iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052541

Ensembl Protein ID

ENSLOCP00000013160.1

UniProt Accession

W5MXQ1; W5MXQ1_LEPOC

Genbank Protein ID

ENSLOCP00000013160

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01003752

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000010734.1	ENSLOCT00000013188.1	ENSLOCP00000013160.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-100	336.8	684	1021

Active Site

Position(s)	Description	Evidence
989	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg... 85
           sd++k+lev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n++  ++pn d+   ++ +lk++ef+Gr++gk+l+++   
   Q: 684  SDWSKNLEVVFQDEEALDWGGPRREWFELICKALFDTSNQLFtRFSDNNQGLVHPNADRP--PHLRLKVYEFAGRVVGKCLYESalg 768
           799***************************************778999999********8..459******************9999 PP
   S: 86   ....rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtn 167
               +l+++++++sf+ +++g +++++ +e+ d+e+yk+ + +i++n   d++e++l ++ ++ +++    k++eL+ gG++i Vtn
   Q: 769  gaykQLVRARFTRSFLAQIIGLRMNYKYFETDDQEFYKTkVCFILNN---DVSEMDLVFAEEKYNRSGHLEKVVELIAGGSQIAVTN 852
           9999***********************************99****99...9************************************ PP
   S: 168  eNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevl 253
           eNk  Y +l+++yrl ++++e+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v d+k+++    g ++ ++++++wFw v+
   Q: 853  ENKIHYLNLLAQYRLANQVREEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVMDFKAHAvIVGGSWHFREKVMKWFWAVV 939
           ******************************************************************445778999************ PP
   S: 254  eefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           ++f++ee +++LqF+Tgss+lP+gGf++l p++ +i    +++ lP+++TCfn+L+LP Y+s+e+l+++L +Ai+e+ +gF++
   Q: 940  SSFTQEELARLLQFTTGSSQLPPGGFNTLCPSFQIIAA-PTHSTLPTAHTCFNQLCLPYYDSYEELHKMLKLAISEGsEGFGM 1021
           ******************************99555555.******************************************97 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MDRRFLLTFA FCSILWVLFW EIRWKKAKEN QIEEWLHGNS LSEYKDIFED VQSLEELTLS 60
LLSRLEEVLQ ETQYWQEIEE SRNQLLRDFA FQEWLCSQGL EHYYHTLKSL GCSSLDDLAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACCGAC GCTTCTTGCT GACTTTTGCC TTTTGTTCGA TTCTGTGGGT TCTTTTCTGG 60
GAAATCAGGT GGAAGAAAGC AAAAGAAAAT CAGATTGAAG AATGGCTCCA TGGCAACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR013761--SAM/pointed

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	82.65	0.00e+00	1395.00
IUUC-Apl-004071	Anas platyrhynchos	80.70	0.00e+00	1332.00
IUUC-Aca-005218	Anolis carolinensis	82.30	0.00e+00	1385.00
IUUC-Ame-011871	Astyanax mexicanus	87.87	0.00e+00	1835.00
IUUC-Bta-012978	Bos taurus	82.18	0.00e+00	1389.00
IUUC-Cja-019081	Callithrix jacchus	82.55	0.00e+00	1393.00
IUUC-Cfa-020736	Canis familiaris	80.54	0.00e+00	1318.00
IUUC-Cpo-021581	Cavia porcellus	82.79	0.00e+00	1395.00
IUUC-Csa-024189	Chlorocebus sabaeus	78.15	0.00e+00	736.00
IUUC-Cho-024751	Choloepus hoffmanni	81.07	0.00e+00	1357.00
IUUC-Cin-025773	Ciona intestinalis	41.77	1.00e-148	520.00
IUUC-Csv-026090	Ciona savignyi	40.84	4.00e-174	605.00
IUUC-Dre-027788	Danio rerio	87.08	0.00e+00	1820.00
IUUC-Dno-030022	Dasypus novemcinctus	82.42	0.00e+00	1392.00
IUUC-Dme-031577	Drosophila melanogaster	43.25	0.00e+00	715.00
IUUC-Ete-032402	Echinops telfairi	81.24	0.00e+00	1331.00
IUUC-Eca-033908	Equus caballus	82.79	0.00e+00	1397.00
IUUC-Eeu-034869	Erinaceus europaeus	86.18	0.00e+00	827.00
IUUC-Fca-036023	Felis catus	82.91	0.00e+00	1398.00
IUUC-Fal-037477	Ficedula albicollis	80.64	0.00e+00	1396.00
IUUC-Gmo-039197	Gadus morhua	90.53	0.00e+00	1507.00
IUUC-Gga-040704	Gallus gallus	80.09	0.00e+00	1385.00
IUUC-Gac-041511	Gasterosteus aculeatus	89.20	0.00e+00	1533.00
IUUC-Ggo-044527	Gorilla gorilla	79.54	0.00e+00	1322.00
IUUC-Hsa-046082	Homo sapiens	82.55	0.00e+00	1393.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	82.91	0.00e+00	1399.00
IUUC-Lch-049772	Latimeria chalumnae	70.61	0.00e+00	1377.00
IUUC-Laf-053852	Loxodonta africana	82.67	0.00e+00	1389.00
IUUC-Mcc-054759	Macaca mulatta	78.85	0.00e+00	671.00
IUUC-Meu-056247	Macropus eugenii	69.01	0.00e+00	759.00
IUUC-Mga-060161	Meleagris gallopavo	80.61	0.00e+00	1362.00
IUUC-Mmr-061447	Microcebus murinus	82.67	0.00e+00	1396.00
IUUC-Mdo-062110	Monodelphis domestica	81.43	0.00e+00	1368.00
IUUC-Mmu-064349	Mus musculus	82.55	0.00e+00	1395.00
IUUC-Mpu-065824	Mustela putorius furo	82.91	0.00e+00	1389.00
IUUC-Mlu-067729	Myotis lucifugus	80.70	0.00e+00	1371.00
IUUC-Nle-069721	Nomascus leucogenys	82.42	0.00e+00	1384.00
IUUC-Opr-070189	Ochotona princeps	82.54	0.00e+00	1383.00
IUUC-Ont-072122	Oreochromis niloticus	89.93	0.00e+00	1491.00
IUUC-Oan-072700	Ornithorhynchus anatinus	74.70	0.00e+00	1109.00
IUUC-Ocu-074057	Oryctolagus cuniculus	82.67	0.00e+00	1397.00
IUUC-Ola-087492	Oryzias latipes	88.96	0.00e+00	1532.00
IUUC-Oga-088084	Otolemur garnettii	83.03	0.00e+00	1392.00
IUUC-Oar-090354	Ovis aries	81.99	0.00e+00	1369.00
IUUC-Ptr-091456	Pan troglodytes	82.42	0.00e+00	1390.00
IUUC-Pan-092596	Papio anubis	81.60	0.00e+00	1368.00
IUUC-Psi-092942	Pelodiscus sinensis	81.43	0.00e+00	1389.00
IUUC-Pma-094662	Petromyzon marinus	62.30	0.00e+00	767.00
IUUC-Pfo-096838	Poecilia formosa	87.57	0.00e+00	1761.00
IUUC-Pab-097849	Pongo abelii	82.30	0.00e+00	1390.00
IUUC-Pca-100498	Procavia capensis	78.24	0.00e+00	759.00
IUUC-Pva-102599	Pteropus vampyrus	80.22	0.00e+00	1370.00
IUUC-Rno-105776	Rattus norvegicus	82.67	0.00e+00	1391.00
IUUC-Sha-106699	Sarcophilus harrisii	81.31	0.00e+00	1375.00
IUUC-Sar-113621	Sorex araneus	81.72	0.00e+00	1350.00
IUUC-Ssc-115742	Sus scrofa	82.42	0.00e+00	1393.00
IUUC-Tgu-116490	Taeniopygia guttata	81.07	0.00e+00	1384.00
IUUC-Tru-117679	Takifugu rubripes	89.68	0.00e+00	1489.00
IUUC-Tsy-119607	Tarsius syrichta	78.12	0.00e+00	956.00
IUUC-Tni-120376	Tetraodon nigroviridis	84.85	0.00e+00	1385.00
IUUC-Tbe-127348	Tupaia belangeri	57.40	2.00e-153	535.00
IUUC-Ttr-128786	Tursiops truncatus	78.91	0.00e+00	1321.00
IUUC-Vpa-130180	Vicugna pacos	80.21	0.00e+00	1076.00
IUUC-Xtr-132631	Xenopus tropicalis	66.71	0.00e+00	1122.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence