iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Meu-056534

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

UBE1Y1

Genbank Nucleotide ID

GATO01000014

Gene Name

UBA7; UBE1Y1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMEUG00000016744.1	ENSMEUT00000016799.1	ENSMEUP00000015306.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.20e-143	478.9	393	812

Active Site

Position(s)	Description	Evidence
632	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G++ q+kl++++++lvGag++GcEllK+++++G+     g +tv+Dmdtve+snl+rqFLfr +d  k+K+e+aa a++ +
   Q: 393  YDGQIAVFGDDFQKKLGKQRYFLVGAGAIGCELLKTFAMLGLgagqgGGVTVTDMDTVELSNLSRQFLFRSQDLNKPKSEAAALAVRSM 481
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np ++v+ h++++ +++e+i+   Ff+ +d+Vv+ald+++ar++v ++c+++ +p++esgt G+ G + ++++ lt  y+   ++ ++ 
   Q: 482  NPTISVTTHTNELGPDTEHIFgdnFFSSLDGVVCALDSFQARKYVSKRCVHYMKPMLESGTQGTQGSAAIFVPSLTQPYNTLSEDAETV 570
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           +P+ctl+++p+++eht++wa            +++n +l+e+      +++++  ++++ ++ v        ++ + +++ +a+ +++ 
   Q: 571  YPVCTLRHFPSTIEHTLQWArnefeglfrlpaEMINRYLQEQ------TSRMEGPQTLDYLKTV----LLSPPQCWRDCVVWARGHWQH 649
           ****************************88888888888554......4455666677777777....556899*************** PP
   S: 248  ttinsikqllksfecdivtkskspfwv...................................................sfcsnaealqv 285
           +++ si  ll++f++d+v+++++pfw+                                                   s + +  ++  
   Q: 650  CFHDSIAHLLQYFPHDKVNTEGVPFWSgtkrcpqplefdvsrdthvdyilaaanlyakthkllgsedrdelrvmlqtlSAPAFHLQAHA 738
           *****************************************************999999999999999988888877666666666666 PP
   S: 286  pekvekdeevvkasap..lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepklddd 356
           p  ++++e +++++++                            ddds  ++d++ aa+nlrae++gi+p +d++
   Q: 739  PIFANDQEFEQASAKWxxXXXXXXXXXXXXXXXXXXXXXXXXXXDDDSnfHMDFIVAASNLRAENYGIPP-ADRS 812
           66666666655555557733333444444444444444555666666668********************.8876 PP

Organism

Macropus eugenii

Protein Sequence
(Fasta)

YVLGTDAMRR LRGSSMLVSG MKGLGVEIAK NLVLAGVGQL TLHDPSPTCW MDLASQFFLS 60
EKDVGRNRAE ASLPHLAQLX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATGTCCTGG GCACAGATGC CATGAGGAGA CTACGGGGGT CTTCCATGCT GGTGTCTGGC 60
ATGAAGGGGC TAGGTGTCGA GATTGCCAAG AACCTAGTCC TGGCCGGAGT GGGCCAACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019047	Callithrix jacchus	48.69	0.00e+00	844.00
IUUC-Csa-023462	Chlorocebus sabaeus	49.65	0.00e+00	848.00
IUUC-Cho-024436	Choloepus hoffmanni	55.30	2.00e-65	243.00
IUUC-Dno-029347	Dasypus novemcinctus	54.73	0.00e+00	832.00
IUUC-Ete-033124	Echinops telfairi	53.93	0.00e+00	677.00
IUUC-Eca-033929	Equus caballus	49.65	0.00e+00	891.00
IUUC-Eeu-034717	Erinaceus europaeus	49.70	0.00e+00	684.00
IUUC-Fca-036564	Felis catus	54.49	0.00e+00	817.00
IUUC-Ggo-044480	Gorilla gorilla	49.24	0.00e+00	829.00
IUUC-Hsa-046498	Homo sapiens	49.35	0.00e+00	817.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	47.81	0.00e+00	807.00
IUUC-Mcc-055597	Macaca mulatta	48.35	0.00e+00	792.00
IUUC-Mdo-063058	Monodelphis domestica	61.59	0.00e+00	1127.00
IUUC-Mlu-067814	Myotis lucifugus	46.77	0.00e+00	760.00
IUUC-Nle-069193	Nomascus leucogenys	49.05	0.00e+00	824.00
IUUC-Oan-073306	Ornithorhynchus anatinus	59.70	0.00e+00	756.00
IUUC-Ocu-074162	Oryctolagus cuniculus	48.89	0.00e+00	843.00
IUUC-Oga-088895	Otolemur garnettii	53.62	0.00e+00	796.00
IUUC-Oar-089579	Ovis aries	51.28	0.00e+00	761.00
IUUC-Ptr-090581	Pan troglodytes	49.45	0.00e+00	815.00
IUUC-Pan-092458	Papio anubis	49.55	0.00e+00	835.00
IUUC-Pab-098653	Pongo abelii	54.24	0.00e+00	800.00
IUUC-Pva-102914	Pteropus vampyrus	52.36	0.00e+00	699.00
IUUC-Sha-107368	Sarcophilus harrisii	64.52	0.00e+00	1236.00
IUUC-Tbe-127587	Tupaia belangeri	54.99	0.00e+00	704.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence