iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036564

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02078539

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000010680.2	ENSFCAT00000010683.2	ENSFCAP00000009918.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.40e-197	655.0	413	884

Active Site

Position(s)	Description	Evidence
597	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+++++llvGag++GcEllK ++l+G+     g +tv Dmd++e snl+rqFLfr +d+g++KAevaaea+++l
   Q: 413  YDGQIAVFGAGFQEKLSRQHYLLVGAGAIGCELLKGFALVGLgagasGGVTVADMDHIERSNLSRQFLFRTQDIGRPKAEVAAEAARRL 501
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           n+d +v++  +++++++e+i+   Ff+++d+V++ald+++arr+v+ +c+++ +pl+e+gt+G+lG+++v+++ +te y+++     ++
   Q: 502  NSDLQVTPLIYPLDPTTEHIYgnnFFSRVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTHGTLGHASVFMPCVTETYRAPAsaiASE 590
           ***************************************************************************************** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           + t+P+ctl+++p+++eht++wa        +l +++++ ++++ + l++ d  + ++ +++v   l+ e+++++++++ +a+ +++ +
   Q: 591  NATYPVCTLRHFPSTVEHTVQWArdefeglfRLSAETINRHQQAPTSLAEPDGLKVLTLLQEVLGVLR-ERPQTWQDCVVWALGHWQLC 678
           ************************************************************99966655.57****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++ +i qll+ f++d+v ++++ fw+                                                ++ ++   ++  +  
   Q: 679  FHDGIMQLLNRFPPDKVLEDGTLFWSgskqcpqplqfdasqdthllyvlaaanlyaqmhglpgsrdqtalrellKLRPLPVPQNLVPIF 767
           ***********************************999999999999999999999999999999999998888777777777766666 PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
             d e   as +     l+ l ++le ++  + ++p  l+fekd ds  +vd+v+aaa+lra+++gi+p ++  + k+i+g+iipai t
   Q: 768  PNDLELARASVEfgpeqLKKLHKVLEVWSGSPPLEP--LKFEKDNDSnfHVDFVAAAASLRAQNYGIPP-ANHAQSKRIVGQIIPAIVT 853
           666666666666776669999999999*99999999..9*******99*********************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknffl 400
           t+a+v+Gl+ +E++Kvv+g  + +++++  l
   Q: 854  TTAAVAGLVGLELYKVVNGprPLSAFRHSHL 884
           ******************9655566666555 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MAAPETSKLL DKERYSRQLY VLDLPAMQKI QGAKVLLSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFFLSE QDLERSRAEA SQELVAKLNR AVQVCIHTGD ITEELLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCCC CGGAGACCTC CAAGTTGCTG GATAAGGAGC GATACTCACG GCAGCTGTGA 60
GGCCCGAGGC GGGGAAGGGA ATGGGGTGGC TTTCTGACTT CTGGTCGCCG ATCGCCTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	85.13	0.00e+00	1607.00
IUUC-Bta-012665	Bos taurus	77.32	0.00e+00	1384.00
IUUC-Cja-019047	Callithrix jacchus	79.09	0.00e+00	1500.00
IUUC-Cfa-021225	Canis familiaris	85.80	0.00e+00	1656.00
IUUC-Cpo-022336	Cavia porcellus	70.00	0.00e+00	1305.00
IUUC-Csa-023462	Chlorocebus sabaeus	82.94	0.00e+00	1513.00
IUUC-Cho-024436	Choloepus hoffmanni	79.24	4.00e-103	369.00
IUUC-Dno-029347	Dasypus novemcinctus	79.88	0.00e+00	1483.00
IUUC-Dor-030997	Dipodomys ordii	74.06	0.00e+00	1402.00
IUUC-Ete-033124	Echinops telfairi	74.30	0.00e+00	963.00
IUUC-Eca-033929	Equus caballus	83.63	0.00e+00	1657.00
IUUC-Eeu-034717	Erinaceus europaeus	69.61	0.00e+00	995.00
IUUC-Ggo-044480	Gorilla gorilla	81.77	0.00e+00	1493.00
IUUC-Hsa-046498	Homo sapiens	81.95	0.00e+00	1475.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	76.21	0.00e+00	1415.00
IUUC-Laf-054119	Loxodonta africana	77.27	0.00e+00	1506.00
IUUC-Mcc-055597	Macaca mulatta	80.91	0.00e+00	1448.00
IUUC-Meu-056534	Macropus eugenii	54.49	0.00e+00	847.00
IUUC-Mdo-063058	Monodelphis domestica	57.78	0.00e+00	1079.00
IUUC-Mmu-063578	Mus musculus	71.10	0.00e+00	1395.00
IUUC-Mpu-066255	Mustela putorius furo	85.50	0.00e+00	1659.00
IUUC-Mlu-067814	Myotis lucifugus	76.93	0.00e+00	1365.00
IUUC-Nle-069193	Nomascus leucogenys	81.36	0.00e+00	1486.00
IUUC-Opr-070715	Ochotona princeps	70.81	0.00e+00	1328.00
IUUC-Oan-073306	Ornithorhynchus anatinus	54.34	0.00e+00	755.00
IUUC-Ocu-074162	Oryctolagus cuniculus	76.45	0.00e+00	1409.00
IUUC-Oga-088895	Otolemur garnettii	76.31	0.00e+00	1398.00
IUUC-Oar-089579	Ovis aries	76.79	0.00e+00	1375.00
IUUC-Ptr-090581	Pan troglodytes	82.31	0.00e+00	1449.00
IUUC-Pan-092458	Papio anubis	82.64	0.00e+00	1502.00
IUUC-Pab-098653	Pongo abelii	76.73	0.00e+00	1407.00
IUUC-Pca-100578	Procavia capensis	74.84	0.00e+00	921.00
IUUC-Pva-102914	Pteropus vampyrus	80.07	0.00e+00	1259.00
IUUC-Rno-106066	Rattus norvegicus	71.88	0.00e+00	1422.00
IUUC-Sha-107368	Sarcophilus harrisii	60.26	0.00e+00	1140.00
IUUC-Ssc-115743	Sus scrofa	81.26	0.00e+00	1518.00
IUUC-Tbe-127587	Tupaia belangeri	73.23	0.00e+00	1213.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence