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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106186
UUCD1 version UUC-SaC-00112
Ensembl Protein ID YBR198C
UniProt Accession P38129; D6VQJ4; TAF5_YEAST
Genbank Protein ID CAA79685.1; CAA85160.1; AAT92909.1; DAA07314.1
Protein Name Transcription initiation factor TFIID subunit 5; TAFII-90; TBP-associated factor 5; TBP-associated factor 90 kDa
Genbank Nucleotide ID Z21487; Z36067; AY692890; BK006936
Gene Name TAF5; TAF90; YBR198C; YBR1410
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YBR198C YBR198C YBR198C
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.10e-38 125.7 523 558
UBD/Beta-Prp 7.40e-68 227.3 461 728
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH++ v++ +f +d ++l+sGs D+t+++W+++t++
   Q: 523  GHSGTVYSTSFsPDnKYLLSGSEDKTVRLWSMDTHT 558
           8***********998****************99886 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.................lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcv 87
           t+++++k+  +c++fs+d ++ a+g++d+ ik+w+++  +l                  ++l gh+++v++++fspd k+l++gseD+t+++w+++t + +
   Q: 461  TFQNTNKDM-SCLDFSDDCRIAAAGFQDSYIKIWSLDGSSLnnpnialnnndkdedptCKTLVGHSGTVYSTSFSPDNKYLLSGSEDKTVRLWSMDTHTAL 560
           566666655.56***************************************************************************************** PP
   S: 88   htlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
           +++kgh++ v+++sfsp g++++++shd+t+r+w  ++ + l+ +++gh   v cv++hp+g+++++Gs D+t+r+Wd++tg+ +r + g ht +v s+++
   Q: 561  VSYKGHNHPVWDVSFSPLGHYFATASHDQTARLWSCDHIYPLR-IFAGHLNDVDCVSFHPNGCYVFTGSSDKTCRMWDVSTGDSVRLFLG-HTAPVISIAV 659
           *******************************************.*********************************************9.********** PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnght.dnvksvrfspnderlvsgssDgsiriWdlrsgdl 256
            ++g+ l +gs+dg +++wd+ tg+ +++++gh  + ++s+  s++++ l+sg++D ++r+Wdl++ ++
   Q: 660  CPDGRWLSTGSEDGIINVWDIGTGKRLKQMRGHGkNAIYSLSYSKEGNVLISGGADHTVRVWDLKKATT 728
           ********************************964789***************************9876 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
 Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
Protein Sequence
(Fasta)
MSQKQSTNQN QNGTHQPQPV KNQRTNNAAG ANSGQQPQQQ SQGQSQQQGR SNGPFSASDL 60
NRIVLEYLNK KGYHRTEAML RAESGRTLTP QNKQSPANTK TGKFPEQSSI PPNPGKTAKP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106186|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCACAGA AGCAAAGTAC GAATCAGAAT CAAAATGGCA CGCATCAGCC ACAACCAGTA 60
AAGAATCAAC GAACTAATAA TGCTGCTGGC GCCAATTCCG GCCAGCAGCC ACAGCAACAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106186|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR007582--TFIID_NTD2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08513--LisH
PF04494--TFIID_NTD2
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0000124--C:SAGA complex
GO:0046695--C:SLIK (SAGA-like) complex
GO:0005669--C:transcription factor TFIID complex
GO:0003682--F:chromatin binding
GO:0042802--F:identical protein binding
GO:0032947--F:protein complex scaffold
GO:0043130--F:ubiquitin binding
GO:0006325--P:chromatin organization
GO:0016573--P:histone acetylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0051123--P:RNA polymerase II transcriptional preinitiation complex assembly
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG sce:YBR198C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000261 Aegilops tauschii 39.39 3.00e-69 254.00
IUUC-Aml-001607 Ailuropoda melanoleuca 42.86 2.00e-91 328.00
IUUC-Atr-003136 Amborella trichopoda 41.34 2.00e-87 314.00
IUUC-Apl-004193 Anas platyrhynchos 43.32 5.00e-92 329.00
IUUC-Aca-004522 Anolis carolinensis 41.81 4.00e-90 323.00
IUUC-Aly-006476 Arabidopsis lyrata 34.24 4.00e-98 350.00
IUUC-Ath-006587 Arabidopsis thaliana 34.60 8.00e-99 352.00
IUUC-Ago-007736 Ashbya gossypii 62.37 0.00e+00 943.00
IUUC-Acl-008092 Aspergillus clavatus 34.47 1.00e-131 461.00
IUUC-Afl-008659 Aspergillus flavus 34.88 3.00e-132 463.00
IUUC-Afu-008902 Aspergillus fumigatus 34.63 2.00e-129 454.00
IUUC-Ani-009462 Aspergillus nidulans 35.38 3.00e-114 403.00
IUUC-Aor-010083 Aspergillus oryzae 34.88 3.00e-132 463.00
IUUC-Ate-010271 Aspergillus terreus 34.68 3.00e-131 460.00
IUUC-Ame-010721 Astyanax mexicanus 42.32 2.00e-91 328.00
IUUC-Bgr-012257 Blumeria graminis 32.71 4.00e-111 393.00
IUUC-Bta-013539 Bos taurus 42.86 2.00e-91 327.00
IUUC-Bci-013737 Botrytis cinerea 33.29 2.00e-114 404.00
IUUC-Bdi-015041 Brachypodium distachyon 43.19 1.00e-74 271.00
IUUC-Bol-015483 Brassica oleracea 35.10 9.00e-102 362.00
IUUC-Bra-017147 Brassica rapa 35.10 8.00e-102 362.00
IUUC-Cel-018451 Caenorhabditis elegans 31.09 5.00e-53 200.00
IUUC-Cja-018881 Callithrix jacchus 42.86 3.00e-91 327.00
IUUC-Cfa-020056 Canis familiaris 42.86 3.00e-91 327.00
IUUC-Cpo-021454 Cavia porcellus 41.94 4.00e-91 327.00
IUUC-Cre-022736 Chlamydomonas reinhardtii 36.09 1.00e-48 185.00
IUUC-Csa-023045 Chlorocebus sabaeus 42.86 7.00e-91 325.00
IUUC-Cho-024284 Choloepus hoffmanni 48.35 4.00e-75 273.00
IUUC-Cin-025457 Ciona intestinalis 45.55 2.00e-69 253.00
IUUC-Csv-025882 Ciona savignyi 41.13 1.00e-80 291.00
IUUC-Cgl-026392 Colletotrichum gloeosporioides 32.01 6.00e-112 396.00
IUUC-Cne-026876 Cryptococcus neoformans 33.23 5.00e-89 320.00
IUUC-Cme-027302 Cyanidioschyzon merolae 32.93 1.00e-90 325.00
IUUC-Dre-027980 Danio rerio 42.82 3.00e-91 327.00
IUUC-Dno-028863 Dasypus novemcinctus 42.86 3.00e-91 327.00
IUUC-Dor-030561 Dipodomys ordii 42.86 3.00e-91 327.00
IUUC-Dse-031547 Dothistroma septosporum 34.85 7.00e-117 412.00
IUUC-Dme-031917 Drosophila melanogaster 37.03 5.00e-72 263.00
IUUC-Ete-032712 Echinops telfairi 38.66 1.00e-67 248.00
IUUC-Eca-033927 Equus caballus 42.75 2.00e-91 328.00
IUUC-Eeu-034449 Erinaceus europaeus 46.01 2.00e-85 308.00
IUUC-Fca-036325 Felis catus 42.86 3.00e-91 327.00
IUUC-Fal-036604 Ficedula albicollis 42.61 6.00e-90 323.00
IUUC-Fox-038049 Fusarium oxysporum 29.56 2.00e-91 328.00
IUUC-Fso-038302 Fusarium solani 32.17 6.00e-99 353.00
IUUC-Gmo-038832 Gadus morhua 41.85 8.00e-90 322.00
IUUC-Ggr-039878 Gaeumannomyces graminis 32.39 7.00e-102 362.00
IUUC-Gga-041147 Gallus gallus 42.96 4.00e-92 330.00
IUUC-Gac-041373 Gasterosteus aculeatus 42.61 8.00e-90 322.00
IUUC-Gma-043230 Glycine max 41.41 1.00e-85 308.00
IUUC-Ggo-044568 Gorilla gorilla 38.10 9.00e-68 249.00
IUUC-Hsa-045971 Homo sapiens 42.86 3.00e-91 327.00
IUUC-Hvu-047695 Hordeum vulgare 43.63 7.00e-77 278.00
IUUC-Itr-048400 Ictidomys tridecemlineatus 43.11 3.00e-91 327.00
IUUC-Kpa-049402 Komagataella pastoris 47.11 0.00e+00 667.00
IUUC-Lch-049526 Latimeria chalumnae 39.45 4.00e-84 303.00
IUUC-Lpe-051560 Leersia perrieri 40.97 1.00e-81 295.00
IUUC-Loc-052882 Lepisosteus oculatus 42.89 8.00e-92 329.00
IUUC-Lma-053212 Leptosphaeria maculans 34.78 2.00e-113 400.00
IUUC-Laf-053859 Loxodonta africana 42.86 4.00e-91 327.00
IUUC-Mcc-054957 Macaca mulatta 41.96 5.00e-91 326.00
IUUC-Meu-056182 Macropus eugenii 37.82 4.00e-67 246.00
IUUC-Mor-057024 Magnaporthe oryzae 31.97 6.00e-99 353.00
IUUC-Mpo-057520 Magnaporthe poae 33.50 5.00e-99 353.00
IUUC-Mtr-058754 Medicago truncatula 32.62 1.00e-105 375.00
IUUC-Mla-058881 Melampsora laricipopulina 30.86 1.00e-105 375.00
IUUC-Mga-059776 Meleagris gallopavo 42.96 6.00e-92 329.00
IUUC-Mvi-060208 Microbotryum violaceum 44.05 8.00e-92 329.00
IUUC-Mmr-061783 Microcebus murinus 41.96 5.00e-91 326.00
IUUC-Mdo-062856 Monodelphis domestica 43.36 6.00e-92 330.00
IUUC-Mmu-064218 Mus musculus 42.86 2.00e-91 327.00
IUUC-Mac-064886 Musa acuminata 48.91 2.00e-68 251.00
IUUC-Mpu-065735 Mustela putorius furo 42.86 3.00e-91 327.00
IUUC-Mlu-067544 Myotis lucifugus 42.75 8.00e-90 322.00
IUUC-Nfi-068502 Neosartorya fischeri 34.50 2.00e-130 457.00
IUUC-Ncr-068891 Neurospora crassa 30.83 9.00e-102 362.00
IUUC-Nle-069389 Nomascus leucogenys 42.86 3.00e-91 327.00
IUUC-Opr-071042 Ochotona princeps 38.27 1.00e-77 282.00
IUUC-Ont-071455 Oreochromis niloticus 43.89 3.00e-93 334.00
IUUC-Oan-073181 Ornithorhynchus anatinus 43.61 8.00e-92 328.00
IUUC-Ocu-073758 Oryctolagus cuniculus 42.75 1.00e-91 328.00
IUUC-Oba-075739 Oryza barthii 41.21 3.00e-75 274.00
IUUC-Obr-076111 Oryza brachyantha 34.62 4.00e-101 360.00
IUUC-Ogl-077914 Oryza glaberrima 32.99 2.00e-89 321.00
IUUC-Ogu-078057 Oryza glumaepatula 39.63 3.00e-67 247.00
IUUC-Oin-079473 Oryza indica 33.58 4.00e-92 330.00
IUUC-Olo-080645 Oryza longistaminata 47.50 5.00e-66 243.00
IUUC-Ome-081831 Oryza meridionalis 39.37 2.00e-66 244.00
IUUC-Oni-082441 Oryza nivara 39.38 3.00e-68 250.00
IUUC-Opu-083239 Oryza punctata 39.01 2.00e-66 245.00
IUUC-Oru-085131 Oryza rufipogon 39.38 4.00e-68 250.00
IUUC-Osa-086189 Oryza sativa 33.58 5.00e-92 329.00
IUUC-Ola-086574 Oryzias latipes 43.07 7.00e-92 329.00
IUUC-Olu-087616 Ostreococcus lucimarinus 38.50 3.00e-75 273.00
IUUC-Oga-088827 Otolemur garnettii 42.86 5.00e-91 327.00
IUUC-Oar-089648 Ovis aries 42.86 2.00e-91 328.00
IUUC-Ptr-091195 Pan troglodytes 42.86 3.00e-91 327.00
IUUC-Pan-091978 Papio anubis 42.86 4.00e-91 327.00
IUUC-Psi-093598 Pelodiscus sinensis 43.00 7.00e-92 329.00
IUUC-Pma-094593 Petromyzon marinus 38.73 5.00e-62 229.00
IUUC-Pno-094823 Phaeosphaeria nodorum 36.43 8.00e-114 402.00
IUUC-Ppa-095455 Physcomitrella patens 31.93 2.00e-99 354.00
IUUC-Pfo-097120 Poecilia formosa 44.39 5.00e-92 330.00
IUUC-Pab-098771 Pongo abelii 42.86 4.00e-91 327.00
IUUC-Pop-099134 Populus trichocarpa 33.18 4.00e-101 360.00
IUUC-Pca-100727 Procavia capensis 38.38 2.00e-67 248.00
IUUC-Ppe-101686 Prunus persica 32.55 6.00e-101 359.00
IUUC-Pva-103211 Pteropus vampyrus 43.39 2.00e-69 254.00
IUUC-Pgr-103603 Puccinia graminis 33.33 2.00e-100 358.00
IUUC-Ptt-103995 Puccinia triticina 30.52 3.00e-81 294.00
IUUC-Pte-104359 Pyrenophora teres 35.51 2.00e-118 417.00
IUUC-Pyt-104523 Pyrenophora triticirepentis 35.54 1.00e-117 415.00
IUUC-Rno-105064 Rattus norvegicus 42.86 3.00e-91 327.00
IUUC-Sha-106582 Sarcophilus harrisii 43.47 2.00e-91 328.00
IUUC-Sja-107683 Schizosaccharomyces japonicus 40.64 2.00e-160 557.00
IUUC-Spo-108142 Schizosaccharomyces pombe 41.33 2.00e-159 553.00
IUUC-Ssl-108456 Sclerotinia sclerotiorum 32.68 5.00e-112 396.00
IUUC-Smo-109111 Selaginella moellendorffii 41.65 5.00e-82 296.00
IUUC-Sit-109804 Setaria italica 35.47 1.00e-98 352.00
IUUC-Sly-111693 Solanum lycopersicum 32.76 5.00e-103 366.00
IUUC-Sar-113381 Sorex araneus 38.38 1.00e-71 261.00
IUUC-Sbi-114849 Sorghum bicolor 35.24 9.00e-96 342.00
IUUC-Sre-114945 Sporisorium reilianum 34.95 4.00e-86 311.00
IUUC-Ssc-115582 Sus scrofa 41.69 8.00e-88 315.00
IUUC-Tgu-116899 Taeniopygia guttata 43.07 2.00e-91 328.00
IUUC-Tru-118011 Takifugu rubripes 42.36 2.00e-89 321.00
IUUC-Tsy-119622 Tarsius syrichta 31.46 8.00e-45 172.00
IUUC-Tni-120598 Tetraodon nigroviridis 42.72 2.00e-90 324.00
IUUC-Tca-121247 Theobroma cacao 34.80 2.00e-107 381.00
IUUC-Tre-121949 Trichoderma reesei 40.00 1.00e-79 288.00
IUUC-Tvi-122626 Trichoderma virens 38.32 1.00e-83 302.00
IUUC-Tae-123335 Triticum aestivum 43.34 7.00e-78 282.00
IUUC-Tur-126316 Triticum urartu 39.77 2.00e-72 264.00
IUUC-Tme-126904 Tuber melanosporum 53.20 4.00e-127 446.00
IUUC-Tbe-127254 Tupaia belangeri 37.34 7.00e-71 259.00
IUUC-Ttr-128544 Tursiops truncatus 42.86 3.00e-91 327.00
IUUC-Uma-129379 Ustilago maydis 36.53 9.00e-89 319.00
IUUC-Vda-129761 Verticillium dahliae 30.28 2.00e-92 332.00
IUUC-Vpa-130485 Vicugna pacos 42.86 4.00e-91 327.00
IUUC-Vvi-131171 Vitis vinifera 34.66 5.00e-109 386.00
IUUC-Xtr-132241 Xenopus tropicalis 40.84 5.00e-66 243.00
IUUC-Xma-133583 Xiphophorus maculatus 44.14 1.00e-91 328.00
IUUC-Yli-134446 Yarrowia lipolytica 44.06 0.00e+00 637.00
IUUC-Zma-135722 Zea mays 35.09 2.00e-96 344.00
Created Date 25-Jun-2017

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