iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18552202; 20933424

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	3.30e-05	25.2	16	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iC + ++d + +  C H+f+++C+ +     k  +    +CP+C+
   Q: 16   CSICDNILRDATTISECLHTFCRKCIyE-----KITEDEIETCPVCN 57
           ****999999999999*********933.....356777779****7 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress. Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A. Functionally redundant with DRIP2.

Protein Sequence
(Fasta)

MMIKVKKETM RACLSCSICD NILRDATTIS ECLHTFCRKC IYEKITEDEI ETCPVCNIDL 60
GSTPLEKLRP DHNLQDLRAK IFALKRRKVK APGIVSLPGK RKERSISSLV VSTPMVSAQA 120

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Nucleotide Sequence
(Fasta)

GATTAACCAA AATAAAGAAT GTTTGACCTA GTTTTCCTAA TTAAAGTAAC ACAAAGATTT 60
TGACCCAAAA AAAAACGTCT TTGAGCGCTC GTTTTCTTGT CGACGAGAGA GCTCTTAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
GO:0009414--P:response to water deprivation

KEGG

ath:AT1G06770

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005422	Arabidopsis lyrata	89.71	0.00e+00	682.00
IUUC-Cel-018403	Caenorhabditis elegans	35.53	2.00e-10	60.10
IUUC-Cpo-021535	Cavia porcellus	40.59	2.00e-12	65.90
IUUC-Cho-024728	Choloepus hoffmanni	48.00	4.00e-12	65.10
IUUC-Cne-026870	Cryptococcus neoformans	37.50	2.00e-06	47.40
IUUC-Dme-032006	Drosophila melanogaster	40.51	6.00e-12	63.50
IUUC-Ete-032808	Echinops telfairi	49.25	4.00e-12	64.70
IUUC-Eeu-035280	Erinaceus europaeus	39.13	3.00e-12	65.50
IUUC-Gma-043895	Glycine max	57.61	2.00e-124	438.00
IUUC-Hsa-046736	Homo sapiens	49.25	4.00e-12	65.10
IUUC-Mtr-058189	Medicago truncatula	52.56	2.00e-107	382.00
IUUC-Mpu-065971	Mustela putorius furo	49.25	3.00e-12	65.50
IUUC-Mlu-068172	Myotis lucifugus	39.13	4.00e-12	64.70
IUUC-Ola-086801	Oryzias latipes	28.38	1.00e-12	66.20
IUUC-Ptr-090745	Pan troglodytes	49.25	4.00e-12	65.10
IUUC-Ppa-095811	Physcomitrella patens	46.02	2.00e-23	103.00
IUUC-Pab-098230	Pongo abelii	49.25	4.00e-12	65.10
IUUC-Pva-102607	Pteropus vampyrus	47.83	4.00e-12	65.10
IUUC-Ttr-129281	Tursiops truncatus	47.83	4.00e-12	64.70
IUUC-Vpa-130504	Vicugna pacos	47.83	6.00e-12	64.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence