iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044689

UUCD1 version

UUC-GoG-01127

Ensembl Protein ID

ENSGGOP00000007389.2

UniProt Accession

G3QX57; G3QX57_GORGO

Protein Name

Uncharacterized protein

Gene Name

USP33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000007543.2	ENSGGOT00000007585.2	ENSGGOP00000007389.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.90e-62	210.0	181	570

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 21   nipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelk 108
           + p+l++++l+     +   +++++k +++ks+ kl++elw ks+ ++v p++l++ +k++++ f+gy+qqDaqEfl++l+d l+eelk
   Q: 181  ARPPLTQFFLD-----CGGLARTDKKPAICKSYLKLMTELWhKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 264
           56899999999.....999999*******************99*********************************************8 PP
   S: 109  k........eknkpkeeeeeedkselsde............................................................ 129
           +         ++ ++ee++eedks+++ +                                                            
   Q: 265  EqvmeveedPQTITTEETMEEDKSQSDVDfqscescsnsdraenengsrcfsednnettmliqddennsemskdwqkekmcnkinkvns 353
           899998887777777788888877777779*********************************************************** PP
   S: 130  .....................................................................................aeek 133
                                                                                                +++k
   Q: 354  egefdkdrdsisetvdlnnqetvkvqihsraseyitdvhsndlstpqilpsnegvnprlsasppksgnlwpglapphkkaqsaspKRKK 442
           *************************************************************************************9*** PP
   S: 134  kkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..................................... 185
           ++kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+                                     
   Q: 443  QHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshptsivkagscgeayapqgwiaffmeyvkrfvv 531
           ***********************************************99888************************************* PP
   S: 186  ............slqdcLesftkeeelegenkyycekck 212
                       +lqdcL++f++++el+g+n+y+cekck
   Q: 532  scvpswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCK 570
           **************************************8 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MTGSNSHITI LTLKVLPHFE SLGKQEKIPN KMSAFRNHCP HLDSVGEITK EDLIQKSHGT 60
CQDCKVQGPN LWACLENRCS YVGCGESQVD HSTIHSQETK HYLTVNLTTL RVWCYACSKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACAGGAT CAAATTCACA CATAACGATA TTAACCTTAA AGGTAAGTGG GCTAAATGCC 60
CCAATTAAAA GACCCAGACT GGCAAATTGG ATAAAAAGTC AAGACCCATC AGTGTGCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005776--C:autophagosome
GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cho-024383	Choloepus hoffmanni	90.44	2.00e-116	413.00
IUUC-Cin-025404	Ciona intestinalis	48.96	9.00e-18	83.20
IUUC-Ete-032994	Echinops telfairi	89.97	0.00e+00	668.00
IUUC-Hsa-045694	Homo sapiens	93.54	0.00e+00	1085.00
IUUC-Oan-073695	Ornithorhynchus anatinus	78.22	0.00e+00	824.00
IUUC-Pva-102820	Pteropus vampyrus	84.43	0.00e+00	956.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence