iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066480

Ensembl Protein ID

ENSMPUP00000005428.1

UniProt Accession

M3Y277; M3Y277_MUSPF

Genbank Protein ID

ENSMPUP00000005428

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01011746

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000005469.1	ENSMPUT00000005519.1	ENSMPUP00000005428.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-65	221.8	105	480
ULD/UDP/UBQ/UBQ_Other	6.80e-10	38.7	5	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lfe++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFESM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+  ++ +++e+e+++       a+  +++k+ksli++ F++++++++kc e +++ +++ + ++l
   Q: 192  qgQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETESSS-------ASAVTPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQL 273
           999*********************775555555554444.......778899*************************999999888888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 274  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 355
           8888877754..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 356  YELCTPelqekmvsfrskfkdledkkvnqqP-----KtsdkksspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 439
           ******6666666666666666665555551.....0555556666677777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 440  VKRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 480
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd +++++++k+g+t++++ +
   Q: 5    SVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNLKIKNGMTLLMMGS 74
           69********99*************************************999.9**************965 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
LKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCACCATC GTAGGGCATT TTATTTAATT ATTTTCTTTT TAATTATTTT AATTTTTTCT 60
TCTCACTGGA TTCAACCTGG AGTCCAAACC GGTTTTGAGG AACAACAGTA ACACATTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	31.18	7.00e-66	244.00
IUUC-Aml-002053	Ailuropoda melanoleuca	98.98	0.00e+00	938.00
IUUC-Atr-002725	Amborella trichopoda	41.83	4.00e-102	364.00
IUUC-Apl-004031	Anas platyrhynchos	91.26	0.00e+00	900.00
IUUC-Aca-004361	Anolis carolinensis	88.89	0.00e+00	915.00
IUUC-Aly-006078	Arabidopsis lyrata	42.00	3.00e-112	398.00
IUUC-Ath-007623	Arabidopsis thaliana	42.57	5.00e-113	401.00
IUUC-Ago-007796	Ashbya gossypii	32.43	4.00e-59	222.00
IUUC-Acl-008258	Aspergillus clavatus	37.68	5.00e-68	252.00
IUUC-Afl-008732	Aspergillus flavus	33.51	3.00e-80	292.00
IUUC-Afu-008755	Aspergillus fumigatus	35.64	1.00e-82	300.00
IUUC-Ani-009148	Aspergillus nidulans	38.88	8.00e-73	268.00
IUUC-Ang-009878	Aspergillus niger	38.48	3.00e-68	252.00
IUUC-Aor-010239	Aspergillus oryzae	33.51	3.00e-80	292.00
IUUC-Ate-010243	Aspergillus terreus	34.79	6.00e-80	291.00
IUUC-Ame-011327	Astyanax mexicanus	51.00	8.00e-129	453.00
IUUC-Bgr-012231	Blumeria graminis	34.50	2.00e-80	293.00
IUUC-Bta-012553	Bos taurus	97.57	0.00e+00	962.00
IUUC-Bci-013606	Botrytis cinerea	39.95	2.00e-70	260.00
IUUC-Bdi-014567	Brachypodium distachyon	44.33	3.00e-114	405.00
IUUC-Bol-016127	Brassica oleracea	42.60	1.00e-114	406.00
IUUC-Bra-017501	Brassica rapa	42.40	7.00e-114	404.00
IUUC-Cel-018140	Caenorhabditis elegans	41.35	1.00e-101	363.00
IUUC-Cja-019516	Callithrix jacchus	97.78	0.00e+00	959.00
IUUC-Cfa-020808	Canis familiaris	99.60	0.00e+00	976.00
IUUC-Cpo-021688	Cavia porcellus	96.96	0.00e+00	947.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.83	1.00e-83	303.00
IUUC-Csa-023429	Chlorocebus sabaeus	98.58	0.00e+00	940.00
IUUC-Cho-024347	Choloepus hoffmanni	97.77	0.00e+00	963.00
IUUC-Cin-025198	Ciona intestinalis	54.58	6.00e-154	537.00
IUUC-Csv-026007	Ciona savignyi	53.82	2.00e-155	542.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	39.22	1.00e-64	241.00
IUUC-Cne-026963	Cryptococcus neoformans	35.03	4.00e-76	278.00
IUUC-Cme-027240	Cyanidioschyzon merolae	31.20	1.00e-60	227.00
IUUC-Dre-027647	Danio rerio	82.24	0.00e+00	833.00
IUUC-Dno-029967	Dasypus novemcinctus	97.77	0.00e+00	938.00
IUUC-Dor-030886	Dipodomys ordii	91.82	0.00e+00	763.00
IUUC-Dse-031466	Dothistroma septosporum	36.10	2.00e-58	220.00
IUUC-Dme-032079	Drosophila melanogaster	55.56	4.00e-161	560.00
IUUC-Ete-032351	Echinops telfairi	86.23	0.00e+00	863.00
IUUC-Eca-033461	Equus caballus	97.77	0.00e+00	1005.00
IUUC-Eeu-035220	Erinaceus europaeus	73.98	0.00e+00	696.00
IUUC-Fca-036210	Felis catus	99.39	0.00e+00	976.00
IUUC-Fal-037528	Ficedula albicollis	90.87	0.00e+00	882.00
IUUC-Fox-037805	Fusarium oxysporum	40.16	2.00e-71	263.00
IUUC-Fso-038177	Fusarium solani	38.34	2.00e-68	253.00
IUUC-Gmo-038953	Gadus morhua	77.80	0.00e+00	774.00
IUUC-Ggr-039972	Gaeumannomyces graminis	33.57	6.00e-75	275.00
IUUC-Gga-040462	Gallus gallus	89.88	0.00e+00	890.00
IUUC-Gac-041312	Gasterosteus aculeatus	82.34	0.00e+00	808.00
IUUC-Gma-043255	Glycine max	43.23	7.00e-110	390.00
IUUC-Ggo-045458	Gorilla gorilla	81.82	0.00e+00	793.00
IUUC-Hsa-045706	Homo sapiens	98.79	0.00e+00	943.00
IUUC-Hvu-047821	Hordeum vulgare	47.22	6.00e-58	217.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	97.57	0.00e+00	960.00
IUUC-Lch-050464	Latimeria chalumnae	82.24	0.00e+00	827.00
IUUC-Lpe-051419	Leersia perrieri	43.33	2.00e-109	389.00
IUUC-Loc-052732	Lepisosteus oculatus	81.25	0.00e+00	848.00
IUUC-Lma-053177	Leptosphaeria maculans	41.54	1.00e-71	263.00
IUUC-Laf-053822	Loxodonta africana	97.97	0.00e+00	962.00
IUUC-Mcc-055893	Macaca mulatta	98.78	0.00e+00	941.00
IUUC-Meu-056307	Macropus eugenii	82.65	0.00e+00	800.00
IUUC-Mor-057171	Magnaporthe oryzae	38.37	3.00e-68	253.00
IUUC-Mpo-057415	Magnaporthe poae	39.85	2.00e-71	263.00
IUUC-Mtr-057901	Medicago truncatula	43.20	8.00e-113	400.00
IUUC-Mla-058897	Melampsora laricipopulina	39.89	4.00e-76	278.00
IUUC-Mga-060016	Meleagris gallopavo	90.45	0.00e+00	895.00
IUUC-Mvi-060562	Microbotryum violaceum	40.11	1.00e-68	254.00
IUUC-Mmr-060624	Microcebus murinus	97.57	0.00e+00	1007.00
IUUC-Mdo-061809	Monodelphis domestica	93.15	0.00e+00	904.00
IUUC-Mmu-063869	Mus musculus	96.36	0.00e+00	947.00
IUUC-Mac-064876	Musa acuminata	39.92	5.00e-97	348.00
IUUC-Mlu-067866	Myotis lucifugus	97.37	0.00e+00	970.00
IUUC-Nfi-068393	Neosartorya fischeri	37.50	3.00e-68	252.00
IUUC-Ncr-068815	Neurospora crassa	35.84	2.00e-81	296.00
IUUC-Nle-070121	Nomascus leucogenys	98.42	2.00e-140	491.00
IUUC-Opr-070712	Ochotona princeps	77.16	7.00e-175	607.00
IUUC-Ont-071544	Oreochromis niloticus	82.28	0.00e+00	774.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.59	0.00e+00	754.00
IUUC-Ocu-074926	Oryctolagus cuniculus	96.36	0.00e+00	929.00
IUUC-Oba-075633	Oryza barthii	42.39	1.00e-109	389.00
IUUC-Obr-076423	Oryza brachyantha	43.23	2.00e-112	399.00
IUUC-Ogl-077913	Oryza glaberrima	42.02	3.00e-112	398.00
IUUC-Ogu-078435	Oryza glumaepatula	42.39	1.00e-109	389.00
IUUC-Oin-080072	Oryza indica	42.36	8.00e-110	390.00
IUUC-Olo-080535	Oryza longistaminata	39.60	4.00e-94	338.00
IUUC-Ome-081309	Oryza meridionalis	42.39	1.00e-109	389.00
IUUC-Oni-083113	Oryza nivara	42.39	1.00e-109	389.00
IUUC-Opu-083168	Oryza punctata	41.24	1.00e-103	369.00
IUUC-Oru-084253	Oryza rufipogon	42.39	1.00e-109	389.00
IUUC-Osa-085554	Oryza sativa	42.02	3.00e-112	398.00
IUUC-Ola-086998	Oryzias latipes	81.34	0.00e+00	799.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.29	1.00e-71	263.00
IUUC-Oga-088571	Otolemur garnettii	97.77	0.00e+00	959.00
IUUC-Oar-089526	Ovis aries	97.36	0.00e+00	956.00
IUUC-Ptr-091433	Pan troglodytes	98.78	0.00e+00	941.00
IUUC-Pan-091966	Papio anubis	98.58	0.00e+00	940.00
IUUC-Psi-093458	Pelodiscus sinensis	89.22	0.00e+00	855.00
IUUC-Pma-094343	Petromyzon marinus	68.86	3.00e-122	431.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.65	5.00e-67	248.00
IUUC-Ppa-095756	Physcomitrella patens	44.88	3.00e-113	402.00
IUUC-Pfo-096514	Poecilia formosa	82.69	0.00e+00	791.00
IUUC-Pab-098477	Pongo abelii	86.17	0.00e+00	743.00
IUUC-Pop-099221	Populus trichocarpa	41.77	3.00e-104	372.00
IUUC-Pca-100791	Procavia capensis	80.89	0.00e+00	630.00
IUUC-Ppe-101812	Prunus persica	41.97	3.00e-108	385.00
IUUC-Pva-102462	Pteropus vampyrus	93.94	0.00e+00	786.00
IUUC-Pgr-103623	Puccinia graminis	40.69	3.00e-75	276.00
IUUC-Ptt-103767	Puccinia triticina	40.00	4.00e-69	255.00
IUUC-Pte-104109	Pyrenophora teres	40.25	2.00e-71	263.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	40.56	1.00e-71	264.00
IUUC-Rno-105351	Rattus norvegicus	96.56	0.00e+00	905.00
IUUC-Sce-106168	Saccharomyces cerevisiae	33.00	3.00e-63	235.00
IUUC-Sha-107491	Sarcophilus harrisii	93.54	0.00e+00	927.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	33.73	7.00e-79	287.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.63	1.00e-80	293.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	35.27	7.00e-85	308.00
IUUC-Smo-108805	Selaginella moellendorffii	43.88	5.00e-111	394.00
IUUC-Sit-110361	Setaria italica	43.55	6.00e-115	407.00
IUUC-Sly-110965	Solanum lycopersicum	41.33	1.00e-108	386.00
IUUC-Sar-113355	Sorex araneus	84.38	0.00e+00	665.00
IUUC-Sbi-114778	Sorghum bicolor	44.44	1.00e-115	409.00
IUUC-Sre-115011	Sporisorium reilianum	36.34	2.00e-62	233.00
IUUC-Ssc-116273	Sus scrofa	97.56	0.00e+00	948.00
IUUC-Tgu-117063	Taeniopygia guttata	90.24	0.00e+00	878.00
IUUC-Tru-118381	Takifugu rubripes	79.67	0.00e+00	800.00
IUUC-Tsy-119076	Tarsius syrichta	81.82	5.00e-119	420.00
IUUC-Tni-119941	Tetraodon nigroviridis	81.10	0.00e+00	790.00
IUUC-Tca-121246	Theobroma cacao	41.68	2.00e-109	389.00
IUUC-Tre-121969	Trichoderma reesei	34.84	4.00e-76	278.00
IUUC-Tvi-122543	Trichoderma virens	35.04	1.00e-78	287.00
IUUC-Tae-125484	Triticum aestivum	43.06	5.00e-111	394.00
IUUC-Tur-126128	Triticum urartu	33.45	2.00e-68	253.00
IUUC-Tbe-128030	Tupaia belangeri	90.78	0.00e+00	863.00
IUUC-Ttr-128701	Tursiops truncatus	96.93	0.00e+00	778.00
IUUC-Uma-129657	Ustilago maydis	36.80	2.00e-65	243.00
IUUC-Vda-129723	Verticillium dahliae	32.48	2.00e-71	263.00
IUUC-Vpa-130284	Vicugna pacos	70.49	0.00e+00	644.00
IUUC-Vvi-131037	Vitis vinifera	43.40	8.00e-110	390.00
IUUC-Xtr-132235	Xenopus tropicalis	85.69	0.00e+00	883.00
IUUC-Xma-133840	Xiphophorus maculatus	82.69	0.00e+00	816.00
IUUC-Yli-134453	Yarrowia lipolytica	36.98	1.00e-82	300.00
IUUC-Zma-135669	Zea mays	37.03	4.00e-97	348.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence