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Tag Content
iUUCD ID IUUC-Sre-115003
Ensembl Protein ID CBQ73553
UniProt Accession E7A246; E7A246_SPORE
Genbank Protein ID CBQ73553.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID FQ311473
Gene Name PAC1; LIS1; sr14206
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
sr14206 CBQ73553 CBQ73553
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.40e-46 152.2 348 387
UBD/Beta-Prp 8.60e-74 246.8 112 403
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH ++v++laf ++ ++l+s sdD+t+++W+l+tg+++k+
   Q: 348 GHDNWVRGLAFsPNgKHLLSVSDDKTMRIWELKTGRCIKT 387
    8***********777**********************985 PP
   


   UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsps 105
    ++ h ++t+v+f+p s++a++s+d t+k+wd++tg++ r+l+gh+++v++v+f+++g++ v++s+D ikvwd + ++k + tl+gh++sv s++f p
   Q: 112 MQGHRMPVTKVAFHPVFSQVASASEDTTVKLWDWETGDFERTLKGHTKAVQDVDFDSKGNFVVSCSSDLSIKVWDANnDYKNIKTLHGHDHSVSSVKFLPG 212
    4456669999****************************************************************998689********************9 PP
   S: 106 gdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.............. 192
    + ++vs+s+d+ti++w+ +tg c + tl gh ++v+++ ++dg+ l+s+s+D+t r+W l+tg+ +l+g h++ v+ +f ++
   Q: 213 DGFIVSASRDKTIKIWEFSTGFCTR-TLHGHAEWVRSAIPSEDGKWLISCSTDQTARVWELSTGETKVELRG-HEHVVEVAIFAPTAsyaairelvgitps 311
    9************************.*********************************************9.*********999999999********** PP
   S: 193 ..........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav..l 273
    +++++gs+d+t++lwd +g+c++tl gh+++v+ ++fspn+++l+s+s+D++ riW l++g ++ktl h++ +sva
   Q: 312 akdasasapaQFVATGSRDKTIRLWDS-AGQCLKTLVGHDNWVRGLAFSPNGKHLLSVSDDKTMRIWELKTGRCIKTLDAHQHFCTSVAWgkA 403
    **************************8.99****************************************************99999998442 PP
   

Organism Sporisorium reilianum
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSSINSTSIL SERQKDELHK SILDYFKTNG LNDSYQTLMR EAGQDGFVPD PKAKYAGLLE 60
KKWTSVIRLQ KKIMEMESRM AQLQEELAAA PSAKRSASLN DWVPRASARH TMQGHRMPVT 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Sre-115003|E3,WD_repeat;UBD,Beta-Prp|Sporisorium reilianum
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCAGCA TCAACAGCAC CAGCATCCTC TCCGAGAGGC AAAAGGATGA GCTGCACAAG 60
TCCATCCTCG ACTACTTCAA GACCAACGGT CTCAACGACT CGTATCAGAC GCTCATGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Sre-115003|E3,WD_repeat;UBD,Beta-Prp|Sporisorium reilianum
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0378--Hydrolase
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0016787--F:hydrolase activity
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 49.53 2.00e-123 433.00
IUUC-Apl-004024 Anas platyrhynchos 50.00 4.00e-128 449.00
IUUC-Aca-004564 Anolis carolinensis 50.00 2.00e-126 443.00
IUUC-Ago-007862 Ashbya gossypii 27.91 1.00e-38 152.00
IUUC-Acl-008360 Aspergillus clavatus 53.61 1.00e-123 434.00
IUUC-Afl-008502 Aspergillus flavus 50.13 3.00e-111 393.00
IUUC-Afu-008848 Aspergillus fumigatus 50.44 1.00e-128 451.00
IUUC-Ani-009173 Aspergillus nidulans 46.88 3.00e-112 396.00
IUUC-Ang-009873 Aspergillus niger 49.15 7.00e-115 405.00
IUUC-Aor-009973 Aspergillus oryzae 48.38 3.00e-109 386.00
IUUC-Ate-010523 Aspergillus terreus 47.45 9.00e-116 408.00
IUUC-Ame-011154 Astyanax mexicanus 50.00 2.00e-128 450.00
IUUC-Bgr-011972 Blumeria graminis 50.33 3.00e-129 453.00
IUUC-Bta-013106 Bos taurus 50.00 2.00e-128 450.00
IUUC-Bci-013615 Botrytis cinerea 49.13 1.00e-124 437.00
IUUC-Cel-018459 Caenorhabditis elegans 43.25 1.00e-106 378.00
IUUC-Cja-018755 Callithrix jacchus 48.63 5.00e-124 435.00
IUUC-Cfa-020749 Canis familiaris 50.00 2.00e-128 450.00
IUUC-Cpo-022371 Cavia porcellus 50.00 2.00e-128 450.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 37.25 9.00e-49 185.00
IUUC-Csa-023524 Chlorocebus sabaeus 49.06 2.00e-106 377.00
IUUC-Cho-024764 Choloepus hoffmanni 46.43 2.00e-101 360.00
IUUC-Cin-025753 Ciona intestinalis 47.49 4.00e-115 406.00
IUUC-Csv-025817 Ciona savignyi 46.35 8.00e-115 405.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 49.68 1.00e-121 427.00
IUUC-Cne-027087 Cryptococcus neoformans 59.35 5.00e-138 482.00
IUUC-Dre-028314 Danio rerio 49.32 1.00e-126 444.00
IUUC-Dno-029050 Dasypus novemcinctus 50.00 3.00e-128 450.00
IUUC-Dor-030222 Dipodomys ordii 46.45 7.00e-115 405.00
IUUC-Dse-031164 Dothistroma septosporum 46.97 2.00e-120 424.00
IUUC-Dme-031745 Drosophila melanogaster 50.76 4.00e-115 406.00
IUUC-Ete-032508 Echinops telfairi 43.38 6.00e-101 358.00
IUUC-Eca-034288 Equus caballus 49.07 3.00e-122 429.00
IUUC-Eeu-034984 Erinaceus europaeus 46.22 8.00e-114 401.00
IUUC-Fca-036498 Felis catus 50.00 2.00e-128 450.00
IUUC-Fal-036920 Ficedula albicollis 50.00 4.00e-128 449.00
IUUC-Fox-037996 Fusarium oxysporum 48.58 2.00e-124 437.00
IUUC-Fso-038160 Fusarium solani 47.15 8.00e-117 412.00
IUUC-Gmo-038983 Gadus morhua 49.77 2.00e-127 447.00
IUUC-Ggr-040051 Gaeumannomyces graminis 47.08 2.00e-118 417.00
IUUC-Gga-040623 Gallus gallus 50.00 4.00e-128 449.00
IUUC-Gac-041613 Gasterosteus aculeatus 49.32 5.00e-126 442.00
IUUC-Ggo-045410 Gorilla gorilla 50.00 2.00e-106 377.00
IUUC-Hsa-046358 Homo sapiens 50.00 3.00e-128 449.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 50.00 2.00e-128 450.00
IUUC-Kpa-049351 Komagataella pastoris 27.87 3.00e-40 157.00
IUUC-Lch-049936 Latimeria chalumnae 49.54 4.00e-127 446.00
IUUC-Loc-052476 Lepisosteus oculatus 49.30 5.00e-122 429.00
IUUC-Lma-053170 Leptosphaeria maculans 48.39 3.00e-124 436.00
IUUC-Laf-053713 Loxodonta africana 48.86 2.00e-124 436.00
IUUC-Mcc-054628 Macaca mulatta 49.77 5.00e-128 449.00
IUUC-Meu-055927 Macropus eugenii 42.62 5.00e-67 245.00
IUUC-Mor-056962 Magnaporthe oryzae 46.55 5.00e-118 416.00
IUUC-Mpo-057583 Magnaporthe poae 47.30 4.00e-115 406.00
IUUC-Mla-058819 Melampsora laricipopulina 58.57 6.00e-152 528.00
IUUC-Mga-059945 Meleagris gallopavo 49.77 9.00e-128 448.00
IUUC-Mvi-060403 Microbotryum violaceum 65.71 2.00e-176 610.00
IUUC-Mmr-061289 Microcebus murinus 49.53 2.00e-123 433.00
IUUC-Mdo-061912 Monodelphis domestica 49.77 2.00e-127 447.00
IUUC-Mmu-063253 Mus musculus 50.00 2.00e-128 450.00
IUUC-Mpu-066638 Mustela putorius furo 50.00 2.00e-128 450.00
IUUC-Mlu-067267 Myotis lucifugus 48.97 1.00e-124 437.00
IUUC-Nfi-068571 Neosartorya fischeri 50.85 3.00e-117 413.00
IUUC-Ncr-068895 Neurospora crassa 52.42 7.00e-130 455.00
IUUC-Nle-069087 Nomascus leucogenys 51.76 1.00e-105 374.00
IUUC-Opr-070579 Ochotona princeps 50.00 3.00e-128 450.00
IUUC-Ont-072432 Oreochromis niloticus 49.54 9.00e-128 448.00
IUUC-Oan-073072 Ornithorhynchus anatinus 50.00 2.00e-128 450.00
IUUC-Ocu-074180 Oryctolagus cuniculus 50.00 3.00e-128 450.00
IUUC-Ola-086815 Oryzias latipes 50.46 2.00e-128 450.00
IUUC-Oga-088219 Otolemur garnettii 49.20 8.00e-124 435.00
IUUC-Oar-090394 Ovis aries 50.00 2.00e-128 450.00
IUUC-Ptr-091517 Pan troglodytes 50.00 2.00e-128 450.00
IUUC-Pan-092421 Papio anubis 49.77 5.00e-128 449.00
IUUC-Psi-093370 Pelodiscus sinensis 50.00 6.00e-128 448.00
IUUC-Pma-094319 Petromyzon marinus 48.01 1.00e-102 364.00
IUUC-Pno-094815 Phaeosphaeria nodorum 48.09 1.00e-124 437.00
IUUC-Pfo-097089 Poecilia formosa 49.77 6.00e-128 448.00
IUUC-Pab-098421 Pongo abelii 50.00 2.00e-128 450.00
IUUC-Pca-100120 Procavia capensis 43.28 8.00e-77 278.00
IUUC-Pva-102960 Pteropus vampyrus 49.77 4.00e-127 446.00
IUUC-Pgr-103538 Puccinia graminis 60.40 1.00e-159 554.00
IUUC-Ptt-103990 Puccinia triticina 53.23 6.00e-61 227.00
IUUC-Pte-104261 Pyrenophora teres 49.35 4.00e-126 442.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 49.57 2.00e-126 444.00
IUUC-Rno-105123 Rattus norvegicus 50.00 2.00e-128 450.00
IUUC-Sce-106208 Saccharomyces cerevisiae 30.26 6.00e-40 156.00
IUUC-Sha-107010 Sarcophilus harrisii 49.77 1.00e-127 447.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 33.77 4.00e-72 263.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 50.23 2.00e-123 434.00
IUUC-Sar-113309 Sorex araneus 48.83 6.00e-121 425.00
IUUC-Ssc-116148 Sus scrofa 50.00 2.00e-128 450.00
IUUC-Tgu-117299 Taeniopygia guttata 49.77 2.00e-127 446.00
IUUC-Tru-118179 Takifugu rubripes 49.32 2.00e-126 444.00
IUUC-Tsy-119493 Tarsius syrichta 50.23 2.00e-127 446.00
IUUC-Tni-120355 Tetraodon nigroviridis 49.09 3.00e-124 436.00
IUUC-Tre-121977 Trichoderma reesei 47.89 1.00e-118 418.00
IUUC-Tvi-122661 Trichoderma virens 48.28 1.00e-117 414.00
IUUC-Tme-127031 Tuber melanosporum 52.22 8.00e-128 448.00
IUUC-Tbe-127492 Tupaia belangeri 40.74 3.00e-65 240.00
IUUC-Ttr-128929 Tursiops truncatus 50.00 4.00e-128 449.00
IUUC-Uma-129347 Ustilago maydis 84.39 0.00e+00 782.00
IUUC-Vda-129837 Verticillium dahliae 50.84 4.00e-118 416.00
IUUC-Vpa-130532 Vicugna pacos 45.38 9.00e-102 361.00
IUUC-Xtr-131985 Xenopus tropicalis 50.00 2.00e-128 450.00
IUUC-Xma-133314 Xiphophorus maculatus 50.00 3.00e-128 449.00
IUUC-Yli-134403 Yarrowia lipolytica 39.10 2.00e-85 307.00
Created Date 25-Jun-2017

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