iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054576

UUCD1 version

UUC-LoA-00583

Ensembl Protein ID

ENSLAFP00000014214.3

UniProt Accession

G3THX9; G3THX9_LOXAF

Protein Name

Uncharacterized protein

Gene Name

WSB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000016956.3	ENSLAFT00000016956.3	ENSLAFP00000014214.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.00e-14	54.5	375	420
E3 adaptor/Cullin RING/DCX/DWD	1.90e-32	110.2	169	203
UBD/Beta-Prp	1.20e-49	169.5	134	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++++ +SLqhLCR++Irr + +q++   +kLP P++  ++L+y+
   Q: 375  VYFWATPRQIPSLQHLCRMSIRRVMATQEV---QKLPVPSKVLEFLSYR 420
           689************************999...**************97 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 169  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 203
           9**********8865668*************9987 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsf 102
            kf +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l+gh++ v+s++f
   Q: 134  FKFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRGHQNWVYSCAF 222
           68899999***********************************************************9799****************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tggh 179
           sp++++l s ++ + + +w++++++ ++  l+gh++ v    ++pdg ll+++s+D+ v +Wd  tg++l ++             g++
   Q: 223  SPDSSVLCSVGASKAVFLWNMDKYTMIR-KLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHTGDILMEFghlfppptpifaGGAN 310
           ****************************.9******************************************************9888* PP
   S: 180  tdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           ++ v+s+sf+++g +++s ++d+ v++w + +      +++  +n ++ +fs ++  l+ g++Dgs+++W
   Q: 311  DRWVRSVSFSHDGLHIASLADDKMVRFWRIDED--YPVQIASLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           ******************************888..6889999**************************** PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MASFPPRVNE KEIVRSRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA WSQGHRTVKL 60
VPWAQCLKNF LLHGTKNVTN SSSLRLSRQN SDGGQKNKPR EHIIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAGCT TTCCCCCGAG GGTCAACGAG AAAGAGATCG GTGAGAAATG GGGCGGGCTT 60
CCCGGAGGCT TGCTGGGTGA AGGGTGGGCG CGCGGGGCCT TAGGAATGGA AGGGACCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

lav:100663815

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	96.67	0.00e+00	832.00
IUUC-Apl-003903	Anas platyrhynchos	89.93	0.00e+00	776.00
IUUC-Aca-005214	Anolis carolinensis	77.00	0.00e+00	695.00
IUUC-Ame-011740	Astyanax mexicanus	76.25	0.00e+00	688.00
IUUC-Bta-013475	Bos taurus	96.91	0.00e+00	833.00
IUUC-Cja-019053	Callithrix jacchus	96.42	0.00e+00	851.00
IUUC-Cfa-020103	Canis familiaris	96.91	0.00e+00	834.00
IUUC-Cpo-022438	Cavia porcellus	94.77	0.00e+00	841.00
IUUC-Csa-024062	Chlorocebus sabaeus	96.91	0.00e+00	858.00
IUUC-Cho-024334	Choloepus hoffmanni	86.22	0.00e+00	714.00
IUUC-Cin-025590	Ciona intestinalis	39.90	3.00e-79	288.00
IUUC-Csv-026023	Ciona savignyi	39.71	9.00e-79	286.00
IUUC-Dre-028089	Danio rerio	76.25	0.00e+00	684.00
IUUC-Dno-029436	Dasypus novemcinctus	92.01	0.00e+00	675.00
IUUC-Dor-031107	Dipodomys ordii	89.31	0.00e+00	751.00
IUUC-Ete-032326	Echinops telfairi	95.58	0.00e+00	794.00
IUUC-Eca-033401	Equus caballus	95.96	0.00e+00	826.00
IUUC-Eeu-034520	Erinaceus europaeus	93.35	0.00e+00	834.00
IUUC-Fca-036386	Felis catus	96.91	0.00e+00	834.00
IUUC-Fal-036616	Ficedula albicollis	86.24	0.00e+00	748.00
IUUC-Gmo-039335	Gadus morhua	71.43	6.00e-180	623.00
IUUC-Gga-040856	Gallus gallus	88.60	0.00e+00	789.00
IUUC-Gac-042140	Gasterosteus aculeatus	74.88	0.00e+00	676.00
IUUC-Ggo-044619	Gorilla gorilla	96.20	0.00e+00	855.00
IUUC-Hsa-046300	Homo sapiens	96.20	0.00e+00	854.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	96.44	0.00e+00	853.00
IUUC-Lch-049550	Latimeria chalumnae	80.92	8.00e-173	599.00
IUUC-Loc-051769	Lepisosteus oculatus	78.38	0.00e+00	689.00
IUUC-Mcc-054666	Macaca mulatta	96.56	1.00e-152	531.00
IUUC-Meu-055989	Macropus eugenii	88.86	0.00e+00	648.00
IUUC-Mga-059722	Meleagris gallopavo	87.95	0.00e+00	782.00
IUUC-Mmr-060970	Microcebus murinus	95.96	0.00e+00	825.00
IUUC-Mdo-062249	Monodelphis domestica	79.81	0.00e+00	657.00
IUUC-Mmu-063742	Mus musculus	92.14	0.00e+00	820.00
IUUC-Mpu-066518	Mustela putorius furo	96.20	0.00e+00	857.00
IUUC-Mlu-068063	Myotis lucifugus	96.20	0.00e+00	822.00
IUUC-Nle-069561	Nomascus leucogenys	95.96	0.00e+00	854.00
IUUC-Opr-071158	Ochotona princeps	90.95	0.00e+00	807.00
IUUC-Ont-072542	Oreochromis niloticus	74.41	0.00e+00	668.00
IUUC-Oan-073217	Ornithorhynchus anatinus	92.87	0.00e+00	815.00
IUUC-Ocu-074251	Oryctolagus cuniculus	94.87	0.00e+00	801.00
IUUC-Ola-086549	Oryzias latipes	73.24	0.00e+00	667.00
IUUC-Oga-088382	Otolemur garnettii	96.44	0.00e+00	831.00
IUUC-Oar-090263	Ovis aries	95.01	0.00e+00	835.00
IUUC-Ptr-090922	Pan troglodytes	96.20	0.00e+00	857.00
IUUC-Pan-092518	Papio anubis	96.91	0.00e+00	858.00
IUUC-Psi-093512	Pelodiscus sinensis	90.02	0.00e+00	797.00
IUUC-Pma-094324	Petromyzon marinus	57.41	2.00e-136	478.00
IUUC-Pfo-096264	Poecilia formosa	74.41	0.00e+00	673.00
IUUC-Pab-098018	Pongo abelii	94.54	0.00e+00	837.00
IUUC-Pca-101034	Procavia capensis	96.31	0.00e+00	778.00
IUUC-Pva-102862	Pteropus vampyrus	92.64	0.00e+00	766.00
IUUC-Rno-106116	Rattus norvegicus	92.64	0.00e+00	822.00
IUUC-Sha-106952	Sarcophilus harrisii	91.20	0.00e+00	764.00
IUUC-Sar-113211	Sorex araneus	84.59	1.00e-150	525.00
IUUC-Ssc-116440	Sus scrofa	96.91	0.00e+00	834.00
IUUC-Tgu-116675	Taeniopygia guttata	86.73	0.00e+00	750.00
IUUC-Tru-118295	Takifugu rubripes	73.94	0.00e+00	652.00
IUUC-Tsy-118916	Tarsius syrichta	84.56	0.00e+00	707.00
IUUC-Tni-120302	Tetraodon nigroviridis	72.07	0.00e+00	641.00
IUUC-Tbe-127416	Tupaia belangeri	83.05	0.00e+00	672.00
IUUC-Ttr-128185	Tursiops truncatus	96.67	0.00e+00	834.00
IUUC-Xtr-132465	Xenopus tropicalis	83.10	0.00e+00	744.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence