iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004577

UUCD1 version

UUC-AnC-00662

Ensembl Protein ID

ENSACAP00000008962.2

UniProt Accession

G1KII6; G1KII6_ANOCA

Protein Name

Uncharacterized protein

Gene Name

UBR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000008995.3	ENSACAT00000009154.3	ENSACAP00000008962.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-79	266.4	2114	2436

Active Site

Position(s)	Description	Evidence
2406	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 2114 ENRKRHGSSRSVVDMELDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 2196
           556777999999999999999988777888234444777777777765....89********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+++G nipVt +N +eYv++++e+r+  
   Q: 2197 LGRKVNWHDFAFFDPVMYESlRQLILASQstDADAVFAAMDLAFAIDLCKEEGGGQVELISNGVNIPVTPQNVYEYVRKYAEHRMLV 2283
           ********************5555666655566889999************************************************ PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2284 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2370
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2371 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2436
           *********999******..799999.99**********************************9.99875 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

DGMKFISIGA LYSELVAVSS KGELYQWKWS ESEPYRNAQN PSIHHPRAGS LGLTNEKIVL 60
LSANSIRATV ATENNKVATW VDETLSSVAS KLEHTAQTYS ELQGERIVSL HCCALYTCAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGGAATGA AATTTATTTC TATTGGTGCT TTGTATTCTG AACTAGTAGC AGTGAGCAGT 60
AAAGGGGAAC TCTATCAGTG GAAGTGGAGT GAATCTGAAC CATACCGGAA CGCACAGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	97.17	0.00e+00	3971.00
IUUC-Apl-004165	Anas platyrhynchos	97.33	0.00e+00	4005.00
IUUC-Ame-010702	Astyanax mexicanus	84.98	0.00e+00	2476.00
IUUC-Bta-012313	Bos taurus	96.84	0.00e+00	3986.00
IUUC-Cel-018165	Caenorhabditis elegans	35.08	5.00e-67	251.00
IUUC-Cja-019858	Callithrix jacchus	96.76	0.00e+00	4006.00
IUUC-Cfa-020973	Canis familiaris	97.05	0.00e+00	3994.00
IUUC-Cpo-022108	Cavia porcellus	95.22	0.00e+00	1851.00
IUUC-Csa-023985	Chlorocebus sabaeus	96.92	0.00e+00	4011.00
IUUC-Cho-025034	Choloepus hoffmanni	87.66	0.00e+00	978.00
IUUC-Cin-025715	Ciona intestinalis	45.30	0.00e+00	799.00
IUUC-Csv-026088	Ciona savignyi	39.69	6.00e-153	534.00
IUUC-Dre-027730	Danio rerio	88.40	0.00e+00	3554.00
IUUC-Dno-029123	Dasypus novemcinctus	94.06	0.00e+00	3826.00
IUUC-Dor-030757	Dipodomys ordii	91.87	0.00e+00	2321.00
IUUC-Dme-032192	Drosophila melanogaster	52.07	1.00e-173	605.00
IUUC-Ete-032292	Echinops telfairi	93.81	0.00e+00	2105.00
IUUC-Eca-034347	Equus caballus	96.64	0.00e+00	3933.00
IUUC-Eeu-034873	Erinaceus europaeus	91.71	0.00e+00	3768.00
IUUC-Fca-036485	Felis catus	95.54	0.00e+00	3885.00
IUUC-Fal-037071	Ficedula albicollis	98.03	0.00e+00	4002.00
IUUC-Gmo-039589	Gadus morhua	88.19	0.00e+00	3565.00
IUUC-Gga-041195	Gallus gallus	96.14	0.00e+00	3896.00
IUUC-Gac-042538	Gasterosteus aculeatus	88.02	0.00e+00	3596.00
IUUC-Ggo-045351	Gorilla gorilla	95.94	0.00e+00	4045.00
IUUC-Hsa-045941	Homo sapiens	96.76	0.00e+00	4027.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	96.47	0.00e+00	3988.00
IUUC-Lch-050480	Latimeria chalumnae	94.46	0.00e+00	3901.00
IUUC-Loc-052664	Lepisosteus oculatus	89.50	0.00e+00	3683.00
IUUC-Laf-053960	Loxodonta africana	95.07	0.00e+00	1532.00
IUUC-Mcc-054703	Macaca mulatta	96.92	0.00e+00	4013.00
IUUC-Meu-056431	Macropus eugenii	88.10	0.00e+00	803.00
IUUC-Mga-059289	Meleagris gallopavo	97.61	0.00e+00	3590.00
IUUC-Mmr-061737	Microcebus murinus	96.43	0.00e+00	3938.00
IUUC-Mdo-062499	Monodelphis domestica	97.01	0.00e+00	3976.00
IUUC-Mmu-063273	Mus musculus	95.86	0.00e+00	3943.00
IUUC-Mpu-066907	Mustela putorius furo	97.01	0.00e+00	3959.00
IUUC-Mlu-067942	Myotis lucifugus	96.68	0.00e+00	3991.00
IUUC-Nle-069527	Nomascus leucogenys	96.76	0.00e+00	4034.00
IUUC-Opr-070626	Ochotona princeps	84.16	0.00e+00	1367.00
IUUC-Ont-071951	Oreochromis niloticus	88.10	0.00e+00	3556.00
IUUC-Oan-072958	Ornithorhynchus anatinus	97.58	0.00e+00	3964.00
IUUC-Ocu-074503	Oryctolagus cuniculus	94.10	0.00e+00	3882.00
IUUC-Ola-086757	Oryzias latipes	87.95	0.00e+00	3611.00
IUUC-Oga-088781	Otolemur garnettii	96.72	0.00e+00	3975.00
IUUC-Oar-089274	Ovis aries	96.80	0.00e+00	3952.00
IUUC-Ptr-090669	Pan troglodytes	96.77	0.00e+00	3917.00
IUUC-Pan-092226	Papio anubis	96.80	0.00e+00	4004.00
IUUC-Psi-093502	Pelodiscus sinensis	97.83	0.00e+00	3993.00
IUUC-Pma-094454	Petromyzon marinus	82.60	0.00e+00	731.00
IUUC-Pfo-096173	Poecilia formosa	88.00	0.00e+00	3589.00
IUUC-Pab-098355	Pongo abelii	96.66	0.00e+00	2828.00
IUUC-Pca-100570	Procavia capensis	95.10	0.00e+00	1109.00
IUUC-Pva-102572	Pteropus vampyrus	92.51	0.00e+00	1292.00
IUUC-Rno-104916	Rattus norvegicus	94.18	0.00e+00	3855.00
IUUC-Sha-106653	Sarcophilus harrisii	97.21	0.00e+00	3996.00
IUUC-Sar-113517	Sorex araneus	96.54	0.00e+00	1115.00
IUUC-Ssc-115470	Sus scrofa	97.97	0.00e+00	2490.00
IUUC-Tgu-116932	Taeniopygia guttata	97.75	0.00e+00	3984.00
IUUC-Tru-117682	Takifugu rubripes	88.23	0.00e+00	2585.00
IUUC-Tsy-119417	Tarsius syrichta	93.32	0.00e+00	2432.00
IUUC-Tni-120442	Tetraodon nigroviridis	83.93	0.00e+00	3268.00
IUUC-Tbe-127456	Tupaia belangeri	83.94	0.00e+00	2043.00
IUUC-Ttr-128606	Tursiops truncatus	94.69	0.00e+00	1087.00
IUUC-Vpa-130112	Vicugna pacos	94.26	0.00e+00	3632.00
IUUC-Xtr-131929	Xenopus tropicalis	93.77	0.00e+00	3915.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence