iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000020034.1	ENSONIT00000025254.1	ENSONIP00000025233.1
ENSONIG00000020034.1	ENSONIT00000025255.1	ENSONIP00000025234.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.80e-94	315.7	89	736

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenp..................kepkgellkslqklfeelwkskkk 66
           GlkN+gNtC+mN++LQcLsn++ ++e+l        +   ++ +  +                  + ++ge++++l  l+++lw+ + +
   Q: 89   GLKNHGNTCFMNAILQCLSNTELFAEYLALeqfkggE---TTGN--NdkaksngvlvqkkgggqqQPETGEVTEQLSGLVRALWTFEYT 172
           9**************************9986664431...2222..123556677777777777677788******************* PP
   S: 67   avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsdeaeekkkkknkslisdlFq 147
               r+++++++k a +f+g++q+DaqEfl +lld+++e+l++         ++ p+e          +   e ++     s++++lFq
   Q: 173  PQHSRDFKNVVSKSALQFKGNSQHDAQEFLLWLLDRVHEDLNQivpldsrlPRKPPVE---------EETVPEGSPLPAPGSFVQELFQ 252
           *****************************************77543333222222222.........22223456677777******** PP
   S: 148  gqlksqikclecdnvssreepfldlslpvpgkeetkke................................................... 185
            q++s+++c++c+++s++++pfl +slp+p  +++ ++                                                   
   Q: 253  AQYRSSLTCPHCQKQSNTFDPFLCISLPIPVPHTR-PLyvtvvyqgkcshcmrvgvavplsgtvsrlrqavaqetkipaqqivltemyy 340
           ******************************88855.44699************************************************ PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 341  dgfhrsfcdddddleiiqesdsifafetpelfrpeqirskrcgsphanlnqnnlkygtdnnrmstqiqepttppqspnknsgqaekivl 429
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 430  lvcnracagqqgrrfgnpfilylertvtwdvlqkeilekmrhllrpgvfvqvgpftlrvvgvvgityllpqeeqplchpsveraykscg 518
           ***************************************************************************************** PP
   S: 186  .................................................slqdcLesftkeeelegenkyycekckkkqeaekklklkk 225
                                                            +l +c++ +tkee+l  ++++ c++ck++q+ + kl+l++
   Q: 519  pggpphvkivvewdketkdylfkrtedeyipdaesvrqvkeqhlqpqtcTLAQCFQLYTKEEQLAPDDAWRCPHCKQLQQGSIKLSLWT 607
           ***************************************************************************************** PP
   S: 226  lPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekqke...................kkkYeLiavvvHsGslssGH 294
           lP++LilhLkRf  ++++++r k+++ v+fpl+ +d++p+++++++++ +                   ++ Y+L+av++H+G++++GH
   Q: 608  LPDILILHLKRF--RQDGDRRMKMQNMVKFPLTgMDMAPHMVKRSQSSWSlpshwspwrrpygmgrdpeDYLYDLYAVCNHHGTMQGGH 694
           ************..89999************************66665558999999999999999999******************** PP
   S: 295  Yvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           Y+a++kn  +g+W++fdDs V++++e+ev++   +taY+lfY+rr
   Q: 695  YTAHCKNsIDGQWYCFDDSDVHPMSEDEVCK---QTAYILFYQRR 736
           *******66888*******************...*********96 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSKVVSNKEK KSFSKKLFRR SSVRSVGSFM SRVLRTLSTL SHFGTDEQAA EDETDEATLL 60
PNTTGGSLPS DDSDCGGFPF GDKVPGVAGL KNHGNTCFMN AILQCLSNTE LFAEYLALEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAAAG TTGTGAGTAA CAAGGAGAAA AAATCCTTCA GCAAAAAGCT GTTCCGGAGG 60
AGCTCGGTGC GCTCCGTGGG GAGCTTTATG AGCAGAGTTC TCCGGACTCT CTCGACTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001207	Ailuropoda melanoleuca	67.56	0.00e+00	1083.00
IUUC-Aca-004949	Anolis carolinensis	67.00	0.00e+00	1092.00
IUUC-Bta-013271	Bos taurus	73.93	0.00e+00	1091.00
IUUC-Cja-019663	Callithrix jacchus	75.25	0.00e+00	980.00
IUUC-Cfa-021258	Canis familiaris	67.10	0.00e+00	1116.00
IUUC-Cho-024813	Choloepus hoffmanni	63.84	0.00e+00	833.00
IUUC-Csv-026086	Ciona savignyi	40.66	2.00e-135	476.00
IUUC-Dno-029964	Dasypus novemcinctus	67.66	0.00e+00	1003.00
IUUC-Ete-032975	Echinops telfairi	55.24	0.00e+00	724.00
IUUC-Eca-034030	Equus caballus	69.44	0.00e+00	1067.00
IUUC-Eeu-034629	Erinaceus europaeus	57.81	0.00e+00	683.00
IUUC-Fca-035788	Felis catus	69.35	0.00e+00	1058.00
IUUC-Fal-036874	Ficedula albicollis	74.43	0.00e+00	981.00
IUUC-Gmo-039164	Gadus morhua	85.81	0.00e+00	1276.00
IUUC-Gga-041092	Gallus gallus	67.91	0.00e+00	1132.00
IUUC-Gac-041609	Gasterosteus aculeatus	83.90	0.00e+00	1850.00
IUUC-Hsa-046805	Homo sapiens	74.53	0.00e+00	1122.00
IUUC-Itr-048158	Ictidomys tridecemlineatus	68.88	0.00e+00	1011.00
IUUC-Mga-060115	Meleagris gallopavo	72.28	0.00e+00	1016.00
IUUC-Mmr-061150	Microcebus murinus	66.52	0.00e+00	1088.00
IUUC-Mmu-063512	Mus musculus	68.81	0.00e+00	1094.00
IUUC-Mpu-066059	Mustela putorius furo	64.32	0.00e+00	920.00
IUUC-Mlu-067870	Myotis lucifugus	71.66	0.00e+00	1040.00
IUUC-Nle-069898	Nomascus leucogenys	68.65	0.00e+00	1121.00
IUUC-Opr-070338	Ochotona princeps	60.37	0.00e+00	642.00
IUUC-Oan-073175	Ornithorhynchus anatinus	75.60	0.00e+00	1015.00
IUUC-Ola-087303	Oryzias latipes	79.11	0.00e+00	1740.00
IUUC-Oar-090016	Ovis aries	74.16	0.00e+00	1097.00
IUUC-Ptr-090864	Pan troglodytes	68.42	0.00e+00	1120.00
IUUC-Pfo-097427	Poecilia formosa	83.10	0.00e+00	1809.00
IUUC-Pab-098104	Pongo abelii	66.59	0.00e+00	1070.00
IUUC-Pca-100640	Procavia capensis	72.93	2.00e-95	344.00
IUUC-Pva-102287	Pteropus vampyrus	72.82	0.00e+00	923.00
IUUC-Rno-106033	Rattus norvegicus	66.99	0.00e+00	1085.00
IUUC-Tru-118340	Takifugu rubripes	82.92	0.00e+00	1786.00
IUUC-Tsy-118887	Tarsius syrichta	61.37	0.00e+00	912.00
IUUC-Tni-120463	Tetraodon nigroviridis	82.21	0.00e+00	1843.00
IUUC-Ttr-128210	Tursiops truncatus	62.66	0.00e+00	1067.00
IUUC-Vpa-130222	Vicugna pacos	64.77	5.00e-173	601.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence