iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.00e-13	49.9	362	406
E3 adaptor/Cullin RING/DCX/DWD	3.90e-29	99.3	156	190
UBD/Beta-Prp	1.10e-43	149.4	121	365

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           ++w ++s++ SLqhLCR+aIrr +++ ++   + LP+P +  ++L y+
   Q: 362  YFWATPSQVSSLQHLCRMAIRRVMPTSQV---KNLPIPGKVVEFLCYQ 406
           79************************777...************9887 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 156  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 190
           9**********8865668*************9987 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsf 102
            kf +d+ llatg  +g+ik+wd+ tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l+gh + v+ ++f
   Q: 121  FKFGQDQLLLATGLNNGRIKIWDAYTGKLLLNLMDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRGHPNWVYGCAF 209
           68899999***********************************************************9799****************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tggh 179
           sp+++ l s ++ + + +wd+++++ l+  l+gh+  v   +++pdg ll+++s+D+ v +Wd   g +lr++             g++
   Q: 210  SPDSSILCSVGASKAVFLWDMDKYSMLR-KLEGHHNDVVACEFSPDGALLATASYDTRVYVWDPHIGVILREFghlfppptpifaGGAN 297
           ****************************.999999999999*******************************************98889 PP
   S: 180  tdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           ++ v+s+ f+++g +++s ++d+ v++w + ++     + +  +n ++  fs ++  l+ g +Dgs+++W 
   Q: 298  DRWVRSVCFSHDGLHVASLADDKMVRFWRIDEE--YPVQVAPLNNGLCCTFSTDGGVLAAG-QDGSLYFWA 365
           ******************************998..688999***********777777766.7*******3 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

ARSRTVGELL APTSPFDKKC GRENWTVAFA PDGSYLAWSQ GHRIVKLVPW AQCLNNFLLH 60
GTKNGANAAS TRLPRQSSEG GQKNKPCEHV IDCGDIVWSL AFGSSVPEKQ SRCVNIEWHR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCGGTCGC GCACGGTAGG AGAGCTCCTG GCCCCCACGT CTCCCTTCGA CAAGAAGTGC 60
GGCCGGGAGA ACTGGACGGT CGCGTTCGCT CCCGATGGCT CGTACCTGGC GTGGTCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR023294--Tachylectin2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	87.71	0.00e+00	736.00
IUUC-Apl-003903	Anas platyrhynchos	94.61	0.00e+00	806.00
IUUC-Aca-005214	Anolis carolinensis	76.76	0.00e+00	671.00
IUUC-Ame-011740	Astyanax mexicanus	74.26	0.00e+00	642.00
IUUC-Bta-013475	Bos taurus	86.98	0.00e+00	736.00
IUUC-Cja-019053	Callithrix jacchus	86.95	0.00e+00	749.00
IUUC-Cfa-020103	Canis familiaris	87.25	0.00e+00	734.00
IUUC-Cpo-022438	Cavia porcellus	86.98	0.00e+00	753.00
IUUC-Csa-024062	Chlorocebus sabaeus	86.98	0.00e+00	753.00
IUUC-Cho-024334	Choloepus hoffmanni	76.17	0.00e+00	625.00
IUUC-Cin-025590	Ciona intestinalis	40.70	6.00e-77	280.00
IUUC-Csv-026023	Ciona savignyi	39.14	3.00e-75	275.00
IUUC-Dre-028089	Danio rerio	74.02	0.00e+00	646.00
IUUC-Dno-029436	Dasypus novemcinctus	82.37	2.00e-177	614.00
IUUC-Dor-031107	Dipodomys ordii	80.10	0.00e+00	657.00
IUUC-Ete-032326	Echinops telfairi	85.01	0.00e+00	721.00
IUUC-Eca-033401	Equus caballus	87.25	0.00e+00	736.00
IUUC-Eeu-034520	Erinaceus europaeus	84.52	0.00e+00	734.00
IUUC-Fca-036386	Felis catus	86.73	0.00e+00	732.00
IUUC-Fal-036616	Ficedula albicollis	94.12	0.00e+00	799.00
IUUC-Gmo-039335	Gadus morhua	71.01	3.00e-173	600.00
IUUC-Gga-040856	Gallus gallus	93.38	0.00e+00	799.00
IUUC-Gac-042140	Gasterosteus aculeatus	72.15	3.00e-180	624.00
IUUC-Ggo-044619	Gorilla gorilla	86.98	0.00e+00	751.00
IUUC-Hsa-046300	Homo sapiens	87.01	0.00e+00	751.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	86.73	0.00e+00	750.00
IUUC-Lch-049550	Latimeria chalumnae	80.64	3.00e-168	583.00
IUUC-Loc-051769	Lepisosteus oculatus	75.74	0.00e+00	651.00
IUUC-Laf-054576	Loxodonta africana	86.73	0.00e+00	732.00
IUUC-Mcc-054666	Macaca mulatta	84.39	3.00e-137	480.00
IUUC-Meu-055989	Macropus eugenii	84.29	5.00e-178	616.00
IUUC-Mga-059722	Meleagris gallopavo	93.38	0.00e+00	802.00
IUUC-Mmr-060970	Microcebus murinus	86.52	0.00e+00	729.00
IUUC-Mdo-062249	Monodelphis domestica	73.77	2.00e-170	591.00
IUUC-Mmu-063742	Mus musculus	83.00	0.00e+00	714.00
IUUC-Mpu-066518	Mustela putorius furo	86.73	0.00e+00	750.00
IUUC-Mlu-068063	Myotis lucifugus	86.24	0.00e+00	723.00
IUUC-Nle-069561	Nomascus leucogenys	87.22	0.00e+00	753.00
IUUC-Opr-071158	Ochotona princeps	84.48	0.00e+00	724.00
IUUC-Ont-072542	Oreochromis niloticus	71.43	7.00e-179	619.00
IUUC-Oan-073217	Ornithorhynchus anatinus	87.68	0.00e+00	748.00
IUUC-Ocu-074251	Oryctolagus cuniculus	85.78	0.00e+00	730.00
IUUC-Ola-086549	Oryzias latipes	69.73	6.00e-177	613.00
IUUC-Oga-088382	Otolemur garnettii	87.71	0.00e+00	742.00
IUUC-Oar-090263	Ovis aries	85.01	0.00e+00	729.00
IUUC-Ptr-090922	Pan troglodytes	87.47	0.00e+00	755.00
IUUC-Pan-092518	Papio anubis	86.98	0.00e+00	753.00
IUUC-Psi-093512	Pelodiscus sinensis	90.69	0.00e+00	779.00
IUUC-Pma-094324	Petromyzon marinus	58.23	1.00e-129	456.00
IUUC-Pfo-096264	Poecilia formosa	71.36	1.00e-179	621.00
IUUC-Pab-098018	Pongo abelii	85.50	0.00e+00	736.00
IUUC-Pca-101034	Procavia capensis	85.01	0.00e+00	700.00
IUUC-Pva-102862	Pteropus vampyrus	83.13	0.00e+00	674.00
IUUC-Rno-106116	Rattus norvegicus	83.78	0.00e+00	724.00
IUUC-Sha-106952	Sarcophilus harrisii	85.50	0.00e+00	722.00
IUUC-Sar-113211	Sorex araneus	78.30	6.00e-142	496.00
IUUC-Ssc-116440	Sus scrofa	87.50	0.00e+00	738.00
IUUC-Tru-118295	Takifugu rubripes	70.63	2.00e-174	604.00
IUUC-Tsy-118916	Tarsius syrichta	75.92	1.00e-177	615.00
IUUC-Tni-120302	Tetraodon nigroviridis	69.17	1.00e-170	592.00
IUUC-Tbe-127416	Tupaia belangeri	74.94	2.00e-176	611.00
IUUC-Ttr-128185	Tursiops truncatus	87.22	0.00e+00	734.00
IUUC-Xtr-132465	Xenopus tropicalis	83.54	0.00e+00	718.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence