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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045972
Ensembl Protein ID ENSP00000368565.3
UniProt Accession Q99543; A4VCI0; Q9BVX1; DNJC2_HUMAN
Genbank Protein ID CAA66913.1; AAH00859.1; AAI39752.1
Protein Name DnaJ homolog subfamily C member 2; M-phase phosphoprotein 11; Zuotin-related factor 1; DnaJ homolog subfamily C member 2, N-terminally processed
Genbank Nucleotide ID X98260; AC004668; BC139751
Gene Name DNAJC2; MPHOSPH11; MPP11; ZRF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000105821.14 ENST00000249270.11 ENSP00000249270.7
ENSG00000105821.14 ENST00000379263.7 ENSP00000368565.3
ENSG00000105821.14 ENST00000426036.6 ENSP00000412611.2
ENSG00000105821.14 ENST00000379257.7 ENSP00000368559.3
ENSG00000105821.14 ENST00000412522.1 ENSP00000406275.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Other/Other UBD/Other/Other 21179169; 25665097
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/Other/Other 94.20 0.00e+00 926.00 IUUC-Mmu-063361
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
 Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
Protein Sequence
(Fasta)
MLLLPSAADG RGTAITHALT SASTLCQVEP VGRWFEAFVK RRNRNASASF QELEDKKELS 60
EESEDEELQL EEFPMLKTLD PKDWKNQDHY AVLGLGHVRY KATQRQIKAA HKAMVLKHHP 120
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Protein Fasta Sequence


>IUUC-Hsa-045972|UBD,UBD/Other/Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGCCGGATCT CAGTCAGTAT AGAACTAGGT TACCGCACAC GTTGGCGGGG GTGGGAGGGT 60
GTGAGACTGG CCTCCACACC ACGAAAGATC CATCCCGGAA GTGCTTACTG GTCGTCTCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045972|UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR001623--DnaJ_domain
IPR018253--DnaJ_domain_CS
IPR009057--Homeobox-like
IPR032003--RAC_head
IPR001005--SANT/Myb
IPR017884--SANT_dom
PROSITE

PS00636--DNAJ_1
PS50076--DNAJ_2
PS51293--SANT
Pfam

PF00226--DnaJ
PF00249--Myb_DNA-binding
PF16717--RAC_head
SMART

SM00271--DnaJ
SM00717--SANT
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0001671--F:ATPase activator activity
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0030544--F:Hsp70 protein binding
GO:0003723--F:RNA binding
GO:0043130--F:ubiquitin binding
GO:0051083--P:'de novo' cotranslational protein folding
GO:0016569--P:covalent chromatin modification
GO:0006260--P:DNA replication
GO:2000279--P:negative regulation of DNA biosynthetic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:1900034--P:regulation of cellular response to heat
GO:0006351--P:transcription, DNA-templated
KEGG hsa:27000
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000523 Aegilops tauschii 48.02 6.00e-51 195.00
IUUC-Aml-001384 Ailuropoda melanoleuca 97.58 0.00e+00 944.00
IUUC-Atr-002863 Amborella trichopoda 49.02 3.00e-52 199.00
IUUC-Apl-004102 Anas platyrhynchos 90.08 1.00e-122 433.00
IUUC-Aca-004586 Anolis carolinensis 87.52 0.00e+00 842.00
IUUC-Aly-006535 Arabidopsis lyrata 47.32 2.00e-48 187.00
IUUC-Ath-007402 Arabidopsis thaliana 47.80 4.00e-50 192.00
IUUC-Afl-008435 Aspergillus flavus 48.66 4.00e-57 215.00
IUUC-Afu-008810 Aspergillus fumigatus 46.97 2.00e-56 213.00
IUUC-Ani-009141 Aspergillus nidulans 48.28 3.00e-56 213.00
IUUC-Aor-010002 Aspergillus oryzae 48.66 4.00e-57 215.00
IUUC-Ame-011909 Astyanax mexicanus 82.73 1.00e-115 410.00
IUUC-Bta-012870 Bos taurus 97.91 0.00e+00 994.00
IUUC-Bci-013889 Botrytis cinerea 45.86 3.00e-54 206.00
IUUC-Bdi-014225 Brachypodium distachyon 48.51 5.00e-52 199.00
IUUC-Bol-015562 Brassica oleracea 47.80 2.00e-50 194.00
IUUC-Bra-017547 Brassica rapa 47.80 3.00e-51 196.00
IUUC-Cel-018685 Caenorhabditis elegans 41.67 4.00e-79 288.00
IUUC-Cja-019293 Callithrix jacchus 98.39 0.00e+00 974.00
IUUC-Cfa-020528 Canis familiaris 90.11 0.00e+00 887.00
IUUC-Cpo-022171 Cavia porcellus 84.47 0.00e+00 847.00
IUUC-Cre-022887 Chlamydomonas reinhardtii 48.72 4.00e-48 186.00
IUUC-Csa-023129 Chlorocebus sabaeus 98.87 0.00e+00 998.00
IUUC-Cho-025056 Choloepus hoffmanni 80.57 0.00e+00 756.00
IUUC-Cin-025527 Ciona intestinalis 60.29 6.00e-68 251.00
IUUC-Cgl-026448 Colletotrichum gloeosporioides 43.98 2.00e-43 170.00
IUUC-Cme-027325 Cyanidioschyzon merolae 37.37 9.00e-29 122.00
IUUC-Dre-028808 Danio rerio 75.99 0.00e+00 753.00
IUUC-Dno-029938 Dasypus novemcinctus 97.11 0.00e+00 934.00
IUUC-Dor-030802 Dipodomys ordii 76.92 2.00e-95 343.00
IUUC-Dme-031862 Drosophila melanogaster 60.49 2.00e-74 273.00
IUUC-Ete-032900 Echinops telfairi 95.65 5.00e-103 368.00
IUUC-Eca-034311 Equus caballus 97.58 0.00e+00 956.00
IUUC-Eeu-034969 Erinaceus europaeus 80.00 4.00e-115 408.00
IUUC-Fca-036146 Felis catus 98.55 0.00e+00 961.00
IUUC-Fal-036866 Ficedula albicollis 87.58 0.00e+00 812.00
IUUC-Fox-038071 Fusarium oxysporum 41.55 5.00e-45 175.00
IUUC-Gmo-039191 Gadus morhua 72.35 0.00e+00 723.00
IUUC-Gga-040158 Gallus gallus 87.88 0.00e+00 814.00
IUUC-Gac-041990 Gasterosteus aculeatus 76.89 0.00e+00 753.00
IUUC-Gma-043759 Glycine max 47.80 1.00e-51 197.00
IUUC-Ggo-045049 Gorilla gorilla 99.26 7.00e-139 487.00
IUUC-Hvu-047309 Hordeum vulgare 47.50 4.00e-50 192.00
IUUC-Itr-048875 Ictidomys tridecemlineatus 97.99 0.00e+00 874.00
IUUC-Kpa-049255 Komagataella pastoris 41.07 1.00e-47 184.00
IUUC-Lch-049756 Latimeria chalumnae 85.05 0.00e+00 805.00
IUUC-Lpe-051235 Leersia perrieri 45.77 5.00e-47 182.00
IUUC-Loc-052580 Lepisosteus oculatus 72.36 4.00e-83 301.00
IUUC-Laf-054095 Loxodonta africana 97.26 0.00e+00 990.00
IUUC-Mcc-054797 Macaca mulatta 94.35 0.00e+00 941.00
IUUC-Meu-056077 Macropus eugenii 96.45 7.00e-89 321.00
IUUC-Mpo-057559 Magnaporthe poae 45.83 6.00e-52 198.00
IUUC-Mtr-058690 Medicago truncatula 48.76 2.00e-50 194.00
IUUC-Mga-059854 Meleagris gallopavo 87.03 0.00e+00 800.00
IUUC-Mmr-061638 Microcebus murinus 97.75 0.00e+00 992.00
IUUC-Mdo-062704 Monodelphis domestica 90.71 1.00e-134 473.00
IUUC-Mmu-063361 Mus musculus 94.20 0.00e+00 993.00
IUUC-Mac-065182 Musa acuminata 48.42 1.00e-48 187.00
IUUC-Mpu-065792 Mustela putorius furo 98.87 0.00e+00 969.00
IUUC-Mlu-067874 Myotis lucifugus 98.07 0.00e+00 953.00
IUUC-Nle-069392 Nomascus leucogenys 99.36 0.00e+00 941.00
IUUC-Opr-070583 Ochotona princeps 98.45 6.00e-130 457.00
IUUC-Ont-071387 Oreochromis niloticus 79.35 8.00e-111 394.00
IUUC-Oan-073081 Ornithorhynchus anatinus 89.02 2.00e-133 469.00
IUUC-Ocu-074901 Oryctolagus cuniculus 98.55 0.00e+00 981.00
IUUC-Oba-075416 Oryza barthii 48.28 9.00e-51 195.00
IUUC-Obr-076383 Oryza brachyantha 48.00 3.00e-50 193.00
IUUC-Ogl-077602 Oryza glaberrima 25.00 8.00e-14 70.90
IUUC-Ogu-078774 Oryza glumaepatula 48.00 4.00e-51 196.00
IUUC-Oin-079255 Oryza indica 44.25 2.00e-20 94.40
IUUC-Olo-080628 Oryza longistaminata 48.00 6.00e-51 195.00
IUUC-Ome-081488 Oryza meridionalis 48.00 5.00e-51 196.00
IUUC-Oni-082149 Oryza nivara 47.13 1.00e-40 161.00
IUUC-Opu-083627 Oryza punctata 47.50 1.00e-50 194.00
IUUC-Oru-084567 Oryza rufipogon 48.00 7.00e-51 195.00
IUUC-Osa-086150 Oryza sativa 24.21 2.00e-13 69.30
IUUC-Ola-086782 Oryzias latipes 80.13 4.00e-69 253.00
IUUC-Olu-087582 Ostreococcus lucimarinus 41.54 4.00e-33 134.00
IUUC-Oga-089051 Otolemur garnettii 96.78 0.00e+00 937.00
IUUC-Oar-090356 Ovis aries 98.07 0.00e+00 994.00
IUUC-Ptr-090858 Pan troglodytes 99.68 0.00e+00 976.00
IUUC-Pan-091826 Papio anubis 98.87 0.00e+00 996.00
IUUC-Psi-094066 Pelodiscus sinensis 88.21 0.00e+00 816.00
IUUC-Ppa-095598 Physcomitrella patens 48.48 2.00e-48 187.00
IUUC-Pfo-097101 Poecilia formosa 80.29 9.00e-114 404.00
IUUC-Pab-098089 Pongo abelii 98.71 0.00e+00 949.00
IUUC-Pop-099771 Populus trichocarpa 47.76 9.00e-52 198.00
IUUC-Pca-100615 Procavia capensis 86.97 0.00e+00 680.00
IUUC-Ppe-101366 Prunus persica 48.77 3.00e-52 199.00
IUUC-Pva-102536 Pteropus vampyrus 96.67 1.00e-135 476.00
IUUC-Pgr-103582 Puccinia graminis 52.43 1.00e-53 203.00
IUUC-Ptt-103970 Puccinia triticina 51.48 3.00e-45 176.00
IUUC-Pte-104323 Pyrenophora teres 46.90 2.00e-53 203.00
IUUC-Rno-105279 Rattus norvegicus 93.72 0.00e+00 993.00
IUUC-Sha-107457 Sarcophilus harrisii 92.14 3.00e-136 478.00
IUUC-Sja-107842 Schizosaccharomyces japonicus 43.77 2.00e-44 173.00
IUUC-Spo-108041 Schizosaccharomyces pombe 48.15 1.00e-54 207.00
IUUC-Ssl-108474 Sclerotinia sclerotiorum 44.78 1.00e-43 171.00
IUUC-Smo-109454 Selaginella moellendorffii 52.28 2.00e-54 207.00
IUUC-Sit-110667 Setaria italica 48.51 7.00e-51 195.00
IUUC-Sly-111760 Solanum lycopersicum 44.25 1.00e-41 164.00
IUUC-Stu-112803 Solanum tuberosum 45.81 2.00e-50 193.00
IUUC-Sar-113066 Sorex araneus 72.30 0.00e+00 699.00
IUUC-Sbi-114777 Sorghum bicolor 48.00 4.00e-50 192.00
IUUC-Ssc-115941 Sus scrofa 98.39 0.00e+00 998.00
IUUC-Tgu-116799 Taeniopygia guttata 89.05 0.00e+00 800.00
IUUC-Tru-118137 Takifugu rubripes 80.71 3.00e-107 382.00
IUUC-Tsy-118984 Tarsius syrichta 97.42 0.00e+00 966.00
IUUC-Tni-120898 Tetraodon nigroviridis 80.22 4.00e-114 405.00
IUUC-Tca-120925 Theobroma cacao 47.29 1.00e-51 197.00
IUUC-Tvi-122560 Trichoderma virens 43.40 4.00e-54 205.00
IUUC-Tae-123257 Triticum aestivum 48.02 7.00e-51 195.00
IUUC-Tur-126859 Triticum urartu 48.02 2.00e-50 194.00
IUUC-Tme-127035 Tuber melanosporum 39.31 3.00e-62 232.00
IUUC-Tbe-127978 Tupaia belangeri 87.86 2.00e-122 432.00
IUUC-Ttr-128247 Tursiops truncatus 90.34 0.00e+00 865.00
IUUC-Uma-129601 Ustilago maydis 55.88 5.00e-55 208.00
IUUC-Vda-129704 Verticillium dahliae 44.15 6.00e-49 188.00
IUUC-Vpa-130249 Vicugna pacos 88.48 0.00e+00 825.00
IUUC-Vvi-131626 Vitis vinifera 48.28 9.00e-53 201.00
IUUC-Xtr-132927 Xenopus tropicalis 80.90 5.00e-127 448.00
IUUC-Xma-133433 Xiphophorus maculatus 78.46 0.00e+00 717.00
IUUC-Zma-135295 Zea mays 49.01 1.00e-51 197.00
Created Date 25-Jun-2017

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