iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006934

UUCD1 version

UUC-ArT-01434

Ensembl Protein ID

AT1G66050.1

UniProt Accession

Q680I0; Q6NQ90; Q9C8E0; ORTH5_ARATH

Genbank Protein ID

AAG51305.1; AEE34456.1; AAQ65191.1; BAD43457.1; BAD43650.1; BAD43775.1

Protein Name

E3 ubiquitin-protein ligase ORTHRUS 5; Protein VARIANT IN METHYLATION 2; RING-type E3 ubiquitin transferase ORTHRUS 5

Genbank Nucleotide ID

AC026480; CP002684; BT010568; AK175694; AK175887; AK176012

Gene Name

ORTH5; VIM2; At1g66050; F15E12.5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G66050	AT1G66050.1	AT1G66050.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18643997

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.30e-07	31.6	127	173
E3 activity/RING/RING	4.50e-13	50.4	129	169

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwlasggk.tcPvtrqplt 51
             C+I  +l++ Pv++p+G+ +  ++ ekw   +gk tc ++r+++ 
   Q: 127  IFCSICIQLPERPVTTPCGHNFCLKCFEKWAVGQGKlTCMICRSKIP 173
           57*****************************999999*****99985 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC + +++ p+++pCgH f+++C++kw     + +++ +C +Cr
   Q: 129  CSICIQLPER-PVTTPCGHNFCLKCFEKW----AVGQGKLTCMICR 169
           **********.9*****************....99**********8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11.

Protein Sequence
(Fasta)

MAIQTQLPCD GDGVCMRCQV NPPSEETLTC GTCVTPWHVS CLLPESLASS TGDWECPDCS 60
GVVVPSAAPG TGISGPESSG SVLVTAIRAI QADVTLTEAE KAKKRQRLMS GGGDDGVDDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTATCTCT TTGTGAGATT TTTTTCTTTT TTTGAAGGAT TTTTACAAAT CATTTTGAAT 60
TCGTCTTCCC AAAATTTCAA AACCCGCCTC TTCACTTTTC GCCTTCCTCT ACTTATTTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015947--PUA-like_domain
IPR003105--SRA_YDG
IPR019786--Zinc_finger_PHD-type_CS
IPR027370--Znf-RING_LisH
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51015--YDG
PS01359--ZF_PHD_1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02182--SAD_SRA
PF13445--zf-RING_UBOX

SMART

SM00249--PHD
SM00184--RING
SM00466--SRA

Gene Ontology

GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0010429--F:methyl-CpNpN binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0010216--P:maintenance of DNA methylation
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0016567--P:protein ubiquitination

KEGG

ath:AT1G66050

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence