iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pma-094387

Ensembl Protein ID

ENSPMAP00000001842.1

UniProt Accession

S4R9G1; S4R9G1_PETMA

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000001685.1	ENSPMAT00000001852.1	ENSPMAP00000001842.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	80.08	2.00e-122	435.00	IUUC-Dme-031700
E3 activity/RING/RING	93.66	5.00e-159	557.00	IUUC-Hsa-046357
E3 activity/RING/RING	93.64	4.00e-158	554.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Petromyzon marinus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

FPADMSRQTG AALPNGASKT TPAQRVPALT GTTASNNDLA SLFECPVCFD YVLPPILQCQ 60
SGHLVCSACR PKLSCCPTCR GPLGSIRNLA MEKVAASVLF PCKYASSGCE VTLPHTEKPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCCAGCAG ACATGAGTCG CCAGACAGGA GCGGCGCTGC CCAACGGGGC ATCGAAAACA 60
ACGCCGGCGC AGCGCGTGCC GGCACTCACG GGCACCACGG CCTCGAACAA CGACCTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0479--Metal-binding
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	38.64	2.00e-46	177.00
IUUC-Aml-001186	Ailuropoda melanoleuca	94.01	2.00e-161	560.00
IUUC-Atr-002857	Amborella trichopoda	33.68	3.00e-45	173.00
IUUC-Apl-003813	Anas platyrhynchos	94.35	2.00e-161	559.00
IUUC-Aca-005014	Anolis carolinensis	93.73	1.00e-162	563.00
IUUC-Aly-006522	Arabidopsis lyrata	36.08	6.00e-42	162.00
IUUC-Ath-007049	Arabidopsis thaliana	33.82	6.00e-42	162.00
IUUC-Ame-011196	Astyanax mexicanus	92.61	1.00e-159	553.00
IUUC-Bta-012887	Bos taurus	93.66	8.00e-161	557.00
IUUC-Bdi-014200	Brachypodium distachyon	38.26	1.00e-45	175.00
IUUC-Bol-015523	Brassica oleracea	35.57	4.00e-42	163.00
IUUC-Bra-017336	Brassica rapa	35.02	4.00e-42	163.00
IUUC-Cel-018320	Caenorhabditis elegans	69.77	8.00e-111	392.00
IUUC-Cja-019796	Callithrix jacchus	93.66	1.00e-160	556.00
IUUC-Cfa-020642	Canis familiaris	94.01	3.00e-162	562.00
IUUC-Cpo-022348	Cavia porcellus	93.99	2.00e-160	556.00
IUUC-Csa-023974	Chlorocebus sabaeus	93.66	9.00e-161	557.00
IUUC-Cho-024933	Choloepus hoffmanni	84.58	1.00e-129	454.00
IUUC-Cin-025674	Ciona intestinalis	76.68	4.00e-132	462.00
IUUC-Csv-026233	Ciona savignyi	82.75	1.00e-129	454.00
IUUC-Dre-028041	Danio rerio	92.61	3.00e-159	552.00
IUUC-Dno-029764	Dasypus novemcinctus	93.71	3.00e-162	562.00
IUUC-Dor-030489	Dipodomys ordii	84.78	2.00e-94	335.00
IUUC-Dme-031700	Drosophila melanogaster	81.93	3.00e-117	412.00
IUUC-Ete-032423	Echinops telfairi	92.96	2.00e-151	526.00
IUUC-Eca-033536	Equus caballus	94.35	2.00e-161	559.00
IUUC-Eeu-035314	Erinaceus europaeus	92.94	6.00e-151	525.00
IUUC-Fca-035362	Felis catus	94.01	1.00e-161	560.00
IUUC-Fal-037487	Ficedula albicollis	94.01	2.00e-161	559.00
IUUC-Gmo-039091	Gadus morhua	80.15	1.00e-127	447.00
IUUC-Gga-040269	Gallus gallus	94.35	2.00e-161	559.00
IUUC-Gac-042282	Gasterosteus aculeatus	92.58	4.00e-158	548.00
IUUC-Gma-042926	Glycine max	34.28	9.00e-42	162.00
IUUC-Ggo-045444	Gorilla gorilla	93.66	9.00e-161	557.00
IUUC-Hsa-046357	Homo sapiens	93.66	9.00e-161	557.00
IUUC-Hvu-047574	Hordeum vulgare	37.23	4.00e-46	176.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	93.99	2.00e-160	556.00
IUUC-Lch-049504	Latimeria chalumnae	93.64	2.00e-160	555.00
IUUC-Lpe-050879	Leersia perrieri	40.08	9.00e-43	165.00
IUUC-Loc-052191	Lepisosteus oculatus	93.31	4.00e-160	555.00
IUUC-Laf-053668	Loxodonta africana	94.35	2.00e-161	559.00
IUUC-Mcc-054640	Macaca mulatta	93.66	9.00e-161	557.00
IUUC-Meu-055922	Macropus eugenii	83.40	3.00e-127	445.00
IUUC-Mtr-058747	Medicago truncatula	36.12	9.00e-44	169.00
IUUC-Mga-059503	Meleagris gallopavo	93.68	1.00e-161	560.00
IUUC-Mmr-060794	Microcebus murinus	93.99	2.00e-160	556.00
IUUC-Mdo-061971	Monodelphis domestica	84.58	2.00e-129	453.00
IUUC-Mmu-064129	Mus musculus	93.64	7.00e-160	554.00
IUUC-Mac-065014	Musa acuminata	35.88	8.00e-42	162.00
IUUC-Mpu-066488	Mustela putorius furo	94.01	2.00e-161	559.00
IUUC-Mlu-067207	Myotis lucifugus	94.01	5.00e-162	561.00
IUUC-Nle-069706	Nomascus leucogenys	93.66	1.00e-160	557.00
IUUC-Opr-070341	Ochotona princeps	55.19	5.00e-49	186.00
IUUC-Ont-071849	Oreochromis niloticus	91.93	9.00e-159	550.00
IUUC-Oan-073701	Ornithorhynchus anatinus	52.23	1.00e-48	184.00
IUUC-Ocu-074876	Oryctolagus cuniculus	93.66	2.00e-160	556.00
IUUC-Oba-075454	Oryza barthii	40.08	4.00e-42	163.00
IUUC-Obr-076037	Oryza brachyantha	34.40	3.00e-41	160.00
IUUC-Ogl-077712	Oryza glaberrima	40.08	4.00e-42	163.00
IUUC-Ogu-078910	Oryza glumaepatula	40.25	7.00e-42	163.00
IUUC-Oin-079749	Oryza indica	40.08	4.00e-42	163.00
IUUC-Olo-080244	Oryza longistaminata	34.13	4.00e-41	160.00
IUUC-Ome-081318	Oryza meridionalis	40.08	4.00e-42	163.00
IUUC-Oni-083109	Oryza nivara	40.08	4.00e-42	163.00
IUUC-Opu-084065	Oryza punctata	40.50	2.00e-42	164.00
IUUC-Oru-084785	Oryza rufipogon	40.08	4.00e-42	163.00
IUUC-Osa-085610	Oryza sativa	40.08	4.00e-42	163.00
IUUC-Ola-086814	Oryzias latipes	92.58	4.00e-158	548.00
IUUC-Oga-088399	Otolemur garnettii	93.99	2.00e-160	556.00
IUUC-Oar-089323	Ovis aries	93.66	9.00e-161	557.00
IUUC-Ptr-090692	Pan troglodytes	93.03	3.00e-161	559.00
IUUC-Pan-092012	Papio anubis	93.66	9.00e-161	557.00
IUUC-Psi-093687	Pelodiscus sinensis	94.01	7.00e-162	561.00
IUUC-Ppa-095212	Physcomitrella patens	34.59	2.00e-40	157.00
IUUC-Pfo-097134	Poecilia formosa	92.58	4.00e-158	548.00
IUUC-Pab-097555	Pongo abelii	93.66	9.00e-161	557.00
IUUC-Pop-099970	Populus trichocarpa	35.04	1.00e-45	174.00
IUUC-Pca-100328	Procavia capensis	82.54	3.00e-125	439.00
IUUC-Ppe-101760	Prunus persica	35.97	6.00e-45	172.00
IUUC-Pva-102368	Pteropus vampyrus	89.09	2.00e-56	211.00
IUUC-Rno-104866	Rattus norvegicus	93.64	7.00e-160	554.00
IUUC-Sha-106547	Sarcophilus harrisii	94.01	1.00e-161	560.00
IUUC-Smo-109412	Selaginella moellendorffii	33.45	8.00e-40	155.00
IUUC-Sit-110595	Setaria italica	38.10	2.00e-43	167.00
IUUC-Sly-111259	Solanum lycopersicum	36.36	1.00e-41	161.00
IUUC-Stu-112474	Solanum tuberosum	34.93	2.00e-43	167.00
IUUC-Sbi-114090	Sorghum bicolor	37.74	5.00e-44	169.00
IUUC-Ssc-116441	Sus scrofa	84.19	2.00e-129	453.00
IUUC-Tgu-116579	Taeniopygia guttata	94.35	2.00e-161	559.00
IUUC-Tru-118250	Takifugu rubripes	90.11	2.00e-153	532.00
IUUC-Tsy-119548	Tarsius syrichta	80.30	3.00e-58	216.00
IUUC-Tni-120488	Tetraodon nigroviridis	92.23	1.00e-154	536.00
IUUC-Tca-121228	Theobroma cacao	33.70	4.00e-42	163.00
IUUC-Tae-123647	Triticum aestivum	38.64	2.00e-46	177.00
IUUC-Tur-126259	Triticum urartu	33.98	4.00e-40	156.00
IUUC-Ttr-129166	Tursiops truncatus	95.04	3.00e-137	479.00
IUUC-Vpa-130799	Vicugna pacos	87.21	1.00e-90	323.00
IUUC-Vvi-131233	Vitis vinifera	34.17	4.00e-43	166.00
IUUC-Xtr-132553	Xenopus tropicalis	93.99	2.00e-160	555.00
IUUC-Xma-133670	Xiphophorus maculatus	92.58	4.00e-158	548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence