iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000017946.1	ENSPSIT00000020417.1	ENSPSIP00000020321.1
ENSPSIG00000017946.1	ENSPSIT00000020428.1	ENSPSIP00000020332.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.60e-119	396.7	1258	1593

Active Site

Position(s)	Description	Evidence
1561	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1258 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1343
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgk...klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeY 173
           ++++++fyk ll+    +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY
   Q: 1344 AFFTRPFYKALLRLtirPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGSNTQVTEKNKKEY 1426
           ************998889*********************99...9***9.************************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefssee 260
           ++++v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t   +gy++ + +i+wFw ++e+f++e+
   Q: 1427 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSIFDARELELVIAGTAEIDLNDWRNNTVSLSGYHDGHIVIRWFWAAVERFNNEQ 1513
           ************************************************************88899********************** PP
   S: 261  rkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           r ++LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1514 RLRLLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1593
           ***************************999***********************************************985 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

ILVHTIPPQN LYQNRFLGLA AMASPSRNSQ NRRRCKEPLR YSYNPDQFNN MDLRNNAHET 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIYW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNGAG 60
CCGGGCGCTG AGCTCTCCCG CCCCCCAGCC TGGCCATGAG CAGCACATGT GGGATCTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	82.25	0.00e+00	1667.00
IUUC-Apl-003299	Anas platyrhynchos	87.79	0.00e+00	2701.00
IUUC-Aca-005024	Anolis carolinensis	87.96	0.00e+00	2672.00
IUUC-Bta-012604	Bos taurus	78.88	0.00e+00	2387.00
IUUC-Cja-019880	Callithrix jacchus	73.14	0.00e+00	2004.00
IUUC-Cfa-021216	Canis familiaris	81.36	0.00e+00	1701.00
IUUC-Cpo-021466	Cavia porcellus	75.79	0.00e+00	2266.00
IUUC-Csa-023080	Chlorocebus sabaeus	79.18	0.00e+00	2407.00
IUUC-Cho-024740	Choloepus hoffmanni	89.81	0.00e+00	1109.00
IUUC-Dre-028750	Danio rerio	73.10	0.00e+00	1578.00
IUUC-Dno-030019	Dasypus novemcinctus	85.53	0.00e+00	1757.00
IUUC-Dor-031030	Dipodomys ordii	71.32	0.00e+00	1103.00
IUUC-Ete-032352	Echinops telfairi	91.40	0.00e+00	1229.00
IUUC-Eca-033948	Equus caballus	82.87	0.00e+00	1685.00
IUUC-Eeu-034474	Erinaceus europaeus	67.55	0.00e+00	804.00
IUUC-Fca-036148	Felis catus	82.70	0.00e+00	1705.00
IUUC-Fal-036957	Ficedula albicollis	89.36	0.00e+00	2678.00
IUUC-Gmo-038714	Gadus morhua	69.00	0.00e+00	1020.00
IUUC-Gga-041194	Gallus gallus	89.05	0.00e+00	2707.00
IUUC-Gac-041366	Gasterosteus aculeatus	71.01	0.00e+00	1433.00
IUUC-Ggo-045442	Gorilla gorilla	67.96	0.00e+00	1800.00
IUUC-Hsa-045730	Homo sapiens	79.38	0.00e+00	2406.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	85.92	0.00e+00	1761.00
IUUC-Lch-050185	Latimeria chalumnae	72.50	0.00e+00	2052.00
IUUC-Loc-052744	Lepisosteus oculatus	75.56	0.00e+00	2264.00
IUUC-Laf-054368	Loxodonta africana	93.32	0.00e+00	1436.00
IUUC-Mcc-055487	Macaca mulatta	79.20	0.00e+00	2409.00
IUUC-Meu-056751	Macropus eugenii	89.32	0.00e+00	713.00
IUUC-Mga-059545	Meleagris gallopavo	89.79	0.00e+00	2681.00
IUUC-Mmr-061078	Microcebus murinus	81.70	0.00e+00	1674.00
IUUC-Mdo-062176	Monodelphis domestica	84.82	0.00e+00	1689.00
IUUC-Mmu-063513	Mus musculus	79.52	0.00e+00	2324.00
IUUC-Mpu-065786	Mustela putorius furo	78.07	0.00e+00	2348.00
IUUC-Mlu-067780	Myotis lucifugus	77.95	0.00e+00	1512.00
IUUC-Nle-069213	Nomascus leucogenys	78.90	0.00e+00	2366.00
IUUC-Opr-070208	Ochotona princeps	93.08	0.00e+00	1439.00
IUUC-Ont-072132	Oreochromis niloticus	70.13	0.00e+00	1420.00
IUUC-Oan-072807	Ornithorhynchus anatinus	87.94	0.00e+00	1779.00
IUUC-Ocu-074745	Oryctolagus cuniculus	79.03	0.00e+00	2330.00
IUUC-Ola-086981	Oryzias latipes	71.48	0.00e+00	1479.00
IUUC-Oga-087965	Otolemur garnettii	83.35	0.00e+00	1704.00
IUUC-Oar-089749	Ovis aries	83.01	0.00e+00	1729.00
IUUC-Ptr-091243	Pan troglodytes	79.32	0.00e+00	2403.00
IUUC-Pan-092201	Papio anubis	79.00	0.00e+00	2412.00
IUUC-Pfo-097001	Poecilia formosa	64.13	0.00e+00	1565.00
IUUC-Pab-098728	Pongo abelii	77.33	0.00e+00	2295.00
IUUC-Pca-100129	Procavia capensis	77.49	0.00e+00	1196.00
IUUC-Pva-102250	Pteropus vampyrus	69.56	0.00e+00	1920.00
IUUC-Rno-105031	Rattus norvegicus	79.90	0.00e+00	2330.00
IUUC-Tgu-117515	Taeniopygia guttata	88.39	0.00e+00	2689.00
IUUC-Tru-117914	Takifugu rubripes	74.03	0.00e+00	1366.00
IUUC-Tsy-119379	Tarsius syrichta	76.84	0.00e+00	766.00
IUUC-Tni-120178	Tetraodon nigroviridis	73.97	0.00e+00	1386.00
IUUC-Tbe-127762	Tupaia belangeri	73.35	0.00e+00	1773.00
IUUC-Ttr-128806	Tursiops truncatus	86.01	0.00e+00	1604.00
IUUC-Xtr-132903	Xenopus tropicalis	79.15	0.00e+00	1950.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence