iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107107

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01069495

Gene Name

FZR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000007954.1	ENSSHAT00000009266.1	ENSSHAP00000009188.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-27	92.1	310	340
E3 adaptor/Cullin RING/APC_C/CDC20	3.80e-121	404.2	212	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH  +v++l++ +d  ll+sG++D+++ vW+
   Q: 310  GHRQEVCGLKWsTDhQLLASGGNDNKLLVWN 340
           8**********98889**************9 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 36   ylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltghsarvgaLsWnaevlssGsrdgeilhrdvr 124
           yl   + g+ ++l+    k lv   +w+e+g+l+avGt+kg v+i+D+++ kk+++l+gh+arvgaL+Wna++lssGsrd++il+rd+r
   Q: 212  YLQVICMGNFTALTIA--KPLVPIFHWCERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNADQLSSGSRDRMILQRDIR 298
           6666667777777655..6788999**************************************************************** PP
   S: 125  vkelkl.stlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavkaiawsPwqkslLasGGGtaDrcikfwntl 212
           ++  ++ ++lq+h+qevCGlkw++d++lLasGGnDn++ vw++ss +P+++++eh aavkaiawsP+q++lLasGGGtaDrci+fwntl
   Q: 299  TPPVQTeRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTL 387
           *****999********************************************************************************* PP
   S: 213  tgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaagDetlrfwklfdkkk 301
           tg+ l++idtgsqvc+l+wsk+++elvsthG+++n+i +wkypsl++va+l+gh++Rvl+la+spdgeaivt+agDetlrfw++f+k++
   Q: 388  TGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTR 476
           **************************************************************************************998 PP
   S: 302  ak 303
           ++
   Q: 477  ST 478
           75 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MDQDYERRLL RQINIQNENT MPCVAEMRRT LTPSNSPMSS PSKHGDRFIP SRAGANWSIN 60
FHRINENEKS PSQNRKAKDA TSDNGKDGLA YSALLKNELL GAGIEKVQDP QTEDRRLQPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACCAAG ATTATGAAAG GCGTCTCCTT CGACAGATCA ACATCCAGAA TGAAAACACA 60
ATGCCTTGTG TAAGTTGTCC ATCTATCTTT CCACGCCTTT TTCAGCTTAG GGAACAGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002003	Ailuropoda melanoleuca	80.40	0.00e+00	775.00
IUUC-Apl-003212	Anas platyrhynchos	85.40	0.00e+00	833.00
IUUC-Ame-011011	Astyanax mexicanus	78.97	0.00e+00	735.00
IUUC-Bta-012586	Bos taurus	84.00	0.00e+00	825.00
IUUC-Cja-019929	Callithrix jacchus	84.00	0.00e+00	825.00
IUUC-Cfa-020977	Canis familiaris	84.20	0.00e+00	829.00
IUUC-Cpo-021537	Cavia porcellus	83.80	0.00e+00	823.00
IUUC-Csa-023389	Chlorocebus sabaeus	83.40	0.00e+00	818.00
IUUC-Dre-027470	Danio rerio	77.73	0.00e+00	729.00
IUUC-Dno-029629	Dasypus novemcinctus	74.29	0.00e+00	640.00
IUUC-Dor-030187	Dipodomys ordii	75.00	0.00e+00	731.00
IUUC-Eca-034210	Equus caballus	83.60	0.00e+00	822.00
IUUC-Fca-035839	Felis catus	78.60	0.00e+00	768.00
IUUC-Fal-036895	Ficedula albicollis	85.20	0.00e+00	831.00
IUUC-Gmo-039544	Gadus morhua	75.99	0.00e+00	701.00
IUUC-Gga-041025	Gallus gallus	85.20	0.00e+00	831.00
IUUC-Gac-041279	Gasterosteus aculeatus	75.85	0.00e+00	748.00
IUUC-Ggo-045599	Gorilla gorilla	83.60	0.00e+00	796.00
IUUC-Hsa-046695	Homo sapiens	83.80	0.00e+00	823.00
IUUC-Itr-048192	Ictidomys tridecemlineatus	82.60	0.00e+00	816.00
IUUC-Lch-049827	Latimeria chalumnae	83.00	0.00e+00	787.00
IUUC-Loc-052856	Lepisosteus oculatus	81.08	0.00e+00	759.00
IUUC-Laf-054321	Loxodonta africana	71.17	6.00e-76	278.00
IUUC-Mcc-055601	Macaca mulatta	83.40	0.00e+00	818.00
IUUC-Mga-060097	Meleagris gallopavo	79.96	0.00e+00	763.00
IUUC-Mmr-061151	Microcebus murinus	75.20	0.00e+00	699.00
IUUC-Mdo-063062	Monodelphis domestica	85.80	0.00e+00	836.00
IUUC-Mmu-063731	Mus musculus	83.40	0.00e+00	818.00
IUUC-Mpu-066173	Mustela putorius furo	83.60	0.00e+00	820.00
IUUC-Mlu-068030	Myotis lucifugus	84.40	0.00e+00	830.00
IUUC-Nle-070163	Nomascus leucogenys	83.40	0.00e+00	819.00
IUUC-Ont-072507	Oreochromis niloticus	74.10	0.00e+00	729.00
IUUC-Oba-075572	Oryza barthii	72.46	4.00e-86	310.00
IUUC-Ola-087094	Oryzias latipes	76.09	0.00e+00	677.00
IUUC-Olu-087864	Ostreococcus lucimarinus	70.75	1.00e-90	325.00
IUUC-Oga-088911	Otolemur garnettii	84.00	0.00e+00	824.00
IUUC-Oar-089508	Ovis aries	84.00	0.00e+00	825.00
IUUC-Ptr-090967	Pan troglodytes	68.18	1.00e-142	499.00
IUUC-Pan-092147	Papio anubis	83.80	0.00e+00	823.00
IUUC-Psi-093702	Pelodiscus sinensis	85.26	0.00e+00	830.00
IUUC-Pma-094581	Petromyzon marinus	72.78	0.00e+00	672.00
IUUC-Pfo-096309	Poecilia formosa	76.94	0.00e+00	714.00
IUUC-Pab-098762	Pongo abelii	66.80	5.00e-173	600.00
IUUC-Pca-100565	Procavia capensis	78.41	0.00e+00	720.00
IUUC-Pva-102602	Pteropus vampyrus	81.67	0.00e+00	788.00
IUUC-Rno-105028	Rattus norvegicus	83.00	0.00e+00	814.00
IUUC-Sar-112962	Sorex araneus	75.00	2.00e-108	384.00
IUUC-Ssc-116171	Sus scrofa	84.00	0.00e+00	825.00
IUUC-Tgu-116878	Taeniopygia guttata	74.41	0.00e+00	692.00
IUUC-Tru-118222	Takifugu rubripes	76.74	0.00e+00	714.00
IUUC-Tni-119863	Tetraodon nigroviridis	76.54	0.00e+00	705.00
IUUC-Tbe-128056	Tupaia belangeri	73.29	2.00e-131	461.00
IUUC-Ttr-129055	Tursiops truncatus	83.40	0.00e+00	814.00
IUUC-Xtr-132808	Xenopus tropicalis	78.80	0.00e+00	764.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence