iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132465

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

WD repeat and SOCS box-containing protein 1

Genbank Nucleotide ID

BC064858

Gene Name

wsb1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000021353.3	ENSXETT00000046179.3	ENSXETP00000046179.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.10e-15	55.6	376	421
E3 adaptor/Cullin RING/DCX/DWD	3.80e-30	102.8	169	203
UBD/Beta-Prp	5.80e-45	153.9	134	388

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++w+++  + SLqhLCR+aIrr + + ++   +kLP+P+++ ++L y++
   Q: 376  YFWSTPKYVSSLQHLCRMAIRRVMNTNEV---KKLPIPQKIMEFLTYQT 421
           79************************888...***************96 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 169  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 203
           9**********8865668*************9987 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsf 102
            kf +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l+gh++ v++++f
   Q: 134  FKFGQDQLLLATGLSNGRIKIWDVYTGKLLLNLMDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRGHQNWVYCCAF 222
           68899999***********************************************************9799****************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tggh 179
           sp+++ l s ++ + + +wd+++++ ++  l+gh   v   +++pdg ll+++s+D+ v +Wd   g++l ++             g++
   Q: 223  SPDSSMLCSVGAGKAVFLWDMDKYTMIR-KLDGHYNDVVACEFSPDGALLATASYDTRVYVWDPHIGSILFEFghlfppptpifaGGDN 310
           ****************************.9******************************************************97778 PP
   S: 180  tdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlq 261
            + v+s+sf+++g +++s ++d+ v++w + ++  v+   +  +  ++ +fs ++  l+ g++Dg  ++W   + +++++lq
   Q: 311  GRWVKSVSFSHDGVHIASLADDNLVRFWRIDKSYPVE--VAPLSKGLCCAFSTDGSVLAAGTQDGNAYFWS--TPKYVSSLQ 388
           899***************************9996666..567777888899999****************5..666666655 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MASFPDFVNE NEIARSRTIG ELITPTSPFE QKYGRENWTV AFAPDGSYFA WSQGHRIVKL 60
VPWSRCLKNF TACSTKNGVN LTNGRLSRQN SDLGQRNKPI EHTIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGTAAGCT CTGCTACCGT ACAGCGTTCT TCTTTGTAAT TGGAATTTAG CGCATATTTT 60
GAAATCTCCC ATTAGCCTTA ATTCACGTGA GACCTTCTAC CTTTGACGTC TGGTTTCTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

xtr:395021

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	83.57	0.00e+00	728.00
IUUC-Apl-003903	Anas platyrhynchos	83.53	0.00e+00	736.00
IUUC-Aca-005214	Anolis carolinensis	73.18	0.00e+00	656.00
IUUC-Ame-011740	Astyanax mexicanus	75.18	0.00e+00	681.00
IUUC-Bta-013475	Bos taurus	83.14	0.00e+00	729.00
IUUC-Cja-019053	Callithrix jacchus	82.90	0.00e+00	741.00
IUUC-Cfa-020103	Canis familiaris	83.57	0.00e+00	727.00
IUUC-Cpo-022438	Cavia porcellus	83.81	0.00e+00	743.00
IUUC-Csa-024062	Chlorocebus sabaeus	83.10	0.00e+00	743.00
IUUC-Cho-024334	Choloepus hoffmanni	74.11	9.00e-180	622.00
IUUC-Cin-025590	Ciona intestinalis	41.92	4.00e-80	291.00
IUUC-Csv-026023	Ciona savignyi	40.00	3.00e-80	291.00
IUUC-Dre-028089	Danio rerio	74.70	0.00e+00	678.00
IUUC-Dno-029436	Dasypus novemcinctus	79.83	5.00e-173	600.00
IUUC-Dor-031107	Dipodomys ordii	77.62	0.00e+00	655.00
IUUC-Ete-032326	Echinops telfairi	82.22	0.00e+00	697.00
IUUC-Eca-033401	Equus caballus	83.33	0.00e+00	726.00
IUUC-Eeu-034520	Erinaceus europaeus	81.43	0.00e+00	730.00
IUUC-Fca-036386	Felis catus	82.86	0.00e+00	725.00
IUUC-Fal-036616	Ficedula albicollis	81.82	0.00e+00	714.00
IUUC-Gmo-039335	Gadus morhua	71.32	2.00e-176	610.00
IUUC-Gga-040856	Gallus gallus	85.00	0.00e+00	751.00
IUUC-Gac-042140	Gasterosteus aculeatus	73.54	0.00e+00	669.00
IUUC-Ggo-044619	Gorilla gorilla	82.90	0.00e+00	743.00
IUUC-Hsa-046300	Homo sapiens	82.86	0.00e+00	741.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	83.33	0.00e+00	746.00
IUUC-Lch-049550	Latimeria chalumnae	79.83	2.00e-168	584.00
IUUC-Loc-051769	Lepisosteus oculatus	76.07	0.00e+00	686.00
IUUC-Laf-054576	Loxodonta africana	83.10	0.00e+00	725.00
IUUC-Mcc-054666	Macaca mulatta	84.67	5.00e-136	476.00
IUUC-Meu-055989	Macropus eugenii	84.68	7.00e-176	609.00
IUUC-Mga-059722	Meleagris gallopavo	84.02	0.00e+00	738.00
IUUC-Mmr-060970	Microcebus murinus	82.86	0.00e+00	720.00
IUUC-Mdo-062249	Monodelphis domestica	72.88	5.00e-172	596.00
IUUC-Mmu-063742	Mus musculus	79.76	0.00e+00	716.00
IUUC-Mpu-066518	Mustela putorius furo	83.57	0.00e+00	746.00
IUUC-Mlu-068063	Myotis lucifugus	83.33	0.00e+00	719.00
IUUC-Nle-069561	Nomascus leucogenys	82.86	0.00e+00	741.00
IUUC-Opr-071158	Ochotona princeps	81.00	0.00e+00	723.00
IUUC-Ont-072542	Oreochromis niloticus	72.37	0.00e+00	657.00
IUUC-Oan-073217	Ornithorhynchus anatinus	85.07	0.00e+00	757.00
IUUC-Ocu-074251	Oryctolagus cuniculus	83.33	0.00e+00	715.00
IUUC-Ola-086549	Oryzias latipes	70.96	0.00e+00	648.00
IUUC-Oga-088382	Otolemur garnettii	83.57	0.00e+00	732.00
IUUC-Oar-090263	Ovis aries	81.90	0.00e+00	726.00
IUUC-Ptr-090922	Pan troglodytes	82.62	0.00e+00	741.00
IUUC-Pan-092518	Papio anubis	83.10	0.00e+00	743.00
IUUC-Psi-093512	Pelodiscus sinensis	84.76	0.00e+00	752.00
IUUC-Pma-094324	Petromyzon marinus	56.81	2.00e-137	481.00
IUUC-Pfo-096264	Poecilia formosa	72.13	0.00e+00	664.00
IUUC-Pab-098018	Pongo abelii	81.67	0.00e+00	728.00
IUUC-Pca-101034	Procavia capensis	82.02	0.00e+00	677.00
IUUC-Pva-102862	Pteropus vampyrus	79.05	0.00e+00	661.00
IUUC-Rno-106116	Rattus norvegicus	80.52	0.00e+00	721.00
IUUC-Sha-106952	Sarcophilus harrisii	83.58	0.00e+00	701.00
IUUC-Sar-113211	Sorex araneus	74.53	8.00e-133	466.00
IUUC-Ssc-116440	Sus scrofa	83.81	0.00e+00	730.00
IUUC-Tgu-116675	Taeniopygia guttata	83.54	0.00e+00	718.00
IUUC-Tru-118295	Takifugu rubripes	70.26	0.00e+00	626.00
IUUC-Tsy-118916	Tarsius syrichta	72.14	3.00e-175	607.00
IUUC-Tni-120302	Tetraodon nigroviridis	70.96	0.00e+00	630.00
IUUC-Tbe-127416	Tupaia belangeri	71.43	9.00e-168	582.00
IUUC-Ttr-128185	Tursiops truncatus	83.37	0.00e+00	728.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence