iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090805

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

OTU domain, ubiquitin aldehyde binding 2

Genbank Nucleotide ID

AACZ03097719

Gene Name

OTUB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000006671.4	ENSPTRT00000012284.4	ENSPTRP00000011373.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.40e-49	168.0	41	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
51	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
224		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+ktkgDGnC++rA+++s                                                          ll+vf+d+s+sd
   Q: 41   AIRKTKGDGNCFYRALGYSylesllgksreifkfkervlqspndllaagfeehkfrnffnafysvvelvekdgsvssLLKVFNDQSASD 129
           79*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts+++++++dff++fi+e++d+k+fc+++vep+a+ +++i+i+aL+q+Ls++++v++vd++++    +l++++fpe++ +
   Q: 130  HIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATeCDHIQITALSQALSIALQVEYVDEMDT----ALNHHVFPEAA-T 213
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 214  PSVYLLYKTSHYNILYA 230
           ***************97 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSETSFNLIS EKCDILSILR DHPENRIYRR KIEELSKRFT AIRKTKGDGN CFYRALGYSY 60
LESLLGKSRE IFKFKERVLQ SPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDGSVSSLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGGTTTG CGGAGCGGTC GGGTGTATTC GCCGCCGCCC CCACGCCCTC GAGGTCCCCG 60
CCACCGAACC AGCGGCGGAG CCCGCCCGCG CCTCCCGCGG CATTCCCGCA CCGGATCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	94.83	4.00e-131	459.00
IUUC-Bta-012766	Bos taurus	95.30	9.00e-132	462.00
IUUC-Cja-019480	Callithrix jacchus	96.15	1.00e-133	468.00
IUUC-Cfa-021106	Canis familiaris	95.26	7.00e-132	462.00
IUUC-Cpo-022187	Cavia porcellus	93.99	5.00e-130	456.00
IUUC-Csa-023493	Chlorocebus sabaeus	99.57	6.00e-137	479.00
IUUC-Cho-024411	Choloepus hoffmanni	74.63	3.00e-83	300.00
IUUC-Dno-029346	Dasypus novemcinctus	94.85	2.00e-131	460.00
IUUC-Dor-031012	Dipodomys ordii	94.85	7.00e-132	462.00
IUUC-Ete-032266	Echinops telfairi	85.34	3.00e-117	413.00
IUUC-Eca-033356	Equus caballus	96.12	3.00e-131	460.00
IUUC-Eeu-034775	Erinaceus europaeus	95.26	4.00e-131	459.00
IUUC-Fca-035363	Felis catus	93.53	6.00e-129	452.00
IUUC-Ggo-045023	Gorilla gorilla	99.15	3.00e-137	479.00
IUUC-Hsa-046984	Homo sapiens	99.57	8.00e-138	482.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	94.87	1.00e-132	465.00
IUUC-Lch-050514	Latimeria chalumnae	61.33	2.00e-83	301.00
IUUC-Loc-052003	Lepisosteus oculatus	50.22	5.00e-64	237.00
IUUC-Laf-054382	Loxodonta africana	94.40	7.00e-131	459.00
IUUC-Mcc-055516	Macaca mulatta	99.57	5.00e-137	479.00
IUUC-Meu-056038	Macropus eugenii	87.30	2.00e-98	351.00
IUUC-Mmr-060918	Microcebus murinus	95.73	6.00e-133	466.00
IUUC-Mdo-062638	Monodelphis domestica	88.84	6.00e-124	436.00
IUUC-Mmu-063973	Mus musculus	94.42	9.00e-131	459.00
IUUC-Mpu-066013	Mustela putorius furo	95.69	4.00e-132	463.00
IUUC-Mlu-067509	Myotis lucifugus	93.53	1.00e-127	448.00
IUUC-Nle-069673	Nomascus leucogenys	99.57	8.00e-138	482.00
IUUC-Opr-070761	Ochotona princeps	86.75	1.00e-80	291.00
IUUC-Oan-072922	Ornithorhynchus anatinus	80.79	4.00e-111	393.00
IUUC-Ocu-074643	Oryctolagus cuniculus	94.02	6.00e-131	459.00
IUUC-Oni-082026	Oryza nivara	28.32	2.00e-16	80.10
IUUC-Oru-084761	Oryza rufipogon	28.32	2.00e-16	80.10
IUUC-Ola-086603	Oryzias latipes	45.37	1.00e-51	196.00
IUUC-Oga-088936	Otolemur garnettii	95.28	9.00e-132	462.00
IUUC-Oar-089460	Ovis aries	95.71	3.00e-131	460.00
IUUC-Pan-091969	Papio anubis	99.57	8.00e-138	482.00
IUUC-Pab-098476	Pongo abelii	99.14	3.00e-136	476.00
IUUC-Pca-100252	Procavia capensis	88.12	4.00e-52	197.00
IUUC-Pva-102204	Pteropus vampyrus	94.02	9.00e-132	462.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.40e-02	31.60
IUUC-Rno-105062	Rattus norvegicus	94.44	7.00e-132	462.00
IUUC-Sha-106968	Sarcophilus harrisii	88.65	2.00e-121	428.00
IUUC-Sar-113295	Sorex araneus	94.83	6.00e-129	452.00
IUUC-Ssc-115288	Sus scrofa	94.85	4.00e-131	459.00
IUUC-Tni-120440	Tetraodon nigroviridis	38.96	3.00e-42	164.00
IUUC-Tbe-127717	Tupaia belangeri	93.92	1.00e-77	281.00
IUUC-Ttr-128221	Tursiops truncatus	76.39	4.00e-100	357.00
IUUC-Uma-129443	Ustilago maydis	32.17	9.00e-25	107.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence