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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045711
Ensembl Protein ID ENSP00000307260.4
UniProt Accession Q9Y4P3; Q9UQE2; TBL2_HUMAN
Genbank Protein ID AAF06823.1; AAF06824.1; CAB45751.1; AAQ88882.1; AAD28083.1
Protein Name Transducin beta-like protein 2; WS beta-transducin repeats protein; Williams-Beuren syndrome chromosomal region 13 protein
Genbank Nucleotide ID AF097484; AF097485; AL080162; AY358518; AF056183
Gene Name TBL2; WBSCR13; UNQ563/PRO1125
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000106638.15 ENST00000305632.9 ENSP00000307260.4
ENSG00000106638.15 ENST00000424598.5 ENSP00000398195.1
ENSG00000106638.15 ENST00000450285.5 ENSP00000409820.1
ENSG00000106638.15 ENST00000432538.5 ENSP00000413979.1
ENSG00000106638.15 ENST00000433464.5 ENSP00000404242.1
ENSG00000106638.15 ENST00000426966.5 ENSP00000410737.1
ENSG00000106638.15 ENST00000437521.5 ENSP00000400569.1
ENSG00000106638.15 ENST00000435792.5 ENSP00000408255.1
ENSG00000106638.15 ENST00000452125.5 ENSP00000414865.1
ENSG00000106638.15 ENST00000610724.4 ENSP00000484750.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
iRefIndexHINTMentha
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.40e-20 71.9 89 122
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           H++ ++c++f s+ ++l++++dD ti++W+++++
   Q: 89   HSGNISCMDFsSNgKYLATCADDRTIRIWSTKDF 122
           9**********777***************98775 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MELSQMSELM GLSVLLGLLA LMATAAVARG WLRAGEERSG RPACQKANGF PPDKSSGSKK 60
QKQYQRIRKE KPQQHNFTHR LLAAALKSHS GNISCMDFSS NGKYLATCAD DRTIRIWSTK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045711|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCAGGCCCCG CCCCTCGAGC GCCACAACAG CCGGGCCCCA CCCCTTGAGG TGCTTTAACG 60
GCCAGGCCCC GCCCTGAAGG CGTTGTAACA ACCAGGCTCC GCCCCCAGGC GCTCTAACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045711|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0856--Williams-Beuren syndrome
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0051219--F:phosphoprotein binding
GO:0019901--F:protein kinase binding
GO:0003723--F:RNA binding
GO:0031369--F:translation initiation factor binding
GO:0042149--P:cellular response to glucose starvation
GO:0071456--P:cellular response to hypoxia
GO:0030968--P:endoplasmic reticulum unfolded protein response
KEGG hsa:26608
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000109 Aegilops tauschii 32.16 6.00e-23 100.00
IUUC-Aml-002212 Ailuropoda melanoleuca 91.54 0.00e+00 736.00
IUUC-Atr-002903 Amborella trichopoda 29.18 2.00e-36 146.00
IUUC-Apl-003635 Anas platyrhynchos 72.83 1.00e-161 562.00
IUUC-Aca-004472 Anolis carolinensis 72.63 2.00e-166 578.00
IUUC-Aly-005761 Arabidopsis lyrata 30.64 7.00e-39 154.00
IUUC-Ath-007476 Arabidopsis thaliana 31.50 1.00e-39 157.00
IUUC-Ame-011221 Astyanax mexicanus 67.82 4.00e-149 521.00
IUUC-Bta-013186 Bos taurus 89.04 0.00e+00 738.00
IUUC-Bdi-014298 Brachypodium distachyon 29.68 4.00e-38 152.00
IUUC-Bol-015192 Brassica oleracea 30.23 1.00e-37 150.00
IUUC-Bra-017078 Brassica rapa 30.79 9.00e-39 154.00
IUUC-Cel-018602 Caenorhabditis elegans 30.51 5.00e-59 221.00
IUUC-Cja-018909 Callithrix jacchus 93.74 0.00e+00 770.00
IUUC-Cfa-020970 Canis familiaris 90.38 0.00e+00 757.00
IUUC-Cpo-022215 Cavia porcellus 85.20 0.00e+00 683.00
IUUC-Cre-022949 Chlamydomonas reinhardtii 33.80 3.00e-20 91.30
IUUC-Csa-023530 Chlorocebus sabaeus 96.20 0.00e+00 806.00
IUUC-Cho-024598 Choloepus hoffmanni 92.34 4.00e-140 491.00
IUUC-Cin-025486 Ciona intestinalis 49.74 3.00e-105 375.00
IUUC-Csv-025930 Ciona savignyi 46.63 4.00e-95 341.00
IUUC-Dre-027507 Danio rerio 67.12 2.00e-150 525.00
IUUC-Dno-029726 Dasypus novemcinctus 89.74 0.00e+00 748.00
IUUC-Dor-030501 Dipodomys ordii 76.96 1.00e-173 602.00
IUUC-Ete-032794 Echinops telfairi 85.09 3.00e-130 457.00
IUUC-Eca-033982 Equus caballus 89.71 0.00e+00 706.00
IUUC-Eeu-035090 Erinaceus europaeus 88.15 1.00e-134 473.00
IUUC-Fca-035944 Felis catus 91.27 0.00e+00 773.00
IUUC-Fal-036992 Ficedula albicollis 65.97 6.00e-149 520.00
IUUC-Gmo-038710 Gadus morhua 62.63 4.00e-146 511.00
IUUC-Gga-040885 Gallus gallus 68.79 7.00e-112 396.00
IUUC-Gac-041922 Gasterosteus aculeatus 64.80 2.00e-152 532.00
IUUC-Gma-044233 Glycine max 29.61 2.00e-37 150.00
IUUC-Ggo-045172 Gorilla gorilla 99.50 0.00e+00 787.00
IUUC-Itr-048196 Ictidomys tridecemlineatus 89.93 0.00e+00 731.00
IUUC-Lch-049739 Latimeria chalumnae 70.78 2.00e-164 572.00
IUUC-Lpe-050795 Leersia perrieri 25.65 3.00e-21 96.70
IUUC-Loc-052113 Lepisosteus oculatus 72.49 3.00e-154 538.00
IUUC-Laf-053751 Loxodonta africana 87.92 0.00e+00 753.00
IUUC-Mcc-055022 Macaca mulatta 96.59 0.00e+00 797.00
IUUC-Meu-056003 Macropus eugenii 73.24 3.00e-162 564.00
IUUC-Mtr-058500 Medicago truncatula 29.55 1.00e-34 140.00
IUUC-Mga-059278 Meleagris gallopavo 68.14 1.00e-123 435.00
IUUC-Mmr-061148 Microcebus murinus 91.28 0.00e+00 756.00
IUUC-Mdo-063002 Monodelphis domestica 71.89 8.00e-161 560.00
IUUC-Mmu-063607 Mus musculus 87.25 0.00e+00 711.00
IUUC-Mac-065359 Musa acuminata 27.96 8.00e-36 144.00
IUUC-Mpu-066323 Mustela putorius furo 91.82 1.00e-177 615.00
IUUC-Mlu-067946 Myotis lucifugus 91.05 0.00e+00 764.00
IUUC-Nle-069019 Nomascus leucogenys 98.66 0.00e+00 821.00
IUUC-Opr-071047 Ochotona princeps 88.59 0.00e+00 729.00
IUUC-Ont-071694 Oreochromis niloticus 66.22 1.00e-151 529.00
IUUC-Oan-073474 Ornithorhynchus anatinus 56.23 4.00e-100 358.00
IUUC-Ocu-074493 Oryctolagus cuniculus 89.04 0.00e+00 711.00
IUUC-Oba-075468 Oryza barthii 26.38 6.00e-32 132.00
IUUC-Obr-076681 Oryza brachyantha 26.55 2.00e-33 136.00
IUUC-Ogl-077870 Oryza glaberrima 26.38 6.00e-32 132.00
IUUC-Ogu-078536 Oryza glumaepatula 26.38 7.00e-32 131.00
IUUC-Oin-080175 Oryza indica 26.38 6.00e-32 132.00
IUUC-Olo-080796 Oryza longistaminata 26.61 7.00e-31 128.00
IUUC-Oni-082076 Oryza nivara 26.38 6.00e-32 132.00
IUUC-Opu-083267 Oryza punctata 26.74 2.00e-32 133.00
IUUC-Oru-084553 Oryza rufipogon 26.67 1.00e-32 134.00
IUUC-Osa-085389 Oryza sativa 26.38 6.00e-32 132.00
IUUC-Ola-086414 Oryzias latipes 65.95 1.00e-149 523.00
IUUC-Oga-088656 Otolemur garnettii 88.59 0.00e+00 752.00
IUUC-Oar-089719 Ovis aries 89.33 0.00e+00 699.00
IUUC-Ptr-091087 Pan troglodytes 99.78 0.00e+00 833.00
IUUC-Pan-091709 Papio anubis 96.87 0.00e+00 811.00
IUUC-Psi-093265 Pelodiscus sinensis 70.97 3.00e-170 591.00
IUUC-Pma-094482 Petromyzon marinus 56.74 4.00e-57 213.00
IUUC-Ppa-095365 Physcomitrella patens 29.04 6.00e-40 158.00
IUUC-Pfo-097494 Poecilia formosa 66.76 8.00e-150 523.00
IUUC-Pab-098362 Pongo abelii 99.11 0.00e+00 831.00
IUUC-Pop-099163 Populus trichocarpa 29.14 3.00e-32 133.00
IUUC-Pca-101019 Procavia capensis 85.57 4.00e-151 528.00
IUUC-Ppe-102101 Prunus persica 28.76 6.00e-39 155.00
IUUC-Pva-102849 Pteropus vampyrus 90.97 0.00e+00 727.00
IUUC-Rno-105511 Rattus norvegicus 87.92 0.00e+00 707.00
IUUC-Sha-107265 Sarcophilus harrisii 68.66 4.00e-166 577.00
IUUC-Smo-108980 Selaginella moellendorffii 32.62 8.00e-37 147.00
IUUC-Sit-110806 Setaria italica 27.09 1.00e-33 137.00
IUUC-Sly-110994 Solanum lycopersicum 28.57 1.00e-34 140.00
IUUC-Stu-112493 Solanum tuberosum 35.42 2.00e-31 129.00
IUUC-Sar-113628 Sorex araneus 85.04 0.00e+00 687.00
IUUC-Sbi-114397 Sorghum bicolor 28.12 4.00e-34 139.00
IUUC-Ssc-116418 Sus scrofa 89.26 0.00e+00 759.00
IUUC-Tgu-117054 Taeniopygia guttata 66.84 4.00e-155 540.00
IUUC-Tru-118504 Takifugu rubripes 66.84 1.00e-158 552.00
IUUC-Tni-120254 Tetraodon nigroviridis 66.33 5.00e-156 544.00
IUUC-Tca-121085 Theobroma cacao 30.36 3.00e-37 149.00
IUUC-Tae-124320 Triticum aestivum 28.74 3.00e-37 149.00
IUUC-Tur-126756 Triticum urartu 26.83 2.00e-31 130.00
IUUC-Tbe-127903 Tupaia belangeri 87.02 0.00e+00 731.00
IUUC-Ttr-129118 Tursiops truncatus 88.31 0.00e+00 750.00
IUUC-Vvi-131125 Vitis vinifera 30.45 5.00e-37 148.00
IUUC-Xtr-132287 Xenopus tropicalis 72.55 2.00e-162 565.00
IUUC-Xma-134246 Xiphophorus maculatus 66.19 1.00e-149 523.00
Created Date 25-Jun-2017

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