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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046876
UUCD1 version UUC-HoS-00393
Ensembl Protein ID ENSP00000428968.1
UniProt Accession Q9NV58; A3KCU9; Q52LG1; Q9H5H9; Q9H8M8; Q9UFG0; Q9UFX6; Q9Y4Y1; RN19A_HUMAN
Genbank Protein ID BAB39353.1; AAH93938.1; AAH93940.1; BAF48117.1; BAA91900.1; BAB14581.1; BAB15647.1; CAB45132.1; CAB53700.1; CAB59264.1
Protein Name E3 ubiquitin-protein ligase RNF19A; Double ring-finger protein; RING finger protein 19A; p38
Genbank Nucleotide ID AB029316; BC093938; BC093940; AB271914; AK001774; AK023455; AK027070; AJ242975; AL110253; AL122096
Gene Name RNF19A; RNF19
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000034677.12 ENST00000519449.5 ENSP00000428968.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 19741096; 19224863; 16513638
Classification
Family E-value Score Start End
E3 activity/RBR 1.00e-52 179.6 132 332
Active Site
Position(s) Description Evidence
316 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++Cll++s+++++ +++C+h+ C +Cl+qyl+++i+e++ ++iscp  ec+e++++++i+ +l+++ l+++ye+++l++++ ad++++w
   Q: 132  CPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESR-VNISCP--ECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRW 218
           ****************************************.9*****..89*************************************** PP
   S: 91   cpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeek.......eeaeskelleanskkCpkCkvyi 171
           cpapdC ++v++  +a  +kl++ +e+cg+efC++Ck++wH++++C+++++++a++ + +       + ++++ ++++++k+Cp+C +yi
   Q: 219  CPAPDCGYAVIAFGCAscPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRtirsssiSYSQESGAAADDIKPCPRCAAYI 308
           *************999889************************************99998999*99999999****************** PP
   S: 172  ek..negCnhmtCakCkaefCwlC 193
           +k  +++CnhmtCa C++efCwlC
   Q: 309  IKmnDGSCNHMTCAVCGCEFCWLC 332
           *997889***************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
Protein Sequence
(Fasta)
MQEQEIGFIS KYNEGLCVNT DPVSILTSIL DMSLHRQMGS DRDLQSSASS VSLPSVKKAP 60
KKRRISIGSL FRRKKDNKRK SRELNGGVDG IASIESIHSE MCTDKNSIFS TNTSSDNGLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046876|E3,RBR|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCTTCGCCG CGCCCTCTTC TCTCATTGGC ACTGCCTGTC TACTGCCGAG GGCATTTGAG 60
TGTGGGACCC ATGCCCTGCA TTTCTTCGCT ACCCCACAGC TTCTGCTCAT GGTAATATCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046876|E3,RBR|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0008134--F:transcription factor binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000226--P:microtubule cytoskeleton organization
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:25897
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001958 Ailuropoda melanoleuca 98.21 0.00e+00 1417.00
IUUC-Apl-003427 Anas platyrhynchos 89.57 0.00e+00 1173.00
IUUC-Aca-004252 Anolis carolinensis 86.55 0.00e+00 1136.00
IUUC-Ame-011434 Astyanax mexicanus 74.94 0.00e+00 887.00
IUUC-Bta-013558 Bos taurus 97.85 0.00e+00 1411.00
IUUC-Cel-018626 Caenorhabditis elegans 55.49 1.00e-111 397.00
IUUC-Cja-019070 Callithrix jacchus 99.16 0.00e+00 1428.00
IUUC-Cfa-020286 Canis familiaris 97.85 0.00e+00 1414.00
IUUC-Cpo-022015 Cavia porcellus 96.54 0.00e+00 1381.00
IUUC-Csa-023975 Chlorocebus sabaeus 98.81 0.00e+00 1400.00
IUUC-Cho-024442 Choloepus hoffmanni 82.82 0.00e+00 1188.00
IUUC-Cin-025143 Ciona intestinalis 55.41 2.00e-43 169.00
IUUC-Dre-028422 Danio rerio 73.34 0.00e+00 882.00
IUUC-Dno-029018 Dasypus novemcinctus 96.92 0.00e+00 1312.00
IUUC-Dor-030548 Dipodomys ordii 93.65 0.00e+00 658.00
IUUC-Eca-034249 Equus caballus 97.85 0.00e+00 1412.00
IUUC-Eeu-035298 Erinaceus europaeus 97.96 0.00e+00 851.00
IUUC-Fca-035912 Felis catus 97.73 0.00e+00 1411.00
IUUC-Fal-037488 Ficedula albicollis 87.74 0.00e+00 1140.00
IUUC-Gmo-038893 Gadus morhua 82.22 0.00e+00 811.00
IUUC-Gga-040380 Gallus gallus 89.22 0.00e+00 1143.00
IUUC-Gac-041421 Gasterosteus aculeatus 76.50 0.00e+00 892.00
IUUC-Ggo-044893 Gorilla gorilla 99.76 0.00e+00 1439.00
IUUC-Itr-048257 Ictidomys tridecemlineatus 98.21 0.00e+00 1414.00
IUUC-Lch-049774 Latimeria chalumnae 84.99 0.00e+00 1132.00
IUUC-Loc-052040 Lepisosteus oculatus 77.19 0.00e+00 1009.00
IUUC-Laf-053874 Loxodonta africana 97.49 0.00e+00 1377.00
IUUC-Mcc-054817 Macaca mulatta 98.67 2.00e-113 401.00
IUUC-Meu-056648 Macropus eugenii 90.68 1.00e-175 610.00
IUUC-Mga-060175 Meleagris gallopavo 88.16 0.00e+00 1166.00
IUUC-Mmr-060800 Microcebus murinus 98.57 0.00e+00 1420.00
IUUC-Mdo-061827 Monodelphis domestica 87.33 0.00e+00 1134.00
IUUC-Mmu-064134 Mus musculus 93.57 0.00e+00 1287.00
IUUC-Mpu-066076 Mustela putorius furo 97.73 0.00e+00 1407.00
IUUC-Mlu-068218 Myotis lucifugus 96.54 0.00e+00 1331.00
IUUC-Nle-069707 Nomascus leucogenys 99.69 0.00e+00 1120.00
IUUC-Opr-070977 Ochotona princeps 96.53 0.00e+00 1374.00
IUUC-Ont-072373 Oreochromis niloticus 79.62 0.00e+00 942.00
IUUC-Oan-073376 Ornithorhynchus anatinus 90.43 7.00e-175 606.00
IUUC-Ocu-074878 Oryctolagus cuniculus 96.54 0.00e+00 1356.00
IUUC-Ola-086472 Oryzias latipes 78.81 0.00e+00 934.00
IUUC-Oga-088377 Otolemur garnettii 98.08 0.00e+00 1402.00
IUUC-Oar-089540 Ovis aries 97.37 0.00e+00 1404.00
IUUC-Ptr-090613 Pan troglodytes 100.00 0.00e+00 1442.00
IUUC-Pan-092879 Papio anubis 99.05 0.00e+00 1401.00
IUUC-Psi-093201 Pelodiscus sinensis 89.94 0.00e+00 1137.00
IUUC-Pma-094620 Petromyzon marinus 69.94 0.00e+00 813.00
IUUC-Pfo-096615 Poecilia formosa 84.14 0.00e+00 899.00
IUUC-Pca-100625 Procavia capensis 95.33 0.00e+00 1364.00
IUUC-Pva-103110 Pteropus vampyrus 87.35 0.00e+00 1076.00
IUUC-Rno-105998 Rattus norvegicus 92.86 0.00e+00 1283.00
IUUC-Sha-107523 Sarcophilus harrisii 86.44 0.00e+00 1133.00
IUUC-Sar-113089 Sorex araneus 94.13 0.00e+00 964.00
IUUC-Ssc-115471 Sus scrofa 97.37 0.00e+00 1369.00
IUUC-Tgu-117080 Taeniopygia guttata 88.11 0.00e+00 1180.00
IUUC-Tru-117547 Takifugu rubripes 79.34 0.00e+00 897.00
IUUC-Tsy-119143 Tarsius syrichta 97.26 0.00e+00 1396.00
IUUC-Tni-119693 Tetraodon nigroviridis 75.47 0.00e+00 892.00
IUUC-Ttr-129175 Tursiops truncatus 97.37 0.00e+00 1389.00
IUUC-Vpa-130594 Vicugna pacos 90.62 0.00e+00 1300.00
IUUC-Xtr-132579 Xenopus tropicalis 87.39 0.00e+00 1152.00
Created Date 25-Jun-2017

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