iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gac-041673

Ensembl Protein ID

ENSGACP00000002409.1

UniProt Accession

G3NAR7; G3NAR7_GASAC

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000001857.1	ENSGACT00000002417.1	ENSGACP00000002409.1
ENSGACG00000001857.1	ENSGACT00000002420.1	ENSGACP00000002412.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	89.72	3.00e-138	488.00	IUUC-Hsa-046179
E3 activity/RING/RING	89.72	1.00e-138	489.00	IUUC-Mmu-063206
E3 activity/RING/RING	89.72	9.00e-139	489.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gasterosteus aculeatus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSAGGG GLGAGKAAGG GKHGGTGGGA AAAAVAAGLS SVAVPGSAAP SSALPLGLPG 60
QSPELTALFE CPVCFDYVLP PILQCQAGHL VCNQCRQKLS CCPTCRGPLS PSIRNLAMEK 120

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Nucleotide Sequence
(Fasta)

TGACGTTACC GCCCGCTCGG CAGTTCACGG GAAACGGACC GCAGCTGGAA GCCATGAGCC 60
GCCCGTCCTC TGCCGGAGGC GGAGGACTCG GTGCCGGGAA AGCAGCGGGC GGAGGAAAGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	89.72	2.00e-140	491.00
IUUC-Ame-011678	Astyanax mexicanus	95.67	7.00e-148	516.00
IUUC-Bta-012750	Bos taurus	89.33	4.00e-140	490.00
IUUC-Cja-019800	Callithrix jacchus	89.72	2.00e-140	491.00
IUUC-Cfa-020505	Canis familiaris	89.33	4.00e-140	490.00
IUUC-Cpo-021394	Cavia porcellus	89.72	3.00e-140	491.00
IUUC-Csa-023374	Chlorocebus sabaeus	89.72	2.00e-140	491.00
IUUC-Cho-024933	Choloepus hoffmanni	89.72	1.00e-140	492.00
IUUC-Dre-027711	Danio rerio	96.46	6.00e-149	519.00
IUUC-Dno-029260	Dasypus novemcinctus	90.53	2.00e-136	478.00
IUUC-Dor-030489	Dipodomys ordii	89.07	2.00e-100	357.00
IUUC-Ete-032946	Echinops telfairi	89.72	5.00e-140	490.00
IUUC-Eca-033546	Equus caballus	85.40	1.00e-141	495.00
IUUC-Eeu-034861	Erinaceus europaeus	87.35	1.00e-135	475.00
IUUC-Gmo-039091	Gadus morhua	95.08	6.00e-152	530.00
IUUC-Gga-040252	Gallus gallus	88.54	7.00e-138	483.00
IUUC-Ggo-044618	Gorilla gorilla	89.72	2.00e-140	491.00
IUUC-Hsa-046179	Homo sapiens	89.72	2.00e-140	491.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	88.93	2.00e-139	488.00
IUUC-Lch-049496	Latimeria chalumnae	89.72	3.00e-141	494.00
IUUC-Loc-052107	Lepisosteus oculatus	96.00	2.00e-146	511.00
IUUC-Laf-054257	Loxodonta africana	89.33	1.00e-138	485.00
IUUC-Mcc-055023	Macaca mulatta	89.72	2.00e-140	491.00
IUUC-Meu-055922	Macropus eugenii	88.14	5.00e-137	479.00
IUUC-Mga-060070	Meleagris gallopavo	85.94	2.00e-134	471.00
IUUC-Mmr-061494	Microcebus murinus	89.72	2.00e-140	491.00
IUUC-Mdo-061971	Monodelphis domestica	89.72	3.00e-140	491.00
IUUC-Mmu-063206	Mus musculus	89.72	1.00e-140	492.00
IUUC-Mpu-066597	Mustela putorius furo	89.72	2.00e-140	491.00
IUUC-Mlu-067199	Myotis lucifugus	89.33	6.00e-140	489.00
IUUC-Nle-069342	Nomascus leucogenys	89.72	2.00e-140	491.00
IUUC-Opr-070341	Ochotona princeps	56.86	4.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	95.51	2.00e-152	531.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	8.00e-50	190.00
IUUC-Ocu-073950	Oryctolagus cuniculus	89.33	5.00e-140	490.00
IUUC-Oga-089154	Otolemur garnettii	89.72	2.00e-140	491.00
IUUC-Oar-089446	Ovis aries	89.33	4.00e-140	490.00
IUUC-Ptr-091088	Pan troglodytes	89.72	2.00e-140	491.00
IUUC-Psi-093079	Pelodiscus sinensis	89.72	4.00e-140	490.00
IUUC-Pfo-097007	Poecilia formosa	93.68	3.00e-143	501.00
IUUC-Pab-098092	Pongo abelii	89.72	2.00e-140	491.00
IUUC-Pca-100328	Procavia capensis	87.35	3.00e-136	478.00
IUUC-Pva-102368	Pteropus vampyrus	96.36	5.00e-61	228.00
IUUC-Rno-105477	Rattus norvegicus	89.72	1.00e-140	492.00
IUUC-Sha-107630	Sarcophilus harrisii	89.33	9.00e-140	489.00
IUUC-Ssc-116441	Sus scrofa	89.33	5.00e-140	490.00
IUUC-Tru-118004	Takifugu rubripes	95.31	2.00e-147	514.00
IUUC-Tsy-119548	Tarsius syrichta	85.61	3.00e-64	238.00
IUUC-Tni-120846	Tetraodon nigroviridis	96.05	5.00e-148	516.00
IUUC-Vpa-130799	Vicugna pacos	91.81	2.00e-96	344.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence