iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062110

UUCD1 version

UUC-MoD-00515

Ensembl Protein ID

ENSMODP00000007685.3

UniProt Accession

F6ZTK0; F6ZTK0_MONDO

Protein Name

Uncharacterized protein

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000006202.3	ENSMODT00000007840.3	ENSMODP00000007685.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.60e-101	338.4	485	822

Active Site

Position(s)	Description	Evidence
790	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l +++l++++++lf ++s+n+++ ++pnp++   ++ +lk++ef+Grl+gk+l+++     
   Q: 485  SDWSKNFEVIFQDEEALDWGGPRREWFELTCRALFDTTNQLFtRFSDNNQALVHPNPNRP--PHLRLKVYEFAGRLVGKCLYESslgga 571
           7999**************************************888999***********8..459******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k++eL+ gG+++pVtn+Nk 
   Q: 572  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSGQLDKVVELMNGGAQVPVTNSNKT 657
           99***********************************99****99...9****9****9999999************************ PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++ike+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v++++++e
   Q: 658  FYLNLLAQYRLASQIKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVSDFKAHAvVVGGSWHFREKVMRWFWTVVSSLTQE 746
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e ++++L++Ai+e+ +gF++
   Q: 747  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEDVHKMLQLAISEGcEGFGM 822
           ************************99555555.**************************************9***97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MFYVIGGITV SVVAFFFTIK FFFELAARVV SFLQNENRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVD IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCAAGAGG CCTTTCATGT CTTCTGAGTC TATAAGTTGT GTGTAGTTAC ATGCAAACCT 60
TTGCATGCTC TGTCCTGTGT GAAGTTTCAT AATCAAAACC AATTTGGAGA ATATTCTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mdo:100018773

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	94.77	0.00e+00	1578.00
IUUC-Apl-004071	Anas platyrhynchos	90.62	0.00e+00	1459.00
IUUC-Aca-005218	Anolis carolinensis	91.50	0.00e+00	1484.00
IUUC-Ame-011871	Astyanax mexicanus	79.47	0.00e+00	1379.00
IUUC-Bta-012978	Bos taurus	93.80	0.00e+00	1566.00
IUUC-Cja-019081	Callithrix jacchus	94.65	0.00e+00	1575.00
IUUC-Cfa-020736	Canis familiaris	92.07	0.00e+00	1479.00
IUUC-Cpo-021581	Cavia porcellus	93.80	0.00e+00	1565.00
IUUC-Csa-024189	Chlorocebus sabaeus	92.90	0.00e+00	866.00
IUUC-Cho-024751	Choloepus hoffmanni	93.44	0.00e+00	1502.00
IUUC-Cin-025773	Ciona intestinalis	42.88	1.00e-148	520.00
IUUC-Csv-026090	Ciona savignyi	39.83	5.00e-170	591.00
IUUC-Dre-027788	Danio rerio	79.71	0.00e+00	1380.00
IUUC-Dno-030022	Dasypus novemcinctus	94.29	0.00e+00	1570.00
IUUC-Dme-031577	Drosophila melanogaster	47.45	0.00e+00	713.00
IUUC-Ete-032402	Echinops telfairi	92.06	0.00e+00	1489.00
IUUC-Eca-033908	Equus caballus	94.90	0.00e+00	1581.00
IUUC-Eeu-034869	Erinaceus europaeus	95.03	0.00e+00	905.00
IUUC-Fca-036023	Felis catus	94.78	0.00e+00	1578.00
IUUC-Fal-037477	Ficedula albicollis	91.62	0.00e+00	1509.00
IUUC-Gmo-039197	Gadus morhua	80.32	0.00e+00	1367.00
IUUC-Gga-040704	Gallus gallus	91.01	0.00e+00	1495.00
IUUC-Gac-041511	Gasterosteus aculeatus	79.10	0.00e+00	1370.00
IUUC-Ggo-044527	Gorilla gorilla	91.50	0.00e+00	1504.00
IUUC-Hsa-046082	Homo sapiens	94.78	0.00e+00	1578.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	94.90	0.00e+00	1580.00
IUUC-Lch-049772	Latimeria chalumnae	77.16	0.00e+00	1237.00
IUUC-Loc-052541	Lepisosteus oculatus	82.18	0.00e+00	1404.00
IUUC-Laf-053852	Loxodonta africana	94.05	0.00e+00	1565.00
IUUC-Mcc-054759	Macaca mulatta	93.30	0.00e+00	783.00
IUUC-Meu-056247	Macropus eugenii	81.38	0.00e+00	874.00
IUUC-Mga-060161	Meleagris gallopavo	90.17	0.00e+00	1478.00
IUUC-Mmr-061447	Microcebus murinus	94.65	0.00e+00	1575.00
IUUC-Mmu-064349	Mus musculus	93.80	0.00e+00	1568.00
IUUC-Mpu-065824	Mustela putorius furo	94.78	0.00e+00	1566.00
IUUC-Mlu-067729	Myotis lucifugus	94.29	0.00e+00	1542.00
IUUC-Nle-069721	Nomascus leucogenys	94.29	0.00e+00	1558.00
IUUC-Opr-070189	Ochotona princeps	93.88	0.00e+00	1553.00
IUUC-Ont-072122	Oreochromis niloticus	80.19	0.00e+00	1362.00
IUUC-Oan-072700	Ornithorhynchus anatinus	84.83	0.00e+00	1235.00
IUUC-Ocu-074057	Oryctolagus cuniculus	94.29	0.00e+00	1571.00
IUUC-Ola-087492	Oryzias latipes	79.13	0.00e+00	1369.00
IUUC-Oga-088084	Otolemur garnettii	94.53	0.00e+00	1567.00
IUUC-Oar-090354	Ovis aries	93.98	0.00e+00	1545.00
IUUC-Ptr-091456	Pan troglodytes	94.65	0.00e+00	1574.00
IUUC-Pan-092596	Papio anubis	93.33	0.00e+00	1546.00
IUUC-Psi-092942	Pelodiscus sinensis	93.07	0.00e+00	1522.00
IUUC-Pma-094662	Petromyzon marinus	61.71	0.00e+00	758.00
IUUC-Pfo-096838	Poecilia formosa	79.83	0.00e+00	1337.00
IUUC-Pab-097849	Pongo abelii	94.29	0.00e+00	1571.00
IUUC-Pca-100498	Procavia capensis	92.59	0.00e+00	887.00
IUUC-Pva-102599	Pteropus vampyrus	94.29	0.00e+00	1549.00
IUUC-Rno-105776	Rattus norvegicus	94.05	0.00e+00	1558.00
IUUC-Sha-106699	Sarcophilus harrisii	97.81	0.00e+00	1594.00
IUUC-Sar-113621	Sorex araneus	92.37	0.00e+00	1511.00
IUUC-Ssc-115742	Sus scrofa	94.17	0.00e+00	1571.00
IUUC-Tgu-116490	Taeniopygia guttata	91.13	0.00e+00	1507.00
IUUC-Tru-117679	Takifugu rubripes	79.47	0.00e+00	1350.00
IUUC-Tsy-119607	Tarsius syrichta	90.26	0.00e+00	1102.00
IUUC-Tni-120376	Tetraodon nigroviridis	75.49	0.00e+00	1268.00
IUUC-Tbe-127348	Tupaia belangeri	64.22	3.00e-177	614.00
IUUC-Ttr-128786	Tursiops truncatus	90.77	0.00e+00	1500.00
IUUC-Vpa-130180	Vicugna pacos	93.23	0.00e+00	1233.00
IUUC-Xtr-132631	Xenopus tropicalis	67.03	0.00e+00	1123.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence