iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093392

Ensembl Protein ID

ENSPSIP00000005127.1

UniProt Accession

K7FAR7; K7FAR7_PELSI

Genbank Protein ID

ENSPSIP00000005127

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01121413

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000004776.1	ENSPSIT00000005156.1	ENSPSIP00000005127.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	5.10e-13	48.7	348	394
E3 adaptor/Cullin RING/DCX/DWD	1.40e-31	107.2	142	177
UBD/Beta-Prp	8.30e-46	156.5	116	359

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           ++++w+++    +L+hLCR+a r +l+++++    +LP+Pk++k++L y+
   Q: 348  HVQFWSAPKTLSTLKHLCRKALRTFLTTYQV---LALPIPKKMKEFLTYR 394
           689****************************...**************97 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtg 33
           gH d v++l+f  ++ ++lvs+s+D t+++WDl+++
   Q: 142  GHLDVVRDLCFapHGsPILVSASRDRTLRIWDLSRD 177
           8***********74479***************9765 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ikvw+v+tg ll slsgh + v++++f p+g+ ilv++s+Drt+++wdls +gk+v++l+gh++ v+++s+sp  + l 
   Q: 116  ILATGLNDGQIKVWEVQTGGLLFSLSGHLDVVRDLCFAPHGSpILVSASRDRTLRIWDLSrDGKQVQVLSGHTQWVYCCSISPHCSMLC 204
           689**************************************99****************999*********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tgghtdsvysls 187
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lrtl            +  h +s +s+ 
   Q: 205  SAAGEKSALLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGEQLRTLrhvalppaldygSDIHASSLRSVC 292
           ********************.********************************************************889********* PP
   S: 188  fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllk 258
           f+++g +l+++++d+ +++wdl+  +      +  +n ++   +p++    + + Dg +++W     ++l+
   Q: 293  FSPEGLYLATVADDRLLRIWDLELRT--PVAFAPMTNGLCCVYFPHGCVCSVQTRDGHVQFWS--APKTLS 359
           **********************9665..34455666666666666898888899********4..444444 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

LLLAELKPGR PQQYDWKSSC ETWSVAFSPD GTWFAWSQGH CIVKLIPWPL EEAELSCKTS 60
ERKSRGVKAD VRGRGGAKEK TLDCGQIVWG LAFSSWPLGR TKERDRLPAP DRSCLILATG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTACTGCTGG CAGAGCTGAA GCCAGGGCGA CCCCAGCAGT ACGACTGGAA GTCGAGCTGC 60
GAGACGTGGA GTGTTGCGTT TTCCCCCGAC GGCACCTGGT TTGCCTGGTC TCAGGGTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	79.65	0.00e+00	642.00
IUUC-Apl-004107	Anas platyrhynchos	69.74	9.00e-129	452.00
IUUC-Aca-004354	Anolis carolinensis	72.47	2.00e-167	581.00
IUUC-Bta-012627	Bos taurus	79.59	0.00e+00	626.00
IUUC-Cja-018897	Callithrix jacchus	78.21	1.00e-178	619.00
IUUC-Cfa-020122	Canis familiaris	79.90	0.00e+00	642.00
IUUC-Cpo-022540	Cavia porcellus	79.85	0.00e+00	636.00
IUUC-Csa-023719	Chlorocebus sabaeus	78.66	2.00e-180	624.00
IUUC-Cho-024367	Choloepus hoffmanni	83.16	7.00e-140	489.00
IUUC-Dno-029021	Dasypus novemcinctus	79.59	0.00e+00	633.00
IUUC-Dor-030321	Dipodomys ordii	79.69	0.00e+00	630.00
IUUC-Ete-032955	Echinops telfairi	79.90	0.00e+00	629.00
IUUC-Eca-033485	Equus caballus	79.59	2.00e-176	611.00
IUUC-Fca-035389	Felis catus	79.23	0.00e+00	627.00
IUUC-Fal-037184	Ficedula albicollis	86.88	3.00e-144	503.00
IUUC-Gga-041014	Gallus gallus	82.23	5.00e-180	623.00
IUUC-Ggo-045585	Gorilla gorilla	79.08	0.00e+00	632.00
IUUC-Hsa-046344	Homo sapiens	79.08	0.00e+00	633.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	79.74	0.00e+00	630.00
IUUC-Lch-050131	Latimeria chalumnae	68.17	3.00e-162	563.00
IUUC-Loc-052807	Lepisosteus oculatus	52.66	7.00e-111	393.00
IUUC-Laf-053528	Loxodonta africana	79.85	2.00e-180	625.00
IUUC-Mcc-055665	Macaca mulatta	79.08	0.00e+00	633.00
IUUC-Meu-056054	Macropus eugenii	77.53	1.00e-174	605.00
IUUC-Mga-059326	Meleagris gallopavo	81.98	0.00e+00	648.00
IUUC-Mmr-060815	Microcebus murinus	78.32	0.00e+00	628.00
IUUC-Mdo-062000	Monodelphis domestica	80.65	0.00e+00	644.00
IUUC-Mmu-063927	Mus musculus	79.23	0.00e+00	628.00
IUUC-Mpu-065726	Mustela putorius furo	79.74	0.00e+00	625.00
IUUC-Nle-069680	Nomascus leucogenys	78.83	0.00e+00	625.00
IUUC-Opr-070356	Ochotona princeps	80.65	0.00e+00	648.00
IUUC-Oan-073647	Ornithorhynchus anatinus	80.22	7.00e-130	456.00
IUUC-Ocu-073973	Oryctolagus cuniculus	80.10	0.00e+00	635.00
IUUC-Oga-088797	Otolemur garnettii	79.39	0.00e+00	630.00
IUUC-Oar-089187	Ovis aries	79.59	1.00e-180	625.00
IUUC-Ptr-091317	Pan troglodytes	79.08	0.00e+00	632.00
IUUC-Pan-092694	Papio anubis	71.83	1.00e-154	538.00
IUUC-Pab-098145	Pongo abelii	78.92	1.00e-180	625.00
IUUC-Pca-100454	Procavia capensis	71.86	1.00e-161	562.00
IUUC-Pva-102986	Pteropus vampyrus	72.36	2.00e-163	568.00
IUUC-Rno-104931	Rattus norvegicus	78.66	6.00e-179	619.00
IUUC-Sha-106476	Sarcophilus harrisii	80.65	0.00e+00	640.00
IUUC-Ssc-115643	Sus scrofa	79.43	0.00e+00	626.00
IUUC-Tgu-117522	Taeniopygia guttata	65.51	3.00e-141	494.00
IUUC-Tsy-119301	Tarsius syrichta	79.65	0.00e+00	642.00
IUUC-Ttr-128683	Tursiops truncatus	79.43	0.00e+00	627.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence