iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120376

UUCD1 version

UUC-TeN-00753

Ensembl Protein ID

ENSTNIP00000020566.1

UniProt Accession

H3DJ71; H3DJ71_TETNG

Protein Name

Uncharacterized protein

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000017425.1	ENSTNIT00000020798.1	ENSTNIP00000020566.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-101	340.9	483	820

Active Site

Position(s)	Description	Evidence
788	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k l++++++lf ++s+n++  ++pn d+  +   +lk++ef+Gr++gk+l+++     
   Q: 483  SDWSKNFEVVFQDEEALDWGGPRREWFELICKTLFDTSNQLFtRFSDNNQGLVHPNADRPAH--LRLKMYEFAGRIVGKCLFESalgga 569
           7999**************************************7789999**********975..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ d+e+yk+ + +i++n   d++e++l ++ ++ +++ +  k++eL++gG++i VtneNk 
   Q: 570  ykQLVRARFTRSFLAQIIGLRMNYKYFETDDQEFYKTkVCFILNN---DVSEMDLVFAEEKYSKSGQLEKVVELISGGAQIAVTNENKM 655
           99***********************************99****99...9**************************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++ +ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v+++f++e
   Q: 656  HYLNLLAQYRLATQVRDEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVQDFKAHAvIVGGSWHFREKVMKWFWAVVSSFTQE 744
           **************************************************************445778999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGf++l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+l+++L +Ai+e+ +gF++
   Q: 745  ELARLLQFTTGSSQLPPGGFNTLCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEELHKMLKLAISEGsEGFGM 820
           ************************99555555.******************************************97 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MFYVIGGITV SIIAFVFTIK FLCELAARVV SFLQNEDPGR RGDRSIYDYV RGNYLDPRSC 60
KVSWDWKEPQ EVGQTMSFRV QLFYKNGQPF PAHRPVGLRV NITHIELALD IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACG TGATTGGTAA GTGAGTTATA AAAGTTGGAA AAGATAAATG TTAAAATTGG 60
ATGTTTTTCT TTTAAGCTGA TTACTGTCTA TTCTTTTCTA GACAGAAAAA CATCTGTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	77.36	0.00e+00	1278.00
IUUC-Apl-004071	Anas platyrhynchos	74.76	0.00e+00	1212.00
IUUC-Aca-005218	Anolis carolinensis	76.42	0.00e+00	1263.00
IUUC-Ame-011871	Astyanax mexicanus	88.82	0.00e+00	1474.00
IUUC-Bta-012978	Bos taurus	77.15	0.00e+00	1274.00
IUUC-Cja-019081	Callithrix jacchus	77.51	0.00e+00	1274.00
IUUC-Cfa-020736	Canis familiaris	75.21	0.00e+00	1202.00
IUUC-Cpo-021581	Cavia porcellus	77.18	0.00e+00	1281.00
IUUC-Csa-024189	Chlorocebus sabaeus	69.04	2.00e-176	612.00
IUUC-Cho-024751	Choloepus hoffmanni	77.03	0.00e+00	1233.00
IUUC-Cin-025773	Ciona intestinalis	44.41	1.00e-147	516.00
IUUC-Csv-026090	Ciona savignyi	40.69	4.00e-170	591.00
IUUC-Dre-027788	Danio rerio	86.63	0.00e+00	1440.00
IUUC-Dno-030022	Dasypus novemcinctus	77.39	0.00e+00	1278.00
IUUC-Dme-031577	Drosophila melanogaster	46.77	0.00e+00	679.00
IUUC-Ete-032402	Echinops telfairi	75.70	0.00e+00	1211.00
IUUC-Eca-033908	Equus caballus	77.75	0.00e+00	1284.00
IUUC-Eeu-034869	Erinaceus europaeus	86.39	0.00e+00	833.00
IUUC-Fca-036023	Felis catus	77.75	0.00e+00	1283.00
IUUC-Fal-037477	Ficedula albicollis	77.18	0.00e+00	1260.00
IUUC-Gmo-039197	Gadus morhua	90.04	0.00e+00	1461.00
IUUC-Gga-040704	Gallus gallus	75.12	0.00e+00	1256.00
IUUC-Gac-041511	Gasterosteus aculeatus	89.67	0.00e+00	1488.00
IUUC-Ggo-044527	Gorilla gorilla	74.40	0.00e+00	1207.00
IUUC-Hsa-046082	Homo sapiens	77.51	0.00e+00	1275.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	77.63	0.00e+00	1281.00
IUUC-Lch-049772	Latimeria chalumnae	70.74	0.00e+00	1097.00
IUUC-Loc-052541	Lepisosteus oculatus	84.85	0.00e+00	1402.00
IUUC-Laf-053852	Loxodonta africana	77.51	0.00e+00	1269.00
IUUC-Mcc-054759	Macaca mulatta	69.11	6.00e-157	546.00
IUUC-Meu-056247	Macropus eugenii	60.80	4.00e-180	624.00
IUUC-Mga-060161	Meleagris gallopavo	74.67	0.00e+00	1239.00
IUUC-Mmr-061447	Microcebus murinus	77.51	0.00e+00	1280.00
IUUC-Mdo-062110	Monodelphis domestica	74.76	0.00e+00	1235.00
IUUC-Mmu-064349	Mus musculus	77.39	0.00e+00	1279.00
IUUC-Mpu-065824	Mustela putorius furo	77.75	0.00e+00	1275.00
IUUC-Mlu-067729	Myotis lucifugus	77.39	0.00e+00	1254.00
IUUC-Nle-069721	Nomascus leucogenys	77.63	0.00e+00	1265.00
IUUC-Opr-070189	Ochotona princeps	77.34	0.00e+00	1267.00
IUUC-Ont-072122	Oreochromis niloticus	91.61	0.00e+00	1481.00
IUUC-Oan-072700	Ornithorhynchus anatinus	67.96	0.00e+00	991.00
IUUC-Ocu-074057	Oryctolagus cuniculus	77.75	0.00e+00	1283.00
IUUC-Ola-087492	Oryzias latipes	89.79	0.00e+00	1477.00
IUUC-Oga-088084	Otolemur garnettii	77.51	0.00e+00	1272.00
IUUC-Oar-090354	Ovis aries	76.89	0.00e+00	1256.00
IUUC-Ptr-091456	Pan troglodytes	77.27	0.00e+00	1269.00
IUUC-Pan-092596	Papio anubis	76.45	0.00e+00	1253.00
IUUC-Psi-092942	Pelodiscus sinensis	77.06	0.00e+00	1257.00
IUUC-Pma-094662	Petromyzon marinus	62.95	0.00e+00	768.00
IUUC-Pfo-096838	Poecilia formosa	91.01	0.00e+00	1440.00
IUUC-Pab-097849	Pongo abelii	77.27	0.00e+00	1272.00
IUUC-Pca-100498	Procavia capensis	70.58	0.00e+00	647.00
IUUC-Pva-102599	Pteropus vampyrus	77.03	0.00e+00	1260.00
IUUC-Rno-105776	Rattus norvegicus	77.51	0.00e+00	1269.00
IUUC-Sha-106699	Sarcophilus harrisii	75.24	0.00e+00	1245.00
IUUC-Sar-113621	Sorex araneus	76.62	0.00e+00	1236.00
IUUC-Ssc-115742	Sus scrofa	77.27	0.00e+00	1277.00
IUUC-Tgu-116490	Taeniopygia guttata	76.58	0.00e+00	1256.00
IUUC-Tru-117679	Takifugu rubripes	92.35	0.00e+00	1493.00
IUUC-Tsy-119607	Tarsius syrichta	76.40	0.00e+00	924.00
IUUC-Tbe-127348	Tupaia belangeri	56.70	2.00e-148	518.00
IUUC-Ttr-128786	Tursiops truncatus	74.12	0.00e+00	1212.00
IUUC-Vpa-130180	Vicugna pacos	74.44	0.00e+00	966.00
IUUC-Xtr-132631	Xenopus tropicalis	64.65	0.00e+00	1056.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence