iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094662

UUCD1 version

UUC-PeM-00429

Ensembl Protein ID

ENSPMAP00000004038.1

UniProt Accession

S4RFQ6; S4RFQ6_PETMA

Protein Name

Uncharacterized protein

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000003700.1	ENSPMAT00000004055.1	ENSPMAP00000004038.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-90	302.1	267	611

Active Site

Position(s)	Description	Evidence
579	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           +d+ +++ev+f++Ee+ld gG+ re+++l++k+l++p ++lf  + +++++ ++pnp++ ++   +l+l+e++Grl+gk+l++      
   Q: 267  NDWFRSFEVTFENEEALDRGGPRREWFELMCKALFEPANKLFtHFVDDNQALVHPNPHRPHH--MRLRLYELAGRLVGKCLFETslgdt 353
           57778899**********************************5556669999*******975..8******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsl..edleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
             +l+++++++sf+ +l+g  + +    +e+ dpe+yk+ + ++++n   d++e++l+l+ +v +e+ +  + ++L+pgG+ i Vtn+N
   Q: 354  yrQLVRARFTRSFLAQLIGLHVRFlyFYFETDDPEFYKTkVSFVLNN---DVSEMDLTLSEEVYDEQGKLSQLVDLVPGGSGIGVTNAN 439
           999***************9987765699***********89999988...*************************************** PP
   S: 170  keeYvklvveyrlkegikeqveafr.....eGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwev 252
           k +Y + +++yrl ++++++ve+f      +G+ne++p++ll++F+e+ele+l+cG+e+i+v+d+k+++      ++ ++++i wFw v
   Q: 440  KLAYLNVLAQYRLATQVRTEVEHFLkvlsiKGLNEMVPENLLAIFDENELEMLMCGTEDISVDDFKANAvLVGASWHFRKKVILWFWAV 528
           ************************7344446**************************************555888************** PP
   S: 253  leefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +++f++ee +++LqF Tgss lP gGfa+l+p + +++   ++  lP+++TCfn+L+LP+Y+s e+l+++L+yAi+e+ +gF+l
   Q: 529  VSSFTQEELARLLQFSTGSSLLPTGGFAALSPPFQIVSS-PKHGTLPTAHTCFNQLCLPTYDSCEELHKMLRYAITEGsEGFGL 611
           *******************************99555555.9*****************************************97 PP

Organism

Petromyzon marinus

Protein Sequence
(Fasta)

GVCYSYELHA SPALCQLSLR VEVQHVGCFR ARIAHRGGQP LANGDFDIIV LTDEEVAQVD 60
KSVQRTGLSV YHEAFLQQVP SYAHVHWALP DCGPPTGPPE SPPATPGPSA AATWPPSLPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGTGTGCT ACTCGTATGA GTTGCACGCG TCACCTGCAC TCTGCCAGCT GTCGCTGCGT 60
GTTGAGGTGC AGCACGTGGG CTGCTTCCGC GCCCGCATCG CCCACCGCGG GGGCCAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	61.44	0.00e+00	746.00
IUUC-Apl-004071	Anas platyrhynchos	63.21	0.00e+00	741.00
IUUC-Aca-005218	Anolis carolinensis	63.21	0.00e+00	743.00
IUUC-Ame-011871	Astyanax mexicanus	62.13	0.00e+00	783.00
IUUC-Bta-012978	Bos taurus	60.95	0.00e+00	740.00
IUUC-Cja-019081	Callithrix jacchus	61.27	0.00e+00	744.00
IUUC-Cfa-020736	Canis familiaris	62.54	0.00e+00	743.00
IUUC-Cpo-021581	Cavia porcellus	61.76	0.00e+00	750.00
IUUC-Cho-024751	Choloepus hoffmanni	61.11	0.00e+00	742.00
IUUC-Cin-025773	Ciona intestinalis	43.83	5.00e-133	466.00
IUUC-Csv-026090	Ciona savignyi	42.60	4.00e-136	477.00
IUUC-Dre-027788	Danio rerio	62.56	0.00e+00	782.00
IUUC-Dno-030022	Dasypus novemcinctus	61.44	0.00e+00	748.00
IUUC-Dme-031577	Drosophila melanogaster	47.47	9.00e-158	549.00
IUUC-Ete-032402	Echinops telfairi	59.64	0.00e+00	711.00
IUUC-Eca-033908	Equus caballus	61.44	0.00e+00	746.00
IUUC-Eeu-034869	Erinaceus europaeus	69.57	0.00e+00	669.00
IUUC-Fca-036023	Felis catus	61.44	0.00e+00	745.00
IUUC-Fal-037477	Ficedula albicollis	63.55	0.00e+00	754.00
IUUC-Gmo-039197	Gadus morhua	61.58	0.00e+00	761.00
IUUC-Gga-040704	Gallus gallus	63.21	0.00e+00	742.00
IUUC-Gac-041511	Gasterosteus aculeatus	61.64	0.00e+00	778.00
IUUC-Ggo-044527	Gorilla gorilla	58.01	0.00e+00	688.00
IUUC-Hsa-046082	Homo sapiens	61.27	0.00e+00	743.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	61.44	0.00e+00	743.00
IUUC-Lch-049772	Latimeria chalumnae	57.02	0.00e+00	670.00
IUUC-Loc-052541	Lepisosteus oculatus	62.62	0.00e+00	787.00
IUUC-Laf-053852	Loxodonta africana	61.60	0.00e+00	745.00
IUUC-Meu-056247	Macropus eugenii	44.41	2.00e-69	255.00
IUUC-Mga-060161	Meleagris gallopavo	63.21	0.00e+00	742.00
IUUC-Mmr-061447	Microcebus murinus	61.21	0.00e+00	741.00
IUUC-Mdo-062110	Monodelphis domestica	61.71	0.00e+00	736.00
IUUC-Mmu-064349	Mus musculus	61.05	0.00e+00	739.00
IUUC-Mpu-065824	Mustela putorius furo	61.44	0.00e+00	747.00
IUUC-Mlu-067729	Myotis lucifugus	60.95	0.00e+00	738.00
IUUC-Nle-069721	Nomascus leucogenys	61.27	0.00e+00	745.00
IUUC-Opr-070189	Ochotona princeps	62.21	0.00e+00	739.00
IUUC-Ont-072122	Oreochromis niloticus	63.22	0.00e+00	780.00
IUUC-Oan-072700	Ornithorhynchus anatinus	59.13	0.00e+00	666.00
IUUC-Ocu-074057	Oryctolagus cuniculus	61.21	0.00e+00	743.00
IUUC-Ola-087492	Oryzias latipes	61.41	0.00e+00	773.00
IUUC-Oga-088084	Otolemur garnettii	61.11	0.00e+00	736.00
IUUC-Oar-090354	Ovis aries	61.19	0.00e+00	727.00
IUUC-Ptr-091456	Pan troglodytes	61.11	0.00e+00	739.00
IUUC-Pan-092596	Papio anubis	59.97	0.00e+00	720.00
IUUC-Psi-092942	Pelodiscus sinensis	63.38	0.00e+00	748.00
IUUC-Pfo-096838	Poecilia formosa	62.71	0.00e+00	763.00
IUUC-Pab-097849	Pongo abelii	60.95	0.00e+00	739.00
IUUC-Pca-100498	Procavia capensis	68.95	9.00e-69	253.00
IUUC-Pva-102599	Pteropus vampyrus	61.76	0.00e+00	746.00
IUUC-Rno-105776	Rattus norvegicus	61.54	0.00e+00	745.00
IUUC-Sha-106699	Sarcophilus harrisii	62.71	0.00e+00	746.00
IUUC-Sar-113621	Sorex araneus	60.95	0.00e+00	736.00
IUUC-Ssc-115742	Sus scrofa	61.60	0.00e+00	745.00
IUUC-Tgu-116490	Taeniopygia guttata	63.38	0.00e+00	754.00
IUUC-Tru-117679	Takifugu rubripes	62.23	0.00e+00	766.00
IUUC-Tsy-119607	Tarsius syrichta	58.99	0.00e+00	701.00
IUUC-Tni-120376	Tetraodon nigroviridis	63.05	0.00e+00	774.00
IUUC-Tbe-127348	Tupaia belangeri	70.00	8.00e-73	266.00
IUUC-Ttr-128786	Tursiops truncatus	68.69	0.00e+00	645.00
IUUC-Vpa-130180	Vicugna pacos	56.48	3.00e-142	497.00
IUUC-Xtr-132631	Xenopus tropicalis	59.13	0.00e+00	713.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence