iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046389

Ensembl Protein ID

ENSP00000264159.6

UniProt Accession

Q5FWF4; B3KYA1; B4E375; B5MDI3; D3DP76; E9PBP0; Q53SM1; Q6P2C4; Q8N1P4; Q9H0E8; ZRAB3_HUMAN

Genbank Protein ID

CAB66758.1; BAC04536.1; BAG54763.1; BAG65387.1; AAX93066.1; EAX11631.1; EAX11633.1; AAH64616.1; AAH89429.2

Protein Name

DNA annealing helicase and endonuclease ZRANB3; Annealing helicase 2; Zinc finger Ran-binding domain-containing protein 3; DNA annealing helicase ZRANB3; Endonuclease ZRANB3

Genbank Nucleotide ID

AL136824; AK095362; AK131303; AK304601; BX647838; AC020602; CH471058; BC064616; BC089429

Gene Name

ZRANB3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000121988.17	ENST00000401392.5	ENSP00000383979.1
ENSG00000121988.17	ENST00000264159.10	ENSP00000264159.6
ENSG00000121988.17	ENST00000403017.2	ENSP00000384245.2
ENSG00000121988.17	ENST00000619650.4	ENSP00000480120.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	22759634

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	3.70e-11	44.0	623	649

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
           ++W+Cs CT++N++e+++CemC++p+g
   Q: 623  EGWQCSLCTYINNSELPYCEMCETPQG 649
           79***********************97 PP

Organism

Homo sapiens

Functional Description
(View)

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Protein Sequence
(Fasta)

MPRVHNIKKS LTPHISCVTN ESDNLLDFLP DRLRAKLLPF QKDGIIFALK RNGRCMVADE 60
MGLGKTIQAI GITYFYKEEW PLLIVVPSSL RYPWTEEIEK WIPELSPEEI NVIQNKTDVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAATGGTAA AACTAGGAGG ACAGCCATTT TGCCCACTTG TAAAAGAGCT ACCTTTTCCC 60
ACGAGTTGGA GCCTGAGGTG CGGAGTTTCG TGAGTTTTTA CTGACTCGAG GTATTTAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0540--Nuclease
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR002711--HNH
IPR003615--HNH_nuc
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR001876--Znf_RanBP2

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF00271--Helicase_C
PF01844--HNH
PF00176--SNF2_N
PF00641--zf-RanBP

SMART

SM00487--DEXDc
SM00490--HELICc
SM00507--HNHc
SM00547--ZnF_RBZ

Gene Ontology

GO:0043596--C:nuclear replication fork
GO:0005634--C:nucleus
GO:0036310--F:annealing helicase activity
GO:0005524--F:ATP binding
GO:0004520--F:endodeoxyribonuclease activity
GO:0004386--F:helicase activity
GO:0070530--F:K63-linked polyubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0036292--P:DNA rewinding
GO:0045910--P:negative regulation of DNA recombination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0009411--P:response to UV

KEGG

hsa:84083

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001748	Ailuropoda melanoleuca	84.53	0.00e+00	1807.00
IUUC-Ame-010851	Astyanax mexicanus	69.29	0.00e+00	759.00
IUUC-Bta-013559	Bos taurus	82.40	0.00e+00	1669.00
IUUC-Cja-019295	Callithrix jacchus	92.14	0.00e+00	2067.00
IUUC-Cfa-020445	Canis familiaris	83.07	0.00e+00	1862.00
IUUC-Cpo-021752	Cavia porcellus	81.96	0.00e+00	1731.00
IUUC-Cho-024291	Choloepus hoffmanni	77.58	0.00e+00	1394.00
IUUC-Dno-029189	Dasypus novemcinctus	84.74	0.00e+00	1802.00
IUUC-Ete-032675	Echinops telfairi	64.06	0.00e+00	1224.00
IUUC-Eca-034386	Equus caballus	84.72	0.00e+00	1803.00
IUUC-Eeu-034715	Erinaceus europaeus	70.61	0.00e+00	1085.00
IUUC-Fca-035782	Felis catus	81.02	0.00e+00	1679.00
IUUC-Ggo-044474	Gorilla gorilla	99.07	0.00e+00	2232.00
IUUC-Itr-048124	Ictidomys tridecemlineatus	82.00	0.00e+00	1704.00
IUUC-Lch-050057	Latimeria chalumnae	57.26	0.00e+00	977.00
IUUC-Loc-052337	Lepisosteus oculatus	53.31	0.00e+00	1173.00
IUUC-Laf-054123	Loxodonta africana	82.72	0.00e+00	1859.00
IUUC-Mcc-055276	Macaca mulatta	95.90	0.00e+00	2051.00
IUUC-Mmr-061589	Microcebus murinus	87.51	0.00e+00	1956.00
IUUC-Mmu-064119	Mus musculus	77.24	0.00e+00	1693.00
IUUC-Mpu-066729	Mustela putorius furo	82.67	0.00e+00	1852.00
IUUC-Mlu-067857	Myotis lucifugus	76.79	0.00e+00	1488.00
IUUC-Nle-070137	Nomascus leucogenys	97.26	0.00e+00	2120.00
IUUC-Opr-070305	Ochotona princeps	73.93	0.00e+00	1549.00
IUUC-Ont-072504	Oreochromis niloticus	59.97	0.00e+00	825.00
IUUC-Oan-073379	Ornithorhynchus anatinus	65.09	0.00e+00	1450.00
IUUC-Ola-086386	Oryzias latipes	56.00	0.00e+00	1135.00
IUUC-Oga-088489	Otolemur garnettii	83.98	0.00e+00	1383.00
IUUC-Oar-089750	Ovis aries	84.00	0.00e+00	1843.00
IUUC-Pan-092664	Papio anubis	96.25	0.00e+00	1711.00
IUUC-Pma-094301	Petromyzon marinus	53.61	0.00e+00	1120.00
IUUC-Pfo-097036	Poecilia formosa	54.72	0.00e+00	1158.00
IUUC-Pab-098606	Pongo abelii	97.41	0.00e+00	2190.00
IUUC-Pva-103004	Pteropus vampyrus	79.65	0.00e+00	1739.00
IUUC-Sar-112970	Sorex araneus	72.99	0.00e+00	1409.00
IUUC-Ssc-115868	Sus scrofa	84.67	0.00e+00	1800.00
IUUC-Tgu-116905	Taeniopygia guttata	63.68	0.00e+00	1349.00
IUUC-Tsy-118909	Tarsius syrichta	78.22	0.00e+00	1716.00
IUUC-Tni-119749	Tetraodon nigroviridis	55.98	0.00e+00	1161.00
IUUC-Tbe-127972	Tupaia belangeri	86.54	0.00e+00	743.00
IUUC-Ttr-128601	Tursiops truncatus	82.05	0.00e+00	1839.00
IUUC-Vpa-130286	Vicugna pacos	80.57	0.00e+00	1743.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence