iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000012837.3	ENSXETT00000054669.2	ENSXETP00000054669.2
ENSXETG00000012837.3	ENSXETT00000028042.1	ENSXETP00000028042.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.00e-33	115.2	8	148
UBD/Alpha-Helix/UBA	5.40e-10	39.3	163	201

Active Site

Position(s)	Description	Evidence
92	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkel...ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsi 85
           R+k+e+ke+   e++++++i++++vde ++ e++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+i
   Q: 8    RIKREFKEVlksEETSKNQIKVDLVDE-NFSELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDI 95
           7888888873335556699********.9***************************************************99******* PP
   S: 86   lkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lk++ +    ls+++ +++++s+ +    + p+  ++++++k+n+e++k+++r
   Q: 96   LKDQCASCHSLSLANFIITLCSVSRIGMRSLPQILQSSNQYKQNPEMFKQTAR 148
           *9555555689999*********999999*********************986 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL +  +++e A+e+Ll+
   Q: 163  EYTKKIENLCAMGFDRNAVIAALSSKAWDVETATELLLS 201
           6789*********************************97 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MANIAAQRIK REFKEVLKSE ETSKNQIKVD LVDENFSELR GEIAGPPDTP YEGGRYQLEI 60
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQC ASCHSLSLAN FIITLCSVSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGAACA TCGCAGCACA GAGGATCAAA AGGGAGTTCA AGGAGGTGCT CAAAAGCGAA 60
GAGGTGAGAG GAGACAGAAG TGCGTCTGGC TATATACAAT GAGGGGCAAC AATTGGTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	32.46	3.00e-28	117.00
IUUC-Aml-001286	Ailuropoda melanoleuca	83.17	2.00e-95	341.00
IUUC-Atr-003063	Amborella trichopoda	38.54	4.00e-31	127.00
IUUC-Apl-004122	Anas platyrhynchos	75.25	5.00e-82	296.00
IUUC-Aca-004565	Anolis carolinensis	77.60	8.00e-85	305.00
IUUC-Aly-006390	Arabidopsis lyrata	37.69	1.00e-33	135.00
IUUC-Ath-006637	Arabidopsis thaliana	36.36	4.00e-31	127.00
IUUC-Ame-011454	Astyanax mexicanus	80.20	6.00e-93	332.00
IUUC-Bta-012992	Bos taurus	83.17	2.00e-95	341.00
IUUC-Bdi-015024	Brachypodium distachyon	38.69	1.00e-32	132.00
IUUC-Bol-015985	Brassica oleracea	38.19	8.00e-34	136.00
IUUC-Bra-016805	Brassica rapa	38.19	3.00e-34	137.00
IUUC-Cel-018353	Caenorhabditis elegans	42.29	1.00e-45	175.00
IUUC-Cja-019051	Callithrix jacchus	82.67	2.00e-94	338.00
IUUC-Cfa-020016	Canis familiaris	83.17	2.00e-95	341.00
IUUC-Cpo-022026	Cavia porcellus	83.17	2.00e-95	341.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	40.72	5.00e-35	140.00
IUUC-Csa-023059	Chlorocebus sabaeus	83.17	2.00e-95	341.00
IUUC-Cho-024276	Choloepus hoffmanni	75.84	4.00e-61	226.00
IUUC-Cin-025598	Ciona intestinalis	47.98	5.00e-47	180.00
IUUC-Csv-025831	Ciona savignyi	48.48	1.00e-44	172.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	36.14	3.00e-28	117.00
IUUC-Dre-028139	Danio rerio	80.20	9.00e-93	332.00
IUUC-Dno-029169	Dasypus novemcinctus	76.73	2.00e-87	314.00
IUUC-Dor-030382	Dipodomys ordii	69.80	4.00e-75	273.00
IUUC-Dse-031335	Dothistroma septosporum	42.77	2.00e-30	125.00
IUUC-Dme-032003	Drosophila melanogaster	54.23	3.00e-58	217.00
IUUC-Ete-032868	Echinops telfairi	78.22	3.00e-86	310.00
IUUC-Eca-033428	Equus caballus	83.17	2.00e-95	341.00
IUUC-Eeu-035103	Erinaceus europaeus	70.00	7.00e-47	178.00
IUUC-Fca-035366	Felis catus	83.17	2.00e-95	341.00
IUUC-Fal-037016	Ficedula albicollis	83.17	2.00e-95	341.00
IUUC-Fso-038296	Fusarium solani	36.76	7.00e-30	123.00
IUUC-Gmo-039135	Gadus morhua	79.21	2.00e-91	327.00
IUUC-Gga-041018	Gallus gallus	82.67	4.00e-95	340.00
IUUC-Gac-041503	Gasterosteus aculeatus	79.70	3.00e-92	330.00
IUUC-Ggo-045032	Gorilla gorilla	83.17	2.00e-95	341.00
IUUC-Hsa-046490	Homo sapiens	83.17	2.00e-95	341.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	83.17	2.00e-95	341.00
IUUC-Lch-050588	Latimeria chalumnae	54.46	4.00e-63	233.00
IUUC-Lpe-051070	Leersia perrieri	38.19	5.00e-30	123.00
IUUC-Loc-052549	Lepisosteus oculatus	80.69	3.00e-93	333.00
IUUC-Laf-053688	Loxodonta africana	78.57	1.00e-85	308.00
IUUC-Mcc-055606	Macaca mulatta	83.17	2.00e-95	341.00
IUUC-Mga-059254	Meleagris gallopavo	80.77	1.00e-83	301.00
IUUC-Mmr-061211	Microcebus murinus	83.17	2.00e-95	341.00
IUUC-Mdo-062458	Monodelphis domestica	82.18	7.00e-93	332.00
IUUC-Mmu-063648	Mus musculus	83.17	2.00e-95	341.00
IUUC-Mac-065447	Musa acuminata	37.95	3.00e-30	124.00
IUUC-Mpu-066407	Mustela putorius furo	83.17	6.00e-95	340.00
IUUC-Mlu-067682	Myotis lucifugus	76.50	2.00e-85	307.00
IUUC-Ncr-068749	Neurospora crassa	41.77	1.00e-32	132.00
IUUC-Nle-069712	Nomascus leucogenys	80.77	2.00e-83	301.00
IUUC-Opr-070651	Ochotona princeps	83.17	2.00e-95	341.00
IUUC-Ont-071433	Oreochromis niloticus	80.69	2.00e-93	334.00
IUUC-Oan-073058	Ornithorhynchus anatinus	78.67	7.00e-65	238.00
IUUC-Ocu-074939	Oryctolagus cuniculus	83.17	2.00e-95	341.00
IUUC-Oba-075530	Oryza barthii	38.50	4.00e-29	120.00
IUUC-Obr-076838	Oryza brachyantha	38.00	2.00e-28	118.00
IUUC-Ogl-077606	Oryza glaberrima	38.50	4.00e-29	120.00
IUUC-Ogu-078238	Oryza glumaepatula	38.50	4.00e-29	120.00
IUUC-Oin-079643	Oryza indica	38.50	9.00e-29	119.00
IUUC-Ome-081274	Oryza meridionalis	38.50	4.00e-29	120.00
IUUC-Oni-082651	Oryza nivara	38.50	4.00e-29	120.00
IUUC-Opu-083933	Oryza punctata	38.50	9.00e-29	119.00
IUUC-Oru-085054	Oryza rufipogon	38.50	6.00e-29	120.00
IUUC-Osa-085716	Oryza sativa	38.50	9.00e-29	119.00
IUUC-Ola-087278	Oryzias latipes	79.70	2.00e-92	331.00
IUUC-Oga-088897	Otolemur garnettii	79.79	1.00e-85	308.00
IUUC-Oar-089673	Ovis aries	76.50	6.00e-87	312.00
IUUC-Ptr-091295	Pan troglodytes	83.17	2.00e-95	341.00
IUUC-Pan-092034	Papio anubis	81.77	2.00e-83	301.00
IUUC-Psi-093498	Pelodiscus sinensis	83.17	2.00e-95	341.00
IUUC-Pma-094115	Petromyzon marinus	68.16	5.00e-76	276.00
IUUC-Pfo-096940	Poecilia formosa	80.69	2.00e-93	334.00
IUUC-Pab-098279	Pongo abelii	83.17	2.00e-95	341.00
IUUC-Pca-100782	Procavia capensis	82.67	2.00e-93	334.00
IUUC-Pva-102147	Pteropus vampyrus	53.93	7.00e-44	169.00
IUUC-Rno-104984	Rattus norvegicus	83.17	2.00e-95	341.00
IUUC-Sha-106624	Sarcophilus harrisii	77.23	1.00e-89	322.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	35.16	2.00e-31	128.00
IUUC-Smo-109656	Selaginella moellendorffii	39.69	5.00e-31	127.00
IUUC-Sit-110639	Setaria italica	39.00	8.00e-32	129.00
IUUC-Sar-113285	Sorex araneus	66.85	1.00e-63	234.00
IUUC-Sbi-113986	Sorghum bicolor	39.00	1.00e-31	129.00
IUUC-Ssc-116314	Sus scrofa	83.17	2.00e-95	341.00
IUUC-Tgu-117427	Taeniopygia guttata	81.32	7.00e-84	302.00
IUUC-Tru-118618	Takifugu rubripes	75.74	3.00e-88	317.00
IUUC-Tsy-119208	Tarsius syrichta	81.00	7.00e-92	329.00
IUUC-Tni-119667	Tetraodon nigroviridis	80.20	1.00e-92	332.00
IUUC-Tca-121446	Theobroma cacao	38.97	3.00e-34	137.00
IUUC-Tae-125119	Triticum aestivum	37.69	3.00e-30	124.00
IUUC-Tme-127024	Tuber melanosporum	40.79	8.00e-32	130.00
IUUC-Tbe-127752	Tupaia belangeri	79.70	2.00e-90	324.00
IUUC-Ttr-128287	Tursiops truncatus	81.77	9.00e-84	301.00
IUUC-Vpa-130481	Vicugna pacos	82.91	1.00e-93	334.00
IUUC-Xma-134308	Xiphophorus maculatus	80.20	5.00e-93	333.00
IUUC-Zma-135733	Zea mays	38.10	9.00e-31	126.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence