iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.16	0.00e+00	1183.00	IUUC-Hsa-046146
E3 activity/RING/RING	28.30	6.00e-28	120.00	IUUC-Spo-108339

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MADSAELKQM VMSLRVSELQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS PAVQMKIKEL 60
YRRRFPQKIM TPADLSIPNV HSSPMPATLS PSTIPQLTYD GHPASSPLLP VSLLGPKHEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTGACAGA CGCAAGATGG CGGACAGTGC GGAACTAAAG GTAAAGCGCA GCTCGAATTC 60
ACTTCTAATA TTCGGCCGCG GAGACGGCGC CGCTGGTGCC GGGGGGGATG GGTCGGACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027227--PIAS1
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ

PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING

Pfam

PF14324--PINIT
PF02891--zf-MIZ

SMART

SM00513--SAP

Gene Ontology

GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0008022--F:protein C-terminus binding
GO:0019904--F:protein domain specific binding
GO:0061665--F:SUMO ligase activity
GO:0008270--F:zinc ion binding
GO:0045444--P:fat cell differentiation
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0043066--P:negative regulation of apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033235--P:positive regulation of protein sumoylation
GO:0051152--P:positive regulation of smooth muscle cell differentiation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0065004--P:protein-DNA complex assembly
GO:0042127--P:regulation of cell proliferation
GO:0007283--P:spermatogenesis
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001984	Ailuropoda melanoleuca	98.29	0.00e+00	1174.00
IUUC-Apl-003376	Anas platyrhynchos	94.16	0.00e+00	1180.00
IUUC-Aca-004444	Anolis carolinensis	85.95	0.00e+00	1083.00
IUUC-Aly-006507	Arabidopsis lyrata	35.48	2.00e-14	75.10
IUUC-Ame-011812	Astyanax mexicanus	74.96	0.00e+00	811.00
IUUC-Bgr-012177	Blumeria graminis	26.82	2.00e-22	100.00
IUUC-Bta-012457	Bos taurus	98.31	0.00e+00	1190.00
IUUC-Bci-013700	Botrytis cinerea	29.49	1.00e-29	124.00
IUUC-Bol-015250	Brassica oleracea	27.75	2.00e-17	84.70
IUUC-Cel-018231	Caenorhabditis elegans	37.26	4.00e-50	193.00
IUUC-Cfa-020481	Canis familiaris	98.46	0.00e+00	1179.00
IUUC-Cpo-021940	Cavia porcellus	98.31	0.00e+00	1206.00
IUUC-Csa-023964	Chlorocebus sabaeus	98.16	0.00e+00	1177.00
IUUC-Cho-024812	Choloepus hoffmanni	80.57	0.00e+00	718.00
IUUC-Csv-026329	Ciona savignyi	38.51	9.00e-79	288.00
IUUC-Cne-026824	Cryptococcus neoformans	40.37	1.00e-19	91.70
IUUC-Cme-027209	Cyanidioschyzon merolae	33.33	4.00e-15	76.60
IUUC-Dre-027526	Danio rerio	76.58	0.00e+00	892.00
IUUC-Dno-029550	Dasypus novemcinctus	98.14	0.00e+00	1176.00
IUUC-Dor-030325	Dipodomys ordii	83.20	0.00e+00	715.00
IUUC-Dse-031254	Dothistroma septosporum	27.34	3.00e-26	113.00
IUUC-Dme-032018	Drosophila melanogaster	47.17	4.00e-101	362.00
IUUC-Ete-032366	Echinops telfairi	85.63	0.00e+00	681.00
IUUC-Eca-033639	Equus caballus	98.45	0.00e+00	1165.00
IUUC-Eeu-034994	Erinaceus europaeus	85.64	0.00e+00	667.00
IUUC-Fca-035986	Felis catus	98.29	0.00e+00	1162.00
IUUC-Fal-036926	Ficedula albicollis	94.47	0.00e+00	1120.00
IUUC-Fso-038103	Fusarium solani	33.95	1.00e-26	113.00
IUUC-Gmo-039058	Gadus morhua	73.14	0.00e+00	827.00
IUUC-Ggr-039896	Gaeumannomyces graminis	34.10	1.00e-28	121.00
IUUC-Gga-040755	Gallus gallus	94.03	0.00e+00	1182.00
IUUC-Gac-042204	Gasterosteus aculeatus	72.13	0.00e+00	840.00
IUUC-Ggo-044494	Gorilla gorilla	95.50	0.00e+00	1126.00
IUUC-Hsa-046146	Homo sapiens	98.16	0.00e+00	1177.00
IUUC-Itr-048994	Ictidomys tridecemlineatus	97.98	0.00e+00	1160.00
IUUC-Lch-049611	Latimeria chalumnae	84.41	0.00e+00	1037.00
IUUC-Loc-052851	Lepisosteus oculatus	78.00	0.00e+00	857.00
IUUC-Laf-053486	Loxodonta africana	96.27	0.00e+00	1135.00
IUUC-Mcc-055123	Macaca mulatta	98.16	0.00e+00	1177.00
IUUC-Meu-056556	Macropus eugenii	68.36	0.00e+00	753.00
IUUC-Mor-057185	Magnaporthe oryzae	31.86	2.00e-25	110.00
IUUC-Mga-059790	Meleagris gallopavo	96.03	0.00e+00	1057.00
IUUC-Mmr-060785	Microcebus murinus	97.83	0.00e+00	1161.00
IUUC-Mdo-061916	Monodelphis domestica	96.73	0.00e+00	1173.00
IUUC-Mmu-063170	Mus musculus	99.85	0.00e+00	1174.00
IUUC-Mpu-066609	Mustela putorius furo	98.46	0.00e+00	1179.00
IUUC-Mlu-067164	Myotis lucifugus	96.58	0.00e+00	1142.00
IUUC-Ncr-068929	Neurospora crassa	32.72	2.00e-26	113.00
IUUC-Nle-070004	Nomascus leucogenys	98.16	0.00e+00	1177.00
IUUC-Opr-070738	Ochotona princeps	77.76	0.00e+00	810.00
IUUC-Ont-071607	Oreochromis niloticus	77.01	0.00e+00	847.00
IUUC-Oan-073567	Ornithorhynchus anatinus	89.76	0.00e+00	1135.00
IUUC-Ocu-073833	Oryctolagus cuniculus	98.31	0.00e+00	1152.00
IUUC-Ola-086471	Oryzias latipes	73.03	0.00e+00	880.00
IUUC-Olu-087742	Ostreococcus lucimarinus	30.14	1.00e-10	60.80
IUUC-Oga-088527	Otolemur garnettii	97.08	0.00e+00	1147.00
IUUC-Oar-089470	Ovis aries	97.98	0.00e+00	1172.00
IUUC-Ptr-091086	Pan troglodytes	98.16	0.00e+00	1177.00
IUUC-Pan-092236	Papio anubis	98.16	0.00e+00	1177.00
IUUC-Psi-093900	Pelodiscus sinensis	93.01	0.00e+00	1149.00
IUUC-Pma-094693	Petromyzon marinus	65.38	3.00e-177	614.00
IUUC-Pno-094862	Phaeosphaeria nodorum	34.30	2.00e-28	120.00
IUUC-Pfo-096236	Poecilia formosa	75.98	0.00e+00	868.00
IUUC-Pab-098400	Pongo abelii	98.16	0.00e+00	1176.00
IUUC-Pva-102327	Pteropus vampyrus	89.40	0.00e+00	1040.00
IUUC-Pgr-103580	Puccinia graminis	28.03	5.00e-24	106.00
IUUC-Ptt-103870	Puccinia triticina	28.57	2.00e-23	103.00
IUUC-Spo-108339	Schizosaccharomyces pombe	28.30	3.00e-28	120.00
IUUC-Stu-112120	Solanum tuberosum	36.61	1.00e-17	85.10
IUUC-Sar-113126	Sorex araneus	97.36	0.00e+00	1181.00
IUUC-Sbi-114542	Sorghum bicolor	31.38	6.00e-17	82.80
IUUC-Sre-115069	Sporisorium reilianum	34.21	4.00e-21	97.10
IUUC-Ssc-115394	Sus scrofa	98.73	0.00e+00	1061.00
IUUC-Tgu-117164	Taeniopygia guttata	92.96	0.00e+00	876.00
IUUC-Tru-117960	Takifugu rubripes	76.38	0.00e+00	833.00
IUUC-Tsy-119069	Tarsius syrichta	96.73	0.00e+00	1121.00
IUUC-Tni-120583	Tetraodon nigroviridis	73.79	0.00e+00	825.00
IUUC-Tre-122003	Trichoderma reesei	32.92	5.00e-28	119.00
IUUC-Tme-126880	Tuber melanosporum	32.18	6.00e-24	105.00
IUUC-Tbe-127466	Tupaia belangeri	86.21	3.00e-147	515.00
IUUC-Ttr-128717	Tursiops truncatus	91.55	0.00e+00	1047.00
IUUC-Vpa-130624	Vicugna pacos	94.75	0.00e+00	1068.00
IUUC-Vvi-131637	Vitis vinifera	29.32	5.00e-17	83.60
IUUC-Xtr-132733	Xenopus tropicalis	55.67	5.00e-167	580.00
IUUC-Xma-134201	Xiphophorus maculatus	73.38	0.00e+00	832.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence