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Tag Content
iUUCD ID IUUC-Pfo-097089
Ensembl Protein ID ENSPFOP00000015128.1
UniProt Accession A0A087YAS5; A0A087YAS5_POEFO
Genbank Protein ID ENSPFOP00000015128
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID AYCK01017763
Gene Name pafah1b1b (1 of many); PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPFOG00000015100.1 ENSPFOT00000015150.1 ENSPFOP00000015128.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-59 195.8 336 374
UBD/Beta-Prp 1.80e-94 316.9 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++vs++dD+t+++WD++ ++ k
   Q: 336 GHDNWVRGILFhPGgKFIVSCADDKTLRIWDYKNKRCMK 374
    8***********999****************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h +++t v f+p s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRNPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5668888********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+ti++w++ tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTIKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ + f+p ++++vs+++D+++riWd++++
   Q: 283 SWAPESahptildatgseskksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGILFHPGGKFIVSCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl+ h++ v+s ++ + + +v+gs d++v++w+++
   Q: 372 CMKTLSAHEHFVTSLDF-HRAAPFVVTGSVDQTVKVWECR 410
    *****************.999****************985 PP
   

Organism Poecilia formosa
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDNN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPVSQKRD PKEWIPRPPE RYALSGHRNP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Pfo-097089|E3,WD_repeat;UBD,Beta-Prp|Poecilia formosa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTTGTGCAA GGAGGAAAGA GTTAATGCCT AGATATAAAA ATAATAAATA GATTTTCTGT 60
TGTCAAGGGC GTGCGCGCTC CCGTCGAGCA GTGAACGCGA CCAGGCTGCG CGCTCCCTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Pfo-097089|E3,WD_repeat;UBD,Beta-Prp|Poecilia formosa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 93.48 0.00e+00 791.00
IUUC-Apl-004024 Anas platyrhynchos 93.66 0.00e+00 813.00
IUUC-Aca-004564 Anolis carolinensis 93.17 0.00e+00 806.00
IUUC-Acl-008360 Aspergillus clavatus 46.27 4.00e-105 375.00
IUUC-Afl-008502 Aspergillus flavus 45.29 5.00e-94 338.00
IUUC-Afu-008848 Aspergillus fumigatus 46.95 7.00e-108 384.00
IUUC-Ani-009173 Aspergillus nidulans 42.93 7.00e-91 327.00
IUUC-Ang-009873 Aspergillus niger 44.56 7.00e-94 337.00
IUUC-Aor-009973 Aspergillus oryzae 43.84 1.00e-91 330.00
IUUC-Ate-010523 Aspergillus terreus 42.32 1.00e-90 327.00
IUUC-Ame-010969 Astyanax mexicanus 96.10 0.00e+00 833.00
IUUC-Bgr-011972 Blumeria graminis 47.97 9.00e-106 377.00
IUUC-Bta-013106 Bos taurus 93.66 0.00e+00 813.00
IUUC-Bci-013615 Botrytis cinerea 45.78 2.00e-100 359.00
IUUC-Cel-018459 Caenorhabditis elegans 57.42 5.00e-149 520.00
IUUC-Cja-018755 Callithrix jacchus 91.22 0.00e+00 795.00
IUUC-Cfa-020749 Canis familiaris 93.66 0.00e+00 813.00
IUUC-Cpo-022371 Cavia porcellus 93.66 0.00e+00 813.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 36.39 1.00e-52 199.00
IUUC-Csa-023524 Chlorocebus sabaeus 92.46 0.00e+00 682.00
IUUC-Cho-024764 Choloepus hoffmanni 83.29 0.00e+00 644.00
IUUC-Cin-025753 Ciona intestinalis 71.78 0.00e+00 630.00
IUUC-Csv-025817 Ciona savignyi 70.00 0.00e+00 639.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 47.51 2.00e-99 356.00
IUUC-Cne-027087 Cryptococcus neoformans 50.90 2.00e-111 396.00
IUUC-Dre-028314 Danio rerio 94.88 0.00e+00 828.00
IUUC-Dno-029050 Dasypus novemcinctus 93.41 0.00e+00 813.00
IUUC-Dor-030222 Dipodomys ordii 85.61 0.00e+00 731.00
IUUC-Dse-031164 Dothistroma septosporum 43.58 3.00e-101 362.00
IUUC-Ete-032508 Echinops telfairi 78.05 0.00e+00 656.00
IUUC-Eca-034288 Equus caballus 92.98 0.00e+00 788.00
IUUC-Eeu-034984 Erinaceus europaeus 85.37 0.00e+00 728.00
IUUC-Fca-036498 Felis catus 93.66 0.00e+00 813.00
IUUC-Fal-036920 Ficedula albicollis 93.66 0.00e+00 813.00
IUUC-Fox-037996 Fusarium oxysporum 45.91 4.00e-104 371.00
IUUC-Fso-038160 Fusarium solani 43.57 3.00e-98 352.00
IUUC-Gmo-038983 Gadus morhua 95.12 0.00e+00 823.00
IUUC-Ggr-040051 Gaeumannomyces graminis 46.06 4.00e-99 355.00
IUUC-Gga-040623 Gallus gallus 93.66 0.00e+00 813.00
IUUC-Gac-041613 Gasterosteus aculeatus 96.83 0.00e+00 836.00
IUUC-Ggo-045410 Gorilla gorilla 83.21 0.00e+00 684.00
IUUC-Hsa-046358 Homo sapiens 93.66 0.00e+00 813.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 93.66 0.00e+00 813.00
IUUC-Lch-049936 Latimeria chalumnae 94.39 0.00e+00 817.00
IUUC-Loc-052476 Lepisosteus oculatus 95.24 0.00e+00 803.00
IUUC-Lma-053170 Leptosphaeria maculans 46.43 9.00e-100 357.00
IUUC-Laf-053713 Loxodonta africana 91.69 0.00e+00 795.00
IUUC-Mcc-054628 Macaca mulatta 93.17 0.00e+00 811.00
IUUC-Meu-055927 Macropus eugenii 80.14 7.00e-133 466.00
IUUC-Mor-056962 Magnaporthe oryzae 45.08 1.00e-98 353.00
IUUC-Mpo-057583 Magnaporthe poae 45.97 2.00e-95 343.00
IUUC-Mla-058819 Melampsora laricipopulina 48.31 7.00e-119 420.00
IUUC-Mga-059945 Meleagris gallopavo 93.41 0.00e+00 812.00
IUUC-Mvi-060403 Microbotryum violaceum 50.68 6.00e-131 460.00
IUUC-Mmr-061289 Microcebus murinus 93.48 0.00e+00 791.00
IUUC-Mdo-061912 Monodelphis domestica 92.93 0.00e+00 806.00
IUUC-Mmu-063253 Mus musculus 93.66 0.00e+00 813.00
IUUC-Mpu-066638 Mustela putorius furo 93.66 0.00e+00 813.00
IUUC-Mlu-067267 Myotis lucifugus 92.16 0.00e+00 796.00
IUUC-Nfi-068571 Neosartorya fischeri 45.39 3.00e-100 358.00
IUUC-Ncr-068895 Neurospora crassa 48.77 1.00e-105 376.00
IUUC-Nle-069087 Nomascus leucogenys 94.33 0.00e+00 664.00
IUUC-Opr-070579 Ochotona princeps 93.41 0.00e+00 813.00
IUUC-Ont-072432 Oreochromis niloticus 97.07 0.00e+00 839.00
IUUC-Oan-073072 Ornithorhynchus anatinus 93.66 0.00e+00 813.00
IUUC-Ocu-074180 Oryctolagus cuniculus 93.41 0.00e+00 813.00
IUUC-Ola-086772 Oryzias latipes 97.80 0.00e+00 842.00
IUUC-Oga-088219 Otolemur garnettii 91.44 0.00e+00 794.00
IUUC-Oar-090394 Ovis aries 93.66 0.00e+00 813.00
IUUC-Ptr-091517 Pan troglodytes 93.66 0.00e+00 813.00
IUUC-Pan-092421 Papio anubis 93.17 0.00e+00 811.00
IUUC-Psi-093370 Pelodiscus sinensis 93.41 0.00e+00 813.00
IUUC-Pma-094319 Petromyzon marinus 85.67 0.00e+00 634.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.78 5.00e-103 368.00
IUUC-Pab-098421 Pongo abelii 93.66 0.00e+00 813.00
IUUC-Pca-100120 Procavia capensis 68.56 3.00e-155 541.00
IUUC-Pva-102960 Pteropus vampyrus 93.41 0.00e+00 809.00
IUUC-Pgr-103538 Puccinia graminis 47.65 4.00e-119 421.00
IUUC-Ptt-103990 Puccinia triticina 43.09 8.00e-45 175.00
IUUC-Pte-104261 Pyrenophora teres 47.02 3.00e-103 368.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.26 1.00e-103 370.00
IUUC-Rno-105123 Rattus norvegicus 93.66 0.00e+00 813.00
IUUC-Sha-107010 Sarcophilus harrisii 92.68 0.00e+00 805.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 33.26 2.00e-67 249.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 45.91 8.00e-101 360.00
IUUC-Sar-113309 Sorex araneus 92.73 0.00e+00 782.00
IUUC-Sre-115003 Sporisorium reilianum 49.77 3.00e-125 441.00
IUUC-Ssc-116148 Sus scrofa 93.66 0.00e+00 813.00
IUUC-Tgu-117299 Taeniopygia guttata 93.41 0.00e+00 810.00
IUUC-Tru-117721 Takifugu rubripes 96.10 0.00e+00 831.00
IUUC-Tsy-119493 Tarsius syrichta 92.93 0.00e+00 802.00
IUUC-Tni-120355 Tetraodon nigroviridis 97.07 0.00e+00 812.00
IUUC-Tre-121977 Trichoderma reesei 43.43 7.00e-101 361.00
IUUC-Tvi-122661 Trichoderma virens 43.84 2.00e-100 359.00
IUUC-Tme-127031 Tuber melanosporum 49.01 2.00e-104 372.00
IUUC-Tbe-127492 Tupaia belangeri 61.07 8.00e-122 430.00
IUUC-Ttr-128929 Tursiops truncatus 93.66 0.00e+00 811.00
IUUC-Uma-129347 Ustilago maydis 48.40 4.00e-124 438.00
IUUC-Vda-129837 Verticillium dahliae 46.88 3.00e-101 362.00
IUUC-Vpa-130532 Vicugna pacos 80.05 0.00e+00 630.00
IUUC-Xtr-131985 Xenopus tropicalis 93.41 0.00e+00 814.00
IUUC-Xma-133314 Xiphophorus maculatus 99.51 0.00e+00 855.00
IUUC-Yli-134403 Yarrowia lipolytica 38.65 2.00e-75 276.00
Created Date 25-Jun-2017

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