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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046289
UUCD1 version UUC-HoS-00879
Ensembl Protein ID ENSP00000448122.1
UniProt Accession F8VUX9; F8VUX9_HUMAN
Genbank Protein ID ENSP00000448122
Protein Name WD repeat-containing protein 90
Genbank Nucleotide ID AL022341
Gene Name WDR90
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000161996.18 ENST00000549091.5 ENSP00000448122.1
ENSG00000161996.18 ENST00000293879.8 ENSP00000293879.4
ENSG00000161996.18 ENST00000552728.5 ENSP00000448603.1
ENSG00000161996.18 ENST00000550739.1 ENSP00000447435.1
ENSG00000161996.18 ENST00000547944.5 ENSP00000449576.1
ENSG00000161996.18 ENST00000315764.8 ENSP00000322808.4
ENSG00000161996.18 ENST00000551100.1 ENSP00000450308.1
ENSG00000161996.18 ENST00000546896.1 ENSP00000447915.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
HINTInWeb_IM
Disease-associated Variation
GWASdb
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.40e-36 123.0 1435 1467
UBD/Beta-Prp 1.30e-79 269.2 1306 1608
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH ++v+ + f ++  + +++s Dg+++vW l 
   Q: 1435 GHRSKVNEVVFsPGeSHCATCSEDGSVRVWALA 1467
           8***********8889**************875 PP
   

   UBD/Beta-Prp
   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvw...dls..........tgkcvhtlk. 91
           +++    +ll  g  +g + vwd++ g ++ s + +++++  + fs +   lv+gs+ + +++w    +s          +++ ++  + 
   Q: 1306 LCY-GAPPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGS--RLVSGSSTGRLRLWavgAVSelrckgsgarSSSVFMEHEl 1392
           555.344566777778********************************..7*************66633366788876554444444444 PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
             +  v+s sf+ s d  v+G+   t+    + +g+  + + sgh++ vn vv++p ++ ++++s D+ vr+W l++++l+ +++   ++
   Q: 1393 VLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTR-LISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQV-LNQ 1480
           56899999*****99************997778888888.88**************99**************************98.9** PP
   S: 182  svysls......fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn. 264
           s  +l+       ++++++l++g  dg++++++++++ +  +++ h    + v+fs +++ ++sg +Dg + +    +g++ ++l+ h+ 
   Q: 1481 SCLCLAwsppccGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQg 1570
           ******55555555666*********************************************************99*************9 PP
   S: 265  ..ssvisvav.....lsfgdnvlvlgse.dskvniwkl 294
              s i+v++     l++++  l l+++ d++v +w+ 
   Q: 1571 apISTICVTCkecedLGVEGTDLWLAASgDQRVSVWAS 1608
           99999999999999999998888777666*******85 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MARAWQHPFL NVFRHFRVDE WKRSAKQGDV AVVTDKTLKG AVYRIRGSVS AANYIQLPKS 60
STQSLGLTGR YLYVLFRPLP SKHFVIHLDV SSKDNQVIRV SFSNLFKEFK STATWLQFPL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046289|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATGGCGGAA GTGGCACCGT TGCCAGGCAG CCGTTGCCTG GCGTCGCGGG GCGTACTCTG 60
CGCTGGGCGC GCGGAGGCCT AGGCGGGAAG CTCGAGCGGC GGCGCCATGG CCCGAGGTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046289|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR007714--CFA20/WDR90/C3orf67
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR030466--WDR90
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF05018--DUF667
PF00400--WD40
SMART

SM00320--WD40
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001801 Ailuropoda melanoleuca 70.54 0.00e+00 1372.00
IUUC-Apl-003387 Anas platyrhynchos 52.79 0.00e+00 1631.00
IUUC-Aca-005235 Anolis carolinensis 52.24 0.00e+00 1639.00
IUUC-Ame-011595 Astyanax mexicanus 53.46 0.00e+00 718.00
IUUC-Bta-012328 Bos taurus 68.93 0.00e+00 2278.00
IUUC-Cja-019058 Callithrix jacchus 83.42 0.00e+00 2594.00
IUUC-Cfa-020934 Canis familiaris 65.31 0.00e+00 2040.00
IUUC-Cpo-022025 Cavia porcellus 67.85 0.00e+00 2296.00
IUUC-Cre-022928 Chlamydomonas reinhardtii 29.36 1.00e-60 229.00
IUUC-Csa-023022 Chlorocebus sabaeus 88.75 0.00e+00 3028.00
IUUC-Cin-025133 Ciona intestinalis 36.41 0.00e+00 708.00
IUUC-Csv-025816 Ciona savignyi 36.07 3.00e-169 590.00
IUUC-Dre-028823 Danio rerio 46.35 0.00e+00 1568.00
IUUC-Dno-029211 Dasypus novemcinctus 74.50 0.00e+00 861.00
IUUC-Dor-030211 Dipodomys ordii 71.74 0.00e+00 2058.00
IUUC-Ete-032363 Echinops telfairi 58.96 0.00e+00 879.00
IUUC-Eca-034296 Equus caballus 71.21 0.00e+00 1347.00
IUUC-Eeu-035226 Erinaceus europaeus 60.94 0.00e+00 876.00
IUUC-Fca-035384 Felis catus 69.21 0.00e+00 2319.00
IUUC-Fal-037660 Ficedula albicollis 55.66 0.00e+00 1002.00
IUUC-Gga-040666 Gallus gallus 55.22 0.00e+00 1307.00
IUUC-Gac-041358 Gasterosteus aculeatus 46.21 0.00e+00 1511.00
IUUC-Ggo-045121 Gorilla gorilla 97.94 0.00e+00 3364.00
IUUC-Itr-048485 Ictidomys tridecemlineatus 69.94 0.00e+00 2228.00
IUUC-Lch-050009 Latimeria chalumnae 48.41 0.00e+00 1631.00
IUUC-Loc-052629 Lepisosteus oculatus 45.38 0.00e+00 822.00
IUUC-Mcc-055834 Macaca mulatta 85.93 0.00e+00 2791.00
IUUC-Meu-056162 Macropus eugenii 49.55 0.00e+00 927.00
IUUC-Mga-060167 Meleagris gallopavo 52.19 0.00e+00 1604.00
IUUC-Mmr-060761 Microcebus murinus 82.89 1.00e-149 522.00
IUUC-Mdo-061886 Monodelphis domestica 57.22 0.00e+00 2097.00
IUUC-Mmu-063652 Mus musculus 68.71 0.00e+00 2382.00
IUUC-Mlu-068141 Myotis lucifugus 64.90 0.00e+00 2128.00
IUUC-Nle-069133 Nomascus leucogenys 92.49 0.00e+00 2139.00
IUUC-Ont-072496 Oreochromis niloticus 47.21 0.00e+00 1663.00
IUUC-Oan-072833 Ornithorhynchus anatinus 50.78 0.00e+00 896.00
IUUC-Ola-086564 Oryzias latipes 45.46 0.00e+00 1557.00
IUUC-Oga-088919 Otolemur garnettii 74.26 0.00e+00 2516.00
IUUC-Oar-089946 Ovis aries 72.52 0.00e+00 910.00
IUUC-Ptr-090755 Pan troglodytes 98.30 0.00e+00 2837.00
IUUC-Pan-092054 Papio anubis 87.15 0.00e+00 2994.00
IUUC-Psi-093467 Pelodiscus sinensis 55.22 0.00e+00 1103.00
IUUC-Pma-094573 Petromyzon marinus 42.47 0.00e+00 810.00
IUUC-Pfo-096849 Poecilia formosa 46.06 0.00e+00 1452.00
IUUC-Pab-098320 Pongo abelii 90.97 0.00e+00 2989.00
IUUC-Pca-100172 Procavia capensis 65.91 0.00e+00 2043.00
IUUC-Pva-102772 Pteropus vampyrus 70.60 0.00e+00 1362.00
IUUC-Rno-105046 Rattus norvegicus 68.90 0.00e+00 2395.00
IUUC-Sha-107094 Sarcophilus harrisii 57.36 0.00e+00 2135.00
IUUC-Ssc-116257 Sus scrofa 67.36 0.00e+00 2196.00
IUUC-Tgu-117323 Taeniopygia guttata 59.47 0.00e+00 826.00
IUUC-Tru-118717 Takifugu rubripes 45.11 0.00e+00 1481.00
IUUC-Tni-120108 Tetraodon nigroviridis 45.87 0.00e+00 889.00
IUUC-Ttr-128378 Tursiops truncatus 72.30 0.00e+00 1684.00
IUUC-Xtr-131760 Xenopus tropicalis 49.89 0.00e+00 1692.00
Created Date 25-Jun-2017

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