUC-Aor-009905	Aspergillus oryzae	33.27	6.00e-74	269.00
IUUC-Ate-010412	Aspergillus terreus	32.54	1.00e-63	234.00
IUUC-Ame-011561	Astyanax mexicanus	51.82	6.00e-33	132.00
IUUC-Bgr-012283	Blumeria graminis	32.66	1.00e-64	238.00
IUUC-Bta-013242	Bos taurus	32.40	9.00e-52	196.00
IUUC-Bci-013901	Botrytis cinerea	34.13	3.00e-72	263.00
IUUC-Bdi-014277	Brachypodium distachyon	29.79	3.00e-49	187.00
IUUC-Bol-016045	Brassica oleracea	30.14	4.00e-45	173.00
IUUC-Bra-017902	Brassica rapa	30.52	7.00e-46	176.00
IUUC-Cel-018271	Caenorhabditis elegans	29.55	1.00e-44	172.00
IUUC-Cja-019879	Callithrix jacchus	32.09	3.00e-50	190.00
IUUC-Cfa-020175	Canis familiaris	32.63	1.00e-51	195.00
IUUC-Cpo-022379	Cavia porcellus	32.40	1.00e-51	195.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	32.67	2.00e-50	191.00
IUUC-Csa-023500	Chlorocebus sabaeus	32.17	1.00e-51	195.00
IUUC-Cho-025065	Choloepus hoffmanni	50.69	1.00e-34	137.00
IUUC-Cin-025699	Ciona intestinalis	31.89	2.00e-43	167.00
IUUC-Csv-026128	Ciona savignyi	50.45	6.00e-28	116.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	34.41	1.00e-73	268.00
IUUC-Cne-026860	Cryptococcus neoformans	31.40	5.00e-56	209.00
IUUC-Dre-028187	Danio rerio	29.61	1.00e-43	168.00
IUUC-Dno-029453	Dasypus novemcinctus	32.17	2.00e-51	194.00
IUUC-Dse-031220	Dothistroma septosporum	34.76	6.00e-75	272.00
IUUC-Dme-031906	Drosophila melanogaster	31.53	3.00e-42	164.00
IUUC-Ete-033035	Echinops telfairi	50.69	2.00e-34	138.00
IUUC-Eca-033478	Equus caballus	32.40	1.00e-51	195.00
IUUC-Fca-036194	Felis catus	32.17	1.00e-50	192.00
IUUC-Fal-037417	Ficedula albicollis	32.63	1.00e-51	195.00
IUUC-Fox-037922	Fusarium oxysporum	32.40	2.00e-69	254.00
IUUC-Fso-038256	Fusarium solani	33.40	4.00e-71	259.00
IUUC-Gmo-038713	Gadus morhua	29.60	1.00e-45	175.00
IUUC-Ggr-039854	Gaeumannomyces graminis	30.65	2.00e-54	204.00
IUUC-Gga-041143	Gallus gallus	32.40	9.00e-52	195.00
IUUC-Gac-042129	Gasterosteus aculeatus	30.94	2.00e-48	184.00
IUUC-Gma-043635	Glycine max	28.77	2.00e-49	187.00
IUUC-Ggo-045262	Gorilla gorilla	32.17	1.00e-51	195.00
IUUC-Hsa-046036	Homo sapiens	32.17	1.00e-51	195.00
IUUC-Hvu-047442	Hordeum vulgare	40.00	5.00e-39	152.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	32.40	6.00e-51	192.00
IUUC-Kpa-049195	Komagataella pastoris	27.78	1.00e-33	135.00
IUUC-Lch-050105	Latimeria chalumnae	32.37	5.00e-50	190.00
IUUC-Lpe-050976	Leersia perrieri	30.63	5.00e-50	190.00
IUUC-Loc-052042	Lepisosteus oculatus	46.49	4.00e-20	90.50
IUUC-Lma-053143	Leptosphaeria maculans	35.99	4.00e-71	261.00
IUUC-Laf-053451	Loxodonta africana	30.94	3.00e-48	184.00
IUUC-Mcc-055786	Macaca mulatta	32.17	1.00e-51	195.00
IUUC-Meu-056161	Macropus eugenii	50.00	1.00e-20	92.40
IUUC-Mor-057215	Magnaporthe oryzae	33.73	6.00e-65	239.00
IUUC-Mpo-057419	Magnaporthe poae	30.44	2.00e-51	194.00
IUUC-Mtr-057756	Medicago truncatula	31.60	9.00e-46	176.00
IUUC-Mla-059085	Melampsora laricipopulina	27.31	2.00e-36	144.00
IUUC-Mga-060158	Meleagris gallopavo	30.41	9.00e-40	155.00
IUUC-Mvi-060441	Microbotryum violaceum	30.32	6.00e-47	179.00
IUUC-Mmr-061085	Microcebus murinus	32.17	1.00e-51	195.00
IUUC-Mdo-061804	Monodelphis domestica	32.40	3.00e-52	197.00
IUUC-Mmu-063608	Mus musculus	30.80	6.00e-48	182.00
IUUC-Mac-064972	Musa acuminata	30.82	3.00e-49	187.00
IUUC-Mpu-065700	Mustela putorius furo	32.63	1.00e-51	195.00
IUUC-Mlu-068223	Myotis lucifugus	32.21	3.00e-50	191.00
IUUC-Nfi-068504	Neosartorya fischeri	30.86	6.00e-68	249.00
IUUC-Ncr-068729	Neurospora crassa	34.49	2.00e-73	267.00
IUUC-Nle-069754	Nomascus leucogenys	32.17	1.00e-51	195.00
IUUC-Opr-070621	Ochotona princeps	31.84	4.00e-49	186.00
IUUC-Ont-071377	Oreochromis niloticus	30.04	6.00e-46	176.00
IUUC-Ocu-074182	Oryctolagus cuniculus	30.67	7.00e-48	182.00
IUUC-Oba-075509	Oryza barthii	31.12	8.00e-50	189.00
IUUC-Obr-076480	Oryza brachyantha	31.58	1.00e-51	195.00
IUUC-Ogl-077052	Oryza glaberrima	31.12	8.00e-50	189.00
IUUC-Ogu-078919	Oryza glumaepatula	31.12	9.00e-50	189.00
IUUC-Oin-079357	Oryza indica	31.69	1.00e-51	195.00
IUUC-Olo-080376	Oryza longistaminata	29.14	2.00e-37	148.00
IUUC-Ome-081973	Oryza meridionalis	28.99	2.00e-37	147.00
IUUC-Oni-082849	Oryza nivara	31.12	6.00e-50	189.00
IUUC-Opu-083243	Oryza punctata	31.12	8.00e-50	189.00
IUUC-Oru-084613	Oryza rufipogon	31.12	1.00e-49	189.00
IUUC-Osa-085407	Oryza sativa	31.12	8.00e-50	189.00
IUUC-Ola-086566	Oryzias latipes	29.84	3.00e-44	171.00
IUUC-Olu-087757	Ostreococcus lucimarinus	31.64	3.00e-50	190.00
IUUC-Oga-089010	Otolemur garnettii	31.18	1.00e-49	189.00
IUUC-Oar-089638	Ovis aries	32.40	9.00e-52	196.00
IUUC-Ptr-091141	Pan troglodytes	32.17	1.00e-51	195.00
IUUC-Pan-092662	Papio anubis	32.17	1.00e-51	195.00
IUUC-Pno-095115	Phaeosphaeria nodorum	35.05	1.00e-68	252.00
IUUC-Ppa-095924	Physcomitrella patens	31.07	3.00e-49	187.00
IUUC-Pfo-096390	Poecilia formosa	29.82	6.00e-46	176.00
IUUC-Pab-098250	Pongo abelii	32.17	2.00e-51	194.00
IUUC-Pop-099347	Populus trichocarpa	29.68	1.00e-50	192.00
IUUC-Pca-100553	Procavia capensis	32.87	1.00e-49	188.00
IUUC-Ppe-101383	Prunus persica	32.67	6.00e-49	186.00
IUUC-Pva-102189	Pteropus vampyrus	32.63	4.00e-52	196.00
IUUC-Pgr-103304	Puccinia graminis	30.18	2.00e-40	158.00
IUUC-Ptt-103984	Puccinia triticina	29.36	5.00e-44	170.00
IUUC-Pte-104385	Pyrenophora teres	33.53	3.00e-70	257.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	34.00	2.00e-70	258.00
IUUC-Rno-105581	Rattus norvegicus	32.17	2.00e-51	194.00
IUUC-Sce-106147	Saccharomyces cerevisiae	36.62	1.00e-21	95.50
IUUC-Sha-107071	Sarcophilus harrisii	30.82	1.00e-47	182.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	40.48	3.00e-97	347.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	34.27	4.00e-72	263.00
IUUC-Smo-109648	Selaginella moellendorffii	31.36	4.00e-53	200.00
IUUC-Sit-109873	Setaria italica	29.88	6.00e-52	197.00
IUUC-Sly-111673	Solanum lycopersicum	31.66	2.00e-46	177.00
IUUC-Stu-112125	Solanum tuberosum	31.66	4.00e-46	177.00
IUUC-Sbi-114696	Sorghum bicolor	30.23	7.00e-45	172.00
IUUC-Sre-115134	Sporisorium reilianum	49.03	1.00e-39	155.00
IUUC-Ssc-116260	Sus scrofa	32.40	9.00e-52	195.00
IUUC-Tgu-116533	Taeniopygia guttata	32.40	1.00e-51	195.00
IUUC-Tru-117800	Takifugu rubripes	30.27	3.00e-47	181.00
IUUC-Tsy-118980	Tarsius syrichta	29.25	2.00e-35	141.00
IUUC-Tca-121807	Theobroma cacao	30.02	5.00e-52	196.00
IUUC-Tre-121920	Trichoderma reesei	33.53	5.00e-67	246.00
IUUC-Tvi-122294	Trichoderma virens	32.84	3.00e-54	204.00
IUUC-Tae-125713	Triticum aestivum	31.58	4.00e-51	193.00
IUUC-Tur-126199	Triticum urartu	26.96	3.00e-39	154.00
IUUC-Tme-127026	Tuber melanosporum	33.73	9.00e-73	265.00
IUUC-Ttr-128313	Tursiops truncatus	32.94	3.00e-51	193.00
IUUC-Uma-129626	Ustilago maydis	29.94	9.00e-53	199.00
IUUC-Vda-129699	Verticillium dahliae	34.98	3.00e-73	266.00
IUUC-Vpa-130593	Vicugna pacos	32.08	4.00e-49	186.00
IUUC-Vvi-131668	Vitis vinifera	38.50	1.00e-38	152.00
IUUC-Xtr-132186	Xenopus tropicalis	30.44	8.00e-47	179.00
IUUC-Xma-133212	Xiphophorus maculatus	29.82	1.00e-45	175.00
IUUC-Yli-134607	Yarrowia lipolytica	55.88	3.00e-41	158.00
IUUC-Zma-135662	Zea mays	31.05	1.00e-51	195.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence