iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bci-013959

Ensembl Protein ID

Bcin02g02570.1

UniProt Accession

A6RPU4; ATG8_BOTFB

Genbank Protein ID

EDN32090.1

Protein Name

Autophagy-related protein 8; Autophagy-related ubiquitin-like modifier atg8

Genbank Nucleotide ID

CH476849

Gene Name

atg8; BC1G_02467

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bcin02g02570	Bcin02g02570.1	Bcin02g02570.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	1.20e-47	159.6	13	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgflyv 95
           krk+e+e+ir+k++d+iPvi+ek +k++i+++dkkkylvPsdltvgq+v++irkr++l +e+a+f++v+++l++++a +++iyee+kdedgfly+
   Q: 13   KRKAEAERIRQKYNDRIPVICEKVEKSDIATIDKKKYLVPSDLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYI 107
           699******************************************************************************************** PP
   S: 96   ayaseetfG 104
           +y++e+tfG
   Q: 108  SYSGENTFG 116
           ********9 PP

Organism

Botrytis cinerea

Functional Description
(View)

Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.

Protein Sequence
(Fasta)

MRSKFKDEHP FEKRKAEAER IRQKYNDRIP VICEKVEKSD IATIDKKKYL VPSDLTVGQF 60
VYVIRKRIKL SPEKAIFIFV DEVLPPTAAL MSSIYEEHKD EDGFLYISYS GENTFGEALE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGATCCA AGTTTAAGGA CGAGCACCCA TTCGAGAAGC GCAAGGCTGA AGCTGAACGC 60
ATCGTACGTC GCATTCCAAC CTCCTAACCA TTACCTCCCC TTCCCCACCA TCACCATCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0968--Cytoplasmic vesicle
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0653--Protein transport
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0926--Vacuole

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

bfu:BC1G_02467

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000059	Aegilops tauschii	75.21	3.00e-51	191.00
IUUC-Aml-001323	Ailuropoda melanoleuca	60.34	9.00e-40	153.00
IUUC-Atr-002791	Amborella trichopoda	80.87	5.00e-52	194.00
IUUC-Apl-003994	Anas platyrhynchos	56.03	7.00e-38	147.00
IUUC-Aca-005288	Anolis carolinensis	59.48	2.00e-39	152.00
IUUC-Aly-005987	Arabidopsis lyrata	81.58	8.00e-53	196.00
IUUC-Ath-006958	Arabidopsis thaliana	80.87	2.00e-44	168.00
IUUC-Ago-007898	Ashbya gossypii	71.93	2.00e-48	182.00
IUUC-Acl-008314	Aspergillus clavatus	95.76	1.00e-63	232.00
IUUC-Afl-008708	Aspergillus flavus	96.58	1.00e-63	232.00
IUUC-Afu-009097	Aspergillus fumigatus	95.76	1.00e-63	232.00
IUUC-Ani-009196	Aspergillus nidulans	94.92	8.00e-63	229.00
IUUC-Ang-009530	Aspergillus niger	95.76	1.00e-63	232.00
IUUC-Aor-009909	Aspergillus oryzae	96.58	1.00e-63	232.00
IUUC-Ate-010358	Aspergillus terreus	95.76	1.00e-63	232.00
IUUC-Ame-010914	Astyanax mexicanus	60.68	2.00e-40	155.00
IUUC-Bgr-012248	Blumeria graminis	95.76	5.00e-63	230.00
IUUC-Bta-012805	Bos taurus	60.34	9.00e-40	153.00
IUUC-Bdi-014390	Brachypodium distachyon	79.66	9.00e-52	193.00
IUUC-Bol-016488	Brassica oleracea	80.34	3.00e-52	195.00
IUUC-Bra-016921	Brassica rapa	81.58	8.00e-53	196.00
IUUC-Cel-018200	Caenorhabditis elegans	56.20	1.00e-37	146.00
IUUC-Cja-019369	Callithrix jacchus	60.34	9.00e-40	153.00
IUUC-Cfa-020603	Canis familiaris	60.34	9.00e-40	153.00
IUUC-Cpo-021831	Cavia porcellus	59.48	2.00e-39	152.00
IUUC-Cre-022866	Chlamydomonas reinhardtii	83.33	7.00e-46	174.00
IUUC-Csa-024117	Chlorocebus sabaeus	60.34	9.00e-40	153.00
IUUC-Cho-025008	Choloepus hoffmanni	52.14	3.00e-35	138.00
IUUC-Cin-025297	Ciona intestinalis	58.62	1.00e-39	152.00
IUUC-Csv-026146	Ciona savignyi	36.75	9.00e-21	90.50
IUUC-Cgl-026691	Colletotrichum gloeosporioides	70.62	5.00e-57	211.00
IUUC-Cne-026889	Cryptococcus neoformans	87.18	1.00e-58	216.00
IUUC-Cme-027158	Cyanidioschyzon merolae	27.50	2.10e+00	24.30
IUUC-Dre-028351	Danio rerio	60.68	2.00e-40	156.00
IUUC-Dno-029331	Dasypus novemcinctus	59.48	2.00e-39	152.00
IUUC-Dor-030245	Dipodomys ordii	60.34	9.00e-40	153.00
IUUC-Dse-031428	Dothistroma septosporum	97.46	1.00e-64	235.00
IUUC-Dme-031813	Drosophila melanogaster	61.86	1.00e-41	159.00
IUUC-Ete-032671	Echinops telfairi	61.21	5.00e-40	154.00
IUUC-Eca-034113	Equus caballus	59.48	3.00e-39	152.00
IUUC-Eeu-035131	Erinaceus europaeus	59.30	3.00e-27	110.00
IUUC-Fca-036493	Felis catus	60.34	1.00e-39	153.00
IUUC-Fal-036896	Ficedula albicollis	59.48	3.00e-39	151.00
IUUC-Fox-037846	Fusarium oxysporum	95.83	7.00e-65	236.00
IUUC-Fso-038134	Fusarium solani	96.61	4.00e-64	234.00
IUUC-Gmo-039671	Gadus morhua	60.17	1.00e-40	156.00
IUUC-Ggr-039770	Gaeumannomyces graminis	91.80	1.00e-62	229.00
IUUC-Gga-040257	Gallus gallus	60.34	4.00e-40	154.00
IUUC-Gac-041604	Gasterosteus aculeatus	60.34	2.00e-40	155.00
IUUC-Gma-044021	Glycine max	78.26	8.00e-52	193.00
IUUC-Ggo-044860	Gorilla gorilla	60.34	1.00e-39	152.00
IUUC-Hsa-045905	Homo sapiens	60.34	9.00e-40	153.00
IUUC-Hvu-047588	Hordeum vulgare	79.13	5.00e-51	191.00
IUUC-Itr-048405	Ictidomys tridecemlineatus	60.34	9.00e-40	153.00
IUUC-Kpa-049124	Komagataella pastoris	82.05	8.00e-55	203.00
IUUC-Lch-049542	Latimeria chalumnae	58.62	2.00e-39	152.00
IUUC-Lpe-051292	Leersia perrieri	80.87	4.00e-52	194.00
IUUC-Loc-052290	Lepisosteus oculatus	58.68	2.00e-40	155.00
IUUC-Laf-054203	Loxodonta africana	60.34	9.00e-40	153.00
IUUC-Mcc-055307	Macaca mulatta	60.34	9.00e-40	153.00
IUUC-Meu-056515	Macropus eugenii	59.48	2.00e-39	152.00
IUUC-Mor-057276	Magnaporthe oryzae	90.98	2.00e-62	228.00
IUUC-Mpo-057469	Magnaporthe poae	91.80	3.00e-62	228.00
IUUC-Mtr-057664	Medicago truncatula	77.39	1.00e-45	172.00
IUUC-Mla-059098	Melampsora laricipopulina	87.80	4.00e-61	224.00
IUUC-Mga-060108	Meleagris gallopavo	55.83	1.00e-38	149.00
IUUC-Mvi-060496	Microbotryum violaceum	89.57	3.00e-58	215.00
IUUC-Mmr-061776	Microcebus murinus	60.34	9.00e-40	153.00
IUUC-Mdo-061915	Monodelphis domestica	59.48	2.00e-39	152.00
IUUC-Mmu-064157	Mus musculus	60.34	9.00e-40	153.00
IUUC-Mac-064739	Musa acuminata	78.26	3.00e-44	168.00
IUUC-Mpu-066028	Mustela putorius furo	60.34	2.00e-39	152.00
IUUC-Mlu-067166	Myotis lucifugus	60.34	9.00e-40	153.00
IUUC-Nfi-068367	Neosartorya fischeri	95.76	1.00e-63	232.00
IUUC-Ncr-068894	Neurospora crassa	96.58	7.00e-64	233.00
IUUC-Nle-069220	Nomascus leucogenys	60.34	9.00e-40	153.00
IUUC-Opr-070777	Ochotona princeps	60.34	1.00e-39	153.00
IUUC-Ont-072343	Oreochromis niloticus	59.48	3.00e-39	151.00
IUUC-Oan-073485	Ornithorhynchus anatinus	61.90	2.00e-36	142.00
IUUC-Ocu-074148	Oryctolagus cuniculus	60.34	9.00e-40	153.00
IUUC-Oba-075238	Oryza barthii	75.21	2.00e-51	192.00
IUUC-Obr-076830	Oryza brachyantha	80.00	3.00e-52	194.00
IUUC-Ogl-077457	Oryza glaberrima	80.00	2.00e-51	191.00
IUUC-Ogu-078489	Oryza glumaepatula	75.21	2.00e-51	192.00
IUUC-Oin-079330	Oryza indica	75.21	2.00e-51	192.00
IUUC-Olo-080412	Oryza longistaminata	80.00	2.00e-51	191.00
IUUC-Ome-082013	Oryza meridionalis	75.21	2.00e-51	192.00
IUUC-Oni-082811	Oryza nivara	75.21	2.00e-51	192.00
IUUC-Opu-083501	Oryza punctata	80.00	3.00e-52	194.00
IUUC-Oru-084197	Oryza rufipogon	75.21	2.00e-51	192.00
IUUC-Osa-085654	Oryza sativa	75.21	2.00e-51	192.00
IUUC-Ola-086310	Oryzias latipes	58.62	8.00e-39	150.00
IUUC-Olu-087892	Ostreococcus lucimarinus	80.36	2.00e-52	196.00
IUUC-Oga-088312	Otolemur garnettii	60.34	9.00e-40	153.00
IUUC-Oar-089989	Ovis aries	60.34	9.00e-40	153.00
IUUC-Ptr-091108	Pan troglodytes	60.34	9.00e-40	153.00
IUUC-Pan-092269	Papio anubis	59.48	2.00e-39	152.00
IUUC-Psi-093055	Pelodiscus sinensis	55.56	7.00e-38	147.00
IUUC-Pma-094337	Petromyzon marinus	56.90	4.00e-40	154.00
IUUC-Pno-095035	Phaeosphaeria nodorum	97.48	1.00e-65	239.00
IUUC-Ppa-095701	Physcomitrella patens	79.66	2.00e-46	176.00
IUUC-Pfo-096380	Poecilia formosa	58.62	4.00e-39	151.00
IUUC-Pab-097660	Pongo abelii	60.34	9.00e-40	153.00
IUUC-Pop-099400	Populus trichocarpa	79.13	8.00e-46	173.00
IUUC-Pca-100230	Procavia capensis	60.34	9.00e-40	153.00
IUUC-Ppe-101670	Prunus persica	78.26	1.00e-44	169.00
IUUC-Pva-103103	Pteropus vampyrus	55.56	7.00e-38	147.00
IUUC-Pte-104230	Pyrenophora teres	98.32	6.00e-66	240.00
IUUC-Rno-105497	Rattus norvegicus	60.34	9.00e-40	153.00
IUUC-Sce-106150	Saccharomyces cerevisiae	77.59	5.00e-52	194.00
IUUC-Sha-106656	Sarcophilus harrisii	60.34	9.00e-40	153.00
IUUC-Sja-107857	Schizosaccharomyces japonicus	85.71	5.00e-58	214.00
IUUC-Spo-108156	Schizosaccharomyces pombe	84.03	4.00e-49	184.00
IUUC-Ssl-108578	Sclerotinia sclerotiorum	99.19	3.00e-68	248.00
IUUC-Smo-109082	Selaginella moellendorffii	77.97	2.00e-51	192.00
IUUC-Sit-110531	Setaria italica	79.82	8.00e-51	190.00
IUUC-Sly-111700	Solanum lycopersicum	80.17	1.00e-51	192.00
IUUC-Stu-112612	Solanum tuberosum	79.31	8.00e-52	193.00
IUUC-Sar-113670	Sorex araneus	55.17	3.00e-35	138.00
IUUC-Sbi-113877	Sorghum bicolor	80.70	4.00e-51	191.00
IUUC-Sre-114964	Sporisorium reilianum	88.14	2.00e-58	215.00
IUUC-Ssc-116182	Sus scrofa	60.34	9.00e-40	153.00
IUUC-Tgu-117195	Taeniopygia guttata	59.48	2.00e-39	152.00
IUUC-Tru-118632	Takifugu rubripes	58.68	2.00e-40	155.00
IUUC-Tsy-118919	Tarsius syrichta	55.56	7.00e-38	147.00
IUUC-Tni-120706	Tetraodon nigroviridis	58.62	8.00e-39	150.00
IUUC-Tca-121335	Theobroma cacao	75.21	1.00e-46	177.00
IUUC-Tre-122077	Trichoderma reesei	96.61	3.00e-64	234.00
IUUC-Tvi-122400	Trichoderma virens	96.61	3.00e-64	234.00
IUUC-Tae-122697	Triticum aestivum	75.21	9.00e-51	191.00
IUUC-Tur-126158	Triticum urartu	74.36	1.00e-50	189.00
IUUC-Tme-126955	Tuber melanosporum	96.55	4.00e-62	228.00
IUUC-Tbe-127765	Tupaia belangeri	63.95	2.00e-30	121.00
IUUC-Ttr-128205	Tursiops truncatus	59.48	2.00e-39	152.00
IUUC-Uma-129435	Ustilago maydis	88.03	2.00e-58	215.00
IUUC-Vda-129807	Verticillium dahliae	95.76	7.00e-64	233.00
IUUC-Vpa-130804	Vicugna pacos	58.62	5.00e-39	150.00
IUUC-Vvi-130830	Vitis vinifera	80.87	2.00e-45	172.00
IUUC-Xtr-132685	Xenopus tropicalis	59.48	1.00e-39	152.00
IUUC-Xma-133400	Xiphophorus maculatus	58.68	3.00e-40	155.00
IUUC-Yli-134327	Yarrowia lipolytica	88.89	4.00e-52	194.00
IUUC-Zma-135270	Zea mays	80.87	5.00e-52	194.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence