iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089673

Ensembl Protein ID

ENSOARP00000012921.1

UniProt Accession

W5PR43; W5PR43_SHEEP

Genbank Protein ID

ENSOARP00000012921

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01098092

Gene Name

UBE2K

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000012052.1	ENSOART00000013109.1	ENSOARP00000012921.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.40e-44	151.4	20	145
UBD/Alpha-Helix/UBA	5.30e-11	42.5	160	198

Active Site

Position(s)	Description	Evidence
91	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 11   kdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsv 98
           ++++++i++++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+ilk  ++W +a+++
   Q: 20   ETSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDILK--DQWAAAMTL 105
           556789********.9***************************************************99********9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 106  RTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 145
           *************************************986 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL + ++++e A+e+Ll+
   Q: 160  EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLS 198
           6789*********************************97 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

INIIQKSVLK KWRNVVKNIE TSKNQIKVDL VDENFTELRG EIAGPPDTPY EGGRYQLEIK 60
IPETYPFNPP KVRFITKIWH PNISSVTGAI CLDILKDQWA AAMTLRTVLL SLQALLAAAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAAATATAA TACAAAAATC TGTTTTGAAA AGTAAGTAAT TGCCATTGAA GTAAACTAAG 60
CAAAAAAACA GATTGAGGAA GGCATTGGAA GATTCTAGTG GGCATTTAGG CTTCAGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0032433--C:filopodium tip
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0035458--P:cellular response to interferon-beta
GO:0010994--P:free ubiquitin chain polymerization
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0070936--P:protein K48-linked ubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	66.67	2.00e-25	108.00
IUUC-Aml-001286	Ailuropoda melanoleuca	92.93	1.00e-100	358.00
IUUC-Atr-003063	Amborella trichopoda	51.46	6.00e-38	150.00
IUUC-Apl-004122	Anas platyrhynchos	99.43	5.00e-95	339.00
IUUC-Aca-004565	Anolis carolinensis	92.46	3.00e-100	357.00
IUUC-Aly-006390	Arabidopsis lyrata	48.96	1.00e-42	166.00
IUUC-Ath-006637	Arabidopsis thaliana	47.03	1.00e-39	155.00
IUUC-Ago-007714	Ashbya gossypii	43.55	1.00e-36	145.00
IUUC-Acl-008189	Aspergillus clavatus	55.65	6.00e-26	110.00
IUUC-Afl-008489	Aspergillus flavus	44.57	5.00e-27	114.00
IUUC-Afu-008850	Aspergillus fumigatus	40.87	9.00e-27	113.00
IUUC-Ani-009361	Aspergillus nidulans	57.26	2.00e-24	105.00
IUUC-Ang-009548	Aspergillus niger	54.55	7.00e-25	107.00
IUUC-Aor-010105	Aspergillus oryzae	44.57	5.00e-27	114.00
IUUC-Ate-010389	Aspergillus terreus	43.48	7.00e-27	113.00
IUUC-Ame-011454	Astyanax mexicanus	89.90	4.00e-98	350.00
IUUC-Bgr-012255	Blumeria graminis	54.76	1.00e-31	129.00
IUUC-Bta-012992	Bos taurus	92.93	1.00e-100	358.00
IUUC-Bci-013806	Botrytis cinerea	44.15	3.00e-35	141.00
IUUC-Bdi-015024	Brachypodium distachyon	50.00	2.00e-38	151.00
IUUC-Bol-015985	Brassica oleracea	48.96	2.00e-42	165.00
IUUC-Bra-016805	Brassica rapa	48.96	6.00e-43	166.00
IUUC-Cel-018353	Caenorhabditis elegans	50.25	3.00e-52	197.00
IUUC-Cja-019051	Callithrix jacchus	92.42	8.00e-100	355.00
IUUC-Cfa-020016	Canis familiaris	92.93	1.00e-100	358.00
IUUC-Cpo-022026	Cavia porcellus	92.93	1.00e-100	358.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	52.60	7.00e-40	156.00
IUUC-Csa-023059	Chlorocebus sabaeus	92.93	1.00e-100	358.00
IUUC-Cho-024276	Choloepus hoffmanni	96.60	2.00e-73	267.00
IUUC-Cin-025598	Ciona intestinalis	62.50	5.00e-51	193.00
IUUC-Csv-025831	Ciona savignyi	63.64	2.00e-50	191.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	44.65	4.00e-33	134.00
IUUC-Cne-027068	Cryptococcus neoformans	42.05	6.00e-39	153.00
IUUC-Dre-028139	Danio rerio	89.90	5.00e-98	349.00
IUUC-Dno-029169	Dasypus novemcinctus	92.96	1.00e-100	358.00
IUUC-Dor-030382	Dipodomys ordii	78.79	1.00e-79	288.00
IUUC-Dse-031335	Dothistroma septosporum	60.17	1.00e-35	143.00
IUUC-Dme-032003	Drosophila melanogaster	61.93	5.00e-63	233.00
IUUC-Ete-032868	Echinops telfairi	83.84	4.00e-79	286.00
IUUC-Eca-033428	Equus caballus	92.93	1.00e-100	358.00
IUUC-Eeu-035103	Erinaceus europaeus	73.44	5.00e-49	186.00
IUUC-Fca-035366	Felis catus	92.93	1.00e-100	358.00
IUUC-Fal-037016	Ficedula albicollis	92.93	1.00e-100	358.00
IUUC-Fox-037969	Fusarium oxysporum	44.57	3.00e-33	134.00
IUUC-Fso-038296	Fusarium solani	42.39	1.00e-34	139.00
IUUC-Gmo-039135	Gadus morhua	88.89	8.00e-97	345.00
IUUC-Ggr-039768	Gaeumannomyces graminis	47.74	5.00e-24	104.00
IUUC-Gga-041018	Gallus gallus	92.42	2.00e-100	357.00
IUUC-Gac-041503	Gasterosteus aculeatus	89.39	1.00e-97	348.00
IUUC-Gma-042779	Glycine max	51.37	3.00e-41	161.00
IUUC-Ggo-045032	Gorilla gorilla	92.93	1.00e-100	358.00
IUUC-Hsa-046490	Homo sapiens	92.93	1.00e-100	358.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	92.93	1.00e-100	358.00
IUUC-Lch-050588	Latimeria chalumnae	68.25	1.00e-75	275.00
IUUC-Lpe-051070	Leersia perrieri	48.44	5.00e-30	123.00
IUUC-Loc-052549	Lepisosteus oculatus	90.40	1.00e-98	351.00
IUUC-Lma-052949	Leptosphaeria maculans	57.72	5.00e-36	144.00
IUUC-Laf-053688	Loxodonta africana	100.00	1.00e-97	348.00
IUUC-Mcc-055606	Macaca mulatta	92.93	1.00e-100	358.00
IUUC-Mor-056946	Magnaporthe oryzae	38.42	4.00e-22	98.20
IUUC-Mpo-057441	Magnaporthe poae	49.67	4.00e-24	104.00
IUUC-Mtr-058002	Medicago truncatula	50.00	2.00e-41	162.00
IUUC-Mla-059007	Melampsora laricipopulina	44.39	6.00e-38	150.00
IUUC-Mga-059254	Meleagris gallopavo	98.89	3.00e-97	347.00
IUUC-Mvi-060346	Microbotryum violaceum	41.75	5.00e-32	130.00
IUUC-Mmr-061211	Microcebus murinus	92.93	1.00e-100	358.00
IUUC-Mdo-062458	Monodelphis domestica	91.92	5.00e-98	349.00
IUUC-Mmu-063648	Mus musculus	92.93	1.00e-100	358.00
IUUC-Mac-065447	Musa acuminata	50.54	1.00e-39	155.00
IUUC-Mpu-066407	Mustela putorius furo	92.93	6.00e-100	356.00
IUUC-Mlu-067682	Myotis lucifugus	92.42	2.00e-99	354.00
IUUC-Nfi-068517	Neosartorya fischeri	40.48	8.00e-27	113.00
IUUC-Ncr-068749	Neurospora crassa	48.34	2.00e-36	145.00
IUUC-Nle-069712	Nomascus leucogenys	98.34	2.00e-97	347.00
IUUC-Opr-070651	Ochotona princeps	92.93	1.00e-100	358.00
IUUC-Ont-071595	Oreochromis niloticus	89.39	1.00e-97	348.00
IUUC-Oan-073058	Ornithorhynchus anatinus	100.00	2.00e-78	284.00
IUUC-Ocu-074939	Oryctolagus cuniculus	92.93	1.00e-100	358.00
IUUC-Oba-075530	Oryza barthii	54.27	1.00e-29	122.00
IUUC-Obr-076838	Oryza brachyantha	53.99	4.00e-29	120.00
IUUC-Ogl-077606	Oryza glaberrima	54.27	1.00e-29	122.00
IUUC-Ogu-078238	Oryza glumaepatula	54.27	1.00e-29	122.00
IUUC-Oin-079643	Oryza indica	54.27	3.00e-29	121.00
IUUC-Ome-081274	Oryza meridionalis	54.27	1.00e-29	122.00
IUUC-Oni-082651	Oryza nivara	54.27	1.00e-29	122.00
IUUC-Opu-083933	Oryza punctata	54.27	2.00e-29	121.00
IUUC-Oru-085054	Oryza rufipogon	54.27	3.00e-29	121.00
IUUC-Osa-085716	Oryza sativa	54.27	3.00e-29	121.00
IUUC-Ola-087043	Oryzias latipes	89.39	1.00e-97	348.00
IUUC-Olu-087846	Ostreococcus lucimarinus	45.83	6.00e-42	163.00
IUUC-Oga-088897	Otolemur garnettii	97.84	3.00e-98	350.00
IUUC-Ptr-091295	Pan troglodytes	92.93	1.00e-100	358.00
IUUC-Pan-092034	Papio anubis	100.00	2.00e-97	347.00
IUUC-Psi-093498	Pelodiscus sinensis	92.93	1.00e-100	358.00
IUUC-Pma-094115	Petromyzon marinus	87.15	1.00e-84	305.00
IUUC-Pno-095102	Phaeosphaeria nodorum	41.50	3.00e-37	148.00
IUUC-Ppa-095326	Physcomitrella patens	48.85	2.00e-37	148.00
IUUC-Pfo-096940	Poecilia formosa	89.39	9.00e-98	348.00
IUUC-Pab-098279	Pongo abelii	92.93	1.00e-100	358.00
IUUC-Pop-099543	Populus trichocarpa	49.48	4.00e-43	167.00
IUUC-Pca-100782	Procavia capensis	92.42	1.00e-98	352.00
IUUC-Ppe-101789	Prunus persica	52.00	4.00e-36	144.00
IUUC-Pva-102147	Pteropus vampyrus	100.00	3.00e-52	197.00
IUUC-Pgr-103643	Puccinia graminis	43.83	5.00e-37	147.00
IUUC-Ptt-103772	Puccinia triticina	47.26	7.00e-36	144.00
IUUC-Pte-104370	Pyrenophora teres	51.01	1.00e-35	143.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	41.63	1.00e-35	143.00
IUUC-Rno-104984	Rattus norvegicus	92.93	1.00e-100	358.00
IUUC-Sce-106394	Saccharomyces cerevisiae	41.97	3.00e-34	137.00
IUUC-Sha-106848	Sarcophilus harrisii	97.85	2.00e-99	354.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	42.18	1.00e-38	153.00
IUUC-Smo-109656	Selaginella moellendorffii	50.87	2.00e-38	151.00
IUUC-Sit-110639	Setaria italica	52.41	3.00e-37	147.00
IUUC-Sly-110978	Solanum lycopersicum	48.96	1.00e-42	165.00
IUUC-Stu-112088	Solanum tuberosum	48.96	5.00e-43	167.00
IUUC-Sar-113285	Sorex araneus	84.36	4.00e-76	276.00
IUUC-Sbi-113986	Sorghum bicolor	52.41	3.00e-37	147.00
IUUC-Ssc-116314	Sus scrofa	92.93	1.00e-100	358.00
IUUC-Tgu-117427	Taeniopygia guttata	99.44	1.00e-97	347.00
IUUC-Tru-118618	Takifugu rubripes	84.85	5.00e-93	333.00
IUUC-Tsy-119208	Tarsius syrichta	92.96	9.00e-101	358.00
IUUC-Tni-119667	Tetraodon nigroviridis	89.90	4.00e-98	350.00
IUUC-Tca-121446	Theobroma cacao	51.67	4.00e-43	167.00
IUUC-Tre-122053	Trichoderma reesei	37.13	1.00e-30	126.00
IUUC-Tvi-122533	Trichoderma virens	36.32	5.00e-30	124.00
IUUC-Tae-124726	Triticum aestivum	48.96	8.00e-31	126.00
IUUC-Tme-127024	Tuber melanosporum	50.00	3.00e-39	154.00
IUUC-Tbe-127752	Tupaia belangeri	92.78	2.00e-98	350.00
IUUC-Ttr-128287	Tursiops truncatus	100.00	3.00e-97	347.00
IUUC-Uma-129512	Ustilago maydis	39.71	1.00e-35	142.00
IUUC-Vda-129947	Verticillium dahliae	42.20	9.00e-31	126.00
IUUC-Vpa-130481	Vicugna pacos	92.89	5.00e-100	356.00
IUUC-Vvi-131429	Vitis vinifera	47.40	4.00e-40	157.00
IUUC-Xtr-132710	Xenopus tropicalis	76.50	7.00e-87	312.00
IUUC-Xma-134165	Xiphophorus maculatus	88.89	3.00e-97	347.00
IUUC-Yli-134523	Yarrowia lipolytica	42.29	2.00e-33	135.00
IUUC-Zma-135733	Zea mays	51.12	1.00e-35	142.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence