iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108158

UUCD1 version

UUC-ScP-00289

Ensembl Protein ID

SPBC32H8.02c.1:pep

UniProt Accession

O13612; Q9UTT9; NEP2_SCHPO

Genbank Protein ID

BAA21400.1; CAC37492.1; BAA87311.1

Protein Name

NEDD8-specific protease 2; Meiotically up-regulated gene 120 protein

Genbank Nucleotide ID

AB004535; CU329671; AB028007

Gene Name

nep2; mug120; pi021; SPBC32H8.02c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC32H8.02c	SPBC32H8.02c.1	SPBC32H8.02c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/ULP	29.28	8.00e-12	69.30	IUUC-Hsa-046446

Active Site

Position(s)	Description	Evidence
171	N/A	{ECO:0000250}
188		{ECO:0000250}
229		{ECO:0000250}

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins (By similarity). Has a role in meiosis.

Protein Sequence
(Fasta)

MRSNSIFTKE IDSEAVKKSS NLRPPSTGSS NSNGSDTASP KKKKKGFFRS LFGSSSSGSK 60
SCGSPFTRIW LEYFEVSLRK NDVDHFRPGY WILDTNIDFF YEIMLRQVLL KRPKEESQQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCACCCATC TCCATCTTCA CCTCCACATT CTGGGTCTGT CTTTTTGCCC TTTACCCCAA 60
CTTTTTGCCA ACCACAAAAG TACGTGTTGG ACGGTCATTG CCGGCTCCTT TTCTGAACAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0469--Meiosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0019784--F:NEDD8-specific protease activity
GO:0016929--F:SUMO-specific protease activity
GO:0051321--P:meiotic cell cycle
GO:0000338--P:protein deneddylation

KEGG

spo:SPBC32H8.02c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003013	Amborella trichopoda	28.74	1.00e-12	64.30
IUUC-Acl-008184	Aspergillus clavatus	34.95	6.00e-26	108.00
IUUC-Afl-008691	Aspergillus flavus	33.96	2.00e-27	113.00
IUUC-Afu-008846	Aspergillus fumigatus	36.65	7.00e-26	108.00
IUUC-Ani-009338	Aspergillus nidulans	33.02	5.00e-22	95.90
IUUC-Ang-009621	Aspergillus niger	33.49	6.00e-24	102.00
IUUC-Aor-010058	Aspergillus oryzae	35.60	1.00e-25	107.00
IUUC-Ate-010257	Aspergillus terreus	33.98	1.00e-23	101.00
IUUC-Bgr-012027	Blumeria graminis	40.89	1.00e-34	137.00
IUUC-Bta-013318	Bos taurus	30.46	1.00e-13	67.80
IUUC-Bci-013780	Botrytis cinerea	37.32	8.00e-30	121.00
IUUC-Cja-019384	Callithrix jacchus	29.83	7.00e-14	68.20
IUUC-Cfa-021012	Canis familiaris	29.12	3.00e-13	66.20
IUUC-Csa-023063	Chlorocebus sabaeus	29.83	3.00e-14	69.30
IUUC-Cin-025409	Ciona intestinalis	33.55	2.00e-14	70.10
IUUC-Csv-025804	Ciona savignyi	28.50	7.00e-12	61.60
IUUC-Cgl-026720	Colletotrichum gloeosporioides	37.26	2.00e-32	130.00
IUUC-Dno-028918	Dasypus novemcinctus	29.83	4.00e-14	68.90
IUUC-Dor-030731	Dipodomys ordii	29.03	2.00e-12	63.50
IUUC-Dse-031309	Dothistroma septosporum	36.49	3.00e-32	129.00
IUUC-Eca-034335	Equus caballus	29.83	2.00e-14	70.10
IUUC-Fca-036443	Felis catus	28.57	1.00e-12	64.70
IUUC-Fox-037732	Fusarium oxysporum	36.79	5.00e-32	129.00
IUUC-Fso-038212	Fusarium solani	36.32	1.00e-31	128.00
IUUC-Ggr-039866	Gaeumannomyces graminis	35.93	4.00e-23	99.40
IUUC-Gac-041495	Gasterosteus aculeatus	27.50	4.00e-09	52.40
IUUC-Gma-043532	Glycine max	24.72	1.00e-10	57.80
IUUC-Ggo-045516	Gorilla gorilla	29.28	7.00e-14	68.60
IUUC-Hsa-046446	Homo sapiens	29.28	4.00e-14	69.30
IUUC-Itr-048831	Ictidomys tridecemlineatus	29.67	2.00e-13	67.00
IUUC-Kpa-049383	Komagataella pastoris	31.65	4.00e-27	113.00
IUUC-Lch-049930	Latimeria chalumnae	28.50	3.00e-13	66.20
IUUC-Lma-053175	Leptosphaeria maculans	35.14	1.00e-21	95.50
IUUC-Laf-053748	Loxodonta africana	30.39	8.00e-15	71.60
IUUC-Mcc-055121	Macaca mulatta	29.28	1.00e-13	67.80
IUUC-Mor-057015	Magnaporthe oryzae	36.31	1.00e-23	101.00
IUUC-Mpo-057551	Magnaporthe poae	35.21	2.00e-28	117.00
IUUC-Mmr-061606	Microcebus murinus	29.95	6.00e-15	72.00
IUUC-Mmu-063494	Mus musculus	29.28	2.00e-13	67.00
IUUC-Mac-064771	Musa acuminata	25.23	3.00e-10	56.60
IUUC-Mlu-068110	Myotis lucifugus	29.83	2.00e-14	70.10
IUUC-Nfi-068584	Neosartorya fischeri	36.65	4.00e-26	109.00
IUUC-Ncr-068707	Neurospora crassa	38.21	2.00e-31	127.00
IUUC-Nle-069021	Nomascus leucogenys	28.73	3.00e-13	66.20
IUUC-Opr-070594	Ochotona princeps	29.79	3.00e-13	66.20
IUUC-Oan-073506	Ornithorhynchus anatinus	31.25	5.00e-13	65.50
IUUC-Ocu-074685	Oryctolagus cuniculus	27.93	3.00e-12	62.80
IUUC-Oar-090151	Ovis aries	29.28	2.00e-14	70.50
IUUC-Ptr-091183	Pan troglodytes	29.28	6.00e-14	68.60
IUUC-Pan-092515	Papio anubis	29.28	9.00e-14	68.20
IUUC-Pma-094504	Petromyzon marinus	30.34	2.00e-13	67.00
IUUC-Pno-094778	Phaeosphaeria nodorum	42.75	5.00e-22	95.90
IUUC-Ppa-095729	Physcomitrella patens	23.56	1.00e-13	67.80
IUUC-Pab-098456	Pongo abelii	28.73	2.00e-13	67.00
IUUC-Pva-103087	Pteropus vampyrus	29.28	2.00e-13	67.00
IUUC-Pte-104338	Pyrenophora teres	36.36	4.00e-29	119.00
IUUC-Pyt-104743	Pyrenophora triticirepentis	37.13	4.00e-29	119.00
IUUC-Sha-107481	Sarcophilus harrisii	33.33	7.00e-14	68.60
IUUC-Sja-107774	Schizosaccharomyces japonicus	56.81	1.00e-102	363.00
IUUC-Sly-110870	Solanum lycopersicum	32.61	1.00e-06	43.90
IUUC-Sar-113306	Sorex araneus	31.61	2.00e-14	70.10
IUUC-Ssc-116172	Sus scrofa	30.39	4.00e-14	69.30
IUUC-Tsy-119532	Tarsius syrichta	29.83	4.00e-14	68.90
IUUC-Tni-119854	Tetraodon nigroviridis	31.54	1.00e-08	50.80
IUUC-Tca-121178	Theobroma cacao	26.97	1.00e-14	71.20
IUUC-Tre-121875	Trichoderma reesei	35.98	2.00e-30	123.00
IUUC-Tvi-122665	Trichoderma virens	34.58	8.00e-30	121.00
IUUC-Tme-126891	Tuber melanosporum	39.15	3.00e-34	136.00
IUUC-Tbe-127748	Tupaia belangeri	28.73	5.00e-13	65.90
IUUC-Vda-129820	Verticillium dahliae	38.74	4.00e-31	125.00
IUUC-Vpa-130744	Vicugna pacos	29.28	5.00e-14	68.90
IUUC-Xtr-132666	Xenopus tropicalis	28.99	4.00e-13	66.20
IUUC-Yli-134333	Yarrowia lipolytica	38.99	1.00e-41	162.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence