iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020258

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03016159

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000015977.3	ENSCAFT00000025378.3	ENSCAFP00000023564.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-134	447.8	991	1320

Active Site

Position(s)	Description	Evidence
1290	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 991  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1077
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1078 FFIRPFYKMMLHKPITLHDMESVDGEYYNSLRWILEN---DPTE--LDLRFVIDEELFGQTHQHELKIGGSEIVVTNKNKKEYIYLV 1159
           ***********************************99...6666..79*************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r ++
   Q: 1160 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRL 1246
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1247 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1320
           *************************************************************************8 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ETSGDDLDSN VHMCFKRPTR ISTSNVVQMK LTPRQTALAP 60
LIQENVNSQE RSSVPSPENV NKKSSCLQIS LQPTRYSGCL QSGNVLADGD DASFTSVFKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA TCCTTTGTCA 60
GAAACCTCCG GAGATGATTT GGATAGCAAT GTTCACATGT GCTTCAAAAG ACCAACACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

cfa:608738

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	94.10	0.00e+00	2462.00
IUUC-Apl-003886	Anas platyrhynchos	76.76	0.00e+00	1287.00
IUUC-Ame-011138	Astyanax mexicanus	83.75	0.00e+00	853.00
IUUC-Bgr-012148	Blumeria graminis	46.86	5.00e-155	541.00
IUUC-Bta-012453	Bos taurus	90.30	0.00e+00	2323.00
IUUC-Bci-013785	Botrytis cinerea	47.36	5.00e-158	551.00
IUUC-Cja-019034	Callithrix jacchus	93.90	0.00e+00	1415.00
IUUC-Cpo-021648	Cavia porcellus	89.17	0.00e+00	1464.00
IUUC-Csa-023334	Chlorocebus sabaeus	95.39	0.00e+00	1508.00
IUUC-Cho-024672	Choloepus hoffmanni	82.88	0.00e+00	710.00
IUUC-Cin-025157	Ciona intestinalis	55.60	0.00e+00	880.00
IUUC-Csv-026098	Ciona savignyi	58.61	0.00e+00	657.00
IUUC-Dno-029159	Dasypus novemcinctus	89.68	0.00e+00	1332.00
IUUC-Dor-030729	Dipodomys ordii	79.11	0.00e+00	1055.00
IUUC-Dme-032166	Drosophila melanogaster	67.78	0.00e+00	712.00
IUUC-Ete-032409	Echinops telfairi	85.68	0.00e+00	1194.00
IUUC-Eca-033441	Equus caballus	96.14	0.00e+00	1475.00
IUUC-Eeu-034546	Erinaceus europaeus	78.06	0.00e+00	1199.00
IUUC-Fca-036384	Felis catus	94.72	0.00e+00	2454.00
IUUC-Fal-037547	Ficedula albicollis	81.02	0.00e+00	1326.00
IUUC-Gmo-039679	Gadus morhua	68.20	0.00e+00	1093.00
IUUC-Gga-040524	Gallus gallus	82.63	0.00e+00	1331.00
IUUC-Hsa-046479	Homo sapiens	91.76	0.00e+00	2368.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	83.13	0.00e+00	1224.00
IUUC-Lch-050445	Latimeria chalumnae	60.09	0.00e+00	1477.00
IUUC-Loc-052645	Lepisosteus oculatus	73.96	0.00e+00	1207.00
IUUC-Laf-053638	Loxodonta africana	84.06	0.00e+00	1357.00
IUUC-Mcc-055585	Macaca mulatta	91.53	0.00e+00	2339.00
IUUC-Meu-056897	Macropus eugenii	95.12	1.00e-170	593.00
IUUC-Mla-058996	Melampsora laricipopulina	46.39	3.00e-153	535.00
IUUC-Mga-059362	Meleagris gallopavo	76.01	0.00e+00	1298.00
IUUC-Mvi-060395	Microbotryum violaceum	53.58	5.00e-150	525.00
IUUC-Mmr-061061	Microcebus murinus	91.77	0.00e+00	2373.00
IUUC-Mmu-063318	Mus musculus	80.20	0.00e+00	1287.00
IUUC-Mpu-066567	Mustela putorius furo	96.65	0.00e+00	1580.00
IUUC-Mlu-068148	Myotis lucifugus	89.35	0.00e+00	2298.00
IUUC-Nle-069225	Nomascus leucogenys	91.46	0.00e+00	2356.00
IUUC-Oan-073019	Ornithorhynchus anatinus	85.09	0.00e+00	1389.00
IUUC-Ocu-074409	Oryctolagus cuniculus	87.32	0.00e+00	2232.00
IUUC-Oga-088241	Otolemur garnettii	86.12	0.00e+00	2124.00
IUUC-Oar-089797	Ovis aries	94.28	0.00e+00	1526.00
IUUC-Ptr-091629	Pan troglodytes	94.44	0.00e+00	1389.00
IUUC-Psi-093618	Pelodiscus sinensis	68.61	0.00e+00	1668.00
IUUC-Pfo-097145	Poecilia formosa	68.98	0.00e+00	1076.00
IUUC-Pab-098394	Pongo abelii	95.02	0.00e+00	1516.00
IUUC-Pca-100568	Procavia capensis	77.90	0.00e+00	1155.00
IUUC-Rno-106095	Rattus norvegicus	79.70	0.00e+00	1281.00
IUUC-Sha-107370	Sarcophilus harrisii	67.40	0.00e+00	1771.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.71	2.00e-157	549.00
IUUC-Spo-108171	Schizosaccharomyces pombe	49.56	4.00e-162	565.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.33	1.00e-158	553.00
IUUC-Sre-114929	Sporisorium reilianum	47.18	8.00e-155	540.00
IUUC-Tgu-117474	Taeniopygia guttata	81.51	0.00e+00	1334.00
IUUC-Tru-117675	Takifugu rubripes	65.55	0.00e+00	1077.00
IUUC-Tre-122203	Trichoderma reesei	46.81	3.00e-154	539.00
IUUC-Tvi-122595	Trichoderma virens	46.58	8.00e-155	540.00
IUUC-Tbe-127408	Tupaia belangeri	86.83	0.00e+00	1166.00
IUUC-Ttr-128437	Tursiops truncatus	86.12	0.00e+00	1211.00
IUUC-Vpa-130503	Vicugna pacos	88.87	0.00e+00	1310.00
IUUC-Xtr-132431	Xenopus tropicalis	70.87	0.00e+00	1207.00
IUUC-Xma-133630	Xiphophorus maculatus	65.93	0.00e+00	1053.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence